Main kinase page
CaMK kinases

camk tree, pdf
CaMK tree with Pfam domains included
camk alinment, pdf (warning!! residues are deleted)

Additional domains and groups (E.lt.10)(classification is based on catalytic domain only, and subgroups are sometimes quite arbitrary, see tree in pdf format, above, and groupings, listed below)

Pfam links
efhand NAF FHA fn3 ig UBA PH DAG_PE-bind POLO_box PDZ L27 MIT RCC1 DCX RhoGEF PASTA Death SH3 Ank Arm Spectrin

pdb links
(1tki) Titin
(1koa) Twitc
(1kob) Aplysia Twitchen kinase
(1ig1) (1jkk) (1jkl) (1jks) (1jkt) DAPK
(1ia8) (1nvq) (1nvr) (1nvs) Chk1
(1phk) (1ql6) (2phk) Phk
(1a06) CDPK
(1nxk) (1kwp) (1ny3) MPKP2

Phospho.ELM links AMPKx (A); CHK2 (C); PLKx (D);

group A - PASK.h PIM2.h PIM3.h PIM1.h BRSK1.h BRSK2.h MELK.h HUNK.h TSSK4.h TSSK3.h SSTK.h TSSK1.h TSSK2.h NIM1.h SNRK.h AMPKa2.h AMPKa1.h
group B - CaMK2d.h CaMKK2.h CaMK2a.h CaMK2b.h CASK.h CaMK1g.h CaMK1a.h CaMK1d.h CaMK1b.h DAPK3.h CaMK2g.h
group C - STK33.h PKD3.h PKD2.h PKD1.h CHK2.h
group D - PLK4.h PLK2.h PLK3.h NEK10.h NEK9.h NEK2.h NEK4.h NEK11.h NEK3.h NEK5.h NEK1.h ULK4.h Fused.h ULK3.h NEK7.h NEK6.h NuaK2.h NuaK1.h NEK8.h
group E - CHK1.h
group F - CaMK4.h PSKH2.h PSKH1.h VACAMKL.h PHKg2.h PHKg1.h MNK2.h MNK1.h MAPKAPK5.h MAPKAPK3.h MAPKAPK2.h DCAMKL3.h DCAMKL2.h DCAMKL1.h
group G - smMLCK.h SgK085.h caMLCK.h skMLCK.h Obscn.h SPEG.h Trad.h Trio.h DRAK2.h DRAK1.h DAPK2.h DAPK1.h TTN.h
group H - MARK2.h MARK4.h MARK1.h MARK3.h QSK.h SIK.h QIK.h
group I - CaMKK1.h LKB1.h SgK495.h Trb3.h Trb2.h Trb1.h

site map

Sequence entropy, over all 5915 protein kinases (red) and 930 camk kinases (green)
residues which distinguish CaMK kinases from all (PHK as ref): F265 P264 L370 G215 E61 P222 E223 W248 F398 I280

residues in order of increasing entropy
34 223 380 154 246 61 156 161 251 180 182 222 248 158 181 10 146 157 264 105 178 15 32 77 219 249 142 141 155 163 13 221 97 145 162 252 216 152 184 74 257 8 95 138 78 159 215 94 7 255

covariation analysis
crystal structure of PHK (2phk.pdb) with residues numbered according to alignment
residues in order of decreasing number of covariation partners
224 160 255 106 128 256 131 240 213 212 358 38 250 352 362 110 265 366 268 175 54 348 248 209 132 159 135 91 166 173 86 216 179 218 220 176 20 215 369 185 219 1 245 263 363 351 242 393 59 207

list of covariation partners, PHK.human sequence as reference
PHK residue,number (entropy) -- covariation partners

Y1 (3.23) covaries with -- 7 9 10 12 14 16 17 20 66 94 99 186 209 213 215 227 265 368
E2 (3.89) covaries with -- 3 5 14 22 48 82 155 227 230 346
P3 (3.66) covaries with -- 2 8 16 18 20 131 254 255 269 280 367
K4 (3.88) covaries with -- 17 19 33 39 54 204
E5 (3.63) covaries with -- 2 6 19 40 42 55 59 181 220 395
I6 (3.80) covaries with -- 5 9 81 225 263 372
L7 (2.51) covaries with -- 1 12 15 98 161 183 185
G8 (2.43) covaries with -- 3 9 14 15 33 34 82 161 162 213
R9 (3.63) covaries with -- 1 6 8 11 14 142 174 254
G10 (1.71) covaries with -- 1 14 15 32 180 227
V11 (3.36) covaries with -- 9 57 66 67 112 160 174 212 216 262 266 393
S12 (2.86) covaries with -- 1 7 37 78 98 182 238
S13 (2.14) covaries with -- 15 34 54 180 256
V14 (3.69) covaries with -- 1 2 8 9 10 16 17 20 22 29 82 98 165 211 223 266
V15 (1.99) covaries with -- 7 8 10 13 57 81 175 179 368
R16 (3.55) covaries with -- 1 3 14 19 20 33 38 77 247 256 268 371
R17 (3.51) covaries with -- 1 4 14 52 53 55 98 142
C18 (2.69) covaries with -- 3 98 124 186 345
I19 (3.83) covaries with -- 4 5 16 20 27 30 40 132 166 362
H20 (3.73) covaries with -- 1 3 14 16 19 37 40 106 131 142 162 211 216 224 239 348 358 359 394
K21 (3.82) covaries with -- 22 54 96 216 225 269 353 379 397
P22 (4.03) covaries with -- 2 14 21 224 391
-23 (3.81) covaries with --
-24 (3.66) covaries with --
-25 (3.63) covaries with --
-26 (3.63) covaries with -- 211 349
T27 (3.47) covaries with -- 19 31 59 106 128 217 354 391
S28 (3.56) covaries with -- 166 239
Q29 (3.82) covaries with -- 14 31 140 142 348
E30 (3.99) covaries with -- 19 52 70 89 211 231 268 332
Y31 (2.95) covaries with -- 27 29 32 81 165 250
A32 (1.99) covaries with -- 10 31 59 95 99 115 179 180
V33 (2.70) covaries with -- 4 8 16 81 93 175 250 377
K34 (0.60) covaries with -- 8 13 127 158 355
V35 (3.60) covaries with -- 106 130 131 144 179 209 210 248 358
I36 (2.67) covaries with -- 38 63 68 154 161 185 213 216 224 369
D37 (3.72) covaries with -- 12 20 56 66 90 92 95 226 351
V38 (3.80) covaries with -- 16 36 114 125 132 135 139 207 209 213 214 215 263 265 268 360 363 364 366 367 369 370 390
T39 (3.85) covaries with -- 4 53 112 128 160 208 370
G40 (3.95) covaries with -- 5 19 20 41 100 110 352
G41 (3.93) covaries with -- 40 112 213 268 362
G42 (3.90) covaries with -- 5 66 230
S43 (3.99) covaries with --
F44 (3.83) covaries with -- 368
-45 (3.97) covaries with --
-46 (3.69) covaries with --
S47 (3.91) covaries with --
P48 (3.83) covaries with -- 2
E49 (4.03) covaries with -- 51 57 151 159 346
E50 (4.10) covaries with -- 113 125
V51 (3.87) covaries with -- 49 56 57 137 175 240 351
R52 (3.92) covaries with -- 17 30 124 227
E53 (3.90) covaries with -- 17 39 54 75 84 224 228 277 280
L54 (4.04) covaries with -- 4 13 21 53 55 86 111 127 143 160 173 174 179 187 188 211 255 274 277 352 380
R55 (4.01) covaries with -- 5 17 54 57 91 118 153 217 259 367
E56 (3.90) covaries with -- 37 51 361 363
A57 (3.81) covaries with -- 11 15 49 51 55 58 211 220 279 360
T58 (3.16) covaries with -- 57 99 132 160 176 185 207 263 264 398
L59 (3.87) covaries with -- 5 27 32 60 85 101 103 106 112 151 159 185 276 350 351 368 395
K60 (3.74) covaries with -- 59 77 82 238 245 372
E61 (1.02) covaries with -- 62 63 64 78 205
V62 (3.06) covaries with -- 61 91 94 136 173 219
D63 (3.83) covaries with -- 36 61 64 68 85 92 110 151 154 255 276 320
I64 (3.10) covaries with -- 61 63 136 151 184 239
L65 (2.96) covaries with -- 80 84 110
R66 (3.38) covaries with -- 1 11 37 42 76 137 148 215 240 250 257 273 282 330 366
K67 (3.76) covaries with -- 11 80 81 112 175 209
V68 (2.98) covaries with -- 36 63 152
S69 (3.61) covaries with --
G70 (3.66) covaries with -- 30
-71 (3.52) covaries with --
-72 (3.11) covaries with --
-73 (3.48) covaries with --
H74 (2.37) covaries with -- 83 166
P75 (3.45) covaries with -- 53 148 213
N76 (2.91) covaries with -- 66 112 175 254
I77 (2.00) covaries with -- 16 60 82
I78 (2.45) covaries with -- 12 61 179 216
Q79 (3.54) covaries with -- 225
L80 (2.86) covaries with -- 65 67 91 162 337
K81 (3.39) covaries with -- 6 15 31 33 67 82 97 227 327
D82 (3.27) covaries with -- 2 8 14 60 77 81 84 91 92 99 131 135 140 166 256 371
T83 (3.61) covaries with -- 74 85 91 95 131 144 213 225 256 267 276 348 352 355 390 393
Y84 (3.46) covaries with -- 53 65 82 85 91 92 111 135 211 228 256 381
E85 (3.88) covaries with -- 59 63 83 84 91 110 160 173 213 220 349 350 360
T86 (3.56) covaries with -- 54 104 110 128 146 160 172 173 207 208 210 217 224 334 351 362 364 366 368
N87 (3.69) covaries with -- 89 111 164
-88 (3.92) covaries with -- 326
-89 (3.77) covaries with -- 30 87
T90 (3.74) covaries with -- 37 91 139 226 346 352 391
F91 (3.94) covaries with -- 55 62 80 82 83 84 85 90 113 136 175 183 224 226 243 260 263 341 351 352
F92 (3.40) covaries with -- 37 63 82 84 111 141 155 177 214 217 248 265 365 370
F93 (3.50) covaries with -- 33 112 155 214 224 276 283 355 372
L94 (2.51) covaries with -- 1 62 95 96
V95 (2.43) covaries with -- 32 37 83 94
F96 (2.83) covaries with -- 21 94 136 215 245 264 267 358 366 393
D97 (2.24) covaries with -- 81 99 358
L98 (2.91) covaries with -- 7 12 14 17 18 101 103 115 162 179 185
M99 (2.99) covaries with -- 1 32 58 82 97 101 114 131 143 148 165 214 220 222 247 263
K100 (3.72) covaries with -- 40 114 136 165 174 182 206 218
R101 (3.52) covaries with -- 59 98 99 111 148 166 186 210 245 358 368 372
-102 (3.46) covaries with --
G103 (2.84) covaries with -- 59 98
E104 (2.70) covaries with -- 86 109 131 132 135 160 179 185 210 220 224 240 248 250 255 351 358
L105 (1.90) covaries with -- 109 134
F106 (3.72) covaries with -- 20 27 35 59 112 113 128 130 133 140 159 172 179 186 209 212 213 216 218 219 220 225 248 256 259 263 359 396
D107 (3.55) covaries with -- 110
Y108 (3.69) covaries with -- 111 114 133 164 220 250
L109 (2.82) covaries with -- 104 105 240 259
T110 (3.93) covaries with -- 40 63 65 85 86 107 111 114 124 131 132 139 160 176 212 224 240 242 248 263 265 369
E111 (3.78) covaries with -- 54 84 87 92 101 108 110 175 208 245 277 279 350
K112 (3.87) covaries with -- 11 39 41 59 67 76 93 106 124 162 212 221 251 255 368 391
V113 (3.75) covaries with -- 50 91 106 167 240 267 268
T114 (3.96) covaries with -- 38 99 100 108 110 131 136 144 173 174 205 208 212 256 273
-115 (3.94) covaries with -- 32 98
-116 (4.02) covaries with --
-117 (3.77) covaries with -- 379
-118 (3.59) covaries with -- 55 121
-119 (3.23) covaries with --
-120 (2.90) covaries with --
-121 (3.07) covaries with -- 118
-122 (3.06) covaries with --
-123 (3.83) covaries with --
-124 (3.83) covaries with -- 18 52 110 112 278
-125 (3.96) covaries with -- 38 50
L126 (2.82) covaries with -- 175 253
S127 (3.56) covaries with -- 34 54
E128 (3.23) covaries with -- 27 39 86 106 129 132 135 142 149 151 152 158 160 173 176 208 212 217 225 226 240 265 280 350 370 395 399
K129 (3.92) covaries with -- 128 143 173 211
E130 (3.75) covaries with -- 35 106 160 238 246
T131 (2.91) covaries with -- 3 20 35 82 83 99 104 110 114 134 160 207 214 216 218 248 263 264 268 359 362 366 369 370 372 393
R132 (3.52) covaries with -- 19 38 58 104 110 128 133 135 165 166 187 226 242 245 265 352 357 358 370 396
K133 (4.00) covaries with -- 106 108 132 165 210 259 266 269
I134 (2.94) covaries with -- 105 131 151 173
M135 (3.05) covaries with -- 38 82 84 104 128 132 141 142 152 153 159 160 165 187 218 219 263 358 362 390
R136 (3.83) covaries with -- 62 64 91 96 100 114 205 215 218 248 351 362 365 368 399
A137 (2.95) covaries with -- 51 66 138 162 173 178 185 238 395
L138 (2.44) covaries with -- 137 139 157 176 248 250 268 366 369 396 398
L139 (2.98) covaries with -- 38 90 110 138 242 352 366
E140 (3.84) covaries with -- 29 82 106 141 174 238
V141 (2.09) covaries with -- 92 135 140 142
I142 (2.07) covaries with -- 9 17 20 29 128 135 141 158 268
C143 (3.74) covaries with -- 54 99 129 147 153 379 391
T144 (3.02) covaries with -- 35 83 114 224
L145 (2.24) covaries with --
H146 (1.71) covaries with -- 86
K147 (3.72) covaries with -- 143 271
L148 (3.65) covaries with -- 66 75 99 101 156 160 166 175 186 211 239 240 253 255 349 394
-149 (3.80) covaries with -- 128 216
-150 (3.80) covaries with --
N151 (3.53) covaries with -- 49 59 63 64 128 134 176 253 348 358 366 369 381 398
I152 (2.31) covaries with -- 68 128 135 158 160 175 216 255 358 362 369 370 398
V153 (2.82) covaries with -- 55 135 143 156 160 185 243 347 352 357
H154 (0.95) covaries with -- 36 63 157 161 180
R155 (2.11) covaries with -- 2 92 93 158 174 185 213 216 240
D156 (1.02) covaries with -- 148 153 157 160 184
L157 (1.77) covaries with -- 138 154 156 178 378
K158 (1.46) covaries with -- 34 128 142 152 155 180 205 268
P159 (2.48) covaries with -- 49 59 106 135 166 175 213 214 219 224 242 250 253 256 263 268 269 358 381 396
E160 (2.90) covaries with -- 11 39 54 58 85 86 104 110 128 130 131 135 148 152 153 156 163 176 179 183 185 207 212 216 221 245 250 255 348 359 396
N161 (1.14) covaries with -- 7 8 36 154 162 183
I162 (2.26) covaries with -- 8 20 80 98 112 137 161 176 185 209 216
L163 (2.14) covaries with -- 160 351
L164 (2.61) covaries with -- 87 108 165 256
D165 (3.67) covaries with -- 14 31 99 100 132 133 135 164 167 174 185 344
D166 (3.82) covaries with -- 19 28 74 82 101 132 148 159 174 188 204 225 252 256 265 278 350 360 362 363
N167 (3.82) covaries with -- 113 165
-168 (3.93) covaries with -- 214
-169 (3.82) covaries with --
-170 (3.89) covaries with --
-171 (4.05) covaries with --
-172 (3.80) covaries with -- 86 106
-173 (3.87) covaries with -- 54 62 85 86 114 128 129 134 137 207 214 244 250 273 350 354 357 368 381 394
M174 (3.93) covaries with -- 9 11 54 100 114 140 155 165 166 179 210 213 218 262 363
N175 (3.90) covaries with -- 15 33 51 67 76 91 111 126 148 152 159 178 186 209 210 250 259 266 273 362 390
I176 (2.60) covaries with -- 58 110 128 138 151 160 162 179 212 214 215 216 240 248 265 344 363 366 398
K177 (2.72) covaries with -- 92 179 188 358 361 391
L178 (1.95) covaries with -- 137 157 175 179 180
T179 (2.85) covaries with -- 15 32 35 54 78 98 104 106 160 174 176 177 178 180 181 186 256 351 398
D180 (1.25) covaries with -- 10 13 32 154 158 178 179 183 184
F181 (1.49) covaries with -- 5 179 209
G182 (1.30) covaries with -- 12 100
F183 (3.04) covaries with -- 7 91 160 161 180 185
S184 (2.32) covaries with -- 64 156 180
C185 (3.48) covaries with -- 7 36 58 59 98 104 137 153 155 160 162 165 183 187 219 239 262 266 274
Q186 (3.97) covaries with -- 1 18 101 106 148 175 179 187 213 271
L187 (3.86) covaries with -- 54 132 135 185 186 227 367 379 395
E188 (3.96) covaries with -- 54 166 177
-189 (3.81) covaries with -- 208 265
-190 (3.89) covaries with --
-191 (3.60) covaries with --
-192 (3.56) covaries with --
-193 (3.50) covaries with --
-194 (3.37) covaries with --
-195 (3.31) covaries with --
-196 (3.30) covaries with -- 211 376
-197 (3.61) covaries with -- 228
-198 (3.29) covaries with --
-199 (3.83) covaries with --
-200 (3.96) covaries with --
-201 (3.74) covaries with --
-202 (4.15) covaries with --
-203 (3.92) covaries with --
-204 (3.95) covaries with -- 4 166 209 217
-205 (3.89) covaries with -- 61 114 136 158 243 256 357
P206 (3.92) covaries with -- 100 207 208 209 210 253 259 354 358
G207 (3.96) covaries with -- 38 58 86 131 160 173 206 209 215 228 240 242 255 260 265 278 282
E208 (3.97) covaries with -- 39 86 111 114 128 189 206 209 226 263 274 350 351 391
R209 (4.01) covaries with -- 1 35 38 67 106 162 175 181 204 206 207 208 212 218 240 255 282 327 334 351
L210 (3.63) covaries with -- 35 86 101 104 133 174 175 206 215 216 224 245 256 265 355
R211 (3.83) covaries with -- 14 20 26 30 54 57 84 129 148 196 218 239 278
E212 (3.60) covaries with -- 11 106 110 112 114 128 160 176 209 215 216 218 219 220 238 245 249 250 266 355 358 369 372 393
V213 (3.86) covaries with -- 1 8 36 38 41 75 83 85 106 155 159 174 186 216 217 242 243 255 263 326 336 349 352 362
C214 (3.40) covaries with -- 38 92 93 99 131 159 168 173 176 215 240 242 256 262 263 366 393
G215 (2.50) covaries with -- 1 38 66 96 136 176 207 210 212 214 221 222 224 245 251 252 366 370 372
T216 (2.30) covaries with -- 11 20 21 36 78 106 131 149 152 155 160 162 176 210 212 213 220 221 245
P217 (3.42) covaries with -- 27 55 86 92 128 204 213 218 219 221 222 224 228 256 273 363
S218 (3.64) covaries with -- 100 106 131 135 136 174 209 211 212 217 227 239 243 268 273 276 352 357 390
Y219 (2.00) covaries with -- 62 106 135 159 185 212 217 248 249 250 251 252 255 265 351 362 366 369
L220 (3.35) covaries with -- 5 57 85 99 104 106 108 212 216 222 224 228 246 252 258 351 363 372 390
A221 (2.21) covaries with -- 112 160 215 216 217 224 245 246 252 256
P222 (1.32) covaries with -- 99 215 217 220 225 248 252 366
E223 (0.70) covaries with -- 14
I224 (2.95) covaries with -- 20 22 36 53 86 91 93 104 110 144 159 210 215 217 220 221 243 248 255 256 267 326 348 350 352 358 366 369 370 395 396
I225 (3.12) covaries with -- 6 21 79 83 106 128 166 222 239 240 252 255 267 277 278 358
E226 (3.87) covaries with -- 37 90 91 128 132 208 334
C227 (3.76) covaries with -- 1 2 10 52 81 187 218 243 281
S228 (3.98) covaries with -- 53 84 197 207 217 220 360 372
M229 (4.04) covaries with --
N230 (3.83) covaries with -- 2 42
E231 (3.61) covaries with -- 30 233
D232 (3.37) covaries with --
H233 (3.37) covaries with -- 231
-234 (3.39) covaries with --
-235 (3.40) covaries with --
-236 (3.60) covaries with --
-237 (3.76) covaries with --
P238 (3.85) covaries with -- 12 60 130 137 140 212 242 243 273 357
G239 (3.90) covaries with -- 20 28 64 148 185 211 218 225 240 245 266
Y240 (3.17) covaries with -- 51 66 104 109 110 113 128 148 155 176 207 209 214 225 239 245 248 251 252 253 255 265 393 395
-241 (3.75) covaries with -- 244
G242 (2.89) covaries with -- 110 132 139 159 207 213 214 238 244 245 248 256 265 280 349 358 368 393
K243 (3.96) covaries with -- 91 153 205 213 218 224 227 238 250 350 352 363 390
E244 (3.49) covaries with -- 173 241 242 262 381
V245 (2.99) covaries with -- 60 96 101 111 132 160 210 212 215 216 221 239 240 242 246 355 362 363
D246 (1.01) covaries with -- 130 220 221 245 255 267
M247 (2.63) covaries with -- 16 99 251 263 369 381 390
W248 (1.41) covaries with -- 35 92 104 106 110 131 136 138 176 219 222 224 240 242 256 264 355 362 394 396
S249 (2.02) covaries with -- 212 219 250 253 256
T250 (2.96) covaries with -- 31 33 66 104 108 138 159 160 173 175 212 219 243 249 254 265 268 362 369 370 390 393 398
G251 (1.22) covaries with -- 112 215 219 240 247 363 380
V252 (2.26) covaries with -- 166 215 219 220 221 222 225 240 253 264 365 398
I253 (2.73) covaries with -- 126 148 151 159 206 240 249 252 254 255 263
M254 (2.85) covaries with -- 3 9 76 250 253 340 390
Y255 (2.59) covaries with -- 3 54 63 104 112 148 152 160 207 209 213 219 224 225 240 246 253 260 267 268 283 348 359 365 372 393 397 398 399
T256 (3.15) covaries with -- 13 16 82 83 84 106 114 159 164 166 179 205 210 214 217 221 224 242 248 249 259 262 266 348 352 381
L257 (2.42) covaries with -- 66 366
L258 (2.95) covaries with -- 220 260 348 350 363 390 398
A259 (3.37) covaries with -- 55 106 109 133 175 206 256 278 350 354
G260 (2.77) covaries with -- 91 207 255 258 268 363
-261 (3.33) covaries with --
S262 (3.84) covaries with -- 11 174 185 214 244 256 266 348 354 372
P263 (3.63) covaries with -- 6 38 58 91 99 106 110 131 135 159 208 213 214 247 253 277 366 395
P264 (1.77) covaries with -- 58 96 131 248 252 280 351 352
F265 (2.62) covaries with -- 1 38 92 110 128 132 166 176 189 207 210 219 240 242 250 278 282 348 352 359 360 363
W266 (3.98) covaries with -- 11 14 133 175 185 212 239 256 262
H267 (3.54) covaries with -- 83 96 113 224 225 246 255 269 276 282 348 352 358 359
R268 (3.96) covaries with -- 16 30 38 41 113 131 138 142 158 159 218 250 255 260 281 358 362 364 369 372 396
K269 (3.62) covaries with -- 3 21 133 159 267 276 277 352
-270 (3.73) covaries with --
-271 (3.88) covaries with -- 147 186
-272 (3.97) covaries with --
Q273 (3.97) covaries with -- 66 114 173 175 217 218 238 277 362
M274 (4.05) covaries with -- 54 185 208 275 336 354
L275 (3.85) covaries with -- 274 357
M276 (3.41) covaries with -- 59 63 83 93 218 267 269 278 281 361 372
L277 (3.84) covaries with -- 53 54 111 225 263 269 273 334 352 379 393
R278 (3.92) covaries with -- 124 166 207 211 225 259 265 276 321 398
M279 (3.72) covaries with -- 57 111 283
I280 (3.29) covaries with -- 3 53 128 242 264 283 350 366 372 394
M281 (3.94) covaries with -- 227 268 276 322 337
S282 (3.85) covaries with -- 66 207 209 265 267 283 368
G283 (3.65) covaries with -- 93 255 279 280 282 361
-284 (0.00) covaries with --
-285 (0.00) covaries with --
-286 (0.00) covaries with --
-287 (0.00) covaries with --
-288 (1.00) covaries with --
-289 (0.00) covaries with --
-290 (0.00) covaries with --
-291 (0.00) covaries with --
-292 (0.00) covaries with --
-293 (0.00) covaries with --
-294 (1.00) covaries with --
-295 (1.00) covaries with --
-296 (1.00) covaries with --
-297 (0.00) covaries with --
-298 (1.00) covaries with --
-299 (0.00) covaries with --
-300 (1.00) covaries with --
-301 (1.00) covaries with --
-302 (1.00) covaries with --
-303 (1.00) covaries with --
-304 (1.58) covaries with --
-305 (2.00) covaries with --
-306 (2.00) covaries with --
-307 (2.00) covaries with --
-308 (2.32) covaries with --
-309 (2.32) covaries with --
-310 (1.99) covaries with --
-311 (1.99) covaries with --
-312 (2.32) covaries with --
-313 (1.99) covaries with --
-314 (2.32) covaries with --
-315 (2.52) covaries with --
-316 (2.79) covaries with --
-317 (2.98) covaries with --
-318 (2.70) covaries with -- 320
-319 (3.25) covaries with -- 341
-320 (3.36) covaries with -- 63 318
-321 (3.31) covaries with -- 278
-322 (3.09) covaries with -- 281
-323 (3.14) covaries with --
-324 (3.51) covaries with --
-325 (3.63) covaries with --
-326 (3.91) covaries with -- 88 213 224 327 340 342 350
-327 (3.68) covaries with -- 81 209 326
-328 (3.72) covaries with --
-329 (3.61) covaries with --
-330 (3.77) covaries with -- 66
-331 (3.78) covaries with --
-332 (3.72) covaries with -- 30 333
-333 (3.78) covaries with -- 332
-334 (3.85) covaries with -- 86 209 226 277
-335 (3.75) covaries with --
-336 (3.90) covaries with -- 213 274
-337 (3.93) covaries with -- 80 281
-338 (3.96) covaries with --
-339 (4.05) covaries with --
-340 (4.00) covaries with -- 254 326
-341 (3.92) covaries with -- 91 319
-342 (4.20) covaries with -- 326 344
-343 (4.19) covaries with -- 355
-344 (4.05) covaries with -- 165 176 342 353
-345 (4.06) covaries with -- 18
-346 (4.14) covaries with -- 2 49 90
N347 (4.00) covaries with -- 153 348
Y348 (3.90) covaries with -- 20 29 83 151 160 224 255 256 258 262 265 267 347 349 351 358 364 371 394 398
Q349 (4.05) covaries with -- 26 85 148 213 242 348
F350 (4.01) covaries with -- 59 85 111 128 166 173 208 224 243 258 259 280 326 351 366
G351 (4.04) covaries with -- 37 51 59 86 91 104 136 163 179 208 209 219 220 264 348 350 357 370
S352 (4.01) covaries with -- 40 54 83 90 91 132 139 153 213 218 224 243 256 264 265 267 269 277 357 362 369 390 393
P353 (3.94) covaries with -- 21 344 354 358
E354 (4.00) covaries with -- 27 173 206 259 262 274 353 363 364
W355 (3.75) covaries with -- 34 83 93 210 212 245 248 343 356 362 367 393
D356 (4.03) covaries with -- 355 371
D357 (4.13) covaries with -- 132 153 173 205 218 238 275 351 352 363 390
Y358 (3.54) covaries with -- 20 35 96 97 101 104 132 135 151 152 159 177 206 212 224 225 242 267 268 348 353 361 367
S359 (3.36) covaries with -- 20 106 131 160 255 265 267 361 368 369 396
D360 (4.00) covaries with -- 38 57 85 166 228 265 367 370
T361 (3.81) covaries with -- 56 177 276 283 358 359 362 366 397
V362 (3.51) covaries with -- 19 41 86 131 135 136 152 166 175 213 219 245 248 250 268 273 352 355 361 381 393 399
K363 (3.77) covaries with -- 38 56 166 174 176 217 220 243 245 251 258 260 265 354 357 368 394 396
D364 (3.70) covaries with -- 38 86 268 348 354 371 397
L365 (3.17) covaries with -- 92 136 252 255 367 380 390
V366 (2.63) covaries with -- 38 66 86 96 131 138 139 151 176 214 215 219 222 224 257 263 280 350 361 376 397
S367 (3.86) covaries with -- 3 38 55 187 355 358 360 365 368 393
R368 (3.79) covaries with -- 1 15 44 59 86 101 112 136 173 242 282 359 363 367 392 396
F369 (3.04) covaries with -- 36 38 110 131 138 151 152 212 219 224 247 250 268 352 359 371 372 376 393
L370 (2.82) covaries with -- 38 39 92 128 131 132 152 215 224 250 351 360 371 372 398
V371 (3.86) covaries with -- 16 82 348 356 364 369 370 381
V372 (3.82) covaries with -- 6 60 93 101 131 212 215 220 228 255 262 268 276 280 369 370
-373 (2.58) covaries with --
-374 (2.58) covaries with --
-375 (2.32) covaries with --
Q376 (3.26) covaries with -- 196 366 369 378
P377 (3.17) covaries with -- 33
Q378 (3.93) covaries with -- 157 376
N379 (3.75) covaries with -- 21 117 143 187 277 380
R380 (0.87) covaries with -- 54 251 365 379 390
Y381 (3.21) covaries with -- 84 151 159 173 244 247 256 362 371 396
T382 (3.24) covaries with -- 394
-383 (2.89) covaries with --
-384 (3.32) covaries with --
-385 (2.98) covaries with --
-386 (3.42) covaries with --
-387 (2.97) covaries with --
-388 (2.57) covaries with --
-389 (2.61) covaries with --
A390 (3.28) covaries with -- 38 83 135 175 218 220 243 247 250 254 258 352 357 365 380 395
E391 (3.88) covaries with -- 22 27 90 112 143 177 208
E392 (3.41) covaries with -- 368 393 394 398
A393 (3.12) covaries with -- 11 83 96 131 212 214 240 242 250 255 277 352 355 362 367 369 392 395
L394 (3.59) covaries with -- 20 148 173 248 280 348 363 382 392 397 398 399
A395 (3.70) covaries with -- 5 59 128 137 187 224 240 263 390 393
H396 (3.54) covaries with -- 106 132 138 159 160 224 248 268 359 363 368 381
P397 (3.74) covaries with -- 21 255 361 364 366 394
F398 (3.19) covaries with -- 58 138 151 152 176 179 250 252 255 258 278 348 370 392 394 399
F399 (2.95) covaries with -- 128 136 255 362 394 398