Main kinase page
CKI kinase statistical analysis
cki tree, pdf
CKI tree with Pfam domains included
cki alignment, pdf (warning!! residues are deleted)
Additional domains and groups
Pfam links :
WD40
Kdo
HEAT
RIO1
pdb links
(1cki)
(1ckj) CK 1d
(1csn)
(2csn)
(1eh4) CK 1
Phospho.ELM link:
CK1x (A);
cki A group, including CK1g3.h CK1g2.h CK1g1.h CK1a2.h CK1a.h CK1d.h CK1e.h
cki B group, including VRK3.h VRK2.h VRK1.h
cki C group, including TTBK2.h TTBK1.h
cki D group, including Wee1B.h Wee1.h SCYL2.h SCYL3.h SCYL1.h PIK3R4.h SgK396.h BUB1.h Haspin.h
Sequence entropy, over all 5915 protein kinases (red) and 309 cki kinases (green)
residues which distinguish CKI kinases from others (CKId.h as ref): F395 T130 H225 L3 W265 R243 L398 Y388 H146 T201
residues in order of increasing entropy
154 34 246 180 161 156 146 157 142 10 181 178 32 158 145 182 15 33 7 152 134 155 248 153 162 250 225 395 176 164 8 249 96 163 13 138 61 159 247 179 184 16 139 264 141 95 254 105 130
covariation analysis
crystal structure of CKI (1csn.pdb) with residues numbered according to alignment
residues in order of decreasing number of covariation partners
219 228 187 386 21 216 130 213 133 388 208 214 243 204 221 215 100 245 265 259 36 83 82 96 77 148 91 256 352 127 54 93 92 98 115 361 165 222 205 95 79 185 225 372 373 2 217 252 266 241
list of covariation partners, CKId sequence as reference
CKI residue,number (entropy) -- covariation partners
Y1 (3.23) covaries with --8 11 22 31 45 81 82 95 187 215 219 221 245 249 265 388 391
R2 (3.92) covaries with --3 4 13 21 36 37 43 133 139 143 148 187 201 213 217 219 243 245 265 372 373 378 381 386
L3 (3.18) covaries with --2 7 10 11 18 35 94 95 99 159 187 219 225 244 270 366 369 386 387
G4 (3.77) covaries with --2 14 46 60 95 115 130 205 228 264 384 388
R5 (3.57) covaries with --21 63 196 279 374 384 398
K6 (3.63) covaries with --358
I7 (2.44) covaries with --3 8 10 16 127 240 243 353
G8 (2.74) covaries with --1 7 10 12 158
S9 (3.54) covaries with --88 132
G10 (2.16) covaries with --3 7 8 12 15 32 64
S11 (3.16) covaries with --1 3 16 18 81 93 136 160 184 215 243 386
F12 (3.08) covaries with --8 10 13 15 18 36 43 45 85 96 98 129 175 179 180 187 220 222 352 387
G13 (2.78) covaries with --2 12 18 32 64 93 95 131 156 158 161 179 372 391
D14 (3.76) covaries with --4 16 19 54 77 97 110 155 165 208 213 245 362
I15 (2.38) covaries with --10 12 21 32 45
Y16 (2.88) covaries with --7 11 14 18 165 183 184 216 263 369 386
L17 (3.74) covaries with --35 86 115 166 361
G18 (3.05) covaries with --3 11 12 13 16 35 36 127 133 156 158 176 179 256 358 386
T19 (3.92) covaries with --14 51 97 118
D20 (3.77) covaries with --110 148
i21 (3.77) covaries with --2 5 15 30 57 60 61 87 95 97 99 106 108 109 112 135 165 183 185 201 205 208 213 215 216 222 241 243 256 267 269 275 284 356 361 366 374 396
-22 (3.82) covaries with --1 36 216 243 263 265 267
-23 (3.62) covaries with --
-24 (3.60) covaries with --
-25 (3.71) covaries with --
a26 (3.94) covaries with --38 154 214 281 356
A27 (3.61) covaries with --37 76 162 270 280 361 395
G28 (3.67) covaries with --
E29 (3.97) covaries with --70 82 127 352
E30 (4.01) covaries with --21 186 188 216 353
V31 (3.51) covaries with --1 93
A32 (2.27) covaries with --10 13 15 36 74 81 98 156 161 185 208 216
I33 (2.43) covaries with --137 367
K34 (0.84) covaries with --139
L35 (3.42) covaries with --3 17 18 38 82 93 94 96 133 148 173 177 227 239 252 264 265 266
E36 (3.10) covaries with --2 12 18 22 32 40 44 92 95 96 98 100 108 127 135 156 177 183 203 208 213 214 217 228 245 248 259 270 372 378 387
C37 (3.77) covaries with --2 27 54 133 175 190 212
V38 (3.84) covaries with --26 35 59 60
K39 (3.92) covaries with --43 45 57 62 74 76 87 139 142 204 205 209 213 214 217 267 268 283 353
T40 (3.88) covaries with --36 56 57 82 92 133 189 208 260 276 397
-41 (3.85) covaries with --45 93 115 117 133 143 186 204 219 227 244
-42 (3.42) covaries with --97 147 158 178 204
-43 (3.47) covaries with --2 12 39 45 148
-44 (3.24) covaries with --36 45 227
-45 (3.60) covaries with --1 12 15 39 41 43 44 112 129 147 158 220 257
-46 (2.99) covaries with --4 129 140 219 262
-47 (3.66) covaries with --60
-48 (3.59) covaries with --50 54 63
-49 (3.00) covaries with --53
-50 (3.63) covaries with --48 222
-51 (3.98) covaries with --19 52 66 134
-52 (3.94) covaries with --51 134 176 177 183
-53 (3.98) covaries with --49 54 66 77 165 186
K54 (4.08) covaries with --14 37 48 53 57 63 72 73 74 82 86 97 98 131 134 137 147 172 185 204 212 213 214 220 228 240 259 396
H55 (4.05) covaries with --57 63 86 127 133 209 228 279
P56 (3.98) covaries with --40 57 59 65 85 87 106 111 115 130 133 141 211 212 241 355
Q57 (3.95) covaries with --21 39 40 54 55 56 59 62 112 128 129 170 188 211 212 354 362
L58 (3.70) covaries with --109 155 204 205 208 213 222 240 275 358 374
H59 (3.77) covaries with --38 56 57 93 110
I60 (3.82) covaries with --4 21 38 47 64 79 106 110 228
E61 (2.79) covaries with --21 64 65 179 211
S62 (3.86) covaries with --39 57 80 173 188 201 204 211 214 255 356 365
K63 (4.03) covaries with --5 48 54 55 68 133 218 261 272 283 355 367 369
I64 (3.47) covaries with --10 13 60 61 68 74 91 127 155 159 183 184 214 216 241 281 385
Y65 (3.60) covaries with --56 61 68 83 96 97 111 185 208 228 266 272 278 394
K66 (3.92) covaries with --51 53 68 98 214 226 283
M67 (3.92) covaries with --82 93 189 191 204 390
M68 (3.46) covaries with --63 64 65 66 262 358
Q69 (3.89) covaries with --79 364
G70 (3.86) covaries with --29 77 84
-71 (3.89) covaries with --190
-72 (3.30) covaries with --54 98 258 266
-73 (3.71) covaries with --54
G74 (3.92) covaries with --32 39 54 64 80 83 133 213 214 256
V75 (3.71) covaries with --133 175 185 205 369
G76 (3.50) covaries with --27 39 82
I77 (3.50) covaries with --14 53 70 83 85 91 92 93 130 143 165 172 177 186 208 215 216 222 223 241 255 273 279 359 373 374 381 387 391 393
P78 (3.54) covaries with --79 81 82 95 96 148 219 252 279 386
T79 (4.05) covaries with --60 69 78 82 83 88 98 103 112 117 126 128 130 155 187 211 217 219 220 221 240 248 259 270 381
I80 (3.28) covaries with --62 74 98 141 214 228 372
R81 (3.96) covaries with --1 11 32 78 84 97 112 130 177 179 212 215 217 219 221 252 256 265 274 386 391
W82 (3.88) covaries with --1 29 35 40 54 67 76 78 79 86 87 88 95 110 129 148 166 177 207 208 216 217 219 221 223 245 246 270 372 392
C83 (3.89) covaries with --65 74 77 79 84 91 99 112 114 129 130 144 158 172 205 206 211 214 218 219 225 227 244 251 256 274 278 282 353 359 360
G84 (3.52) covaries with --70 81 83 88 92 115 139 187 203 208 221 225 227 245 248 264 271 372 375 388 393
A85 (4.01) covaries with --12 56 77 96 100 146 185 245 388
E86 (3.97) covaries with --17 54 55 82 87 88 92 109 355
G87 (3.92) covaries with --21 39 56 82 86 88 177 248 359 361 373
-88 (3.98) covaries with --9 79 82 84 86 87 91 106 109 174 248 253 273 360
-89 (3.73) covaries with --97 268
D90 (3.79) covaries with --93
Y91 (3.74) covaries with --64 77 83 88 92 93 127 130 133 143 152 165 182 183 187 218 221 225 227 228 243 248 259 264 266 363 369 387
N92 (3.78) covaries with --36 40 77 84 86 91 94 95 97 99 133 175 181 187 206 212 216 217 224 227 228 241 245 264 265 386 388
V93 (3.61) covaries with --11 13 31 35 41 59 67 77 90 91 98 102 113 130 136 139 181 187 207 243 245 255 256 263 373 386 391
M94 (3.37) covaries with --3 35 92 95 99 100 216 264 265 277 359 365 386 388
V95 (2.95) covaries with --1 3 4 13 21 36 78 82 92 94 96 99 108 127 186 187 208 216 218 220 224 352 386 388 393
M96 (2.77) covaries with --12 35 36 65 78 85 95 97 100 108 115 116 130 139 165 186 187 204 215 218 219 220 252 265 283 368 375 386 387 391
E97 (3.70) covaries with --14 19 21 42 54 65 81 89 92 96 98 115 129 134 148 179 219 245 248 257 361 386 392
L98 (3.53) covaries with --12 32 36 54 66 72 79 80 93 97 102 129 130 155 159 174 182 214 228 252 256 259 265 268 278 283 388
L99 (3.36) covaries with --3 21 83 92 94 95 100 115 139 171 172 187 205 208 215 216 219 224 225 265 361 386 398
G100 (3.52) covaries with --36 85 94 96 99 103 115 132 133 175 183 186 204 208 214 217 220 222 225 241 242 243 255 256 352 360 372 378 384 386 387 393
-101 (3.83) covaries with --216 392
-102 (3.81) covaries with --93 98
P103 (3.85) covaries with --79 100 108 110 111 115 133 173 204 208 214 228 240 268
S104 (3.15) covaries with --
L105 (3.03) covaries with --
E106 (3.80) covaries with --21 56 60 88 109 110 112 114 115 185 211 212 355 396
D107 (3.73) covaries with --214
L108 (3.50) covaries with --21 36 95 96 103 130 143 259 265
F109 (3.57) covaries with --21 58 86 88 106 110 128 141 160 172 174 213 268
N110 (3.87) covaries with --14 20 59 60 82 103 106 109 148 160 245 274 277
F111 (3.96) covaries with --56 65 103 112 133 350
C112 (4.11) covaries with --21 45 57 79 81 83 106 111 114 117 204 259 355 370
S113 (3.69) covaries with --93 166 256
R114 (3.84) covaries with --83 106 112 358 362 365
K115 (3.98) covaries with --4 17 41 56 84 96 97 99 100 103 106 126 130 133 163 171 187 216 227 241 244 245 256 268 284 353 388
-116 (3.83) covaries with --96 185 186 215 219 388
-117 (3.55) covaries with --41 79 112 256
-118 (3.47) covaries with --19 364
-119 (3.20) covaries with --
-120 (3.38) covaries with --
-121 (2.74) covaries with --
-122 (3.32) covaries with --
-123 (2.77) covaries with --
-124 (3.00) covaries with --
-125 (3.16) covaries with --
F126 (3.18) covaries with --79 115 144 187 221 222 252
S127 (3.19) covaries with --7 18 29 36 55 64 91 95 130 152 174 177 179 187 201 213 214 218 222 241 242 243 277 283 359 386 396 398
L128 (3.88) covaries with --57 79 109 258
K129 (3.87) covaries with --12 45 46 57 82 83 97 98 133 148 187 211 227 244 284 375
T130 (3.04) covaries with --4 56 77 79 81 83 91 93 96 98 108 115 127 139 143 174 204 205 212 216 217 222 224 228 241 243 248 256 259 274 278 360 369 386 388 391 393
V131 (3.25) covaries with --13 54 140 148 188 211 219 227 245 258 271 384
L132 (3.50) covaries with --9 100 213 244 245 275 391 392
L133 (3.77) covaries with --2 18 35 37 40 41 55 56 63 74 75 91 92 100 103 111 115 129 162 172 173 175 183 201 205 213 214 241 272 274 277 281 352 361 369 371 372
L134 (2.47) covaries with --51 52 54 97 135 149 156 158 228 255 388
A135 (3.04) covaries with --21 36 134 139 140 165 215 218 219 228 255 388
D136 (3.78) covaries with --11 93 147 214 216 228 247 355 362 371 372 390
Q137 (3.05) covaries with --33 54 175
M138 (2.79) covaries with --144 160 162 211 250 251 375
I139 (2.89) covaries with --2 34 39 84 93 96 99 130 135 143 158 219 243 252 386 387 388
S140 (3.77) covaries with --46 131 135 144 188
R141 (2.95) covaries with --56 80 109 171 211 256 362 374
I142 (2.12) covaries with --39
E143 (3.25) covaries with --2 41 77 91 108 130 139 146 215 216 224 244 252 259 263 264 279 369 373 386 387
Y144 (3.62) covaries with --83 126 138 140 190 210 222 253 355 361 395 398
I145 (2.35) covaries with --
H146 (1.40) covaries with --85 143 219 249 259 265
S147 (3.65) covaries with --42 45 54 136
K148 (3.80) covaries with --2 20 35 43 78 82 97 110 129 131 158 160 161 163 205 207 209 213 257 258 259 266 267 279 280 359 361 369 392
-149 (3.12) covaries with --134
-150 (1.58) covaries with --
N151 (3.14) covaries with --373
F152 (2.45) covaries with --91 127 163 185 187 208 210 214 215 216 218 221 243 255 256 263 276 372 378
I153 (2.59) covaries with --159 208 240
H154 (0.75) covaries with --26
R155 (2.48) covaries with --14 58 64 79 98 187 201 213 219 241 266
D156 (1.23) covaries with --13 18 32 36 134 160 179 180 202 216
V157 (1.86) covaries with --181
K158 (2.29) covaries with --8 13 18 42 45 83 134 139 148 160 180 182 183 185 186 187 366 369
P159 (2.81) covaries with --3 64 98 153 165 204 214 241
D160 (3.29) covaries with --11 109 110 138 148 156 158 183 188 211 270
N161 (1.17) covaries with --13 32 148 187 216
F162 (2.59) covaries with --27 133 138 170 224 398
L163 (2.77) covaries with --115 148 152 171 251 280
M164 (2.74) covaries with --
G165 (3.25) covaries with --14 16 21 53 77 91 96 135 159 214 221 222 224 225 228 241 248 252 256 259 263 266 282 380 386 387 388
-166 (3.36) covaries with --17 82 113
-167 (3.67) covaries with --
-168 (3.84) covaries with --170
L169 (4.06) covaries with --170
g170 (3.94) covaries with --57 162 168 169 201 220 354 360 394
K171 (3.94) covaries with --99 115 141 163 184 204 213 256 359
K172 (3.71) covaries with --54 77 83 99 109 133 220 228 265 395
G173 (4.04) covaries with --35 62 103 133 203
N174 (3.77) covaries with --88 98 109 127 130 175 186 187 204 214 215 224 248 259 273 363 386
L175 (3.78) covaries with --12 37 75 92 100 133 137 174 183 187 208 213 243 263 264 388 392
V176 (2.73) covaries with --18 52 180 183 369 385
Y177 (3.41) covaries with --35 36 52 77 81 82 87 127 183 211 222 228 248 252 265 268 375 386 387 393
I178 (2.21) covaries with --42
I179 (2.86) covaries with --12 13 18 61 81 97 127 156 213 215 219 221 266
D180 (0.96) covaries with --12 156 158 176 182
F181 (2.20) covaries with --92 93 157 182 183 215
G182 (2.37) covaries with --91 98 158 180 181 184 186 211 215 219 229
L183 (3.44) covaries with --16 21 36 52 64 91 100 133 158 160 175 176 177 181 211 213 220 228
A184 (2.88) covaries with --11 16 64 171 182
K185 (3.62) covaries with --21 32 54 65 75 85 106 116 152 158 188 205 215 216 218 219 228 243 244 256 266 369 373 387 388
K186 (3.54) covaries with --30 41 53 77 95 96 100 116 158 174 182 187 215 216 222 225 245 249 257 366 384
Y187 (3.47) covaries with --1 2 3 12 79 84 91 92 93 95 96 99 115 126 127 129 152 155 158 161 174 175 186 188 205 208 213 218 225 241 256 259 268 372 373 378 379 391
R188 (3.64) covaries with --30 57 62 131 140 160 185 187 205 245
D189 (3.77) covaries with --40 67
A190 (3.98) covaries with --37 71 144 210
R191 (3.72) covaries with --67
-192 (2.50) covaries with --
-193 (3.16) covaries with --
-194 (2.31) covaries with --
-195 (2.00) covaries with --
-196 (2.58) covaries with --5
-197 (3.11) covaries with --
-198 (3.23) covaries with --
-199 (3.67) covaries with --
-200 (3.19) covaries with --219 256
T201 (3.48) covaries with --2 21 62 127 133 155 170 207 214 219 244 266 275 355
H202 (3.84) covaries with --156 203 205 219 228
Q203 (3.79) covaries with --36 84 173 202 205 208 215 219 243 244 252 267
H204 (3.89) covaries with --39 41 42 54 58 62 67 96 100 103 112 130 159 171 174 208 211 215 216 221 224 227 228 243 245 265 361 362 372 374 381 386 393 394
I205 (3.71) covaries with --4 21 39 58 75 83 99 130 133 148 185 187 188 202 203 215 216 218 219 225 243 265 270 353 373 391
P206 (3.90) covaries with --83 92 208 212 218
Y207 (3.84) covaries with --82 93 148 201 256 279 393
R208 (3.70) covaries with --14 21 32 36 40 58 65 77 82 84 95 99 100 103 152 153 175 187 203 204 206 212 221 223 228 243 252 256 266 268 278 281 374 386 391
E209 (3.94) covaries with --39 55 148 354 355 358
N210 (3.88) covaries with --144 152 190 214 215 216 244 270 372 393
K211 (3.91) covaries with --56 57 61 62 79 83 106 129 131 138 141 160 177 182 183 204 216 217 219 272 352 355
N212 (3.97) covaries with --37 54 56 57 81 92 106 130 206 208 213 214 224 241 268 359
L213 (3.64) covaries with --2 14 21 36 39 54 58 74 109 127 132 133 148 155 171 175 179 183 187 212 217 221 224 226 240 252 259 266 269 270 273 277 362 372 378 381 386
T214 (3.75) covaries with --26 36 39 54 62 64 66 74 80 83 98 100 103 107 127 133 136 152 159 165 174 201 210 212 217 222 225 227 243 244 255 256 270 362
G215 (3.46) covaries with --1 11 21 77 81 96 99 116 135 143 152 174 179 181 182 185 186 203 204 205 210 224 241 244 266 273 279 281 352 366 373 393
T216 (3.50) covaries with --16 21 22 30 32 64 77 82 92 94 95 99 101 115 130 136 143 152 156 161 185 186 204 205 210 211 228 242 272 352 361 363 366 373 375 381 384
A217 (3.82) covaries with --2 36 39 79 81 82 92 100 130 211 213 214 221 222 225 227 228 243 248 252 354 362 384 388
R218 (3.68) covaries with --63 83 91 95 96 127 135 152 185 187 205 206 221 224 228 248 259 374 388
Y219 (3.32) covaries with --1 2 3 41 46 78 79 81 82 83 96 97 99 116 131 135 139 146 155 179 182 185 200 201 202 203 205 211 227 228 241 242 264 268 270 273 363 366 372 373 375 381 387
A220 (3.62) covaries with --12 45 54 79 95 96 100 170 172 183 225 227 228 248 259 265 268 369 380 386
S221 (3.04) covaries with --1 79 81 82 84 91 126 152 165 179 204 208 213 217 218 222 223 249 256 259 277 279 281 352 363 364 366 372 373 381 386 393
I222 (3.59) covaries with --12 21 50 58 77 100 126 127 130 144 165 177 186 214 217 221 225 228 245 248 249 252 264 275 387 388
N223 (3.25) covaries with --77 82 208 221 224 244 245
T224 (3.27) covaries with --92 95 99 130 143 162 165 174 204 212 213 215 218 223 249 369 394
H225 (2.64) covaries with --3 83 84 91 99 100 165 186 187 205 214 217 220 222 227 245 255 266 363 371 380 381 387 388 391
L226 (3.86) covaries with --66 213 227 229
G227 (3.62) covaries with --35 41 44 83 84 91 92 115 129 131 204 214 217 219 220 225 226 254 255 352 387
I228 (3.92) covaries with --4 36 54 55 60 65 80 91 92 98 103 130 134 135 136 165 172 177 183 185 202 204 208 216 217 218 219 220 222 243 252 253 262 264 265 361 366 378 380 384 388 393 396
-229 (3.49) covaries with --182 226 240
-230 (3.38) covaries with --282
-231 (1.58) covaries with --
-232 (1.00) covaries with --
-233 (2.00) covaries with --
-234 (3.32) covaries with --
-235 (3.32) covaries with --
-236 (3.58) covaries with --
-237 (3.45) covaries with --
-238 (3.55) covaries with --
-239 (3.48) covaries with --35
E240 (3.67) covaries with --7 54 58 79 103 153 213 229 257 278 362
Q241 (3.57) covaries with --21 56 64 77 92 100 115 127 130 133 155 159 165 187 212 215 219 256 266 268 281 361 387
S242 (3.15) covaries with --100 127 216 219 243 270 279
R243 (3.38) covaries with --2 7 11 21 22 91 93 100 127 130 139 152 175 185 203 204 205 208 214 217 228 242 245 255 279 352 363 365 372 373 375 391 392 393
R244 (3.53) covaries with --3 41 83 115 129 132 143 185 201 203 210 214 215 223 255 259 369 380 384 387 392
D245 (3.05) covaries with --1 2 14 36 82 84 85 92 93 97 110 115 131 132 186 188 204 222 223 225 243 251 257 267 281 358 366 369 373 375 386 391
D246 (0.92) covaries with --82
L247 (2.81) covaries with --136 279
E248 (2.52) covaries with --36 79 84 87 88 91 97 130 165 174 177 217 218 220 222 273 363 369 370 372
S249 (2.76) covaries with --1 146 186 221 222 224 252 257 268
L250 (2.59) covaries with --138
G251 (3.11) covaries with --83 138 163 245 258
Y252 (3.14) covaries with --35 78 81 96 98 126 139 143 165 177 203 208 213 217 222 228 249 256 264 270 373 375 378
V253 (3.07) covaries with --88 144 228 261
L254 (2.98) covaries with --227 255
M255 (3.21) covaries with --62 77 93 100 134 135 152 214 225 227 243 244 254 263 359 362 384 388
Y256 (3.55) covaries with --18 21 74 81 83 93 98 100 113 115 117 130 141 152 165 171 185 187 200 207 208 214 221 241 252 268 278 352
F257 (3.12) covaries with --45 97 148 186 240 245 249 369
N258 (3.68) covaries with --72 128 131 148 251 259
L259 (3.78) covaries with --36 54 79 91 98 108 112 130 143 146 148 165 174 187 213 218 220 221 244 258 262 264 265 267 269 279 361 380 388 391 397
G260 (3.44) covaries with --40
-261 (3.60) covaries with --63 253
S262 (4.01) covaries with --46 68 228 259 353
L263 (3.40) covaries with --16 22 93 143 152 165 175 255 267 372 378 380 384 388
P264 (2.93) covaries with --4 35 84 91 92 94 143 175 219 222 228 252 259 266 373
W265 (3.19) covaries with --1 2 22 35 81 92 94 96 98 99 108 146 172 177 204 205 220 228 259 267 270 273 274 276 284 361 363 375 378 381 389
Q266 (3.78) covaries with --35 65 72 91 148 155 165 179 185 201 208 213 215 225 241 264 268 272 279 352 366 380 381
G267 (3.87) covaries with --21 22 39 148 203 245 259 263 265 272 352 353
L268 (3.84) covaries with --39 89 98 103 109 115 177 187 208 212 219 220 241 249 256 266 270 278 352 363 366 374
K269 (3.81) covaries with --21 213 259 270 361 393
A270 (3.86) covaries with --3 27 36 79 82 160 205 210 213 214 219 242 252 265 268 269 272 361 388
A271 (3.98) covaries with --84 131
T272 (4.05) covaries with --63 65 133 211 216 266 267 270 277 363 378
K273 (3.98) covaries with --77 88 174 213 215 219 248 265 388
R274 (4.06) covaries with --81 83 110 130 133 265 276 278 279 352 359
Q275 (4.09) covaries with --21 58 132 201 222 279 282 364 381
K276 (3.99) covaries with --40 152 265 274 381
Y277 (3.84) covaries with --94 110 127 133 213 221 272 354 358 393
E278 (3.75) covaries with --65 83 98 130 208 240 256 268 274 282 359
R279 (3.82) covaries with --5 55 77 78 143 148 207 215 221 242 243 247 259 266 274 275 282 380 387 398
I280 (3.94) covaries with --27 148 163 282 352 361 363 374
S281 (4.03) covaries with --26 64 133 208 215 221 241 245 282
E282 (3.77) covaries with --83 165 230 275 278 279 280 281 285
K283 (3.93) covaries with --39 63 66 96 98 127
K284 (3.90) covaries with --21 115 129 265 352
M285 (4.16) covaries with --282
-286 (3.68) covaries with --362
-287 (3.33) covaries with --
-288 (3.28) covaries with --
-289 (3.13) covaries with --
-290 (2.77) covaries with --
-291 (2.80) covaries with --
-292 (2.00) covaries with --
-293 (0.00) covaries with --
-294 (1.00) covaries with --
-295 (1.00) covaries with --
-296 (1.00) covaries with --
-297 (0.00) covaries with --
-298 (0.00) covaries with --
-299 (0.00) covaries with --
-300 (0.00) covaries with --
-301 (0.00) covaries with --
-302 (0.00) covaries with --
-303 (0.00) covaries with --
-304 (0.00) covaries with --
-305 (0.00) covaries with --
-306 (0.00) covaries with --
-307 (0.00) covaries with --
-308 (0.00) covaries with --
-309 (0.00) covaries with --
-310 (0.00) covaries with --
-311 (0.00) covaries with --
-312 (0.00) covaries with --
-313 (0.00) covaries with --
-314 (0.00) covaries with --
-315 (0.00) covaries with --
-316 (0.00) covaries with --
-317 (0.00) covaries with --
-318 (0.00) covaries with --
-319 (0.00) covaries with --
-320 (0.00) covaries with --
-321 (0.00) covaries with --
-322 (0.00) covaries with --
-323 (0.00) covaries with --
-324 (0.00) covaries with --
-325 (0.00) covaries with --
-326 (0.00) covaries with --
-327 (0.00) covaries with --
-328 (0.00) covaries with --
-329 (0.00) covaries with --
-330 (0.00) covaries with --
-331 (0.00) covaries with --
-332 (0.00) covaries with --
-333 (0.00) covaries with --
-334 (0.00) covaries with --
-335 (0.00) covaries with --
-336 (0.00) covaries with --
-337 (0.00) covaries with --
-338 (0.00) covaries with --
-339 (0.00) covaries with --
-340 (0.00) covaries with --
-341 (0.00) covaries with --
-342 (0.00) covaries with --
-343 (3.15) covaries with --
-344 (3.12) covaries with --
-345 (3.37) covaries with --
-346 (3.06) covaries with --
-347 (3.66) covaries with --
-348 (3.65) covaries with --
-349 (3.70) covaries with --352 365
-350 (4.00) covaries with --111 354
-351 (3.93) covaries with --
S352 (4.06) covaries with --12 29 95 100 133 211 215 216 221 227 243 256 266 267 268 274 280 284 349 355 359 363 368 369 371 386 388 389
T353 (3.95) covaries with --7 30 39 83 115 205 262 267 358 362
P354 (4.09) covaries with --57 170 209 217 277 350 365 366
I355 (3.97) covaries with --56 63 86 106 112 136 144 201 209 211 352 359 361 374 392
E356 (4.13) covaries with --21 26 62 357 359 360 366 380
V357 (4.05) covaries with --356 372 374
L358 (3.98) covaries with --6 18 58 68 114 209 245 277 353 359 360 361 386
C359 (4.06) covaries with --77 83 87 94 127 148 171 212 255 274 278 352 355 356 358 361 362 365 373 378 381 385 390
K360 (4.08) covaries with --83 88 100 130 170 356 358 361 363 374 385
G361 (4.03) covaries with --17 21 27 87 97 99 133 144 148 204 216 228 241 259 265 269 270 280 355 358 359 360 365 369 372 375 388
Y362 (4.12) covaries with --14 57 114 136 141 204 213 214 217 240 255 286 353 359 363 365 381 395
P363 (4.06) covaries with --91 174 216 219 221 225 243 248 265 268 272 280 352 360 362 372 374 375 378 384 385 388
S364 (4.11) covaries with --69 118 221 275 380 385
E365 (4.02) covaries with --62 94 114 243 349 354 359 361 362 370 388
F366 (3.70) covaries with --3 21 158 186 215 216 219 221 228 245 266 268 354 356 373 384 386
A367 (4.06) covaries with --33 63
T368 (3.94) covaries with --96 352
Y369 (3.67) covaries with --3 16 63 75 91 130 133 143 148 158 176 185 220 224 244 245 248 257 352 361 378 381
L370 (3.89) covaries with --112 248 365 373 380 384
N371 (4.04) covaries with --133 136 225 352 373 375
F372 (3.94) covaries with --2 13 36 80 82 84 100 133 136 152 187 204 210 213 219 221 243 248 263 357 361 363 373 386 390
C373 (3.67) covaries with --2 77 87 93 143 151 185 187 205 215 216 219 221 243 245 252 264 359 366 370 371 372 384 385 389
R374 (3.87) covaries with --5 21 58 77 141 204 208 218 268 280 355 357 360 363 381
S375 (3.93) covaries with --84 96 129 138 177 216 219 243 245 252 265 361 363 371 384 386 391
-376 (0.00) covaries with --
-377 (0.00) covaries with --
L378 (3.94) covaries with --2 36 100 152 187 213 228 252 263 265 272 359 363 369 381 388
R379 (3.89) covaries with --187
F380 (3.53) covaries with --165 220 225 228 244 259 263 266 279 356 364 370 384 387
D381 (3.80) covaries with --2 77 79 204 213 216 219 221 225 265 266 275 276 359 362 369 374 378 386
-382 (0.00) covaries with --
-383 (0.00) covaries with --
D384 (3.63) covaries with --4 5 100 131 186 216 217 228 244 255 263 363 366 370 373 375 380 387 392 394
K385 (3.93) covaries with --64 176 359 360 363 364 373
P386 (3.54) covaries with --2 3 11 16 18 78 81 92 93 94 95 96 97 99 100 127 130 139 143 165 174 177 204 208 213 220 221 245 352 358 366 372 375 381 389 393 394 395
D387 (3.47) covaries with --3 12 36 77 91 96 100 139 143 165 177 185 219 222 225 227 241 244 279 380 384 393 394
Y388 (3.37) covaries with --1 4 84 85 92 94 95 98 115 116 130 134 135 139 165 175 185 217 218 222 225 228 255 259 263 270 273 352 361 363 365 378 389 393 395
S389 (4.04) covaries with --265 352 373 386 388 391
Y390 (3.95) covaries with --67 136 359 372
L391 (3.64) covaries with --1 13 77 81 93 96 130 132 187 205 208 225 243 245 259 375 389 393 394
R392 (3.96) covaries with --82 97 101 132 148 175 243 244 355 384
Q393 (4.02) covaries with --77 84 95 100 130 177 204 207 210 215 221 228 243 269 277 386 387 388 391
L394 (3.87) covaries with --65 170 204 224 384 386 387 391
F395 (2.72) covaries with --27 144 172 362 386 388
R396 (3.92) covaries with --21 54 106 127 228 398
N397 (3.77) covaries with --40 259
L398 (3.49) covaries with --5 99 127 144 162 279 396
F399 (3.52) covaries with --