Main kinase page
CMGC I kinases
CMGC II family kinases
cmgc tree (pdf)
CMGCI tree with Pfam domains included
cmgc alinment, pdf (warning!! lots of residues are deleted)
Additional domains and groups
Pfam links :
PASTA
Ribonuc_2-5A
GAF
HATPase_c
RWD
TPR
WD40
PQQ
dsrm
DUF323
FHA
NHL
TBC
Usp
Response_reg
pdb links
(1gii)
(1gij)
(1gz8)
(1oit)
(1fin)
(1fvv)
(1g5s)
(1gih)
(1h0v)
(1h0w)
(1hcl)
(1jvp)
(1ke6)
(1ke7)
(1ke8)
(1ke9)
(1oku)
(1okv)
(1okw)
(1ol1)
(1ol2)
(1p2a)
(1pf8)
(1pw2)
(1pxi)
(1pxj)
(1pxk)
(1pxl)
(1h01)
(1oir)
(1b38)
(1b39)
(1e1v)
(1e1x)
(1h00)
(1h06)
(1h07)
(1h08)
(1oiq)
(1hck)
(1jsv)
(1ke5)
(1r78)
(1fvt)
(1f5q)
(1dm2)
(1di8)
(1ckp)
(1buh)
(1aq1)
(1e9h)
(1ogu)
(1pkd)
(1gy3)
(1p5e)
(1qmz)
(1h1p)
(1h1q)
(1h1r)
(1h1s)
(1h24)
(1h25)
(1h26)
(1h27)
(1h28)
(1fq1)
(1jst)
(1jsu) CDK2
(1ob3) CDK5
(1h4l)
(1bi7)
(1bi8)
(1blx)
(1g3n)
(1jow) CDK6
(1jnk)
(1pmn)
(1pmq)
(1pmu)
(1pmv) JNK
(1cm8) p38g
(1ove)
(1r3c)
(1kv1)
(1m7q)
(1ouk)
(1ouy)
(1r39)
(1wfc)
(1a9u)
(1bl6)
(1bl7)
(1di9)
(1kv2)
(1oz1)
(1ian)
(1bmk)
(1p38)
(1lew)
(1lez) p38
(1gol)
(1erk)
(3erk)
(4erk)
(2erk)
(1pme) ERK2
(1how)
(1q8y)
(1q8z)
(1q97)
(1q99) Ymr216
(1daw)
(1ds5)
(1f0q)
(1j91)
(1jam)
(1lp4)
(1lpu)
(1lr4)
(1day)
(1m2q)
(1m2r)
(1m2p) CK2a
(1na7)
(1jwh) CK2a
(1pjk)
(1o9u)
(1h8f)
(1i09)
(1pyx)
(1j1b)
(1j1c)
(1q3d)
(1q3w)
(1q41)
(1q4l)
(1gng) GSK3b
Phospho.ELM links
CDKx (A);
p38a (A);
6323872.y (D);
CK2x (E);
GSK3x (E);
group A (p38g.h p38d.h p38a.h p38b.h JNK2.h JNK1.h JNK3.h Erk4.h Erk3.h Erk1.h Erk2.h Erk7.h Erk5.h NLK.h)
group B (CDK3.h 1h28_CDK2 CDK2.h CDK6.h CDK4.h CDC2.h CDK5ps.h CDK5.h 1h4l_CDK5 PFTAIRE2.h PFTAIRE1.h CDK8.h CDK11.h PCTAIRE1.h PCTAIRE2.h PCTAIRE3.h)
group C (MOK.h MAK.h ICK.h CDK9.h CRK7.h CHED.h CDK10.h PITSLRE.h CCRK.h CDK7.h CDKL5.h CDKL2.h CDKL3.h CDKL1.h CDKL4.h)
group D (CLK2.h CLK3.h CLK4.h CLK1.h 1how_Ymr216 MSSK1.h SRPK1.h SRPK2.h DYRK4.h DYRK2.h DYRK3.h DYRK1B.h DYRK1A.h HIPK3.h HIPK2.h HIPK1.h HIPK4.h PRP4.h)
group E (GSK3A.h GSK3B.h CK2a2.h CK2a1-rs.h CK2a1.h)
Tree-corrected sequence entropy, over all 4600 kinases (red) and 807 cmgc kinases (green)
click on the alignment below to see distribution of residues at each site across human kinases
Residues which distinguish cmgcI kinases from all kinases (cdk2 seqence as reference): Y240 E256 F398 R220 W248 F265 L370 F399 V214 L217
covariation analysis
crystal structure of erk2 (2erk.pdb) with residues numbered according to alignment
