Main kinase page
CMGC II kinases
cmgc tree (pdf)
CMGCII tree with Pfam domains included
cmgc alinment, pdf (warning!! lots of residues are deleted)
Additional domains and groups
Pfam links :
PASTA
Ribonuc_2-5A
GAF
HATPase_c
RWD
TPR
WD40
PQQ
dsrm
DUF323
FHA
NHL
TBC
Usp
Response_reg
pdb links
(1mru)
(1o6y) PKNb (Tuberculosis)
Phospho.ELM links:
IKK (A);
PKR (B);
cmgc A group, including SgK069.h SgK110.h SBK.h TLK2ps1.h TLK2.h TBK1.h IKKe.h SgK269.h RSKL1.h TBCK.h IKKa.h IKKb.h
cmgc B group, including PINK1.h CLIK1L.h CLIK1.h TTK.h GAK.h AAK1.h BIKE.h MPSK1.h CDC7.h SgK071.h RNAseL.h GCN2.h HRI.h PKR.h PEK.h
cmgc C group, including lots of bacterial kinases and KIS.h
Sequence entropy, over all 5915 kinases (red) and 671 cmgcII kinases (green)
residues which distinguish CMGC II from all (pkn sequence for reference): L370 V366 D156 P159 A369 E61 E223 K158 T216 K34
covariation analysis
crystal structure of erk2 (2erk.pdb) with residues numbered according to alignment
