Theoretical Biology and Biophysics Group (T-10),
Los Alamos National Laboratory,
Los Alamos, NM 87544, USA
Phone: (505) 667-4111 (w), (505) 983-2060 (h)
Fax: (505) 665-3493
e-mail: mblinov@lanl.gov (w)
URR: http://cellsignaling.lanl.gov/mblinov
HIGHLIGHTS
Development of algorithms and software tools for modeling and analysis of biomolecular interactions.
Modeling of complex signal-transduction systems (EGF receptor system , FceRI receptor system for the IgE antibody, MAPK cascade).
Extensive database, Perl and web programming experience.
Extensive research experience with ODE and dynamical systems. Extensive math background.
Project management skills (coordinator of several programming and educational projects).
M.L. Blinov, J. Yang, J.R. Faeder, and W.S. Hlavacek
(in press)
Graph Theory for Rule-based Modeling of Biochemical Networks, Lect. Notes Comp. Sc. Trans. Syst. Biol. [pdf]
M.L. Blinov, J. Yang, J.R. Faeder and W.S. Hlavacek (2006) Depicting signaling cascades Nat. Biotech.24.
M.L. Blinov, J.R. Faeder, J. Yang, B. Goldstein and W.S. Hlavacek (2005) 'On-the-fly' or 'generate-first' modeling? Nat. Biotech.23, 1344-45.[pdf]
M.L. Blinov, J.R. Faeder, B. Goldstein & W.S. Hlavacek (2005) A network model of early events in epidermal growth factor receptor signaling that accounts for combinatorial complexity. BioSystems[pdf]
J.R. Faeder*, M.L. Blinov*, B. Goldstein & W.S. Hlavacek (2005) "Rule-based modeling of biochemical networks." Complexity10, 22-41. [pdf]
* These two authors contributed equally to the manuscript
J.R. Faeder, M.L. Blinov, B. Goldstein & W.S. Hlavacek (2005) "Combinatorial complexity and dynamical restriction of network flows in signal transduction." Syst. Biol.2, 5-15 [Reprint (pdf)]
M. Blinov, M. Briskin, Y. Yomdin. (2004) "Local Center Conditions for Abel Equation and Cyclicity of it Zero Solution." J. d'Anal. Math. (in press, pdf)
M. L. Blinov, J. R. Faeder, B. Goldstein, W. S. Hlavacek. (2004) "BioNetGen: software for rule-based modeling of signal transduction based on the interactions of molecular domains." Bioinformatics20, 3289-3291.(pdf)
W. S. Hlavacek, J. R.
Faeder, M. L. Blinov, A. S. Perelson, B. Goldstein. (2003) "The complexity of
complexes in signal transduction." Biotechnol. Bioeng. 84: 783-794. ( pdf )
M. Blinov, N. Roytvarf, Y. Yomdin. (2003) "Center and Moment Conditions for Rational Abel Equation." Funct. Diff. Equations,
10: 95-106 ( pdf )
J. R. Faeder, W. S. Hlavacek, I. Reischl, M. L. Blinov, H. Metzger, A. Redondo, C. Wofsy, and B. Goldstein. (2003) "Investigation of early
events in FceRI-mediated signaling using a detailed mathematical model." J. Immunol.170: 3769-81 ( pdf )
M. Blinov, N. Zehavi, S. Black. (2003) "A Computer Motivated Study of Problems in Number Theory." The International Journal of Computer Algebra in Mathematics Education9: 315-330 ( MS Word).
B. Goldstein, J. R. Faeder, W. S. Hlavacek, M. L. Blinov, A. Redondo, and C. Wofsy.
(2002) "Modeling the early signaling events mediated by aggregation of FceRI." Mol Immunol38: 1213-1219.
(PUBMED abstract | Full text pdf)
M. Blinov, Y. Yomdin. (2001) "Center and Composition Conditions for Abel Differential Equation, and rational curves." ,
Qualitative Theory of Dynamical Systems2: 111-127
(Postscript)
M. Blinov, Y. Yomdin. (1999) "Generalized center conditions and multiplicities for polynomial Abel
equations of small degrees." Nonlinearity , 12: 1013-1028.
(Abstract, ps, pdf).
PATENTS
Blinov M, Faeder J, Hlavacek W, Software and procedures for creating mathematical/computational models of cellular signaling. US Patent Application 20050042663 (2005), available at http://uspto.gov.
Patent application in preparation
PROPOSALS
M.L. Blinov, J.R. Faeder, B. Goldstein, A. Finney & W.S. Hlavacek (2004) "Rule-based modeling of multi-component species." A proposal for SBML Level 3 presented at the 9th SBML Forum. [pdf]
Reviwer for
Bioinformatics
BioSystems
TALKS
"Graph Theory for Rule-based Modeling of Biochemical Networks"BioConcur 2005, San Francisco, CA, August 27th, 2005
"A Model of Epidermal Growth Factor Receptor Signaling: accounting for
combinatorial complexity"TJU, Philadelphia, February 10th, 2005
"Rule-based modeling of multi-component species." 9th SBML Forum, Heidelberg, Germany, October 14-15, 2004
"Modeling and analysis of signal transduction without ignoring combinatorial complexity." 4th International Conference of Systems Biology, Heidelberg, Germany, October 8-13, 2004
"Modeling and analysis of combinatorial complexity in signal transduction." Understanding Complex Systems Symposium, Urbana-Champaign, IL, May 17-20, 2004
"Center and moment conditions for rational Abel equations on a closed curve. ",
Conference on "Bifurcations de systèmes différentiels, applications à la biologie."
Marseiile, France, December 16-20, 2002
Abel Differential Equations on Rational Curves." Summer School on Dynamics Systems, CIME, Cetraro, Italy, June
18-26, 2000
"Center and Composition Conditions for Abel equation, and Rational Curves."
Conference on "Geometrie des equations differentielles",
Marseille, France, October 3-10, 1999
SELECTED PUBLISHED ABSTRACTS
M. L. Blinov, J. R. Faeder, B. Goldstein, W. S. Hlavacek. "BIONETGEN: a modeling tool that handles combinatorial complexity", Mathematical Models in Signaling Systems, Nashville, TN, June 16-18, 2004
M. L. Blinov, J. R. Faeder, B. Goldstein, W. S. Hlavacek. "Modeling and analysis of combinatorial complexity in signal transduction", International Conference on Complex Systems (ICCS2004), Boston, MA, May 19-21, 2004
W. S. Hlavacek, M. L. Blinov, M. A. Savageau, M. E. Wall "The EcoTFs Database: Escherichia Coli Transcription Factors and Signals", RECOMB 2004, San Diego, CA, March 27-31, 2004
M. L. Blinov, J. R. Faeder, W. S. Hlavacek, B. Goldstein
"Network model for early events in EGFR signaling that accounts for hundreds of protein complexes and phosphoforms", Proceedings of the Fourth International Conference on Systems Biology, St Louis, USA, 2003, p. 89-90
(pdf)
J. R. Faeder, M. L. Blinov, W. S. Hlavacek, B. Goldstein. "Networks that govern Complex Formation during Signal Transduction Exibit Narrow Flows", Proceedings of the 4th International Conference on Systems Biology, St Louis, USA, November 5-9, 2003, p. 115-116
M. L. Blinov, J. R. Faeder, W. S. Hlavacek, "Combinatorial complexity in immunoreceptor signaling", Proceedings of the Third International Conference on Systems Biology, Stockholm, Sweden, December 10-15, 2002, p. 58 (pdf)
M. L. Blinov, W. S. Hlavacek, J. R. Faeder, B. Goldstein
"Database of Models for Ligand-Receptor Binding in XML-based formats", Proceedings of the Second International Conference on Systems Biology, Pasadena, USA, November 4-7, 2001, p. 125 (pdf)
J. R. Faeder, W. S. Hlavacek, A. Redondo, C. Wofsy, M. L. Blinov, and Byron Goldstein. "A detailed kinetic model of immuno-receptor signaling", Proceedings of the 2nd International Conference on Systems Biology, Pasadena, USA, November 4-7, 2001, p. 17
M. L. Blinov, W. S. Hlavacek, J. R. Faeder, B. Goldstein. "Analysis of Cell-Signaling Networks: Which Reactions in the Network are Important?" Bridging the Canyon: Biology at LANL", Santa Fe, NM, September 12-13, 2001
THESISES
"Center and Composition Conditions for Abel Equation", Ph.D. Thesis, Weizmann Institute
of Science, 2002 ( ps | pdf ).
"Some computations around the Center problem, related to the
algebra of univalued polynomials", M.Sc. Thesis, Weizmann Institute
of Science, 1997 (ps | pdf).
VISITING SCIENTIST
2004, October-November Weizmann Institute of Science
AWARDS
"BioNetGen" software nominated by Los Alamos National Lab for 2004 R&D 100 competition.
Student Distinguished Performance Award, Los Alamos Natl Lab, 2003
Fellowships of the Weizmann Institute of Sciences, 1995-2002
The National Academy of Sciences Travel Grant, 1999
International Science Foundation Research Grant #MQO000, 1994-1995
International Science Foundation Student Grant for distinguished
successes in studies, 1994-1995
2003 Lecturer at the Summer School on Neural Networks, Santa Fe Institute.
1999-2000 Lecturer for the course "Mathematical Modeling in Biology" (Prof. Lee Segel, WIS)
1998 Teaching assistant for the course "Computer Algebra Systems" (Dr. N. Zehavi, WIS)
1997-1998 Mentor, Summer Science Institute of the WIS, International and Israeli Camps. Supervised 2 preuniversity students working on
scientific projects.
PROJECT MANAGEMENT SKILLS
Programming Team leader, 1999-2001. Supervised stuff of 2
programmers. Duties included software and hardware purchase, projects
description and negotiations with customers.
Coordinator of Math projects, 1999-2000. Summer Science Institute of the WIS,
International Camp. Duties included hiring mentors and selecting students
(interviewing and overall assessment), training mentors, preparation of reports,
presentations, checking results and considering all the claims.
ADDITIONAL MATH SKILLS
Vision algorithms and image processing
Bioinformatics
Numerical methods, cryptography
Low dimensional topology, knots and links
Educational methods
REFERENCES
B. Goldstein, Lab Fellow, Theor. Biol., Los Alamos National Lab,
bxg@lanl.gov