Main kinase page
AGC kinases

agc tree, pdf
AGC tree with Pfam domains included
agc alinment, pdf (warning!! residues are deleted)

Additional domains and groups

Pfam links : DAG_PE-bind cNMP_binding PH HR1 Pkinase_C RGS C2 CNH POLO_box PDZ PAC PB1 PX M MIT NAF

pdb links
(1ol6) (1ol5) (1ol7) (1mq4) AUR1
(1muo) AUR2
(1omw) GPRK2 / bARK1
(1h1w) PDK1
(1o6k) (1gzk) (1gzn) (1mrv) (1mry) (1gzo) (1o6l) AKT 2
(1fot) yeast PKA
(1q8w) (1q24) (1q62) (1q61) (1q8t) (1q8u) (1stc) (1ydr) (1yds) (1ydt) (1cdk) (1cmk) (1ctp) (1apm) (1atp) (2cpk) (1j3h) (1fmo) (1jlu) (1l3r) (1jbp) (1bkx) (1bx6) PKACa

Phospho.ELM links: PKA x (A); Akt x (B); SGK x (C); p70S6K x (F); PDK1 (G);

AGC A group, including PRKY.h PRKX.h PKACa.h PKACg.h PKACb.h
AGC B group, including PKCt.h PKCd.h PKCe.h PKCi.h PKCz.h PKCh.h PKCa.h PKCb.h PKCg.h PKN3.h PKN1.h PKN2.h AKT3.h AKT1.h AKT2.h
AGC C group, including RHOK.h GPRK7.h GPRK6ps.h GPRK6.h GPRK5.h GPRK4.h BARK2.h BARK1.h SGK3.h SGK2.h SGK.h
AGC D group, including MASTL.h NDR2.h NDR1.h ROCK2.h ROCK1.h CRIK.h DMPK1.h MRCKb.h MRCKa.h DMPK2.h LATS2.h LATS1.h
AGC E group, including ULK2.h ULK1.h PLK1.h PKG2.h PKG1.h MAST2.h MAST1.h MAST3.h MAST4.h
AGC F group, including MSK2.h MSK1.h RSK3.h RSK4.h RSK2.h RSK1.h SgK494.h p70S6Kb.h p70S6K.h RSKL2.h
AGC G group, including TLK1.h PDK1.h AurC.h AurB.h AurA.h AurAps1.h YANK1.h YANK3.h YANK2.h

Sequence entropy, over all 4600 protein kinases (red) and 511 agc kinases (green)
residues which distinguish AGC family from other families (PKA as ref): F265 G103 P264 K38 G174 F399 G10 V15 W398 I280

residues in order of increasing entropy
246 10 161 156 34 223 251 61 15 380 222 248 154 158 180 155 13 103 182 146 159 264 32 8 181 163 265 215 221 216 260 219 141 255 178 249 174 145 104 164 38 252 12 7 160 157 134 126 105 399

covariation analysis
crystal structure of PKA (1l3r.pdb) with residues numbered according to alignment
residues in order of decreasing number of covariation partners
283 57 106 213 62 37 218 54 83 107 371 273 76 210 91 82 30 60 85 266 133 56 372 263 44 217 175 6 40 14 65 358 214 212 354 352 279 112 187 59 185 276 274 239 369 136 211 42 67 41

list of covariation partners, PKACa.human sequence as reference
PKA residue,number (entropy) -- covariation partners

F1 (2.07) covaries with -- 5 19 30 32 38 66 82 84 85 108
E2 (3.53) covaries with -- 9 19 20 21 30 33 37 57 106 112 188 206 227 240 256 262 266 279 280
R3 (3.44) covaries with -- 16 18 33 37 54 60 135 188 213 273
I4 (2.97) covaries with -- 17 33 37 44 57 60 63 107 137 174 175 239 247 283 389
K5 (3.11) covaries with -- 1 16 30 82 98 106 108 134 175 226 243 371 372
T6 (3.36) covaries with -- 9 12 14 36 37 40 53 54 56 62 66 83 85 92 133 147 164 185 186 188 205 210 217 271 283 354 386
L7 (1.90) covaries with --
G8 (1.15) covaries with -- 67 68 77 114 210 212 214 372 378
T9 (3.27) covaries with -- 2 6 14 29 30 40 59 66 82 130 206 211 278
G10 (0.15) covaries with --
S11 (2.50) covaries with -- 40 44 65 78 83 92 107 115 175 187 188 206 226 239 273 371
F12 (1.89) covaries with -- 6 40 42 83 92 147 165 177 182 185 188 354 355
G13 (1.06) covaries with -- 17 57 240 283
R14 (3.01) covaries with -- 6 9 30 42 56 82 106 107 114 147 185 187 188 203 207 210 218 244 266 271 273 352 356 371 378 386
V15 (0.57) covaries with -- 18 33 55 57 58 136 174 179
M16 (3.51) covaries with -- 3 5 35 53 152 166 183 184 188 208 213 227 274 279 354 364 365 368 369 372
L17 (2.84) covaries with -- 4 13 30 33 40 57 60 80 81 133 136 213 218 244 256 267
V18 (2.30) covaries with -- 3 15 31 33 79 174
K19 (2.98) covaries with -- 1 2 20 30 36 65 76 82 109 188 278
H20 (3.64) covaries with -- 2 19 22 30 37 39 60 66 82 83 106 188 203 371
K21 (3.34) covaries with -- 2 91
E22 (3.75) covaries with -- 20 188 211 392
-23 (3.35) covaries with --
-24 (3.18) covaries with --
-25 (3.66) covaries with --
-26 (2.93) covaries with -- 107
T27 (3.14) covaries with --
G28 (3.47) covaries with --
N29 (3.78) covaries with -- 9 42 44 55 56 67 82 83 186 206 266 268 275
H30 (3.53) covaries with -- 1 2 5 9 14 17 19 20 37 40 57 59 60 66 77 82 84 85 93 98 106 108 128 131 174 175 178 218 271 279 283
Y31 (2.43) covaries with -- 18 37 38 42 44 76 82 83 85 91 136 140 175 247
A32 (1.13) covaries with -- 1 33 63 77 158
M33 (2.69) covaries with -- 2 3 4 15 17 18 32 59 83 84 85 91 95
K34 (0.48) covaries with --
I35 (3.10) covaries with -- 16 91 98 144 152 188 210
L36 (2.31) covaries with -- 6 19 41 94
D37 (3.29) covaries with -- 2 3 4 6 20 30 31 39 42 44 54 55 62 65 66 76 78 83 85 87 101 106 130 133 165 175 185 187 188 203 217 226 239 244 247 259 266 358 389
K38 (1.85) covaries with -- 1 31 83 84 85 86 91 92 93 224
Q39 (3.48) covaries with -- 20 37 67 91 107 112 206 262 274
K40 (3.85) covaries with -- 6 9 11 12 17 30 43 57 59 60 66 79 86 90 107 189 213 218 238 247 259 262 266 279 282 283 398
V41 (2.52) covaries with -- 36 42 62 76 77 83 91 94 126 134 182 188 204 212 213 214 269 276 283 354
V42 (3.49) covaries with -- 12 14 29 31 37 41 54 55 76 83 85 87 92 106 143 165 185 243 244 254 268
K43 (3.73) covaries with -- 40 93 189 279
L44 (3.44) covaries with -- 4 11 29 31 37 54 60 62 65 76 82 83 101 107 143 165 174 175 183 187 224 229 239 247 254 256 273 390 394
-45 (2.76) covaries with --
-46 (2.58) covaries with --
-47 (1.99) covaries with --
-48 (2.00) covaries with --
-49 (0.94) covaries with --
-50 (1.53) covaries with --
-51 (2.26) covaries with --
-52 (3.52) covaries with --
K53 (3.27) covaries with -- 6 16 179 235
Q54 (3.37) covaries with -- 3 6 37 42 44 56 57 58 62 65 67 99 107 110 112 133 143 177 183 185 187 188 210 211 213 214 217 218 239 254 266 273 277 283 371 398 399
I55 (3.39) covaries with -- 15 29 37 42 57 58 59 62 83 85 126 174 185 273
E56 (3.63) covaries with -- 6 14 29 54 57 59 60 62 67 82 87 92 106 114 133 159 185 186 187 188 189 217 243 259 263 276 280 282 358 382
H57 (3.12) covaries with -- 2 4 13 15 17 30 40 54 55 56 58 59 60 62 65 67 79 91 99 106 107 109 130 133 135 143 159 160 166 174 181 183 184 185 188 210 211 212 213 214 218 239 240 263 266 273 276 278 279 283 390
T58 (2.90) covaries with -- 15 54 55 57 61 65 92 93 159 160 187 283
L59 (3.69) covaries with -- 9 30 33 40 55 56 57 60 62 94 100 103 106 107 108 129 130 202 206 210 252 276 278
N60 (3.56) covaries with -- 3 4 17 20 30 40 44 56 57 59 62 67 76 83 107 109 135 154 157 175 183 186 188 210 226 253 266 278 283 389
E61 (0.56) covaries with -- 58
K62 (2.69) covaries with -- 6 37 41 44 54 55 56 57 59 60 63 65 76 82 83 85 91 92 93 94 96 101 107 133 135 136 143 174 175 186 213 217 224 226 254 263 273 276 394
R63 (3.56) covaries with -- 4 32 62 66 93 130 131 186 210 276 361
I64 (2.18) covaries with -- 76 145 186 213 271 283
L65 (2.11) covaries with -- 11 19 37 44 54 57 58 62 66 82 83 92 95 101 107 129 130 133 136 140 143 154 175 183 186 217
Q66 (3.65) covaries with -- 1 6 9 20 30 37 40 63 65 67 68 74 82 207 208 218 266 271 353 356
A67 (3.91) covaries with -- 8 29 39 54 56 57 60 66 77 106 114 130 135 185 202 203 206 210 211 273 354
V68 (3.11) covaries with -- 8 66 74 76 79 81 144 162 188 205 266 283 356 363 369
-69 (3.47) covaries with -- 79 133 143 148 187 214 278 353 387
-70 (3.22) covaries with --
-71 (2.29) covaries with --
-72 (3.75) covaries with --
n73 (3.46) covaries with -- 154 253
F74 (2.81) covaries with -- 66 68 112 144 270 372
P75 (2.86) covaries with -- 76 138 372
F76 (2.27) covaries with -- 19 31 37 41 42 44 60 62 64 68 75 83 85 91 94 101 103 133 136 140 143 144 175 188 244 247 269 273 283 354 367 369 371 372 389
L77 (2.22) covaries with -- 8 30 32 41 67 130 177 188
V78 (2.43) covaries with -- 11 37 166 203
K79 (3.44) covaries with -- 18 40 57 68 69 81 86 127 143 188 238 263 271 276 283 390
L80 (2.02) covaries with -- 17 133 256 269
E81 (3.31) covaries with -- 17 68 79 96 97 206 258 271 283
F82 (3.37) covaries with -- 1 5 9 14 19 20 29 30 31 44 56 62 65 66 83 84 85 92 106 107 108 112 136 137 140 165 175 187 188 247 271 274
S83 (3.13) covaries with -- 6 11 12 20 29 31 33 37 38 41 42 44 55 60 62 65 76 82 85 91 92 94 96 101 107 133 136 165 174 175 217 224 243 247 273
F84 (2.67) covaries with -- 1 30 33 38 82 85 86 91 93
K85 (2.78) covaries with -- 1 6 30 31 33 37 38 42 55 62 76 82 83 84 91 92 93 98 104 106 108 137 140 165 175 179 210 224 273 274
D86 (2.54) covaries with -- 38 40 79 84 93 283 348
-87 (3.58) covaries with -- 37 42 56
-88 (1.58) covaries with --
n89 (3.62) covaries with -- 112 211 226 271 353
S90 (3.57) covaries with -- 40 107 108
N91 (3.30) covaries with -- 21 31 33 35 38 39 41 57 62 76 83 84 85 92 93 96 107 148 211 217 220 239 240 242 263 268 274 277 278 282 355 371 389
L92 (2.30) covaries with -- 6 11 12 38 42 56 58 62 65 82 83 85 91 107 165 185 217 224 355 394
Y93 (2.39) covaries with -- 30 38 43 58 62 63 84 85 86 91 212 217 263 280
M94 (2.33) covaries with -- 36 41 59 62 76 83
V95 (2.12) covaries with -- 33 65 242
M96 (2.07) covaries with -- 62 81 83 91 182 217 263 268 279
E97 (2.04) covaries with -- 81 177 258 259 268
Y98 (2.30) covaries with -- 5 30 35 85 100 184 188 268
V99 (2.79) covaries with -- 54 57 106 113 185 188 207 239 277 283 364 371
P100 (3.66) covaries with -- 59 98 112 176 276
G101 (2.23) covaries with -- 37 44 62 65 76 83 107 129 133 159 174 175 247 273 283 386 389
-102 (0.00) covaries with --
G103 (1.11) covaries with -- 59 76
E104 (1.82) covaries with -- 85 106 131 158 262
M105 (1.98) covaries with -- 204 371
F106 (2.96) covaries with -- 2 5 14 20 30 37 42 56 57 59 67 82 85 99 104 111 114 138 160 183 185 188 203 210 212 213 214 218 220 239 242 243 244 253 257 263 268 273 277 283 351 352 358
S107 (3.49) covaries with -- 4 11 14 26 39 40 44 54 57 59 60 62 65 82 83 90 91 92 101 108 110 140 148 165 175 187 210 217 239 240 247 276 283 371 389
H108 (3.09) covaries with -- 1 5 30 59 82 85 90 107 130 140 188 273
L109 (2.02) covaries with -- 19 57 60 278
R110 (3.42) covaries with -- 54 107 114 144 211 252 266 277 283 367 369 371
R111 (3.38) covaries with -- 106 132 133 216 220 222 395
I112 (3.91) covaries with -- 2 39 54 74 82 89 100 113 114 130 143 151 187 206 207 208 239 257 269 273 274 283 351 369
G113 (3.44) covaries with -- 99 112 188 272 278 356
R114 (3.99) covaries with -- 8 14 56 67 106 110 112 148 188 211 212 253 276 354 357 364 371
-115 (3.50) covaries with -- 11 263 352
-116 (3.66) covaries with --
-117 (2.48) covaries with --
-118 (2.54) covaries with --
-119 (1.54) covaries with --
-120 (2.00) covaries with --
-121 (1.52) covaries with --
-122 (2.00) covaries with --
-123 (2.00) covaries with --
-124 (2.00) covaries with --
-125 (3.31) covaries with --
F126 (1.98) covaries with -- 41 55 167 283
S127 (3.33) covaries with -- 79 130
E128 (2.99) covaries with -- 30 139 359
P129 (3.70) covaries with -- 59 65 101 133 137 175
H130 (3.67) covaries with -- 9 37 57 59 63 65 67 77 108 112 127 166 186 187 188 212 213 262 283 351
A131 (2.67) covaries with -- 30 63 104
R132 (3.08) covaries with -- 111
F133 (3.17) covaries with -- 6 17 37 54 56 57 62 65 69 76 80 83 101 111 129 134 136 140 174 175 210 224 240 247 250 266 269 372 378 399
Y134 (1.95) covaries with -- 5 41 133 136 140 224 244 276 372 394
A135 (2.89) covaries with -- 3 57 60 62 67 210 250 254 276 367 372
A136 (3.07) covaries with -- 15 17 31 62 65 76 82 83 133 134 137 140 143 160 174 175 218 247 250 281 394 399
Q137 (2.03) covaries with -- 4 82 85 129 136 140 175 247
I138 (2.36) covaries with -- 75 106 152 387
V139 (2.87) covaries with -- 128 142 250 394
L140 (3.38) covaries with -- 31 65 76 82 85 107 108 133 134 136 137 154 175 186 188 247 394
T141 (1.71) covaries with --
F142 (2.07) covaries with -- 139 253 283
E143 (3.49) covaries with -- 42 44 54 57 62 65 69 76 79 112 136 175 187 188 224 239 389 390 394
Y144 (2.82) covaries with -- 35 68 74 76 110 245 351
L145 (1.80) covaries with -- 64 208 283
H146 (1.11) covaries with -- 227 272 281 398
S147 (3.53) covaries with -- 6 12 14 187 206 349
L148 (3.57) covaries with -- 69 91 107 114 212 214 227 259 263 354 371
-149 (2.28) covaries with --
-150 (2.71) covaries with --
D151 (2.98) covaries with -- 112
L152 (2.25) covaries with -- 16 35 138 213 283 358 359 362 364 365 368 369 371 372
I153 (2.00) covaries with -- 222
Y154 (0.78) covaries with -- 60 65 73 140 158 163 180 183 188 210 213 244 269 283
R155 (1.05) covaries with -- 212 214 224 263
D156 (0.42) covaries with -- 158
L157 (1.91) covaries with -- 60 245 281 283
K158 (0.86) covaries with -- 32 104 154 156 160 184 216
P159 (1.12) covaries with -- 56 57 58 101 263 279
E160 (1.90) covaries with -- 57 58 106 136 158 218 270
N161 (0.38) covaries with --
L162 (2.04) covaries with -- 68 176 273 365
L163 (1.38) covaries with -- 154
I164 (1.82) covaries with -- 6
D165 (3.00) covaries with -- 12 37 42 44 82 83 85 92 107 166 182 185 203 206 278 357 391
Q166 (3.82) covaries with -- 16 57 78 130 165 203 239 266 367
Q167 (3.75) covaries with -- 126 226 244 372
-168 (2.77) covaries with --
-169 (1.99) covaries with --
-170 (1.99) covaries with --
-171 (2.80) covaries with --
-172 (2.80) covaries with --
-173 (3.16) covaries with --
G174 (1.78) covaries with -- 4 15 18 30 44 55 57 62 83 101 133 136 175 179 247 256
Y175 (2.72) covaries with -- 4 5 11 30 31 37 44 60 62 65 76 82 83 85 101 107 129 133 136 137 140 143 174 224 247 273 394
I176 (2.35) covaries with -- 100 162 279
Q177 (2.59) covaries with -- 12 54 77 97 182 217 259
V178 (1.75) covaries with -- 30
T179 (2.41) covaries with -- 15 53 85 174 188 273
D180 (0.89) covaries with -- 154 182 183 184 185 204 215
F181 (1.17) covaries with -- 57 184 259
G182 (1.11) covaries with -- 12 41 96 165 177 180 184 185 188 215 216 278 354
F183 (2.26) covaries with -- 16 44 54 57 60 65 106 154 180 184 211 225 227 228 239 274 283 390
A184 (2.06) covaries with -- 16 57 98 158 180 181 182 183 187 188 215 216
K185 (3.11) covaries with -- 6 12 14 37 42 54 55 56 57 67 92 99 106 165 180 182 186 210 239 273 283 354 358
R186 (3.82) covaries with -- 6 29 56 60 62 63 64 65 130 140 185 187 188 210 211 217 274 277 278
V187 (3.67) covaries with -- 11 14 37 44 54 56 58 69 82 107 112 130 143 147 184 186 188 189 206 208 211 273 277
-188 (3.96) covaries with -- 2 3 6 11 12 14 16 19 20 22 35 37 41 54 56 57 60 68 76 77 79 82 98 99 106 108 113 114 130 140 143 154 179 182 184 186 187 206 210 217 243 266 269 274 351 355 358 369
-189 (4.07) covaries with -- 40 43 56 187 250 262
-190 (3.76) covaries with --
-191 (3.69) covaries with -- 203
-192 (4.05) covaries with --
-193 (4.03) covaries with -- 195
-194 (3.97) covaries with --
-195 (3.98) covaries with -- 193
-196 (4.02) covaries with -- 202
-197 (3.96) covaries with -- 238
-198 (4.06) covaries with --
-199 (3.92) covaries with --
-200 (4.09) covaries with -- 203 215 260 264
-201 (3.98) covaries with -- 388
-202 (4.03) covaries with -- 59 67 196 203 204 205 208 377
-203 (3.90) covaries with -- 14 20 37 67 78 106 165 166 191 200 202 204 205 206 207 209 210 218 226 243 267 283 356
-204 (3.98) covaries with -- 41 105 180 202 203 205 207 208 213 372
-205 (3.70) covaries with -- 6 68 202 203 204 206
-206 (3.89) covaries with -- 2 9 11 29 39 59 67 81 112 147 165 187 188 203 205 211 215 219 227 243 251 264 281
K207 (3.76) covaries with -- 14 66 99 112 203 204 213 236 359 371
G208 (3.74) covaries with -- 16 66 112 145 187 202 204 243 250 274 281 354
R209 (3.60) covaries with -- 203 210 212 214 369
T210 (3.07) covaries with -- 6 8 14 35 54 57 59 60 63 67 85 106 107 133 135 154 185 186 188 203 209 211 212 213 214 218 220 239 252 269 278 283 354 371
W211 (3.75) covaries with -- 9 22 54 57 67 89 91 110 114 183 186 187 206 210 239 266 274 283 351 353 371
T212 (2.80) covaries with -- 8 41 57 93 106 114 130 148 155 209 210 213 214 215 224 227 244 253 263 266 279 351 353 354 355
L213 (3.20) covaries with -- 3 16 17 40 41 54 57 62 64 106 130 152 154 204 207 210 212 214 215 216 217 218 219 220 225 227 244 253 254 263 266 269 273 277 281 283 358 369 372 377 378 382
C214 (2.62) covaries with -- 8 41 54 57 69 106 148 155 209 210 212 213 215 216 217 218 219 220 225 253 263 266 277 354 358 371
G215 (1.54) covaries with -- 180 182 184 200 206 212 213 214 216 218 219 220 222 265
T216 (1.58) covaries with -- 111 158 182 184 213 214 215 218 219 220
P217 (3.14) covaries with -- 6 37 54 56 62 65 83 91 92 93 96 107 177 186 188 213 214 218 220 225 243 259 262 266 273 277 283 399
E218 (3.06) covaries with -- 14 17 30 40 54 57 66 106 136 160 203 210 213 214 215 216 217 219 220 225 240 243 244 253 256 259 263 265 266 269 275 276 277 279 283 389 393 398
Y219 (1.67) covaries with -- 206 213 214 215 216 218 220 263
L220 (2.68) covaries with -- 91 106 111 210 213 214 215 216 217 218 219 259 274 358
A221 (1.56) covaries with -- 222 224
P222 (0.73) covaries with -- 111 153 215 221
E223 (0.53) covaries with --
I224 (2.29) covaries with -- 38 44 62 83 85 92 133 134 143 155 175 212 221 236 240 254 389
I225 (2.10) covaries with -- 183 213 214 217 218 253
L226 (3.65) covaries with -- 5 11 37 60 62 89 167 203 238 244 266 269 273 279 283 372
S227 (3.56) covaries with -- 2 16 146 148 183 206 212 213 254 259 267 269 283 376
-228 (3.40) covaries with -- 183
-229 (2.48) covaries with -- 44
-230 (2.55) covaries with --
-231 (2.00) covaries with --
-232 (0.00) covaries with --
-233 (2.32) covaries with --
-234 (2.97) covaries with --
-235 (3.28) covaries with -- 53
-236 (3.32) covaries with -- 207 224
-237 (3.47) covaries with --
k238 (3.83) covaries with -- 40 79 197 226 243 263 274 276 282 283 351 371
G239 (3.67) covaries with -- 4 11 37 44 54 57 91 99 106 107 112 143 166 183 185 210 211 240 244 245 273 283 394
Y240 (2.52) covaries with -- 2 13 57 91 107 133 218 224 239 245 256
-241 (0.00) covaries with --
N242 (2.59) covaries with -- 91 95 106
K243 (3.89) covaries with -- 5 42 56 83 106 188 203 206 208 217 218 238 266 275 279
A244 (3.33) covaries with -- 14 17 37 42 76 106 134 154 167 212 213 218 226 239 273 378
V245 (2.36) covaries with -- 144 157 239 240 283 367
D246 (0.14) covaries with --
W247 (2.40) covaries with -- 4 31 37 40 44 76 82 83 101 107 133 136 137 140 174 175 283
W248 (0.77) covaries with -- 253 269 348 377
A249 (1.75) covaries with --
L250 (2.60) covaries with -- 133 135 136 139 189 208 394
G251 (0.56) covaries with -- 206 253 255 257
V252 (1.85) covaries with -- 59 110 210 257 377
L253 (2.58) covaries with -- 60 73 106 114 142 212 213 214 218 225 248 251 274 352 358
I254 (2.94) covaries with -- 42 44 54 62 135 213 224 227 258 260 399
Y255 (1.75) covaries with -- 251 264 265
E256 (2.04) covaries with -- 2 17 44 80 174 218 240 271
M257 (2.19) covaries with -- 106 112 251 252 271 372
A258 (2.55) covaries with -- 81 97 254
A259 (3.38) covaries with -- 37 40 56 97 148 177 181 217 218 220 227 262 263 276 279 282 352 357 358
G260 (1.62) covaries with -- 200 254
-261 (2.58) covaries with --
Y262 (3.95) covaries with -- 2 39 40 104 130 189 217 259 273 274 283
P263 (2.97) covaries with -- 56 57 62 79 91 93 96 106 115 148 155 159 212 213 214 218 219 238 259 265 267 269 273 276 277 278 279 354 371
P264 (1.13) covaries with -- 200 206 255 265
F265 (1.50) covaries with -- 215 218 255 263 264
F266 (3.80) covaries with -- 2 14 29 37 40 54 57 60 66 68 110 133 166 188 211 212 213 214 217 218 226 243 267 271 273 279 283 354 357 371
A267 (3.23) covaries with -- 17 203 227 263 266 268 269 276 279 283
D268 (3.80) covaries with -- 29 42 91 96 97 98 106 267 270 275
Q269 (3.19) covaries with -- 41 76 80 112 133 154 188 210 213 218 226 227 248 263 267 271 274 277 372
-270 (3.06) covaries with -- 74 160 268
-271 (3.41) covaries with -- 6 14 30 64 66 79 81 82 89 256 257 266 269 277 279 283 372
-272 (3.25) covaries with -- 113 146
P273 (3.69) covaries with -- 3 11 14 44 54 55 57 62 67 76 83 85 101 106 108 112 162 175 179 185 187 213 217 226 239 244 262 263 266 274 276 277 283 351 352
I274 (3.81) covaries with -- 16 39 82 85 91 112 183 186 188 208 211 220 238 253 262 269 273 275 283 368 369 372 387
Q275 (3.68) covaries with -- 29 218 243 268 274 283 348
I276 (2.92) covaries with -- 41 56 57 59 62 63 79 100 107 114 134 135 218 238 259 263 267 273 277 279 280 390 399
Y277 (3.30) covaries with -- 54 91 99 106 110 186 187 213 214 217 218 263 269 271 273 276 280
E278 (3.77) covaries with -- 9 19 57 59 60 69 91 109 113 165 182 186 210 263 279 352 355 379
K279 (3.40) covaries with -- 2 16 30 40 43 57 96 159 176 212 218 226 243 259 263 266 267 271 276 278 356 360 363 372
I280 (2.24) covaries with -- 2 56 93 276 277 282 358
V281 (3.39) covaries with -- 136 146 157 206 208 213 382
S282 (3.64) covaries with -- 40 56 91 238 259 280 283 371
G283 (3.89) covaries with -- 4 6 13 30 40 41 54 57 58 60 64 68 76 79 81 86 99 101 106 107 110 112 126 130 142 145 152 154 157 183 185 203 210 211 213 217 218 226 227 238 239 245 247 262 266 267 271 273 274 275 282 364 367 371 372 381 382
-284 (0.00) covaries with --
-285 (0.00) covaries with --
-286 (0.00) covaries with --
-287 (0.00) covaries with --
-288 (0.00) covaries with --
-289 (0.00) covaries with --
-290 (0.00) covaries with --
-291 (0.00) covaries with --
-292 (0.00) covaries with --
-293 (0.00) covaries with --
-294 (0.00) covaries with --
-295 (0.00) covaries with --
-296 (0.00) covaries with --
-297 (0.00) covaries with --
-298 (0.00) covaries with --
-299 (0.00) covaries with --
-300 (0.00) covaries with --
-301 (0.00) covaries with --
-302 (0.00) covaries with --
-303 (0.00) covaries with --
-304 (0.00) covaries with --
-305 (0.00) covaries with --
-306 (0.00) covaries with --
-307 (0.00) covaries with --
-308 (0.00) covaries with --
-309 (0.00) covaries with --
-310 (0.00) covaries with --
-311 (0.00) covaries with --
-312 (0.00) covaries with --
-313 (0.00) covaries with --
-314 (0.00) covaries with --
-315 (0.00) covaries with --
-316 (0.00) covaries with --
-317 (0.00) covaries with --
-318 (0.00) covaries with --
-319 (0.00) covaries with --
-320 (0.00) covaries with --
-321 (0.00) covaries with --
-322 (1.00) covaries with --
-323 (0.00) covaries with --
-324 (1.00) covaries with --
-325 (1.00) covaries with --
-326 (1.00) covaries with --
-327 (1.00) covaries with --
-328 (1.00) covaries with --
-329 (1.00) covaries with --
-330 (0.00) covaries with --
-331 (1.00) covaries with --
-332 (1.00) covaries with --
-333 (1.58) covaries with --
-334 (1.58) covaries with --
-335 (1.58) covaries with --
-336 (0.93) covaries with --
-337 (2.32) covaries with --
-338 (2.58) covaries with --
-339 (2.80) covaries with --
-340 (2.80) covaries with --
-341 (2.68) covaries with --
-342 (2.93) covaries with --
-343 (3.54) covaries with --
-344 (3.21) covaries with --
-345 (3.61) covaries with --
-346 (3.97) covaries with --
-347 (3.74) covaries with --
-348 (3.82) covaries with -- 86 248 275 350 351 360 367
-349 (4.02) covaries with -- 147 352 372
-350 (4.09) covaries with -- 348 351 352 353 359
K351 (3.93) covaries with -- 106 112 130 144 188 211 212 238 273 348 350 352 353 354 355 356 358 371
V352 (3.91) covaries with -- 14 106 115 253 259 273 278 349 350 351 353 354 355 356 357 358 359 362 363 364 365 369 371 372
R353 (4.00) covaries with -- 66 69 89 211 212 350 351 352 354 356 359
F354 (3.92) covaries with -- 6 12 16 41 67 76 114 148 182 185 208 210 212 214 263 266 351 352 353 355 356 357 358 378 386
P355 (3.77) covaries with -- 12 91 92 188 212 278 351 352 354 357 358
S356 (3.89) covaries with -- 14 66 68 113 203 279 351 352 353 354 358 367
H357 (4.09) covaries with -- 114 165 259 266 352 354 355 358
F358 (3.65) covaries with -- 37 56 106 152 185 188 213 214 220 253 259 280 351 352 354 355 356 357 359 362 363 364 365 368 369 371
S359 (3.58) covaries with -- 128 152 207 350 352 353 358 362 363 364 365 366 367 369 371 378
S360 (3.84) covaries with -- 279 348 371
D361 (3.87) covaries with -- 63
L362 (3.47) covaries with -- 152 352 358 359 363 364 365 366 368 369 371 382
K363 (3.53) covaries with -- 68 279 352 358 359 362 364 365 366 369 371 372
D364 (3.59) covaries with -- 16 99 114 152 283 352 358 359 362 363 365 368 369 372
L365 (3.02) covaries with -- 16 152 162 352 358 359 362 363 364 366 367 368 369 370 371 372 393
L366 (2.76) covaries with -- 359 362 363 365 368 370 382 383
R367 (3.76) covaries with -- 76 110 135 166 245 283 348 356 359 365 369 371 372
N368 (3.56) covaries with -- 16 152 274 358 362 364 365 366 369 370 397
L369 (3.08) covaries with -- 16 68 76 110 112 152 188 209 213 274 352 358 359 362 363 364 365 367 368 371 372 379
L370 (2.42) covaries with -- 365 366 368
Q371 (3.72) covaries with -- 5 11 14 20 54 76 91 99 105 107 110 114 148 152 207 210 211 214 238 263 266 282 283 351 352 358 359 360 362 363 365 367 369 372 379
V372 (3.69) covaries with -- 5 8 16 74 75 76 133 134 135 152 167 204 213 226 257 269 271 274 279 283 349 352 363 364 365 367 369 371 379
-373 (0.00) covaries with --
-374 (0.00) covaries with --
-375 (0.00) covaries with --
D376 (3.27) covaries with -- 227
L377 (3.32) covaries with -- 202 213 248 252
T378 (3.67) covaries with -- 8 14 133 213 244 354 359 385
K379 (3.72) covaries with -- 278 369 371 372
R380 (0.65) covaries with --
F381 (2.57) covaries with -- 283 382
G382 (2.40) covaries with -- 56 213 281 283 362 366 381 389
-383 (2.79) covaries with -- 366 389
-384 (3.46) covaries with --
N385 (3.60) covaries with -- 378 386
L386 (3.87) covaries with -- 6 14 101 354 385 387
K387 (3.97) covaries with -- 69 138 274 386
N388 (3.71) covaries with -- 201 391
G389 (3.07) covaries with -- 4 37 60 76 91 101 107 143 218 224 382 383 394
V390 (3.35) covaries with -- 44 57 79 143 183 276
N391 (3.85) covaries with -- 165 388 394 397
D392 (3.11) covaries with -- 22
I393 (2.22) covaries with -- 218 365
K394 (3.15) covaries with -- 44 62 92 134 136 139 140 143 175 239 250 389 391 399
N395 (3.72) covaries with -- 111
H396 (2.68) covaries with --
K397 (3.66) covaries with -- 368 391
W398 (2.28) covaries with -- 40 54 146 218
F399 (2.00) covaries with -- 54 133 136 217 254 276 394