>FER
VILGELLGKGNFGEVYKGTLKD-----------------------------
-------KTSVAVKTCKEDLPQEL-------------------------K
IKFLQEAKILKQYD------------------HPNIVKLIGVCTQ-----
-----------------------------------------RQPVYIIME
LVSG----------------------------------------------
--GDFLTFLRRKKDE-----------------------------------
--------------------------------------------------
-------------------------------------LKLKQLVKFSLDA
AAGMLYLESK------------NCIHRDLAARNCLVGEN-----------
--------NVLKISDFGMSRQEDG--------------------------
--------------------------GVYSSSGLKQIPIKWTAPEALNY-
--------------------GRY-------SSESDVWSFGILLWETFSLG
-----------VCPYPGMT------------------NQQAREQVERG--
--------------------------------------------------
---------------------YRMSAPQHCP---EDISKIMMKCWD----
YKPENRPKF---------SELQKELTI----------------------
>FES
LVLGEQIGRGNFGEVFSGRLRAD---------------------------
-------NTLVAVKSCRETLPPDL-------------------------K
AKFLQEARILKQYS------------------HPNIVRLIGVCTQ-----
-----------------------------------------KQPIYIVME
LVQG----------------------------------------------
--GDFLTFLRTEGAR-----------------------------------
--------------------------------------------------
-------------------------------------LRVKTLLQMVGDA
AAGMEYLESK------------CCIHRDLAARNCLVTEK-----------
--------NVLKISDFGMSREEAD--------------------------
-------------------------GVYAASGGSRQVPVKWTAPEALNY-
--------------------GRY-------SSESDVWSFGILLWETFSLG
-----------ASPYPNLS------------------NQQTREFVEKG--
--------------------------------------------------
---------------------GRLPCPELCP---DAVFRLMEQCWA----
YEPGQRPSF---------STIYQELQS----------------------
>abl_1fpu.PDB
ITMKHKLGGGQYGEVYEGVWKKY---------------------------
-------SLTVAVKTLKEDTMEV---------------------------
EEFLKEAAVMKEIK------------------HPNLVQLLGVCTR-----
-----------------------------------------EPPFYIITE
FMTY----------------------------------------------
--GNLLDYLRECNRQE----------------------------------
--------------------------------------------------
-------------------------------------VSAVVLLYMATQI
SSAMEYLEKK------------NFIHRDLAARNCLVGEN-----------
--------HLVKVADFGLSRLMTG--------------------------
--------------------------DTYTAHAGAKFPIKWTAPESLAY-
--------------------NKF-------SIKSDVWAFGVLLWEIATYG
-----------MSPYPGID------------------LSQVYELLEKD--
--------------------------------------------------
---------------------YRMERPEGCP---EKVYELMRACWQ----
WNPSDRPSF---------AEIHQAFETMFQ-------------------
>ABL
ITMKHKLGGGQYGEVYEGVWKKY---------------------------
-------SLTVAVKTLKEDTMEV---------------------------
EEFLKEAAVMKEIK------------------HPNLVQLLGVCTR-----
-----------------------------------------EPPFYIITE
FMTY----------------------------------------------
--GNLLDYLRECNRQE----------------------------------
--------------------------------------------------
-------------------------------------VNAVVLLYMATQI
SSAMEYLEKK------------NFIHRDLAARNCLVGEN-----------
--------HLVKVADFGLSRLMTG--------------------------
--------------------------DTYTAHAGAKFPIKWTAPESLAY-
--------------------NKF-------SIKSDVWAFGVLLWEIATYG
-----------MSPYPGID------------------LSQVYELLEKD--
--------------------------------------------------
---------------------YRMERPEGCP---EKVYELMRACWQ----
WNPSDRPSF---------AEIHQAF------------------------
>ARG
ITMKHKLGGGQYGEVYVGVWKKY---------------------------
-------SLTVAVKTLKEDTMEV---------------------------
EEFLKEAAVMKEIK------------------HPNLVQLLGVCTL-----
-----------------------------------------EPPFYIVTE
YMPY----------------------------------------------
--GNLLDYLRECNREE----------------------------------
--------------------------------------------------
-------------------------------------VTAVVLLYMATQI
SSAMEYLEKK------------NFIHRDLAARNCLVGEN-----------
--------HVVKVADFGLSRLMTG--------------------------
--------------------------DTYTAHAGAKFPIKWTAPESLAY-
--------------------NTF-------SIKSDVWAFGVLLWEIATYG
-----------MSPYPGID------------------LSQVYDLLEKG--
--------------------------------------------------
---------------------YRMEQPEGCP---PKVYELMRACWK----
WSPADRPSF---------AETHQAF------------------------
>csk_1k9a.PDB
LKLLQTIGKGEFGDVMLGDYRG----------------------------
--------NKVAVKCIKNDATA----------------------------
QAFLAEASVMTQLR------------------HSNLVQLLGVIVEE----
-----------------------------------------KGGLYIVTE
YMAK----------------------------------------------
--GSLVDYLRSRGRSV----------------------------------
--------------------------------------------------
-------------------------------------LGGDCLLKFSLDV
CEAMEYLEGN------------NFVHRDLAARNVLVSED-----------
--------NVAKVSDFGLTKEA----------------------------
----------------------------------SKLPVKWTAPEALRE-
--------------------KKF-------STKSDVWSFGILLWEIYSFG
-----------RVPYPRIP------------------LKDVVPRVEKG--
--------------------------------------------------
---------------------YKMDAPDGCP---PAVYDVMKNCWH----
LDAATRPTF---------LQLREQLEHIRTHELH---------------
>CSK
LKLLQTIGKGEFGDVMLGDYRG----------------------------
--------NKVAVKCIKNDATA----------------------------
QAFLAEASVMTQLR------------------HSNLVQLLGVIVEE----
-----------------------------------------KGGLYIVTE
YMAK----------------------------------------------
--GSLVDYLRSRGRSV----------------------------------
--------------------------------------------------
-------------------------------------LGGDCLLKFSLDV
CEAMEYLEGN------------NFVHRDLAARNVLVSED-----------
--------NVAKVSDFGLTKEA----------------------------
----------------------------SSTQDTGKLPVKWTAPEALRE-
--------------------KKF-------STKSDVWSFGILLWEIYSFG
-----------RVPYPRIP------------------LKDVVPRVEKG--
--------------------------------------------------
---------------------YKMDAPDGCP---PAVYEVMKNCWH----
LDAAMRPSF---------LQLREQL------------------------
>CTK
LTLGAQIGEGEFGAVLQGEYLG----------------------------
--------QKVAVKNIKCDVTA----------------------------
QAFLDETAVMTKMQ------------------HENLVRLLGVIL------
-----------------------------------------HQGLYIVME
HVSK----------------------------------------------
--GNLVNFLRTRGRAL----------------------------------
--------------------------------------------------
-------------------------------------VNTAQLLQFSLHV
AEGMEYLESK------------KLVHRDLAARNILVSED-----------
--------LVAKVSDFGLAKAE----------------------------
----------------------------RKGLDSSRLPVKWTAPEALKH-
--------------------GKF-------TSKSDVWSFGVLLWEVFSYG
-----------RAPYPKMS------------------LKEVSEAVEKG--
--------------------------------------------------
---------------------YRMEPPEGCP---GPVHVLMSSCWE----
AEPARRPPF---------RKLAEKL------------------------
>BMX
ITLLKELGSGQFGVVQLGKWKG----------------------------
-------QYDVAVKMIKEGSMSE---------------------------
DEFFQEAQTMMKLS------------------HPKLVKFYGVCSK-----
-----------------------------------------EYPIYIVTE
YISN----------------------------------------------
--GCLLNYLRSHGKG-----------------------------------
--------------------------------------------------
-------------------------------------LEPSQLLEMCYDV
CEGMAFLESH------------QFIHRDLAARNCLVDRD-----------
--------LCVKVSDFGMTRYVLD--------------------------
--------------------------DQYVSSVGTKFPVKWSAPEVFHY-
--------------------FKY-------SSKSDVWAFGILMWEVFSLG
-----------KQPYDLYD------------------NSQVVLKVSQG--
--------------------------------------------------
---------------------HRLYRPHLAS---DTIYQIMYSCWH----
ELPEKRPTF---------QQLLSSIEP----------------------
>BTK
LTFLKELGTGQFGVVKYGKWRG----------------------------
-------QYDVAIKMIKEGSMSE---------------------------
DEFIEEAKVMMNLS------------------HEKLVQLYGVCTK-----
-----------------------------------------QRPIFIITE
YMAN----------------------------------------------
--GCLLNYLREMRHR-----------------------------------
--------------------------------------------------
-------------------------------------FQTQQLLEMCKDV
CEAMEYLESK------------QFLHRDLAARNCLVNDQ-----------
--------GVVKVSDFGLSRYVLD--------------------------
--------------------------DEYTSSVGSKFPVRWSPPEVLMY-
--------------------SKF-------SSKSDIWAFGVLMWEIYSLG
-----------KMPYERFT------------------NSETAEHIAQG--
--------------------------------------------------
---------------------LRLYRPHLAS---EKVYTIMYSCWH----
EKADERPTF---------KILLSNILD----------------------
>TXK
LAFIKEIGSGQFGVVHLGEWRS----------------------------
-------HIQVAIKAINEGSMSE---------------------------
EDFIEEAKVMMKLS------------------HSKLVQLYGVCIQ-----
-----------------------------------------RKPLYIVTE
FMEN----------------------------------------------
--GCLLNYLRENKGK-----------------------------------
--------------------------------------------------
-------------------------------------LRKEMLLSVCQDI
CEGMEYLERN------------GYIHRDLAARNCLVSST-----------
--------CIVKISDFGMTRYVLD--------------------------
--------------------------DEYVSSFGAKFPIKWSPPEVFLF-
--------------------NKY-------SSKSDVWSFGVLMWEVFTEG
-----------KMPFENKS------------------NLQVVEAISEG--
--------------------------------------------------
---------------------FRLYRPHLAP---MSIYEVMYSCWH----
EKPEGRPTF---------AELLRAVTE----------------------
>TEC
LTFMRELGSGLFGVVRLGKWRA----------------------------
-------QYKVAIKAIREGAMCE---------------------------
EDFIEEAKVMMKLT------------------HPKLVQLYGVCTQ-----
-----------------------------------------QKPIYIVTE
FMER----------------------------------------------
--GCLLNFLRQRQGH-----------------------------------
--------------------------------------------------
-------------------------------------FSRDVLLSMCQDV
CEGMEYLERN------------SFIHRDLAARNCLVSEA-----------
--------GVVKVSDFGMARYFLD--------------------------
--------------------------DQYTSSSGAKFPVKWCPPEVFNY-
--------------------SRF-------SSKSDVWSFGVLMWEVFTEG
-----------RMPFEKYT------------------NYEVVTMVTRG--
--------------------------------------------------
---------------------HRLYQPKLAS---NYVYEVMLRCWQ----
EKPEGRPSF---------EDLLRTI------------------------
>ITK
LTFVQEIGSGQFGLVHLGYWLN----------------------------
-------KDKVAIKTIREGAMSE---------------------------
EDFIEEAEVMMKLS------------------HPKLVQLYGVCLE-----
-----------------------------------------QAPICLVFE
FMEH----------------------------------------------
--GCLSDYLRTQRGL-----------------------------------
--------------------------------------------------
-------------------------------------FAAETLLGMCLDV
CEGMAYLEEA------------CVIHRDLAARNCLVGEN-----------
--------QVIKVSDFGMTRFVLD--------------------------
--------------------------DQYTSSTGTKFPVKWASPEVFSF-
--------------------SRY-------SSKSDVWSFGVLMWEVFSEG
-----------KIPYENRS------------------NSEVVEDISTG--
--------------------------------------------------
---------------------FRLYKPRLAS---THVYQIMNHCWK----
ERPEDRPAF---------SRLLRQL------------------------
>BRK
FTLCRKLGSGYFGEVFEGLWKD----------------------------
-------RVQVAIKVISRDNLLHQ--------------------------
QMLQSEIQAMKKLR------------------HKHILALYAVVSV-----
-----------------------------------------GDPVYIITE
LMAK----------------------------------------------
--GSLLELLRDSDEKV----------------------------------
--------------------------------------------------
-------------------------------------LPVSELLDIAWQV
AEGMCYLESQ------------NYIHRDLAARNILVGEN-----------
--------TLCKVGDFGLARLIKE--------------------------
---------------------------DVYLSHDHNIPYKWTAPEALSR-
--------------------GHY-------STKSDVWSFGILLHEMFSRG
-----------QVPYPGMS------------------NHEAFLRVDAG--
--------------------------------------------------
---------------------YRMPCPLECP---PSVHKLMLTCWC----
RDPEQRPCF---------KALRERLSSF---------------------
>SRM
FALGRKLGEGYFGEVWEGLWLG----------------------------
-------SLPVAIKVIKSANMKL---------------------------
TDLAKEIQTLKGLR------------------HERLIRLHAVCSG-----
-----------------------------------------GEPVYIVTE
LMRK----------------------------------------------
--GNLQAFLGTPEGRA----------------------------------
--------------------------------------------------
-------------------------------------LRLPPLLGFACQV
AEGMSYLEEQ------------RVVHRDLAARNVLVDDG-----------
--------LACKVADFGLARLLKD--------------------------
--------------------------DIYSPSSSSKIPVKWTAPEAANY-
--------------------RVF-------SQKSDVWSFGVLLHEVFTYG
-----------QCPYEGMT------------------NHETLQQIMRG--
--------------------------------------------------
---------------------YRLPRPAACP---AEVYVLMLECWR----
SSPEERPSF---------ATLREKL------------------------
>FRK
IQLLKRLGSGQFGEVWEGLWNN----------------------------
-------TTPVAVKTLKPGSMDP---------------------------
NDFLREAQIMKNLR------------------HPKLIQLYAVCTL-----
-----------------------------------------EDPIYIITE
LMRH----------------------------------------------
--GSLQEYLQNDTGSK----------------------------------
--------------------------------------------------
-------------------------------------IHLTQQVDMAAQV
ASGMAYLESR------------NYIHRDLAARNVLVGEH-----------
--------NIYKVADFGLARVFKV--------------------------
-----------------------DNEDIYESRHEIKLPVKWTAPEAIRS-
--------------------NKF-------SIKSDVWSFGILLYEIITYG
-----------KMPYSGMT------------------GAQVIQMLAQN--
--------------------------------------------------
---------------------YRLPQPSNCP---QQFYNIMLECWN----
AEPKERPTF---------ETLRWKLEDYF--------------------
>BLK
LRLVRKLGSGQFGEVWMGYYKN----------------------------
-------NMKVAIKTLKEGTMSP---------------------------
EAFLGEANVMKALQ------------------HERLVRLYAVVT------
-----------------------------------------KEPIYIVTE
YMAR----------------------------------------------
--GCLLDFLKTDEGSR----------------------------------
--------------------------------------------------
-------------------------------------LSLPRLIDMSAQI
AEGMAYIERM------------NSIHRDLRAANILVSEA-----------
--------LCCKIADFGLARIIDS--------------------------
---------------------------EYTAQEGAKFPIKWTAPEAYHF-
--------------------GVF-------TIKADVWSFGVLLMEVVTYG
-----------RVPYPGMS------------------NPEVIRNLERG--
--------------------------------------------------
---------------------YRMPRPDTCP--PELYRGVIAECWR----
SRPEERPTF---------EFLQSVLE-----------------------
>lck_3lck.PDB
LKLVERLGAGQFGEVWMGYYNG----------------------------
-------HTKVAVKSLKQGSMSP---------------------------
DAFLAEANLMKQLQ------------------HQRLVRLYAVVT------
-----------------------------------------QEPIYIITE
YMEN----------------------------------------------
--GSLVDFLKTPSGIK----------------------------------
--------------------------------------------------
-------------------------------------LTINKLLDMAAQI
AEGMAFIEER------------NYIHRDLRAANILVSDT-----------
--------LSCKIADFGLARLIE---------------------------
--------------------------DNETAREGAKFPIKWTAPEAINY-
--------------------GTF-------TIKSDVWSFGILLTEIVTHG
-----------RIPYPGMT------------------NPEVIQNLERG--
--------------------------------------------------
---------------------YRMVRPDNCP---EELYQLMRLCWK----
ERPEDRPTF---------DYLRSVLEDFFTA------------------
>LCK
LKLVERLGAGQFGEVWMGYYNG----------------------------
-------HTKVAVKSLKQGSMSP---------------------------
DAFLAEANLMKQLQ------------------HQRLVRLYAVVT------
-----------------------------------------QEPIYIITE
YMEN----------------------------------------------
--GSLVDFLKTPSGIK----------------------------------
--------------------------------------------------
-------------------------------------LTINKLLDMAAQI
AEGMAFIEER------------NYIHRDLRAANILVSDT-----------
--------LSCKIADFGLARLIE---------------------------
-------------------------DNEYTAREGAKFPIKWTAPEAINY-
--------------------GTF-------TIKSDVWSFGILLTEIVTHG
-----------RIPYPGMT------------------NPEVIQNLERG--
--------------------------------------------------
---------------------YRMVRPDNCP---EELYQLMRLCWK----
ERPEDRPTF---------DYLRSVLE-----------------------
>hck_1ad5.PDB
LKLEKKLGAGQFGEVWMATYNK----------------------------
-------HTKVAVKTMKPGSMSV---------------------------
EAFLAEANVMKTLQ------------------HDKLVKLHAVVT------
-----------------------------------------KEPIYIITE
FMAK----------------------------------------------
--GSLLDFLKSDEGSK----------------------------------
--------------------------------------------------
-------------------------------------QPLPKLIDFSAQI
AEGMAFIEQR------------NYIHRDLRAANILVSAS-----------
--------LVCKIADFGLARV-----------------------------
---------------------------------GAKFPIKWTAPEAINF-
--------------------GSF-------TIKSDVWSFGILLMEIVTYG
-----------RIPYPGMS------------------NPEVIRALERG--
--------------------------------------------------
---------------------YRMPRPENCP---EELYNIMMRCWK----
NRPEERPTF---------EYIQSVLDDFYTATESQ--------------
>HCK
LKLEKKLGAGQFGEVWMATYNK----------------------------
-------HTKVAVKTMKPGSMSV---------------------------
EAFLAEANVMKTLQ------------------HDKLVKLHAVVT------
-----------------------------------------KEPIYIITE
FMAK----------------------------------------------
--GSLLDFLKSDEGSK----------------------------------
--------------------------------------------------
-------------------------------------QPLPKLIDFSAQI
AEGMAFIEQR------------NYIHRDLRAANILVSAS-----------
--------LVCKIADFGLARVIE---------------------------
-------------------------DNEYTAREGAKFPIKWTAPEAINF-
--------------------GSF-------TIKSDVWSFGILLMEIVTYG
-----------RIPYPGMS------------------NPEVIRALERG--
--------------------------------------------------
---------------------YRMPRPENCP---EELYNIMMRCWK----
NRPEERPTF---------EYIQSVLD-----------------------
>LYN
IKLVKRLGAGQFGEVWMGYYNN----------------------------
-------STKVAVKTLKPGTMSV---------------------------
QAFLEEANLMKTLQ------------------HDKLVRLYAVVTR-----
-----------------------------------------EEPIYIITE
YMAK----------------------------------------------
--GSLLDFLKSDEGGK----------------------------------
--------------------------------------------------
-------------------------------------VLLPKLIDFSAQI
AEGMAYIERK------------NYIHRDLRAANVLVSES-----------
--------LMCKIADFGLARVIE---------------------------
-------------------------DNEYTAREGAKFPIKWTAPEAINF-
--------------------GCF-------TIKSDVWSFGILLYEIVTYG
-----------KIPYPGRT------------------NADVMTALSQG--
--------------------------------------------------
---------------------YRMPRVENCP---DELYDIMKMCWK----
EKAEERPTF---------DYLQSVLD-----------------------
>FGR
ITLERRLGTGCFGDVWLGTWNG----------------------------
-------STKVAVKTLKPGTMSP---------------------------
KAFLEEAQVMKLLR------------------HDKLVQLYAVVS------
-----------------------------------------EEPIYIVTE
FMCH----------------------------------------------
--GSLLDFLKNPEGQD----------------------------------
--------------------------------------------------
-------------------------------------LRLPQLVDMAAQV
AEGMAYMERM------------NYIHRDLRAANILVGER-----------
--------LACKIADFGLARLIK---------------------------
-------------------------DDEYNPCQGSKFPIKWTAPEAALF-
--------------------GRF-------TIKSDVWSFGILLTELITKG
-----------RIPYPGMN------------------KREVLEQVEQG--
--------------------------------------------------
---------------------YHMPCPPGCP---ASLYEAMEQTWR----
LDPEERPTF---------EYLQSFL------------------------
>FYN
LQLIKRLGNGQFGEVWMGTWNG----------------------------
-------NTKVAIKTLKPGTMSP---------------------------
ESFLEEAQIMKKLK------------------HDKLVQLYAVVS------
-----------------------------------------EEPIYIVTE
YMNK----------------------------------------------
--GSLLDFLKDGEGRA----------------------------------
--------------------------------------------------
-------------------------------------LKLPNLVDMAAQV
AAGMAYIERM------------NYIHRDLRSANILVGNG-----------
--------LICKIADFGLARLIE---------------------------
-------------------------DNEYTARQGAKFPIKWTAPEAALY-
--------------------GRF-------TIKSDVWSFGILLTELVTKG
-----------RVPYPGMN------------------NREVLEQVERG--
--------------------------------------------------
---------------------YRMPCPQDCP---ISLHELMIHCWK----
KDPEERPTF---------EYLQSFL------------------------
>src_2src.PDB
LRLEVKLGQGCFGEVWMGTWNG----------------------------
-------TTRVAIKTLKPGTMSP---------------------------
EAFLQEAQVMKKLR------------------HEKLVQLYAVVS------
-----------------------------------------EEPIYIVTE
YMSK----------------------------------------------
--GSLLDFLKGETGKY----------------------------------
--------------------------------------------------
-------------------------------------LRLPQLVDMAAQI
ASGMAYVERM------------NYVHRDLRAANILVGEN-----------
--------LVCKVADFGLARLIE---------------------------
-------------------------DNEYTARQGAKFPIKWTAPEAALY-
--------------------GRF-------TIKSDVWSFGILLTELTTKG
-----------RVPYPGMV------------------NREVLDQVERG--
--------------------------------------------------
---------------------YRMPCPPECP---ESLHDLMCQCWR----
KEPEERPTF---------EYLQAFLEDYFTSTEPQQPGEN---------
>SRC
LRLEVKLGQGCFGEVWMGTWNG----------------------------
-------TTRVAIKTLKPGTMSP---------------------------
EAFLQEAQVMKKLR------------------HEKLVQLYAVVS------
-----------------------------------------EEPIYIVTE
YMSK----------------------------------------------
--GSLLDFLKGETGKY----------------------------------
--------------------------------------------------
-------------------------------------LRLPQLVDMAAQI
ASGMAYVERM------------NYVHRDLRAANILVGEN-----------
--------LVCKVADFGLARLIE---------------------------
-------------------------DNEYTARQGAKFPIKWTAPEAALY-
--------------------GRF-------TIKSDVWSFGILLTELTTKG
-----------RVPYPGMV------------------NREVLDQVERG--
--------------------------------------------------
---------------------YRMPCPPECP---ESLHDLMCQCWR----
KEPEERPTF---------EYLQAF-------------------------
>YES
LRLEVKLGQGCFGEVWMGTWNG----------------------------
-------TTKVAIKTLKPGTMMP---------------------------
EAFLQEAQIMKKLR------------------HDKLVPLYAVVS------
-----------------------------------------EEPIYIVTE
FMSK----------------------------------------------
--GSLLDFLKEGDGKY----------------------------------
--------------------------------------------------
-------------------------------------LKLPQLVDMAAQI
ADGMAYIERM------------NYIHRDLRAANILVGEN-----------
--------LVCKIADFGLARLIE---------------------------
-------------------------DNEYTARQGAKFPIKWTAPEAALY-
--------------------GRF-------TIKSDVWSFGILQTELVTKG
-----------RVPYPGMV------------------NREVLEQVERG--
--------------------------------------------------
---------------------YRMPCPQGCP---ESLHELMNLCWK----
KDPDERPTF---------EYIQSFL------------------------
>EphB1
VKIEEVIGAGEFGEVYKGRLKLPG--------------------------
-----KREIYVAIKTLKAGYSEKQ-------------------------R
RDFLSEASIMGQFD------------------HPNIIRLEGVVTK-----
-----------------------------------------SRPVMIITE
FMEN----------------------------------------------
--GALDSFLRQNDGQ-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
AAGMKYLAEM------------NYVHRDLAARNILVNSN-----------
--------LVCKVSDFGLSRYLQD--------------------------
----------------------DTSDPTYTSSLGGKIPVRWTAPEAIAY-
--------------------RKF-------TSASDVWSYGIVMWEVMSFG
-----------ERPYWDMS------------------NQDVINAIEQD--
--------------------------------------------------
---------------------YRLPPPMDCP---AALHQLMLDCWQ----
KDRNSRPRF---------AEIVNTL------------------------
>ephb2_1jpa.PDB
VKIEQVIGAGEFGEVCSGHLKL----------------------------
------REIFVAIKTLKSGYTEKQ-------------------------R
RDFLSEASIMGQFD------------------HPNVIHLEGVVTK-----
-----------------------------------------STPVMIITE
FMEN----------------------------------------------
--GSLDSFLRQNDGQ-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
AAGMKYLADM------------NYVHRDLAARNILVNSN-----------
--------LVCKVSDF----------------------------------
-------------------------------------PIRWTAPEAIQY-
--------------------RKF-------TSASDVWSYGIVMWEVMSYG
-----------ERPYWDMT------------------NQDVINAIEQD--
--------------------------------------------------
---------------------YRLPPPMDCP---SALHQLMLDCWQ----
KDRNHRPKF---------GQIVNTLDKMIRNPNSLK-------------
>EphB2
VKIEQVIGAGEFGEVCSGHLKLPG--------------------------
-----KREIFVAIKTLKSGYTEKQ-------------------------R
RDFLSEASIMGQFD------------------HPNVIHLEGVVTK-----
-----------------------------------------STPVMIITE
FMEN----------------------------------------------
--GSLDSFLRQNDGQ-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
AAGMKYLADM------------NYVHRDLAARNILVNSN-----------
--------LVCKVSDFGLSRFLED--------------------------
----------------------DTSDPTYTSALGGKIPIRWTAPEAIQY-
--------------------RKF-------TSASDVWSYGIVMWEVMSYG
-----------ERPYWDMT------------------NQDVINAIEQD--
--------------------------------------------------
---------------------YRLPPPMDCP---SALHQLMLDCWQ----
KDRNHRPKF---------GQIVNTL------------------------
>EphB3
VKIEEVIGAGEFGEVCRGRLKQPG--------------------------
-----RREVFVAIKTLKVGYTERQ-------------------------R
RDFLSEASIMGQFD------------------HPNIIRLEGVVTK-----
-----------------------------------------SRPVMILTE
FMEN----------------------------------------------
--CALDSFLRLNDGQ-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
AAGMKYLSEM------------NYVHRDLAARNILVNSN-----------
--------LVCKVSDFGLSRFLED--------------------------
----------------------DPSDPTYTSSLGGKIPIRWTAPEAIAY-
--------------------RKF-------TSASDVWSYGIVMWEVMSYG
-----------ERPYWDMS------------------NQDVINAVEQD--
--------------------------------------------------
---------------------YRLPPPMDCP---TALHQLMLDCWV----
RDRNLRPKF---------SQIVNTL------------------------
>EphB4
VKIEEVIGAGEFGEVCRGRLKAPG--------------------------
-----KKESCVAIKTLKGGYTERQ-------------------------R
REFLSEASIMGQFE------------------HPNIIRLEGVVTN-----
-----------------------------------------SMPVMILTE
FMEN----------------------------------------------
--GALDSFLRLNDGQ-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
ASGMRYLAEM------------SYVHRDLAARNILVNSN-----------
--------LVCKVSDFGLSRFLEE--------------------------
----------------------NSSDPTYTSSLGGKIPIRWTAPEAIAF-
--------------------RKF-------TSASDAWSYGIVMWEVMSFG
-----------ERPYWDMS------------------NQDVINAIEQD--
--------------------------------------------------
---------------------YRLPPPPDCP---TSLHQLMLDCWQ----
KDRNARPRF---------PQVVSALDKMIRNPASLKIVARENGGASHPL
>EphB6
IKIEEVIGTGSFGEVRQGRLQPRG--------------------------
-----RREQTVAIQALWAGGAESL-------------------------Q
MTFLGRAAVLGQFQ------------------HPNILRLEGVVTK-----
-----------------------------------------SRPLMVLTE
FMEL----------------------------------------------
--GPLDSFLRQREGQ-----------------------------------
--------------------------------------------------
-------------------------------------FSSLQLVAMQRGV
AAAMQYLSSF------------AFVHRSLSAHSVLVNSH-----------
--------LVCKVARLG---------------------------------
-----------------------------HSPQGPSCLLRWAAPEVIAH-
--------------------GKH-------TTSSDVWSFGILMWEVMSYG
-----------ERPYWDMS------------------EQEVLNAIEQE--
--------------------------------------------------
---------------------FRLPPPPGCP---PGLHLLMLDTWQ----
KDRARRPHF---------DQLVAAF------------------------
>EphA1
LMVDTVIGEGEFGEVYRGTLRLPS--------------------------
-----QDCKTVAIKTLKDTSPGGQ-------------------------W
WNFLREATIMGQFS------------------HPHILHLEGVVTK-----
-----------------------------------------RKPIMIITE
FMEN----------------------------------------------
--AALDAFLREREDQ-----------------------------------
--------------------------------------------------
-------------------------------------LVPGQLVAMLQGI
ASGMNYLSNH------------NYVHRDLAARNILVNQN-----------
--------LCCKVSDFGLTRLLDD--------------------------
-------------------------FDGTYETQGGKIPIRWTAPEAIAH-
--------------------RIF-------TTASDVWSFGIVMWEVLSFG
-----------DKPYGEMS------------------NQEVMKSIEDG--
--------------------------------------------------
---------------------YRLPPPVDCP---APLYELMKNCWA----
YDRARRPHF---------QKLQAHLEQL---------------------
>EphA2
VTRQKVIGAGEFGEVYKGMLKTSSG-------------------------
-----KKEVPVAIKTLKAGYTEKQ-------------------------R
VDFLGEAGIMGQFS------------------HHNIIRLEGVISK-----
-----------------------------------------YKPMMIITE
YMEN----------------------------------------------
--GALDKFLREKDGE-----------------------------------
--------------------------------------------------
-------------------------------------FSVLQLVGMLRGI
AAGMKYLANM------------NYVHRDLAARNILVNSN-----------
--------LVCKVSDFGLSRVLED--------------------------
------------------------DPEATYTTSGGKIPIRWTAPEAISY-
--------------------RKF-------TSASDVWSFGIVMWEVMTYG
-----------ERPYWELS------------------NHEVMKAINDG--
--------------------------------------------------
---------------------FRLPTPMDCP---SAIYQLMMQCWQ----
QERARRPKF---------ADIVSI-------------------------
>EphA3
ISIDKVVGAGEFGEVCSGRLKLPS--------------------------
-----KKEISVAIKTLKVGYTEKQ-------------------------R
RDFLGEASIMGQFD------------------HPNIIRLEGVVTK-----
-----------------------------------------SKPVMIVTE
YMEN----------------------------------------------
--GSLDSFLRKHDAQ-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
ASGMKYLSDM------------GYVHRDLAARNILINSN-----------
--------LVCKVSDFGLSRVLED--------------------------
------------------------DPEAAYTTRGGKIPIRWTSPEAIAY-
--------------------RKF-------TSASDVWSYGIVLWEVMSYG
-----------ERPYWEMS------------------NQDVIKAVDEG--
--------------------------------------------------
---------------------YRLPPPMDCP---AALYQLMLDCWQ----
KDRNNRPKF---------EQIVSI-------------------------
>EphA4
IKIEKVIGVGEFGEVCSGRLKVPG--------------------------
-----KREICVAIKTLKAGYTDKQ-------------------------R
RDFLSEASIMGQFD------------------HPNIIHLEGVVTK-----
-----------------------------------------CKPVMIITE
YMEN----------------------------------------------
--GSLDAFLRKNDGR-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
GSGMKYLSDM------------SYVHRDLAARNILVNSN-----------
--------LVCKVSDFGMSRVLED--------------------------
------------------------DPEAAYTTRGGKIPIRWTAPEAIAY-
--------------------RKF-------TSASDVWSYGIVMWEVMSYG
-----------ERPYWDMS------------------NQDVIKAIEEG--
--------------------------------------------------
---------------------YRLPPPMDCP---IALHQLMLDCWQ----
KERSDRPKF---------GQIVNM-------------------------
>EphA5
ITIERVIGAGEFGEVCSGRLKLPG--------------------------
-----KRELPVAIKTLKVGYTEKQ-------------------------R
RDFLGEASIMGQFD------------------HPNIIHLEGVVTK-----
-----------------------------------------SKPVMIVTE
YMEN----------------------------------------------
--GSLDTFLKKNDGQ-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
SAGMKYLSDM------------GYVHRDLAARNILINSN-----------
--------LVCKVSDFGLSRVLED--------------------------
------------------------DPEAAYTTRGGKIPIRWTAPEAIAF-
--------------------RKF-------TSASDVWSYGIVMWEVVSYG
-----------ERPYWEMT------------------NQDVIKAVEEG--
--------------------------------------------------
---------------------YRLPSPMDCP---AALYQLMLDCWQ----
KERNSRPKF---------DEIVNM-------------------------
>EphA6
IRIERVIGAGEFGEVCSGRLKTPG--------------------------
-----KREIPVAIKTLKGGHMDRQ-------------------------R
RDFLREASIMGQFD------------------HPNIIRLEGVVTKRSFPA
IGVEAFCPSFLRAG----FLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVE
YMEN----------------------------------------------
--GSLDSFLRKHDGH-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
ASGMKYLSDM------------GYVHRDLAARNILVNSN-----------
--------LVCKVSDFGLSRVLED--------------------------
------------------------DPEAAYTTTGGKIPIRWTAPEAIAY-
--------------------RKF-------SSASDAWSYGIVMWEVMSYG
-----------ERPYWEMS------------------NQDVILSIEEG--
--------------------------------------------------
---------------------YRLPAPMGCP---ASLHQLMLHCWQ----
KERNHRPKF---------TDIVSFL------------------------
>EphA7
IKIERVIGAGEFGEVCSGRLKLPG--------------------------
-----KRDVAVAIKTLKVGYTEKQ-------------------------R
RDFLCEASIMGQFD------------------HPNVVHLEGVVTR-----
-----------------------------------------GKPVMIVIE
FMEN----------------------------------------------
--GALDAFLRKHDGQ-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
AAGMRYLADM------------GYVHRDLAARNILVNSN-----------
--------LVCKVSDFGLSRVIED--------------------------
------------------------DPEAVYTTTGGKIPVRWTAPEAIQY-
--------------------RKF-------TSASDVWSYGIVMWEVMSYG
-----------ERPYWDMS------------------NQDVIKAIEEG--
--------------------------------------------------
---------------------YRLPAPMDCP---AGLHQLMLDCWQ----
KERAERPKF---------EQIVGI-------------------------
>EphA8
IHIEKIIGSGDSGEVCYGRLRVPG--------------------------
-----QRDVPVAIKALKAGYTERQ-------------------------R
RDFLSEASIMGQFD------------------HPNIIRLEGVVTR-----
-----------------------------------------GRLAMIVTE
YMEN----------------------------------------------
--GSLDTFLRTHDGQ-----------------------------------
--------------------------------------------------
-------------------------------------FTIMQLVGMLRGV
GAGMRYLSDL------------GYVHRDLAARNVLVDSN-----------
--------LVCKVSDFGLSRVLED--------------------------
------------------------DPDAAYTTTGGKIPIRWTAPEAIAF-
--------------------RTF-------SSASDVWSFGVVMWEVLAYG
-----------ERPYWNMT------------------NRDVISSVEEG--
--------------------------------------------------
---------------------YRLPAPMGCP---HALHQLMLDCWH----
KDRAQRPRF---------SQIVSVL------------------------
>EphA10
VTLERSLGGGRFGELCCGCLQLPG--------------------------
-----RQELLVAVHMLRDSASDSQ-------------------------R
LGFLAEALTLGQFD------------------HSHIVRLEGVVTR-----
-----------------------------------------GSTLMIVTE
YMSH----------------------------------------------
--GALDGFLRRHEGQ-----------------------------------
--------------------------------------------------
-------------------------------------LVAGQLMGLLPGL
ASAMKYLSEM------------GYVHRGLAARHVLVSSD-----------
--------LVCKISGFGRGPRDRS--------------------------
--------------------------EAVYTTMSGRSPALWAAPETLQF-
--------------------GHF-------SSASDVWSFGIIMWEVMAFG
-----------ERPYWDMS------------------GQDVIKAVEDG--
--------------------------------------------------
---------------------FRLPPPRNCP---NLLHRLMLDCWQ----
KDPGERPRF---------SQIHSI-------------------------
>FAK
IELGRCIGEGQFGDVHQGIYMSPE--------------------------
-----NPALAVAIKTCKNCTSDSV-------------------------R
EKFLQEALTMRQFD------------------HPHIVKLIGVIT------
-----------------------------------------ENPVWIIME
LCTL----------------------------------------------
--GELRSFLQVRKYS-----------------------------------
--------------------------------------------------
-------------------------------------LDLASLILYAYQL
STALAYLESK------------RFVHRDIAARNVLVSSN-----------
--------DCVKLGDFGLSRYMEDS-------------------------
---------------------------TYYKASKGKLPIKWMAPESINF-
--------------------RRF-------TSASDVWMFGVCMWEILMHG
-----------VKPFQGVK------------------NNDVIGRIENG--
--------------------------------------------------
---------------------ERLPMPPNCP---PTLYSLMTKCWA----
YDPSRRPRF---------TELKAQL------------------------
>PYK2
VVLNRILGEGLFGEVYEGVYTNHK--------------------------
-----GEKINVAVKTCKKDCTLDN-------------------------K
EKFMSEAVIMKNLD------------------HPHIVKLIGIIE------
-----------------------------------------EEPTWIIME
LYPY----------------------------------------------
--GELGHYLERNKNS-----------------------------------
--------------------------------------------------
-------------------------------------LKVLTLVLYSLQI
CKAMAYLESI------------NCVHRDIAVRNILVASP-----------
--------ECVKLGDFGLSRYIEDE-------------------------
---------------------------DYYKASVTRLPIKWMSPESINF-
--------------------RRF-------TTASDVWMFAVCMWEILSFG
-----------KQPFFWLE------------------NKDVIGVLEKG--
--------------------------------------------------
---------------------DRLPKPDLCP---PVLYTLMTRCWD----
YDPSDRPRF---------TELVCSLSDVYQ-------------------
>SYK
TLEDKELGSGNFGTVKKGYYQMKK--------------------------
------VVKTVAVKILKNEANDPA------------------------LK
DELLAEANVMQQLD------------------NPYIVRMIGICE------
-----------------------------------------AESWMLVME
MAEL----------------------------------------------
--GPLNKYLQQNRH------------------------------------
--------------------------------------------------
-------------------------------------VKDKNIIELVHQV
SMGMKYLEES------------NFVHRDLAARNVLLVTQ-----------
--------HYAKISDFGLSKALRAD-------------------------
-------------------------ENYYKAQTHGKWPVKWYAPECINY-
--------------------YKF-------SSKSDVWSFGVLMWEAFSYG
-----------QKPYRGMK------------------GSEVTAMLEKG--
--------------------------------------------------
---------------------ERMGCPAGCP---REMYDLMNLCWT----
YDVENRPGF----------------------------------------
>ZAP70
LIADIELGCGNFGSVRQGVYRMRK--------------------------
------KQIDVAIKVLKQGTEKA-------------------------DT
EEMMREAQIMHQLD------------------NPYIVRLIGVCQ------
-----------------------------------------AEALMLVME
MAGG----------------------------------------------
--GPLHKFLVGKREE-----------------------------------
--------------------------------------------------
-------------------------------------IPVSNVAELLHQV
SMGMKYLEEK------------NFVHRDLAARNVLLVNR-----------
--------HYAKISDFGLSKALGAD-------------------------
-------------------------DSYYTARSAGKWPLKWYAPECINF-
--------------------RKF-------SSRSDVWSYGVTMWEALSYG
-----------QKPYKKMK------------------GPEVMAFIEQG--
--------------------------------------------------
---------------------KRMECPPECP---PELYALMSDCWI----
YKWEDRPDFL---------------------------------------
>TRKA
IVLKWELGEGAFGKVFLAECHNLLP-------------------------
----EQDKMLVAVKALKEASESA--------------------------R
QDFQREAELLTMLQ------------------HQHIVRFFGVCTE-----
-----------------------------------------GRPLLMVFE
YMRH----------------------------------------------
--GDLNRFLRSHGPDAKLLAGGE---------------------------
--------------------------------------------------
-------------------------------DVAPGPLGLGQLLAVASQV
AAGMVYLAGL------------HFVHRDLATRNCLVGQG-----------
--------LVVKIGDFGMSRDIYST-------------------------
--------------------------DYYRVGGRTMLPIRWMPPESILY-
--------------------RKF-------TTESDVWSFGVVLWEIFTYG
-----------KQPWYQLS------------------NTEAIDCITQG--
--------------------------------------------------
---------------------RELERPRACP---PEVYAIMRGCWQ----
REPQQRHSI---------KDVHARLQAL---------------------
>TRKB
IVLKRELGEGAFGKVFLAECYNLCP-------------------------
----EQDKILVAVKTLKDASDNA--------------------------R
KDFHREAELLTNLQ------------------HEHIVKFYGVCVE-----
-----------------------------------------GDPLIMVFE
YMKH----------------------------------------------
--GDLNKFLRAHGPDAVLMAEGN---------------------------
--------------------------------------------------
---------------------------------PPTELTQSQMLHIAQQI
AAGMVYLASQ------------HFVHRDLATRNCLVGEN-----------
--------LLVKIGDFGMSRDVYST-------------------------
--------------------------DYYRVGGHTMLPIRWMPPESIMY-
--------------------RKF-------TTESDVWSLGVVLWEIFTYG
-----------KQPWYQLS------------------NNEVIECITQG--
--------------------------------------------------
---------------------RVLQRPRTCP---QEVYELMLGCWQ----
REPHMRKNI---------KGIHTLL------------------------
>TRKC
IVLKRELGEGAFGKVFLAECYNLSP-------------------------
----TKDKMLVAVKALKDPTLAA--------------------------R
KDFQREAELLTNLQ------------------HEHIVKFYGVCGD-----
-----------------------------------------GDPLIMVFE
YMKH----------------------------------------------
--GDLNKFLRAHGPNAMILVDGQ---------------------------
--------------------------------------------------
------------------------------PRQAKGELGLSQMLHIASQI
ASGMVYLASQ------------HFVHRDLATRNCLVGAN-----------
--------LLVKIGDFGMSRDVYST-------------------------
--------------------------DYYRVGGHTMLPIRWMPPESIMY-
--------------------RKF-------TTESDVWSFGVILWEIFTYG
-----------KQPWFQLS------------------NTEVIECITQG--
--------------------------------------------------
---------------------RVLERPRVCP---KEVYDVMLGCWQ----
REPQQRLNI---------KEIYKI-------------------------
>musk_1luf.PDB
IEYVRDIGEGAFGRVFQARAPGLLP-------------------------
----YEPFTMVAVKMLKEEASAD-------------------------MQ
ADFQREAALMAEFD------------------NPNIVKLLGVCAV-----
-----------------------------------------GKPMCLLFE
YMAY----------------------------------------------
--GDLNEFLRSMSP------------------------------------
--------------------------------------------------
-----------------------------------PPLSCAEQLCIARQV
AAGMAYLSER------------KFVHRDLATRNCLVGEN-----------
--------MVVKIADFGLSRNIYSA-------------------------
---------------------------DYYK---DAIPIRWMPPESIFY-
--------------------NRY-------TTESDVWAYGVVLWEIFSYG
-----------LQPYYGMA------------------HEEVIYYVRDG--
--------------------------------------------------
---------------------NILACPENCP---LELYNLMRLCWS----
KLPADRPSF---------CSIHRILQRMC--------------------
>MUSK
IEYVRDIGEGAFGRVFQARAPGLLP-------------------------
----YEPFTMVAVKMLKEEASAD-------------------------MQ
ADFQREAALMAEFD------------------NPNIVKLLGVCAV-----
-----------------------------------------GKPMCLLFE
YMAY----------------------------------------------
--GDLNEFLRSMSPHTVCSLSHSDLSMRAQ--------------------
--------------------------------------------------
-----------------------------VSSPGPPPLSCAEQLCIARQV
AAGMAYLSER------------KFVHRDLATRNCLVGEN-----------
--------MVVKIADFGLSRNIYSA-------------------------
--------------------------DYYKANENDAIPIRWMPPESIFY-
--------------------NRY-------TTESDVWAYGVVLWEIFSYG
-----------LQPYYGMA------------------HEEVIYYVRDG--
--------------------------------------------------
---------------------NILSCPENCP---VELYNLMRLCWS----
KLPADRPSF---------TSIHRI-------------------------
>DDR1
LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDF------------------P
LNVRKGHPLLVAVKILRPDATKN-------------------------AR
NDFLKEVKIMSRLK------------------DPNIIRLLGVCVQ-----
-----------------------------------------DDPLCMITD
YMEN----------------------------------------------
--GDLNQFLSAHQLEDKAAEGAPGDGQAAQ--------------------
--------------------------------------------------
----------------------------------GPTISYPMLLHVAAQI
ASGMRYLATL------------NFVHRDLATRNCLVGEN-----------
--------FTIKIADFGMSRNLYAG-------------------------
--------------------------DYYRVQGRAVLPIRWMAWECILM-
--------------------GKF-------TTASDVWAFGVTLWEVLMLC
R----------AQPFGQLT------------------DEQVIENAGEFFR
D-------------------------------------------------
-----------------QGRQVYLSRPPACP---QGLYELMLRCWS----
RESEQRPPF---------SQLHRFL------------------------
>DDR2
LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDF------------------A
LDVSANQPVLVAVKMLRADANKN-------------------------AR
NDFLKEIKIMSRLK------------------DPNIIHLLSVCIT-----
-----------------------------------------DDPLCMITE
YMEN----------------------------------------------
--GDLNQFLSRHEPPNSSSSDVRT--------------------------
--------------------------------------------------
-------------------------------------VSYTNLKFMATQI
ASGMKYLSSL------------NFVHRDLATRNCLVGKN-----------
--------YTIKIADFGMSRNLYSG-------------------------
--------------------------DYYRIQGRAVLPIRWMSWESILL-
--------------------GKF-------TTASDVWAFGVTLWETFTFC
Q----------EQPYSQLS------------------DEQVIENTGEFFR
D-------------------------------------------------
-----------------QGRQTYLPQPAICP---DSVYKLMLSCWR----
RDTKNRPSF---------QEIHLLL------------------------
>ROR1
VRFMEELGECAFGKIYKGHLYLPG--------------------------
----MDHAQLVAIKTLKDYNNPQ-------------------------QW
MEFQQEASLMAELH------------------HPNIVCLLGAVTQ-----
-----------------------------------------EQPVCMLFE
YINQ----------------------------------------------
--GDLHEFLIMRSPHSDVGCSSDEDGTVKSS-------------------
--------------------------------------------------
-------------------------------------LDHGDFLHIAIQI
AAGMEYLSSH------------FFVHKDLAARNILIGEQ-----------
--------LHVKISDLGLSREIYSA-------------------------
--------------------------DYYRVQSKSLLPIRWMPPEAIMY-
--------------------GKF-------SSDSDIWSFGVVLWEIFSFG
-----------LQPYYGFS------------------NQEVIEMVRKR--
--------------------------------------------------
---------------------QLLPCSEDCP---PRMYSLMTECWN----
EIPSRRPRF---------KDIHVRLRSWEGLSSHTSSTTPSGGNATTQT
>ROR2
VRFMEELGEDRFGKVYKGHLFGPAPG------------------------
-----EQTQAVAIKTLKDKAEGP-------------------------LR
EEFRHEAMLRARLQ------------------HPNVVCLLGVVTK-----
-----------------------------------------DQPLSMIFS
YCSH----------------------------------------------
--GDLHEFLVMRSPHSDVGSTDDDRTVKSA--------------------
--------------------------------------------------
-------------------------------------LEPPDFVHLVAQI
AAGMEYLSSH------------HVVHKDLATRNVLVYDK-----------
--------LNVKISDLGLFREVYAA-------------------------
--------------------------DYYKLLGNSLLPIRWMAPEAIMY-
--------------------GKF-------SIDSDIWSYGVVLWEVFSYG
-----------LQPYCGYS------------------NQDVVEMIRNR--
--------------------------------------------------
---------------------QVLPCPDDCP---AWVYALMIECWN----
EFPSRRPRF---------KDIHSRLRAWGNLSNYNSSAQTSGASNTTQT
>IGF1R
ITMSRELGQGSFGMVYEGVAKGVVKD------------------------
-----EPETRVAIKTVNEAASMR-------------------------ER
IEFLNEASVMKEFN------------------CHHVVRLLGVVSQ-----
-----------------------------------------GQPTLVIME
LMTR----------------------------------------------
--GDLKSYLRSLRPEMENNPVLAP--------------------------
--------------------------------------------------
-------------------------------------PSLSKMIQMAGEI
ADGMAYLNAN------------KFVHRDLAARNCMVAED-----------
--------FTVKIGDFGMTRDIYET-------------------------
--------------------------DYYRKGGKGLLPVRWMSPESLKD-
--------------------GVF-------TTYSDVWSFGVVLWEIATLA
-----------EQPYQGLS------------------NEQVLRFVMEG--
--------------------------------------------------
---------------------GLLDKPDNCP---DMLFELMRMCWQ----
YNPKMRPSF---------LEIISSIKE----------------------
>irk_1ir3.PDB
ITLLRELGQGSFGMVYEGNARDIIKG------------------------
-----EAETRVAVKTVNESASLR-------------------------ER
IEFLNEASVMKGFT------------------CHHVVRLLGVVSK-----
-----------------------------------------GQPTLVVME
LMAH----------------------------------------------
--GDLKSYLRSLRPEAENNPGRPP--------------------------
--------------------------------------------------
-------------------------------------PTLQEMIQMAAEI
ADGMAYLNAK------------KFVHRDLAARNCMVAHD-----------
--------FTVKIGDFGMTRDI-ET-------------------------
---------------------------D-RKGGKGLLPVRWMAPESLKD-
--------------------GVF-------TTSSDMWSFGVVLWEITSLA
-----------EQPYQGLS------------------NEQVLKFVMDG--
--------------------------------------------------
---------------------GYLDQPDNCP---ERVTDLMRMCWQ----
FNPKMRPTF---------LEIVNLLKDDLHPSFPEVSFFHSEEN-----
>INSR
ITLLRELGQGSFGMVYEGNARDIIKG------------------------
-----EAETRVAVKTVNESASLR-------------------------ER
IEFLNEASVMKGFT------------------CHHVVRLLGVVSK-----
-----------------------------------------GQPTLVVME
LMAH----------------------------------------------
--GDLKSYLRSLRPEAENNPGRPP--------------------------
--------------------------------------------------
-------------------------------------PTLQEMIQMAAEI
ADGMAYLNAK------------KFVHRDLAARNCMVAHD-----------
--------FTVKIGDFGMTRDIYET-------------------------
--------------------------DYYRKGGKGLLPVRWMAPESLKD-
--------------------GVF-------TTSSDMWSFGVVLWEITSLA
-----------EQPYQGLS------------------NEQVLKFVMDG--
--------------------------------------------------
---------------------GYLDQPDNCP---ERVTDLMRMCWQ----
FNPNMRPTF---------LEIVNLL------------------------
>IRR
ISIIRELGQGSFGMVYEGLARGLEAG------------------------
-----EESTPVALKTVNELASPR-------------------------EC
IEFLKEASVMKAFK------------------CHHVVRLLGVVSQ-----
-----------------------------------------GQPTLVIME
LMTR----------------------------------------------
--GDLKSHLRSLRPEAENNPGLPQ--------------------------
--------------------------------------------------
-------------------------------------PALGEMIQMAGEI
ADGMAYLAAN------------KFVHRDLAARNCMVSQD-----------
--------FTVKIGDFGMTRDVYET-------------------------
--------------------------DYYRKGGKGLLPVRWMAPESLKD-
--------------------GIF-------TTHSDVWSFGVVLWEIVTLA
-----------EQPYQGLS------------------NEQVLKFVMDG--
--------------------------------------------------
---------------------GVLEELEGCP---LQLQELMSRCWQ----
PNPRLRPSF---------THILDSIQE----------------------
>ROS
LTLRLLLGSGAFGEVYEGTAVDILGV------------------------
----GSGEIKVAVKTLKKGSTDQ-------------------------EK
IEFLKEAHLMSKFN------------------HPNILKQLGVCLL-----
-----------------------------------------NEPQYIILE
LMEG----------------------------------------------
--GDLLTYLRKARMATFYGPL-----------------------------
--------------------------------------------------
-------------------------------------LTLVDLVDLCVDI
SKGCVYLERM------------HFIHRDLAARNCLVSVKDYTSP------
--------RIVKIGDFGLARDIYKN-------------------------
--------------------------DYYRKRGEGLLPVRWMAPESLMD-
--------------------GIF-------TTQSDVWSFGILIWEILTLG
-----------HQPYPAHS------------------NLDVLNYVQTG--
--------------------------------------------------
---------------------GRLEPPRNCP---DDLWNLMTQCWA----
QEPDQRPTF---------HRIQNQL------------------------
>ALK
ITLIRGLGHGAFGEVYEGQVSGMPND------------------------
-----PSPLQVAVKTLPEVCSEQ-------------------------DE
LDFLMEALIISKFN------------------HQNIVRCIGVSLQ-----
-----------------------------------------SLPRFILLE
LMAG----------------------------------------------
--GDLKSFLRETRPRPSQPSS-----------------------------
--------------------------------------------------
-------------------------------------LAMLDLLHVARDI
ACGCQYLEEN------------HFIHRDIAARNCLLTCPGPG--------
--------RVAKIGDFGMARDIYRA-------------------------
--------------------------SYYRKGGCAMLPVKWMPPEAFME-
--------------------GIF-------TSKTDTWSFGVLLWEIFSLG
-----------YMPYPSKS------------------NQEVLEFVTSG--
--------------------------------------------------
---------------------GRMDPPKNCP---GPVYRIMTQCWQ----
HQPEDRPNF---------AIILERIEY----------------------
>LTK
VTLLRALGHGAFGEVYEGLVIGLPGD------------------------
-----SSPLQVAIKTLPELCSPQ-------------------------DE
LDFLMEALIISKFR------------------HQNIVRCVGLSLR-----
-----------------------------------------ATPRLILLE
LMSG----------------------------------------------
--GDMKSFLRHSRPHLGQPSP-----------------------------
--------------------------------------------------
-------------------------------------LVMRDLLQLAQDI
AQGCHYLEEN------------HFIHRDIAARNCLLSCAGPS--------
--------RVAKIGDFGMARDIYRA-------------------------
--------------------------SYYRRGDRALLPVKWMPPEAFLE-
--------------------GIF-------TSKTDSWSFGVLLWEIFSLG
-----------YMPYPGRT------------------NQEVLDFVVGG--
--------------------------------------------------
---------------------GRMDPPRGCP---GPVYRIMTQCWQ----
HEPELRPSF---------ASILERLQY----------------------
>CCK4
LQPITTLGKSEFGEVFLAKAQGLEEG------------------------
-----VAETLVLVKSLQSKDEQQ--------------------------Q
LDFRRELEMFGKLN------------------HANVVRLLGLCRE-----
-----------------------------------------AEPHYMVLE
YVDL----------------------------------------------
--GDLKQFLRISKSKDEKLKSQP---------------------------
--------------------------------------------------
-------------------------------------LSTKQKVALCTQV
ALGMEHLSNN------------RFVHKDLAARNCLVSAQ-----------
--------RQVKVSALGLSKDVYNS-------------------------
---------------------------EYYHFRQAWVPLRWMSPEAILE-
--------------------GDF-------STKSDVWAFGVLMWEVFTHG
-----------EMPHGGQA------------------DDEVLADLQAGK-
--------------------------------------------------
---------------------ARLPQPEGCP---SKLYRLMQRCWA----
LSPKDRPSF---------SEIASAL------------------------
>MER
LILGKILGEGEFGSVMEGNLKQEDG-------------------------
------TSLKVAVKTMKLDNSSHR------------------------EI
EEFLSEAACMKDFS------------------HPNVIRLLGVCIEMS---
--------------------------------------SQGIPKPMVILP
FMKY----------------------------------------------
--GDLHTYLLYSRLETGPKH------------------------------
--------------------------------------------------
-------------------------------------IPLQTLLKFMVDI
ALGMEYLSNR------------NFLHRDLAARNCMLRDD-----------
--------MTVCVADFGLSKKIYSG-------------------------
--------------------------DYYRQGRIAKMPVKWIAIESLAD-
--------------------RVY-------TSKSDVWAFGVTMWEIRTRG
-----------MTPYPGVQ------------------NHEMYDYLLHG--
--------------------------------------------------
---------------------HRLKQPEDCL---DELYEIMYSCWR----
TDPLDRPTF---------SVLRL--------------------------
>AXL
VALGKTLGEGEFGAVMEGQLNQDD--------------------------
------SILKVAVKTMKIAICTRS------------------------EL
EDFLSEAVCMKEFD------------------HPNVMRLIGVCFQGSER-
---------------------------------------ESFPAPVVILP
FMKH----------------------------------------------
--GDLHSFLLYSRLGDQPVY------------------------------
--------------------------------------------------
-------------------------------------LPTQMLVKFMADI
ASGMEYLSTK------------RFIHRDLAARNCMLNEN-----------
--------MSVCVADFGLSKKIYNG-------------------------
--------------------------DYYRQGRIAKMPVKWIAIESLAD-
--------------------RVY-------TSKSDVWSFGVTMWEIATRG
-----------QTPYPGVE------------------NSEIYDYLRQG--
--------------------------------------------------
---------------------NRLKQPADCL---DGLYALMSRCWE----
LNPQDRPSF---------TELREDLE-----------------------
>TYRO3
FTLGRMLGKGEFGSVREAQLKQEDG-------------------------
------SFVKVAVKMLKADIIASS------------------------DI
EEFLREAACMKEFD------------------HPHVAKLVGVSLRSRAK-
---------------------------------------GRLPIPMVILP
FMKH----------------------------------------------
--GDLHAFLLASRIGENPFN------------------------------
--------------------------------------------------
-------------------------------------LPLQTLIRFMVDI
ACGMEYLSSR------------NFIHRDLAARNCMLAED-----------
--------MTVCVADFGLSRKIYSG-------------------------
--------------------------DYYRQGCASKLPVKWLALESLAD-
--------------------NLY-------TVQSDVWAFGVTMWEIMTRG
-----------QTPYAGIE------------------NAEIYNYLIGG--
--------------------------------------------------
---------------------NRLKQPPECM---EDVYDLMYQCWS----
ADPKQRPSF----------------------------------------
>MET
VHFNEVIGRGHFGCVYHGTLLDND--------------------------
-----GKKIHCAVKSLNRITDIG-------------------------EV
SQFLTEGIIMKDFS------------------HPNVLSLLGICLRS----
-----------------------------------------EGSPLVVLP
YMKH----------------------------------------------
--GDLRNFIRNETHN-----------------------------------
--------------------------------------------------
-------------------------------------PTVKDLIGFGLQV
AKAMKYLASK------------KFVHRDLAARNCMLDEK-----------
--------FTVKVADFGLARDMYDK-------------------------
------------------------EYYSVHNKTGAKLPVKWMALESLQT-
--------------------QKF-------TTKSDVWSFGVVLWELMTRG
-----------APPYPDVN-----------------TFDITVYLLQG---
--------------------------------------------------
---------------------RRLLQPEYCP---DPLYEVMLKCWH----
PKAEMRPSF---------SELVSRISA----------------------
>RON
THSDRVIGKGHFGVVYHGEYIDQA--------------------------
-----QNRIQCAIKSLSRITEMQ-------------------------QV
EAFLREGLLMRGLN------------------HPNVLALIGIMLPP----
-----------------------------------------EGLPHVLLP
YMCH----------------------------------------------
--GDLLQFIRSPQRN-----------------------------------
--------------------------------------------------
-------------------------------------PTVKDLISFGLQV
ARGMEYLAEQ------------KFVHRDLAARNCMLDES-----------
--------FTVKVADFGLARDILDR-------------------------
------------------------EYYSVQQHRHARLPVKWMALESLQT-
--------------------YRF-------TTKSDVWSFGVLLWELLTRG
-----------APPYRHID-----------------PFDLTHFLAQG---
--------------------------------------------------
---------------------RRLPQPEYCP---DSLYQVMQQCWE----
ADPAVRPTF----------------------------------------
>RYK
ITLKDVLQEGTFGRIFHGILIDEKD-------------------------
----PNKEKQAFVKTVKDQASEI-------------------------QV
TMMLTESCKLRGLH------------------HRNLLPITHVCIEE----
-----------------------------------------GEKPMVILP
YMNW----------------------------------------------
--GNLKLFLRQCKLVEANNPQA----------------------------
--------------------------------------------------
-------------------------------------ISQQDLVHMAIQI
ACGMSYLARR------------EVIHKDLAARNCVIDDT-----------
--------LQVKITDNALSRDLFPM-------------------------
--------------------------DYHCLGDNENRPVRWMALESLVN-
--------------------NEF-------SSASDVWAFGVTLWELMTLG
-----------QTPYVDID-----------------PFEMAAYLKDG---
--------------------------------------------------
---------------------YRIAQPINCP---DELFAVMACCWA----
LDPEERPKF---------QQLVQCL------------------------
>fgfr_1fgk.PDB
LVLGKPLG-----QVVLAEAIGL---------------------------
----PNRVTKVAVKMLKSDATEK-------------------------DL
SDLISEMEMMKMIGK-----------------HKNIINLLGACTQ-----
-----------------------------------------DGPLYVIVE
YASK----------------------------------------------
--GNLREYLQARRPP------------EEQ--------------------
--------------------------------------------------
-------------------------------------LSSKDLVSCAYQV
ARGMEYLASK------------KCIHRDLAARNVLVTED-----------
--------NVMKIADFGLARDIHHI-------------------------
--------------------------DYYKKTTNGRLPVKWMAPEALFD-
--------------------RIY-------THQSDVWSFGVLLWEIFTLG
-----------GSPYPGV------------------PVEELFKLLKEG--
--------------------------------------------------
---------------------HRMDKPSNCT---NELYMMMRDCWH----
AVPSQRPTF---------KQLVEDLDRIVALT-----------------
>FGFR1
LVLGKPLGEGCFGQVVLAEAIGLDKD------------------------
---KPNRVTKVAVKMLKSDATEK-------------------------DL
SDLISEMEMMKMIGK-----------------HKNIINLLGACTQ-----
-----------------------------------------DGPLYVIVE
YASK----------------------------------------------
--GNLREYLQARRPPGLEYCYNPSHNPEEQ--------------------
--------------------------------------------------
-------------------------------------LSSKDLVSCAYQV
ARGMEYLASK------------KCIHRDLAARNVLVTED-----------
--------NVMKIADFGLARDIHHI-------------------------
--------------------------DYYKKTTNGRLPVKWMAPEALFD-
--------------------RIY-------THQSDVWSFGVLLWEIFTLG
-----------GSPYPGV------------------PVEELFKLLKEG--
--------------------------------------------------
---------------------HRMDKPSNCT---NELYMMMRDCWH----
AVPSQRPTF---------KQLVEDL------------------------
>FGFR2
LTLGKPLGEGCFGQVVMAEAVGIDKD------------------------
---KPKEAVTVAVKMLKDDATEK-------------------------DL
SDLVSEMEMMKMIGK-----------------HKNIINLLGACTQ-----
-----------------------------------------DGPLYVIVE
YASK----------------------------------------------
--GNLREYLRARRPPGMEYSYDINRVPEEQ--------------------
--------------------------------------------------
-------------------------------------MTFKDLVSCTYQL
ARGMEYLASQ------------KCIHRDLAARNVLVTEN-----------
--------NVMKIADFGLARDINNI-------------------------
--------------------------DYYKKTTNGRLPVKWMAPEALFD-
--------------------RVY-------THQSDVWSFGVLMWEIFTLG
-----------GSPYPGI------------------PVEELFKLLKEG--
--------------------------------------------------
---------------------HRMDKPANCT---NELYMMMRDCWH----
AVPSQRPTF---------KQLVEDL------------------------
>FGFR3
LTLGKPLGEGCFGQVVMAEAIGIDKD------------------------
---RAAKPVTVAVKMLKDDATDK-------------------------DL
SDLVSEMEMMKMIGK-----------------HKNIINLLGACTQ-----
-----------------------------------------GGPLYVLVE
YAAK----------------------------------------------
--GNLREFLRARRPPGLDYSFDTCKPPEEQ--------------------
--------------------------------------------------
-------------------------------------LTFKDLVSCAYQV
ARGMEYLASQ------------KCIHRDLAARNVLVTED-----------
--------NVMKIADFGLARDVHNL-------------------------
--------------------------DYYKKTTNGRLPVKWMAPEALFD-
--------------------RVY-------THQSDVWSFGVLLWEIFTLG
-----------GSPYPGI------------------PVEELFKLLKEG--
--------------------------------------------------
---------------------HRMDKPANCT---HDLYMIMRECWH----
AAPSQRPTF---------KQLVEDL------------------------
>FGFR4
LVLGKPLGEGCFGQVVRAEAFGMDPA------------------------
---RPDQASTVAVKMLKDNASDK-------------------------DL
ADLVSEMEVMKLIGR-----------------HKNIINLLGVCTQ-----
-----------------------------------------EGPLYVIVE
CAAK----------------------------------------------
--GNLREFLRARRPPGPDLSPDGPRSSEGP--------------------
--------------------------------------------------
-------------------------------------LSFPVLVSCAYQV
ARGMQYLESR------------KCIHRDLAARNVLVTED-----------
--------NVMKIADFGLARGVHHI-------------------------
--------------------------DYYKKTSNGRLPVKWMAPEALFD-
--------------------RVY-------THQSDVWSFGILLWEIFTLG
-----------GSPYPGI------------------PVEELFSLLREG--
--------------------------------------------------
---------------------HRMDRPPHCP---PELYGLMRECWH----
AAPSQRPTF---------KQLVEAL------------------------
>RET
LVLGKTLGEGEFGKVVKATAFHLKG-------------------------
----RAGYTTVAVKMLKENASPS-------------------------EL
RDLLSEFNVLKQVN------------------HPHVIKLYGACSQ-----
-----------------------------------------DGPLLLIVE
YAKY----------------------------------------------
--GSLRGFLRESRKVGPGYLGSGGSRNSSSL-------------------
--------------------------------------------------
------------------------------DHPDERALTMGDLISFAWQI
SQGMQYLAEM------------KLVHRDLAARNILVAEG-----------
--------RKMKISDFGLSRDVYEED------------------------
---------------------------SYVKRSQGRIPVKWMAIESLFD-
--------------------HIY-------TTQSDVWSFGVLLWEIVTLG
-----------GNPYPGI------------------PPERLFNLLKTG--
--------------------------------------------------
---------------------HRMERPDNCS---EEMYRLMLQCWK----
QEPDKRPVF---------ADISKDLEK----------------------
>FLT1
LKLGKSLGRGAFGKVVQASAFGIKK-------------------------
----SPTCRTVAVKMLKEGATAS-------------------------EY
KALMTELKILTHIGH-----------------HLNVVNLLGACTKQ----
-----------------------------------------GGPLMVIVE
YCKY----------------------------------------------
--GNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKP-------
-------------------------------------------------R
LDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQV
ARGMEFLSSR------------KCIHRDLAARNILLSEN-----------
--------NVVKICDFGLARDIYKNP------------------------
---------------------------DYVRKGDTRLPLKWMAPESIFD-
--------------------KIY-------STKSDVWSYGVLLWEIFSLG
-----------GSPYPGVQ-----------------MDEDFCSRLREG--
--------------------------------------------------
---------------------MRMRAPEYST---PEIYQIMLDCWH----
RDPKERPRF---------AELVEKL------------------------
>kdr_1vr2.PDB
LKLGKPLGRGAFGQVIEADAFGIDK-------------------------
----TATCRTVAVKMLKEGATHS-------------------------EH
RALMSELKILIHIGH-----------------HLNVVNLLGACTKP----
-----------------------------------------GGPLMVIVE
FCKF----------------------------------------------
--GNLSTYLRSKRNEFVPYKDF----------------------------
--------------------------------------------------
-------------------------------------LTLEHLICYSFQV
AKGMEFLASR------------KCIHRDLAARNILLSEK-----------
--------NVVKICDF----------------------------------
---------------------------------DARLPLKWMAPETIFD-
--------------------RVY-------TIQSDVWSFGVLLWEIFSLG
-----------ASPYPGVK-----------------IDEEFCRRLKEG--
--------------------------------------------------
---------------------TRMRAPDYTT---PEMYQTMLDCWH----
GEPSQRPTF---------SELVEHLGNLLQAN-----------------
>KDR
LKLGKPLGRGAFGQVIEADAFGIDK-------------------------
----TATCRTVAVKMLKEGATHS-------------------------EH
RALMSELKILIHIGH-----------------HLNVVNLLGACTKP----
-----------------------------------------GGPLMVIVE
FCKF----------------------------------------------
--GNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL------
--------------------------------------------------
-DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQV
AKGMEFLASR------------KCIHRDLAARNILLSEK-----------
--------NVVKICDFGLARDIYKDP------------------------
---------------------------DYVRKGDARLPLKWMAPETIFD-
--------------------RVY-------TIQSDVWSFGVLLWEIFSLG
-----------ASPYPGVK-----------------IDEEFCRRLKEG--
--------------------------------------------------
---------------------TRMRAPDYTT---PEMYQTMLDCWH----
GEPSQRPTF---------SELVEHL------------------------
>FLT4
LHLGRVLGYGAFGKVVEASAFGIHK-------------------------
----GSSCDTVAVKMLKEGATAS-------------------------EH
RALMSELKILIHIGN-----------------HLNVVNLLGACTKP----
-----------------------------------------QGPLMVIVE
FCKY----------------------------------------------
--GNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRP------
--------------------------------------------------
---GSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQV
ARGMEFLASR------------KCIHRDLAARNILLSES-----------
--------DVVKICDFGLARDIYKDP------------------------
---------------------------DYVRKGSARLPLKWMAPESIFD-
--------------------KVY-------TTQSDVWSFGVLLWEIFSLG
-----------ASPYPGVQ-----------------INEEFCQRLRDG--
--------------------------------------------------
---------------------TRMRAPELAT---PAIRRIMLNCWS----
GDPKARPAF---------SELVEIL------------------------
>FMS
LQFGKTLGAGAFGKVVEATAFGLGK-------------------------
----EDAVLKVAVKMLKSTAHAD-------------------------EK
EALMSELKIMSHLGQ-----------------HENIVNLLGACTH-----
-----------------------------------------GGPVLVITE
YCCY----------------------------------------------
--GDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVR------
------------------------------------------------RD
SGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQV
AQGMAFLASK------------NCIHRDVAARNVLLTNG-----------
--------HVAKIGDFGLARDIMNDS------------------------
---------------------------NYIVKGNARLPVKWMAPESIFD-
--------------------CVY-------TVQSDVWSYGILLWEIFSLG
-----------LNPYPGIL-----------------VNSKFYKLVKDG--
--------------------------------------------------
---------------------YQMAQPAFAP---KNIYSIMQACWA----
LEPTHRPTF---------QQICSFL------------------------
>KIT
LSFGKTLGAGAFGKVVEATAYGLIK-------------------------
----SDAAMTVAVKMLKPSAHLT-------------------------ER
EALMSELKVLSYLGN-----------------HMNIVNLLGACTI-----
-----------------------------------------GGPTLVITE
YCCY----------------------------------------------
--GDLLNFLRRKRDSFICSKQEDHAEAAL---YKN---------------
-----LLHSKESSCSDS------------------------TNEYMDMKP
GVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQV
AKGMAFLASK------------NCIHRDLAARNILLTHG-----------
--------RITKICDFGLARDIKNDS------------------------
---------------------------NYVVKGNARLPVKWMAPESIFN-
--------------------CVY-------TFESDVWSYGIFLWELFSLG
-----------SSPYPGMP-----------------VDSKFYKMIKEG--
--------------------------------------------------
---------------------FRMLSPEHAP---AEMYDIMKTCWD----
ADPLKRPTF---------KQIVQLI------------------------
>FLT3
LEFGKVLGSGAFGKVMNATAYGISK-------------------------
----TGVSIQVAVKMLKEKADSS-------------------------ER
EALMSELKMMTQLGS-----------------HENIVNLLGACTL-----
-----------------------------------------SGPIYLIFE
YCCY----------------------------------------------
--GDLLNYLRSKREKFHRTWTEIFKEHNFSF-------------------
------YPTFQSHPNSS------------------------MPGSREVQI
HPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQV
AKGMEFLEFK------------SCVHRDLAARNVLVTHG-----------
--------KVVKICDFGLARDIMSDS------------------------
---------------------------NYVVRGNARLPVKWMAPESLFE-
--------------------GIY-------TIKSDVWSYGILLWEIFSLG
-----------VNPYPGIP-----------------VDANFYKLIQNG--
--------------------------------------------------
---------------------FKMDQPFYAT---EEIYIIMQSCWA----
FDSRKRPSF---------PNLTSFL------------------------
>PDGFRa
LVLGRVLGSGAFGKVVEGTAYGLSR-------------------------
----SQPVMKVAVKMLKPTARSS-------------------------EK
QALMSELKIMTHLGP-----------------HLNIVNLLGACTK-----
-----------------------------------------SGPIYIITE
YCFY----------------------------------------------
--GDLVNYLHKNRDSFLSHHPE-KPKKELDIFGLNPADESTRSYVILSFE
NNGDYMDMKQADTTQYV------------------------PMLERKEVS
KYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQV
ARGMEFLASK------------NCVHRDLAARNVLLAQG-----------
--------KIVKICDFGLARDIMHDS------------------------
---------------------------NYVSKGSTFLPVKWMAPESIFD-
--------------------NLY-------TTLSDVWSYGILLWEIFSLG
-----------GTPYPGMM-----------------VDSTFYNKIKSG--
--------------------------------------------------
---------------------YRMAKPDHAT---SEVYEIMVKCWN----
SEPEKRPSF---------YHLSEIV------------------------
>PDGFRb
LVLGRTLGSGAFGQVVEATAHGLSH-------------------------
----SQATMKVAVKMLKSTARSS-------------------------EK
QALMSELKIMSHLGP-----------------HLNVVNLLGACTK-----
-----------------------------------------GGPIYIITE
YCRY----------------------------------------------
--GDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTG
ESDGGYMDMSKDESVDY------------------------VPMLDMKGD
VKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQV
ANGMEFLASK------------NCVHRDLAARNVLICEG-----------
--------KLVKICDFGLARDIMRDS------------------------
---------------------------NYISKGSTFLPLKWMAPESIFN-
--------------------SLY-------TTLSDVWSFGILLWEIFTLG
-----------GTPYPELP-----------------MNEQFYNAIKRG--
--------------------------------------------------
---------------------YRMAQPAHAS---DEIYEIMQKCWE----
EKFEIRPPF---------SQLVLLL------------------------
>TIE1
ITFEDLIGEGNFGQVIRAMIKKDGL-------------------------
-------KMNAAIKMLKEYASEN-------------------------DH
RDFAGELEVLCKLGH-----------------HPNIINLLGACKN-----
-----------------------------------------RGYLYIAIE
YAPY----------------------------------------------
--GNLLDFLRKSRVLETDPAFAREHGTAST--------------------
--------------------------------------------------
-------------------------------------LSSRQLLRFASDA
ANGMQYLSEK------------QFIHRDLAARNVLVGEN-----------
--------LASKIADFGLSRGEE---------------------------
---------------------------VYVKKTMGRLPVRWMAIESLNY-
--------------------SVY-------TTKSDVWSFGVLLWEIVSLG
-----------GTPYCGMT------------------CAELYEKLPQG--
--------------------------------------------------
---------------------YRMEQPRNCD---DEVYELMRQCWR----
DRPYERPPF---------AQIALQL------------------------
>tie2_1fvr.PDB
IKFQDVIGEGNFGQVLKARIKKDGLR------------------------
--------MDAAIKRMKEYR------------------------------
-DFAGELEVLCKLGH-----------------HPNIINLLGACEH-----
-----------------------------------------RGYLYLAIE
YAPH----------------------------------------------
--GNLLDFLRKSRVLETDPAFAIANSTAST--------------------
--------------------------------------------------
-------------------------------------LSSQQLLHFAADV
ARGMDYLSQK------------QFIHRDLAARNILVGEN-----------
--------YVAKIADFGLSRGQE---------------------------
----------------------------VYVKK---LPVRWMAIESLNY-
--------------------SVY-------TTNSDVWSYGVLLWEIVSLG
-----------GTPYCGMT------------------CAELYEKLPQG--
--------------------------------------------------
---------------------YRLEKPLNCD---DEVYDLMRQCWR----
EKPYERPSF---------AQILVSLNRMLEERKTYVNTTLYEKFTYAGI
>TIE2
IKFQDVIGEGNFGQVLKARIKKDGLR------------------------
--------MDAAIKRMKEYASKD-------------------------DH
RDFAGELEVLCKLGH-----------------HPNIINLLGACEH-----
-----------------------------------------RGYLYLAIE
YAPH----------------------------------------------
--GNLLDFLRKSRVLETDPAFAIANSTAST--------------------
--------------------------------------------------
-------------------------------------LSSQQLLHFAADV
ARGMDYLSQK------------QFIHRDLAARNILVGEN-----------
--------YVAKIADFGLSRGQE---------------------------
---------------------------VYVKKTMGRLPVRWMAIESLNY-
--------------------SVY-------TTNSDVWSYGVLLWEIVSLG
-----------GTPYCGMT------------------CAELYEKLPQG--
--------------------------------------------------
---------------------YRLEKPLNCD---DEVYDLMRQCWR----
EKPYERPSF---------AQILVSL------------------------
>egfr_1m14.PDB
FKKIKVLGSGAFGTVYKGLWIPEGEKV-----------------------
-------KIPVAIKELREATSPK-------------------------AN
KEILDEAYVMASVD------------------NPHVCRLLGICL------
-----------------------------------------TSTVQLITQ
LMPF----------------------------------------------
--GCLLDYVREHKDN-----------------------------------
--------------------------------------------------
-------------------------------------IGSQYLLNWCVQI
AKGMNYLEDR------------RLVHRDLAARNVLVKTP-----------
--------QHVKITDFGLAKLLGAEE------------------------
---------------------------KEYHAEGGKVPIKWMALESILH-
--------------------RIY-------THQSDVWSYGVTVWELMTFG
-----------SKPYDGIP------------------ASEISSILEKG--
--------------------------------------------------
---------------------ERLPQPPICT---IDVYMIMVKCWM----
IDADSRPKF---------RELIIEFSKMARDPQRYLVIQGDDEEDMDDV
>EGFR
FKKIKVLGSGAFGTVYKGLWIPEGEKV-----------------------
-------KIPVAIKELREATSPK-------------------------AN
KEILDEAYVMASVD------------------NPHVCRLLGICL------
-----------------------------------------TSTVQLITQ
LMPF----------------------------------------------
--GCLLDYVREHKDN-----------------------------------
--------------------------------------------------
-------------------------------------IGSQYLLNWCVQI
AKGMNYLEDR------------RLVHRDLAARNVLVKTP-----------
--------QHVKITDFGLAKLLGAEE------------------------
---------------------------KEYHAEGGKVPIKWMALESILH-
--------------------RIY-------THQSDVWSYGVTVWELMTFG
-----------SKPYDGIP------------------ASEISSILEKG--
--------------------------------------------------
---------------------ERLPQPPICT---IDVYMIMVKCWM----
IDADSRPKF---------RELIIEFS-----------------------
>HER2/ErbB2
LRKVKVLGSGAFGTVYKGIWIPDGENV-----------------------
-------KIPVAIKVLRENTSPK-------------------------AN
KEILDEAYVMAGVG------------------SPYVSRLLGICL------
-----------------------------------------TSTVQLVTQ
LMPY----------------------------------------------
--GCLLDHVRENRGR-----------------------------------
--------------------------------------------------
-------------------------------------LGSQDLLNWCMQI
AKGMSYLEDV------------RLVHRDLAARNVLVKSP-----------
--------NHVKITDFGLARLLDIDE------------------------
---------------------------TEYHADGGKVPIKWMALESILR-
--------------------RRF-------THQSDVWSYGVTVWELMTFG
-----------AKPYDGIP------------------AREIPDLLEKG--
--------------------------------------------------
---------------------ERLPQPPICT---IDVYMIMVKCWM----
IDSECRPRF---------RELVSEFS-----------------------
>HER4/ErbB4
LKRVKVLGSGAFGTVYKGIWVPEGETV-----------------------
-------KIPVAIKILNETTGPK-------------------------AN
VEFMDEALIMASMD------------------HPHLVRLLGVCL------
-----------------------------------------SPTIQLVTQ
LMPH----------------------------------------------
--GCLLEYVHEHKDN-----------------------------------
--------------------------------------------------
-------------------------------------IGSQLLLNWCVQI
AKGMMYLEER------------RLVHRDLAARNVLVKSP-----------
--------NHVKITDFGLARLLEGDE------------------------
---------------------------KEYNADGGKMPIKWMALECIHY-
--------------------RKF-------THQSDVWSYGVTIWELMTFG
-----------GKPYDGIP------------------TREIPDLLEKG--
--------------------------------------------------
---------------------ERLPQPPICT---IDVYMVMVKCWM----
IDADSRPKF---------KELAAEFS-----------------------
>HER3/ErbB3
LRKLKVLGSGVFGTVHKGVWIPEGESI-----------------------
-------KIPVCIKVIEDKSGRQ-------------------------SF
QAVTDHMLAIGSLD------------------HAHIVRLLGLCP------
-----------------------------------------GSSLQLVTQ
YLPL----------------------------------------------
--GSLLDHVRQHRGA-----------------------------------
--------------------------------------------------
-------------------------------------LGPQLLLNWGVQI
AKGMYYLEEH------------GMVHRNLAARNVLLKSP-----------
--------SQVQVADFGVADLLPPDD------------------------
---------------------------KQLLYSEAKTPIKWMALESIHF-
--------------------GKY-------THQSDVWSYGVTVWELMTFG
-----------AEPYAGLR------------------LAEVPDLLEKG--
--------------------------------------------------
---------------------ERLAQPQICT---IDVYMVMVKCWM----
IDENIRPTF---------KELANEF------------------------
>TNK1
VCRGELLGSGCFGVVHRGLWTLPSGK------------------------
-------SVPVAVKSLRVGPEGPMG----------------------TEL
GDFLREVSVMMNLE------------------HPHVLRLHGLVL------
-----------------------------------------GQPLQMVME
LAPL----------------------------------------------
--GSLHARLTAPAPTPP---------------------------------
--------------------------------------------------
-------------------------------------LLVALLCLFLRQL
AGAMAYLGAR------------GLVHRDLATRNLQLASP-----------
--------RTIKVADFGLVRPLGGAR------------------------
--------------------------GRYVMGGPRPIPYTWCAPESLRH-
--------------------GAF-------SSASDVWMFGVTLWEMFSGG
-----------EEPWPGVP------------------PYLILQRLEDR--
--------------------------------------------------
---------------------ARLPRPPPSS---RALYSLALRCWA----
PHPADRPSF---------SHLEGLL------------------------
>ACK
LRLLEKLGDGSFGVVRRGEWDAPSGK------------------------
-------TVSVAVKCLKPDVLSQPE-----------------------AM
DDFIREVNAMHSLD------------------HRNLIRLYGVVL------
-----------------------------------------TPPMKMVTE
LAPL----------------------------------------------
--GSLLDRLRKHQGH-----------------------------------
--------------------------------------------------
-------------------------------------FLLGTLSRYAVQV
AEGMGYLESK------------RFIHRDLAARNLLLATR-----------
--------DLVKIGDFGLMRALPQND------------------------
--------------------------DHYVMQEHRKVPFAWCAPESLKT-
--------------------RTF-------SHASDTWMFGVTLWEMFTYG
-----------QEPWIGLN-----------------GSQILHKIDKEG--
--------------------------------------------------
---------------------ERLPRPEDCP---QDIYNVMVQCWA----
HKPEDRPTF---------VALRDFL------------------------
>TYK2
LKKIRDLGEGHFGKVSLYCYDPTNDG------------------------
------TGEMVAVKALKADCGPQ-------------------------HR
SGWKQEIDILRTLY------------------HEHIIKYKGCCEDQ----
----------------------------------------GEKSLQLVME
YVPL----------------------------------------------
--GSLRDYLPRHS-------------------------------------
--------------------------------------------------
-------------------------------------IGLAQLLLFAQQI
CEGMAYLHAH------------DYIHRDLAARNVLLDND-----------
--------RLVKIGDFGLAKAVPEGH------------------------
--------------------------EYYRVREDGDSPVFWYAPECLKE-
--------------------YKF-------YYASDVWSFGVTLYELLTHC
DSS--------QSPPTKFLELIGIAQ-------GQMTVLRLTELLERG--
--------------------------------------------------
---------------------ERLPRPDKCP---CEVYHLMKNCWE----
TEASFRPTF----------------------------------------
>JAK1
LKRIRDLGEGHFGKVELCRYDPEDN-------------------------
------TGEQVAVKSLKPESGGN-------------------------HI
ADLKKEIEILRNLY------------------HENIVKYKGICTED----
----------------------------------------GGNGIKLIME
FLPS----------------------------------------------
--GSLKEYLPKNKNK-----------------------------------
--------------------------------------------------
-------------------------------------INLKQQLKYAVQI
CKGMDYLGSR------------QYVHRDLAARNVLVESE-----------
--------HQVKIGDFGLTKAIETDK------------------------
--------------------------EYYTVKDDRDSPVFWYAPECLMQ-
--------------------SKF-------YIASDVWSFGVTLHELLTYC
DSD--------SSPMALFLKMIGPTH-------GQMTVTRLVNTLKEG--
--------------------------------------------------
---------------------KRLPCPPNCP---DEVYQLMRKCWE----
FQPSNRTSF------QNLIEGFEAL------------------------
>JAK2
LKFLQQLGKGNFGSVEMCRYDPLQDN------------------------
------TGEVVAVKKLQHSTEEH-------------------------LR
-DFEREIEILKSLQ------------------HDNIVKYKGVCYSA----
----------------------------------------GRRNLKLIME
YLPY----------------------------------------------
--GSLRDYLQKHKER-----------------------------------
--------------------------------------------------
-------------------------------------IDHIKLLQYTSQI
CKGMEYLGTK------------RYIHRDLATRNILVENE-----------
--------NRVKIGDFGLTKVLPQDK------------------------
--------------------------EYYKVKEPGESPIFWYAPESLTE-
--------------------SKF-------SVASDVWSFGVVLYELFTYI
EKS--------KSPPAEFMRMIGNDKQ------GQMIVFHLIELLKNN--
--------------------------------------------------
---------------------GRLPRPDGCP---DEIYMIMTECWN----
NNVNQRPSF------RDLALRVDQI------------------------
>JAK3
LKYISQLGKGNFGSVELCRYDPLAHN------------------------
------TGALVAVKQLQHSGPDQ-------------------------QR
-DFQREIQILKAL-------------------HSDFIVKYRGVSYGP---
----------------------------------------GRPELRLVME
YLPS----------------------------------------------
--GCLRDFLQRHRAR-----------------------------------
--------------------------------------------------
-------------------------------------LDASRLLLYSSQI
CKGMEYLGSR------------RCVHRDLAARNILVESE-----------
--------AHVKIADFGLAKLLPLDK------------------------
--------------------------DYYVVREPGQSPIFWYAPESLSD-
--------------------NIF-------SRQSDVWSFGVVLYELFTYC
DKS--------CSPSAEFLRMMGCERDVP-------ALCRLLELLEEG--
--------------------------------------------------
---------------------QRLPAPPACP---AEVHELMKLCWA----
PSPQDRPSF----SALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLS--
>LMR1
LLYLKEIGRGWFGKVFLGEVNSGIS-------------------------
-------SAQVVVKELQASASVQ-------------------------EQ
MQFLEEVQPYRALK------------------HSNLLQCLAQCAE-----
-----------------------------------------VTPYLLVME
FCPL----------------------------------------------
--GDLKGYLRSCRVAESMA-------------------------------
--------------------------------------------------
-------------------------------------PDPRTLQRMACEV
ACGVLHLHRN------------NFVHSDLALRNCLLTAD-----------
--------LTVKIGDYGLAHCKYRE-------------------------
--------------------------DYFVTADQLWVPLRWIAPELVDEV
H-------------------SNL--LVVDQTKSGNVWSLGVTIWELFELG
-----------TQPYPQHSD-----------------QQVLAYTVREQQL
KL------------------------------------------------
---------------------PKPQLQLTLS---DRWYEVMQFCWL----
Q-PEQRPTA------EEVHLLLSYL------------------------
>LMR2
LNYIQEIGNGWFGKVLLGEIYTGTS-------------------------
-------VARVIVKELKASANPK-------------------------EQ
DTFLKNGEPYYILQ------------------HPNILQCVGQCVE-----
-----------------------------------------AIPYLLVFE
FCDL----------------------------------------------
--GDLKAYLRSEQEHMRGD-------------------------------
--------------------------------------------------
-------------------------------------SQTMLLQRMACEV
AAGLAAMHKL------------HFLHSDLALRNCFLTSD-----------
--------LNVKVGDYGIGFSRYKE-------------------------
--------------------------DYIETDDKKVFPLRWTAPELVTSF
Q-------------------DRL--LTADQTKYSNIWSLGVTLWELFDNA
-----------AQPYSNLSN-----------------LDVLNQVIRERDT
KL------------------------------------------------
---------------------PKPQLEQPYS---DRWYEVLQFCWL----
S-PEKRPAA------EDVHRLLTYL------------------------
>LMR3
LSYLQEIGSGWFGKVILGEIFSDYT-------------------------
-------PAQVVVKELRASAGPL-------------------------EQ
RKFISEAQPYRSLQ------------------HPNVLQCLGLCVE-----
-----------------------------------------TLPFLLIME
FCQL----------------------------------------------
--GDLKRYLRAQRPPEGLSPELPP--------------------------
--------------------------------------------------
-------------------------------------RDLRTLQRMGLEI
ARGLAHLHSH------------NYVHSDLALRNCLLTSD-----------
--------LTVRIGDYGLAHSNYKE-------------------------
--------------------------DYYLTPERLWIPLRWAAPELLGEL
H-------------------GTF--MVMDQSRESNIWSLGVTLWELFEFG
-----------AQPYRHLSD-----------------EEVLAFVVRQQHV
KL------------------------------------------------
---------------------ARPKLKLPYA---DYWYDILQSCWR----
P-PAQRPSA----SDLQLQLTYLLSERPPRPPPPPPPPRDGPFPWPWPP
>JAK3-b
LEWHENLGHGSFTKIYRGCRHEVVDGE-----------------------
-----ARKTEVLLKVMDAKHK---------------------------NC
MESFLEAASLMSQVS-----------------YRHLVLLHGVCM------
-----------------------------------------AGDSTMVQE
FVHL----------------------------------------------
--GAIDMYLR----------------------------------------
--------------------------------------------------
------------------------------------KRGHLVPASWKLQV
VKQLAYALN-------------YLEDKGLPHGNVSARKVLLARE------
--GADGSPPFIKLSDPGVSPAVL---------------------------
-----------------------------SLEMLTDRIP-WVAPECLREA
--------------------QTL-------SLEADKWGFGATVWEVFSGV
TMPISA-----LDPA-----------------------KKLQFYEDR---
--------------------------------------------------
---------------------QQLPAPKWT-----ELALLIQQCMA----
YEPVQRPSF----RAVIRDLNSLISSDYELLSDPTP-------------
>JAK2-b
LIFNESLGQGTFTKIFKGVRREVGDYG-----------------------
----QLHETEVLLKVLDKAHR---------------------------NY
SESFFEAASMMSKLS-----------------HKHLVLNYGVCVC-----
-----------------------------------------GDENILVQE
FVKF----------------------------------------------
--GSLDTYLK----------------------------------------
--------------------------------------------------
------------------------------------KNKNCINILWKLEV
AKQLAWAMH-------------FLEENTLIHGNVCAKNILLIREE-----
-DRKTGNPPFIKLSDPGISITVL---------------------------
-----------------------------PKDILQERIP-WVPPECIENP
--------------------KNL-------NLATDKWSFGTTLWEICSGG
-----------DKPLSALDS-----------------QRKLQFYEDR---
--------------------------------------------------
---------------------HQLPAPKWA-----ELANLINNCMD----
YEPDFRPSF----RAIIRDLNSLF-------------------------
>JAK1-b
LVQGEHLGRGTRTHIYSGTLMDYKDDEGTS--------------------
----EEKKIKVILKVLDPSHR---------------------------DI
SLAFFEAASMMRQVS-----------------HKHIVYLYGVCVR-----
-----------------------------------------DVENIMVEE
FVEG----------------------------------------------
--GPLDLFMHRKSDV-----------------------------------
--------------------------------------------------
-------------------------------------LTTPWKFKVAKQL
ASALSYLEDK------------DLVHGNVCTKNLLLAREGIDS-------
-----ECGPFIKLSDPGIPITVL---------------------------
-----------------------------SRQECIERIP-WIAPECVEDS
--------------------KNL-------SVAADKWSFGTTLWEICYNG
-----------EIPLKDKTL-----------------IEKERFYES----
--------------------------------------------------
--------------------RCRPVTPSCK-----ELADLMTRCMN----
YDPNQRPFF--------RAIMRDINK-----------------------
>TYK2-b
ITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDD----------EDPLV
PGRDRGQELRVVLKVLDPSHH---------------------------DI
ALAFYETASLMSQVS-----------------HTHLAFVHGVCVR-----
-----------------------------------------GPENSMVTE
YVEH----------------------------------------------
--GPLDVWLRRERGH-----------------------------------
--------------------------------------------------
-------------------------------------VPMAWKMVVAQQL
ASALSYLENK------------NLVHGNVCGRNILLARLGLAE-------
-----GTSPFIKLSDPGVGLGAL---------------------------
-----------------------------SREERVERIP-WLAPECLPGG
A-------------------NSL-------STAMDKWGFGATLLEICFDG
-----------EAPLQSRSP-----------------SEKEHFYQRQ---
--------------------------------------------------
---------------------HRLPEPSCP-----QLATLTSQCLT----
YEPTQRPSF---------RTILRDL------------------------
>SuRTK106
SEVLEQICSGSCGPIFRANMNTGDPSKP----------------------
--------KSVILKALKEPAGLHEVQ-----------------------D
FLGRIQFHQYLGK-------------------HKNLVQLEGCCTE-----
-----------------------------------------KLPLYMVLE
DVAQ----------------------------------------------
--GDLLGFLWTCRRDVMTMDGLLYD-------------------------
--------------------------------------------------
-------------------------------------LTEKQVYHIGKQV
LLALEFLQEK------------HLFHGDVAARNILMQSD-----------
--------LTAKLCGLGLAYEVY---------------------------
--------------------------TRGAISSTQTIPLKWLAPERLLL-
--------------------RPA-------SIRADVWSFGILLYEMVTLG
-----------APPYPEVPP------------------TSILEHLQRRK-
--------------------------------------------------
---------------------IMKRPSSCTH----TMYSIMKSCWR----
WREADRPSP---------RELRLRL------------------------
>MOS
VCLLQRLGAGGFGSVYKATYRGV---------------------------
---------PVAIKQVNKCTKNRLA-----------------------SR
RSFWAELNVARLR-------------------HDNIVRVVAASTRTP---
--------------------------------------AGSNSLGTIIME
FGGN----------------------------------------------
--VTLHQVIYGAAGHPEGDAGEPHCRTGGQ--------------------
--------------------------------------------------
-------------------------------------LSLGKCLKYSLDV
VNGLLFLHSQ------------SIVHLDLKPANILISEQ-----------
--------DVCKISDFGCSEKLEDLLCF----------------------
----------------------------QTPSYPLGGTYTHRAPELLKG-
--------------------EGV-------TPKADIYSFAITLWQMTTK-
-----------QAPYSGERQ-----------------HILYAVVAYDL--
--------------------------------------------------
-----------------RPSLS--AAVFEDSLPGQRLGDVIQRCWR----
PSAAQRPSA----RLLLVDLTS---------------------------
>SgK496
PKLGQELGRGQYGVVYLCDNWGGHF-------------------------
---------PCALKSVVPPDEK--------------------------HW
NDLALEFHYMRSLPK-----------------HERLVDLHGSVI------
--------------------------------------DYNYGGGSSIAV
LLIM----------------------------------------------
--ERLHRDLYTGLKAG----------------------------------
--------------------------------------------------
-------------------------------------LTLETRLQIALDV
VEGIRFLHSQ------------GLVHRDIKLKNVLLDKQ-----------
--------NRAKITDLGFCKPE----------------------------
----------------------------AMMSGSIVGTPIHMAPELFT--
--------------------GKY-------DNSVDVYAFGILFWYICSGS
V----------KLPEAFERCAS---------------KDHLWNNVRRGA-
--------------------------------------------------
-----------------RPER----LPVFDE----ECWQLMEACWD----
GDPLKRPLL----GIVQPMLQGIMNRLCK--------------------
>PBK
SPFMQKLGFGTGVNVYLMKRSPRGLSHS----------------------
---------PWAVKKINPICNDHYRSV---------------------YQ
KRLMDEAKILKSLH------------------HPNIVGYRAFTE------
---------------------------------------ASDGSLCLAME
YGGE----------------------------------------------
--KSLNDLIEERYKASQDP-------------------------------
--------------------------------------------------
-------------------------------------FPAAIILKVALNM
ARGLKYLHQEK-----------KLLHGDIKSSNVVIKGDF----------
--------ETIKICDVGVSLPLDENMTVT---------------------
-----------------------------DPEACYIGTEPWKPKEAVEEN
--------------------GVI-------TDKADIFAFGLTLWEMMTL-
-----------SIPHINLSNDDDD----EDKTFDESDFDDEAYYAALGT-
--------------------------------------------------
-----------------RPPI--NMEELDESY--QKVIELFSVCTN----
EDPKDRPSA---------AHIVEAL------------------------
>MLKL
LLRENEVSTLYKGEYHRA--------------------------------
---------PVAIKVFKKLQAGSIAIV----------------------R
QTFNKEIKTMKKFE------------------SPNILRIFGICIDE----
--------------------------------------TVTPPQFSIVME
YCEL----------------------------------------------
--GTLRELLDREKD------------------------------------
--------------------------------------------------
-------------------------------------LTLGKRMVLVLGA
ARGLYRLHHSEA----------PELHGKIRSSNFLVTQG-----------
--------YQVKLAGFELRKTQTSMSLGTTRE------------------
------------------------------KTDRVKSTAYLSPQELED--
--------------------VFY---------QYDVKSEIYSFGIVLWEI
ATG--------DIPFQGCNS-----------------EKIRKLVAVKRQQ
--------------------------------------------------
----------------------EPLGEDCPSE----LREIIDECRA----
HDPSVRPSV------DEILKKLSTF------------------------
>IRAK1
FSEELKIGEGGFGCVYRAVMRNT---------------------------
---------VYAVKRLKENADLEWTAV----------------------K
QSFLTEVEQLSRFR------------------HPNIVDFAGYCA------
----------------------------------------QNGFYCLVYG
FLPN----------------------------------------------
--GSLEDRLHCQTQACPP--------------------------------
--------------------------------------------------
-------------------------------------LSWPQRLDILLGT
ARAIQFLHQDSP----------SLIHGDIKSSNVLLDER-----------
--------LTPKLGDFGLARFSRFAGSSPSQSS-----------------
---------------------------MVARTQTVRGT-LAYLPEEYIKT
--------------------GRL-------AVDTDTFSFGVVVLETLAGQ
R----------AVKTHGARTKYLK--------DLVEEEAEEAGVALRSTQ
-------------------------STLQAGLAADAWAAPIAM-------
---------------QIYKKHLDPRPGPCPPELGLGLGQLACCCLH----
RRAKRRPPM----TQVYERLEKL--------------------------
>IRAK2
FNQNRKISQGTFADVYRGHRHGK---------------------------
---------PFVFKKLRETACSSPGSI----------------------E
RFFQAELQICLRCC------------------HPNVLPVLGFCA------
----------------------------------------ARQFHSFIYP
YMAN----------------------------------------------
--GSLQDRLQGQGGSDPLPWPQRVSICSGLL-------------------
--------------------------------------------------
-------------------------CAVEYLHGLEIIHSNVKSSNVLLDQ
NLTPKLAHP----------------MAHLCPVNKRSKYTM----------
--------MKTHLLRTSAAYLPEDFIRVGQ--------------------
---------------------------LTKRVDIFSCG--IVLAEVLTGI
--------------------PAM-----------DNNRSPVYLKDLLLS-
-----------EIPSSTASL------------------------------
--------------------------------------------------
--------------------------CSRKTGVENVMAKEICQKYL----
EKGAGRLPE----DCAEALATA---------------------------
>IRAK3
FHKDFLIGEGEIFEVYRVEIQNL---------------------------
---------TYAVKLFKQEKKMQCKKH----------------------W
KRFLSELEVLLLFH------------------HPNILELAAYFT------
----------------------------------------ETEKFCLIYP
YMRN----------------------------------------------
--GTLFDRLQCVGDTAP---------------------------------
--------------------------------------------------
-------------------------------------LPWHIRIGILIGI
SKAIHYLHNVQPC---------SVICGSISSANILLDDQ-----------
--------FQPKLTDFAMAHFRSHLEHQ----------------------
--------------------------SCTINMTSSSSKHLWYMPEEYIRQ
--------------------GKL-------SIKTDVYSFGIVIMEVLTGC
RVVL-------DDPKHIQLR------------------DLLRELMEKRGL
DSCL----------------------------------------------
-------------------SFLDKKVPPCPRNFSAKLFCLAGRCAA----
TRAKLRPSM---------DEVLNTL------------------------
>IRAK4
SVGGNKMGEGGFGVVYKGYVNNT---------------------------
---------TVAVKKLAAMVDITTEEL----------------------K
QQFDQEIKVMAKCQ------------------HENLVELLGFSS------
----------------------------------------DGDDLCLVYV
YMPN----------------------------------------------
--GSLLDRLSCLDGTPP---------------------------------
--------------------------------------------------
-------------------------------------LSWHMRCKIAQGA
ANGINFLHEN------------HHIHRDIKSANILLDEA-----------
--------FTAKISDFGLARASEKFAQ-----------------------
---------------------------TVMTSRIVGTT-AYMAPEALR--
--------------------GEI-------TPKSDIYSFGVVLLEIITG-
------------LPAVDEHRE----------------PQLLLDIKEEIED
EEKTI---------------------------------------------
------------------EDYIDKKMNDADSTSVEAMYSGASQCRH----
EKKNKSPDI---------KKVHQLL------------------------
>RIPK1
FLESAELDSGGFGKVSLCFHRTQ---------------------------
--------GLMIMKTVYKGPNCIE------------------------HN
EALLEEAKMMNRLR------------------HSRVVKLLGVII------
----------------------------------------EEGKYSLVME
YMEK----------------------------------------------
--GNLMHVLKAEMS------------------------------------
--------------------------------------------------
-------------------------------------TPLSVKGRIILEI
IEGMCYLHGK------------GVIHKDLKPENILVDND-----------
--------FHIKIADLGLASFKMWSKLNNEEHNEL---------------
-------------------------REVDGTAKKNGGTLYYMAPEHLNDV
N-------------------AKP-------TEKSDVYSFAVVLWAIFAN-
-----------KEPYENAIC-----------------EQQLIMCIKSGN-
--------------------------------------------------
-----------------RPDVDDITEYCP-----REIISLMKLCWE----
ANPEARPTF---------PGIEEKF------------------------
>RIPK2
LADLRYLSRGASGTVSSARHADWR--------------------------
--------VQVAVKHLHIHTPLLD-----------------------SER
KDVLREAEIL----------------------HKARFSYILPILGI----
--------------------------------------CNEPEFLGIVTE
YMPN----------------------------------------------
--GSLNELLHRKTEYPD---------------------------------
--------------------------------------------------
-------------------------------------VAWPLRFRILHEI
ALGVNYLHNMTP----------PLLHHDLKTQNILLDNE-----------
--------FHVKIADFGLSKWRMMSLSQS---------------------
---------------------------RSSKSAPEGGTIIYMPPENYEPG
QK------------------SRA-------SIKHDIYSYAVITWEVLSR-
-----------KQPFEDVTN-----------------PLQIMYSVSQGH-
--------------------------------------------------
-----------------RPVINEESLPYDIPHR-ARMISLIESGWA----
QNPDERPSFL---------------------------------------
>RIPK3
LENQELVGKDGFGTVFRAQHRKWG--------------------------
--------YDVAVKIVNSKAISREV----------------------KAM
ASLDNEFVLRLEGVIE----------------KVNWDQDPKP--------
------------------------------------------ALVTKFME
NGSL----------------------------------------------
--SGLLQSQCP---------------------------------------
--------------------------------------------------
-------------------------------------RPWPLLCRLLKEV
VLGMFYLHDQNP----------VLLHRDLKPSNVLPDPE-----------
--------LHVKLADFGLSTFQGGSQS-----------------------
----------------------------GTGSGEPGGTLGYLAPELFVNV
N-------------------RKA-------STASDVYSFGILMWAVLAGR
EV---------ELPTEP--------------------SLVYEAVCNRQN-
--------------------------------------------------
-----------------RPSLAELPQAGPETPGLEGLKELMQLCWS----
SEPKDRPSFQ-----ECLPKTDEVF------------------------
>ANKRD3
FTGWEKVGSGGFGQVYKVRHVHWK--------------------------
--------TWLAIKCSPSLHVDDRERM-------------------ELLE
EAKKMEMAKFRYI-------------------LPVYGICRE---------
-------------------------------------------PVGLVME
YMET----------------------------------------------
--GSLEKLLASEP-------------------------------------
--------------------------------------------------
-------------------------------------LPWDLRFRIIHET
AVGMNFLHCMAP----------PLLHLDLKPANILLDAH-----------
--------YHVKISDFGLAKCNGLSHSH----------------------
----------------------------DLSMDGLFGTIAYLPPERIREK
S-------------------RLF-------DTKHDVYSFAIVIWGVLTQ-
-----------KKPFADEKN-----------------ILHIMVKVVKGH-
--------------------------------------------------
-----------------RPELPPVCRARPRAC--SHLIRLMQRCWQ----
GDPRVRPTFQ-----EITSETED--------------------------
>SgK288
---WRLVASGGFSQVFQARHRRWR--------------------------
--------TEYAIKCAPCLPPDAAS----------------------SDV
NYLIEEAAKMKKIK------------------FQHIVSIYGVCKQ-----
-------------------------------------------PLGIVME
FMAN----------------------------------------------
--GSLEKVLSTHS-------------------------------------
--------------------------------------------------
-------------------------------------LCWKLRFRIIHET
SLAMNFLHSIKP----------PLLHLDLKPGNILLDSN-----------
--------MHVKISDFGLSKWMEQSTRM----------------------
---------------------------QYIERSALRGMLSYIPPEMFLES
N-------------------KAP-------GPKYDVYSFAIVIWELLTQ-
-----------KKPYSGFNM-----------------MMIIIRVAAGM--
--------------------------------------------------
-----------------RPSLQPVSDQWPSEA--QQMVDLMKRCWD----
QDPKKRPCFL---------------------------------------
>LRRK1
EDEGSVLGQGGSGTVIYRARYQG---------------------------
--------QPVAVKRFHIKKFKNFANVPAD-----TMLRHLRATDAMKNF
SEFRQEASMLHALQ------------------HPCIVALIGISIH-----
-------------------------------------------PLCFALE
LAPL----------------------------------------------
--SSLNTVLSENARDSSFIP------------------------------
--------------------------------------------------
-------------------------------------LGHMLTQKIAYQI
ASGLAYLHKK------------NIIFCDLKSDNILVWSLDVK--------
------EHINIKLSDYGISRQSFH--------------------------
-----------------------------EGALGVEGTPGYQAPEIRPR-
--------------------IVY-------DEKVDMFSYGMVLYELLSG-
-----------QRPALGHHQ-----------------LQIAKKLSKGI--
--------------------------------------------------
-----------------RPVLGQPEEVQF-----RRLQALMMECWD----
TKPEKRPLAL----SVVSQMKDPTF------------------------
>LRRK2
TVHGADHGDGSFGSVYRAAYEG----------------------------
--------EEVAVKIFNKHT----------------------------SL
RLLRQELVVLCHLH------------------HPSLISLLAAGIR-----
-------------------------------------------PRMLVME
LASK----------------------------------------------
--GSLDRLLQQDKAS-----------------------------------
--------------------------------------------------
-------------------------------------LTRTLQHRIALHV
ADGLRYLHSA------------MIIYRDLKPHNVLLFTLYPN--------
------AAIIAKIADYGIAQYCCR--------------------------
-----------------------------MGIKTSEGTPGFRAPEVARGN
--------------------VIY-------NQQADVYSFGLLLYDILTTG
GRIVE------GLKFPNEFD------------------ELEIQGKL----
--------------------------------------------------
-----------------PDPVKEYGCAPWPM-----VEKLIKQCLK----
ENPQERPTSA---------QVFDI-------------------------
>LIMK1
LIHGEVLGKGCFGQAIKVTHRETG--------------------------
--------EVMVMKELIRFDEE--------------------------TQ
RTFLKEVKVMRCLE------------------HPNVLKFIGVLYKD----
------------------------------------------KRLNFITE
YIKG----------------------------------------------
--GTLRGIIKSMDSQ-----------------------------------
--------------------------------------------------
-------------------------------------YPWSQRVSFAKDI
ASGMAYLHSM------------NIIHRDLNSHNCLVREN-----------
--------KNVVVADFGLARLMVDEKTQPEGLRSL---------------
-----------------------KKPDRKKRYTVVGNP-YWMAPEMING-
--------------------RSY-------DEKVDVFSFGIVLCEIIGRV
N----------ADPDYLPRTM----------------DFGLNVRGFL---
--------------------------------------------------
----------------------DRYCPPNCPPS---FFPITVRCCD----
LDPEKRPSFV--------KLEHWL-------------------------
>LIMK2
LIHGEVLGKGFFGQAIKVTHKATG--------------------------
--------KVMVMKELIRCDEE--------------------------TQ
KTFLTEVKVMRSLD------------------HPNVLKFIGVLYKD----
------------------------------------------KKLNLLTE
YIEG----------------------------------------------
--GTLKDFLRSMDP------------------------------------
--------------------------------------------------
-------------------------------------FPWQQKVRFAKGI
ASGMAYLHSM------------CIIHRDLNSHNCLIKLD-----------
--------KTVVVADFGLSRLIVEERKRAPMEKAT---------------
------------------TKKRTLRKNDRKKRYTVVGNPYWMAPEMLNG-
--------------------KSY-------DETVDIFSFGIVLCEIIGQV
Y----------ADPDCLPRTL----------------DFGLNVKLFW---
--------------------------------------------------
----------------------EKFVPTDCPPA---FFPLAAICCR----
LEPESRPAFS--------KLEDSF-------------------------
>TESK1
FHCAEKIGAGFFSEVYKVRHRQSG--------------------------
--------QVMVLKMNKLPSN----------------------------R
GNTLREVQLMNRLR------------------HPNILRFMGVCVHQ----
------------------------------------------GQLHALTE
YMNG----------------------------------------------
--GTLEQLLSSPEP------------------------------------
--------------------------------------------------
-------------------------------------LSWPVRLHLALDI
ARGLRYLHSK------------GVFHRDLTSKNCLVRREDRG--------
--------FTAVVGDFGLAEKIPVYRE-----------------------
--------------------------GARKEPLAVVGSPYWMAPEVLRG-
--------------------ELY-------DEKADVFAFGIVLCELIARV
P----------ADPDYLPRTE----------------DFGLDVPAFR---
--------------------------------------------------
-----------------------TLVGDDCPLP---FLLLAIHCCN----
LEPSTRAPFT----EITQHLEWI--------------------------
>TESK2
----EKIGSGFFSEVFKVRHRASG--------------------------
--------QVMALKMNTLSSN----------------------------R
ANMLKEVQLMNRLS------------------HPNILRYIN---------
---------------------------------------------SGNLE
QLL-----------------------------------------------
-----DSNLH----------------------------------------
--------------------------------------------------
-------------------------------------LPWTVRVKLAYDI
AVGLSYLHFK------------GIFHRDLTSKNCLIKRDENG--------
--------YSAVVADFGLAEKIPDV-------------------------
--------------------------SMGSEKLAVVGSPFWMAPEVLRD-
--------------------EPY-------NEKADVFSYGIILCEIIARI
Q----------ADPDYLPRTE----------------NFGLDYDAFQ---
--------------------------------------------------
------------------------HMVGDCPPD---FLQLTFNCCN----
MDPKLRPSFV--------EIGKTL-------------------------
>HH498
IEFHEIIGSGSFGKVYKGRCRN----------------------------
--------KIVAIKRYRANTYCSKS-----------------------DV
DMFCREVSILCQLN------------------HPCVIQFVGACLND----
-----------------------------------------PSQFAIVTQ
YISG----------------------------------------------
--GSLFSLLHEQKRI-----------------------------------
--------------------------------------------------
-------------------------------------LDLQSKLIIAVDV
AKGMEYLHNLTQ----------PIIHRDLNSHNILLYED-----------
--------GHAVVADFGESRFLQS--------------------------
--------------------------LDEDNMTKQPGNLRWMAPEVFTQC
--------------------TRY-------TIKADVFSYALCLWEILTG-
-----------EIPFAHLK--------------PAAAAADMAYHHI----
--------------------------------------------------
--------------------RPPIGYSIPKP-----ISSLLIRGWN----
ACPEGRPEFS----EVVMKLEECL-------------------------
>TAK1
IEVEEVVGRGAFGVVCKAKWRA----------------------------
--------KDVAIKQIES----------------------------ESER
KAFIVELRQLSRVN------------------HPNIVKLYGACLN-----
-------------------------------------------PVCLVME
YAEG----------------------------------------------
--GSLYNVLHGAEPLP----------------------------------
--------------------------------------------------
------------------------------------YYTAAHAMSWCLQC
SQGVAYLHSMQPK---------ALIHRDLKPPNLLLVAG-----------
-------GTVLKICDFGTACDI----------------------------
----------------------------QTHMTNNKGSAAWMAPEVFEG-
--------------------SNY-------SEKCDVFSWGIILWEVITR-
-----------RKPFDEIG--------------GPAFRIMWAVHNGT---
--------------------------------------------------
--------------------RPPLIKNLPKP-----IESLMTRCWS----
KDPSQRPSME---------EIVKI-------------------------
>ILK
LNFLTKLNENHSGELWKGRWQGND--------------------------
-------IVVKVLKVRDW---------------------------STRKS
RDFNEECPRLRIFS------------------HPNVLPVLGACQSP----
----------------------------------------PAPHPTLITH
WMPY----------------------------------------------
--GSLYNVLHEGTNFV----------------------------------
--------------------------------------------------
-------------------------------------VDQSQAVKFALDM
ARGMAFLHTLEP----------LIPRHALNSRSVMIDEDMT---------
--------ARISMADVKFSFQC----------------------------
------------------------------PGRMYA--PAWVAPEALQKK
PE------------------DTN-------RRSADMWSFAVLLWELVTR-
-----------EVPFADLS-------------------NMEIGMKVAL--
--------------------------------------------------
-----------------EGLRPTIPPGISPH-----VCKLMKICMN----
EDPAKRPKFD------MIVPILEKM------------------------
>KSR1
VELGEPIGQGRWGRVHRGRWHG----------------------------
---------EVAIRLLEMDGH------------------------NQDHL
KLFKKEVMNYRQTR------------------HENVVLFMGACMN-----
-----------------------------------------PPHLAIITS
FCKG----------------------------------------------
--RTLHSFVRDPKTS-----------------------------------
--------------------------------------------------
-------------------------------------LDINKTRQIAQEI
IKGMGYLHAK------------GIVHKDLKSKNVFYDN------------
--------GKVVITDFGLFGISGVVREG----------------------
--------------------------RRENQLKLSHDWLCYLAPEIVREM
TPGKDEDQ------------LPF-------SKAADVYAFGTVWYELQAR-
-----------DWPLKNQA------------------AEASIWQIGSG--
--------------------------------------------------
----------------EGMKRVLTSVSLGKE-----VSEILSACWA----
FDLQERPSFS---------LLMDM-------------------------
>KSR2
LEIGELIGKGRFGQVYHGRWHG----------------------------
---------EVAIRLIDIERD------------------------NEDQL
KAFKREVMAYRQTR------------------HENVVLFMGACMS-----
-----------------------------------------PPHLAIITS
LCKG----------------------------------------------
--RTLYSVVRDAKIV-----------------------------------
--------------------------------------------------
-------------------------------------LDVNKTRQIAQEI
VKGMGYLHAK------------GILHKDLKSKNVFYDN------------
--------GKVVITDFGLFSISGVLQAG----------------------
--------------------------RREDKLRIQNGWLCHLAPEIIRQL
SPDTEEDK------------LPF-------SKHSDVFALGTIWYELHAR-
-----------EWPFKTQP------------------AEAIIWQMGTG--
--------------------------------------------------
------------------MKPNLSQIGMGKE-----ISDILLFCWA----
FEQEERPTFT---------KLMDM-------------------------
>ARAF
VQLLKRIGTGSFGTVFRGRWHG----------------------------
---------DVAVKVLKVSQP------------------------TAEQA
QAFKNEMQVLRKTR------------------HVNILLFMGFMT------
-----------------------------------------RPGFAIITQ
WCEG----------------------------------------------
--SSLYHHLHVADTR-----------------------------------
--------------------------------------------------
-------------------------------------FDMVQLIDVARQT
AQGMDYLHAK------------NIIHRDLKSNNIFLHEG-----------
--------LTVKIGDFGLATVKTRWS------------------------
---------------------------GAQPLEQPSGSVLWMAAEVIRMQ
DP------------------NPY-------SFQSDVYAYGVVLYELMTG-
-----------SLPYSHIG-----------------CRDQIIFMVGRG--
--------------------------------------------------
-----------------YLSPDLSKISSNCPKA---MRRLLSDCLK----
FQREERPLFP---------QILATI------------------------
>RAF1
VMLSTRIGSGSFGTVYKGKWHG----------------------------
---------DVAVKILKVVDP------------------------TPEQF
QAFRNEVAVLRKTR------------------HVNILLFMGYMT------
-----------------------------------------KDNLAIVTQ
WCEG----------------------------------------------
--SSLYKHLHVQETK-----------------------------------
--------------------------------------------------
-------------------------------------FQMFQLIDIARQT
AQGMDYLHAK------------NIIHRDMKSNNIFLHEG-----------
--------LTVKIGDFGLATVKSRWS------------------------
---------------------------GSQQVEQPTGSVLWMAPEVIRMQ
DN------------------NPF-------SFQSDVYSYGIVLYELMTG-
-----------ELPYSHIN-----------------NRDQIIFMVGRG--
--------------------------------------------------
-----------------YASPDLSKLYKNCPKA---MKRLVADCVK----
KVKEERPLFP-------QILSSIEL------------------------
>BRAF
ITVGQRIGSGSFGTVYKGKWHG----------------------------
---------DVAVKMLNVTAP------------------------TPQQL
QAFKNEVGVLRKTR------------------HVNILLFMGYST------
-----------------------------------------KPQLAIVTQ
WCEG----------------------------------------------
--SSLYHHLHIIETK-----------------------------------
--------------------------------------------------
-------------------------------------FEMIKLIDIARQT
AQGMDYLHAK------------SIIHRDLKSNNIFLHED-----------
--------LTVKIGDFGLATVKSRWS------------------------
---------------------------GSHQFEQLSGSILWMAPEVIRMQ
DK------------------NPY-------SFQSDVYAFGIVLYELMTG-
-----------QLPYSNIN-----------------NRDQIIFMVGRG--
--------------------------------------------------
-----------------YLSPDLSKVRSNCPKA---MKRLMAECLK----
KKRDERPLFP-------QILASIEL------------------------
>ZAK
LQFFENCGGGSFGSVYRAKWIS----------------------------
------QDKEVAVKKLL---------------------------------
-KIEKEAEILSVLS------------------HRNIIQFYGVILE-----
-----------------------------------------PPNYGIVTE
YASL----------------------------------------------
--GSLYDYINSNRSEE----------------------------------
--------------------------------------------------
-------------------------------------MDMDHIMTWATDV
AKGMHYLHMEAPV---------KVIHRDLKSRNVVIAAD-----------
--------GVLKICDFGASRFHN---------------------------
----------------------------HTTHMSLVGTFPWMAPEVIQS-
--------------------LPV-------SETCDTYSYGVVLWEMLTR-
-----------EVPFKGL--------------------EGLQVAWLVVEK
--------------------------------------------------
--------------------NERLTIPSSCPRS---FAELLHQCWE----
ADAKKRPSFK---------QIISI-------------------------
>LZK
ISELQWLGSGAQGAVFLGKFRA----------------------------
--------EEVAIKKV----------------------------------
-REQNETDIKHLRKLK----------------HPNIIAFKGVCTQ-----
-----------------------------------------APCYCIIME
YCAH----------------------------------------------
--GQLYEVLRAGRK------------------------------------
--------------------------------------------------
-------------------------------------ITPRLLVDWSTGI
ASGMNYLHLH------------KIIHRDLKSPNVLVTHT-----------
--------DAVKISDFGTSKELSD--------------------------
----------------------------KSTKMSFAGTVAWMAPEVIRN-
--------------------EPV-------SEKVDIWSFGVVLWELLTG-
-----------EIPYKDV--------------------DSSAIIWGVGSN
--------------------------------------------------
--------------------SLHLPVPSTCPDG---FKILMKQTWQ----
SKPRNRPSFR---------QTLMHL------------------------
>DLK
ILDLQWVGSGAQGAVFLGRFHG----------------------------
--------EEVAVKKV----------------------------------
-RDLKETDIKHLRKLK----------------HPNIITFKGVCTQ-----
-----------------------------------------APCYCILME
FCAQ----------------------------------------------
--GQLYEVLRAGRP------------------------------------
--------------------------------------------------
-------------------------------------VTPSLLVDWSMGI
AGGMNYLHLH------------KIIHRDLKSPNMLITYD-----------
--------DVVKISDFGTSKELSD--------------------------
----------------------------KSTKMSFAGTVAWMAPEVIRN-
--------------------EPV-------SEKVDIWSFGVVLWELLTG-
-----------EIPYKDV--------------------DSSAIIWGVGSN
--------------------------------------------------
--------------------SLHLPVPSSCPDG---FKILLRQCWN----
SKPRNRPSFR---------QILLHL------------------------
>MLK1
LTLEEIIGIGGFGKVYRAFWIG----------------------------
--------DEVAVKAARHDPDED----------------------ISQTI
ENVRQEAKLFAMLK------------------HPNIIALRGVCLK-----
-----------------------------------------EPNLCLVME
FARG----------------------------------------------
--GPLNRVLSGKRI------------------------------------
--------------------------------------------------
--------------------------------------PPDILVNWAVQI
ARGMNYLHDEAIV---------PIIHRDLKSSNILILQKVENG-------
----DLSNKILKITDFGLAREWH---------------------------
----------------------------RTTKMSAAGTYAWMAPEVIRA-
--------------------SMF-------SKGSDVWSYGVLLWELLTG-
-----------EVPFRGI--------------------DGLAVAYGVAMN
--------------------------------------------------
--------------------KLALPIPSTCPEP---FAKLMEDCWN----
PDPHSRPSFT---------NILDQL------------------------
>MLK2
LQLEEIIGVGGFGKVYRALWRG----------------------------
--------EEVAVKAARLDPEKD----------------------PAVTA
EQVCQEARLFGALQ------------------HPNIIALRGACLN-----
-----------------------------------------PPHLCLVME
YARG----------------------------------------------
--GALSRVLAGRRV------------------------------------
--------------------------------------------------
--------------------------------------PPHVLVNWAVQV
ARGMNYLHNDAPV---------PIIHRDLKSINILILEAIENH-------
----NLADTVLKITDFGLAREWH---------------------------
----------------------------KTTKMSAAGTYAWMAPEVIRL-
--------------------SLF-------SKSSDVWSFGVLLWELLTG-
-----------EVPYREI--------------------DALAVAYGVAMN
--------------------------------------------------
--------------------KLTLPIPSTCPEP---FARLLEECWD----
PDPHGRPDFG------SILKRLEVI------------------------
>MLK3
LRLEEVIGIGGFGKVYRGSWRG----------------------------
--------ELVAVKAARQDPDED----------------------ISVTA
ESVRQEARLFAMLA------------------HPNIIALKAVCLE-----
-----------------------------------------EPNLCLVME
YAAG----------------------------------------------
--GPLSRALAGRRV------------------------------------
--------------------------------------------------
--------------------------------------PPHVLVNWAVQI
ARGMHYLHCEALV---------PVIHRDLKSNNILLLQPIESD-------
----DMEHKTLKITDFGLAREWH---------------------------
----------------------------KTTQMSAAGTYAWMAPEVIKA-
--------------------STF-------SKGSDVWSFGVLLWELLTG-
-----------EVPYRGI--------------------DCLAVAYGVAVN
--------------------------------------------------
--------------------KLTLPIPSTCPEP---FAQLMADCWA----
QDPHRRPDF---------ASILQQL------------------------
>MLK4
LELKELIGAGGFGQVYRATWQG----------------------------
--------QEVAVKAARQDPEQD----------------------AAAAA
ESVRREARLFAMLR------------------HPNIIELRGVCLQ-----
-----------------------------------------QPHLCLVLE
FARG----------------------------------------------
--GALNRALAAANAAPDPRAP-----------------------------
--------------------------------------------------
------------------------------GPRRARRIPPHVLVNWAVQI
ARGMLYLHEEAFV---------PILHRDLKSSNILLLEKIEHD-------
----DICNKTLKITDFGLAREWH---------------------------
----------------------------RTTKMSTAGTYAWMAPEVIKS-
--------------------SLF-------SKGSDIWSYGVLLWELLTG-
-----------EVPYRGI--------------------DGLAVAYGVAVN
--------------------------------------------------
--------------------KLTLPIPSTCPEP---FAKLMKECWQ----
QDPHIRPSF---------ALILEQL------------------------
>ALK4
IVLQEIIGKGRFGEVWRGRWRG----------------------------
--------GDVAVKIFSSRE-----------------------------E
RSWFREAEIYQTVMLR----------------HENILGFIAADNKD----
--------------------------------------NGTWTQLWLVSD
YHEH----------------------------------------------
--GSLFDYLNRYTV------------------------------------
--------------------------------------------------
--------------------------------------TIEGMIKLALSA
ASGLAHLHMEIVGT---Q-GKPGIAHRDLKSKNILVKKN-----------
--------GMCAIADLGLAVRHDAVTD-----------------------
--------------------------TIDIAPNQRVGTKRYMAPEVLDET
INMKHF--------------DSF--------KCADIYALGLVYWEIARRC
NSGG--VHEEYQLPYYDLVPS-------------DPSIEEMRKVVCDQ--
--------------------------------------------------
------------------KLRPNIPNWWQSYEALRVMGKMMRECWY----
ANGAARLTA---------LRIKKTL------------------------
>TGFbR1
IVLQESIGKGRFGEVWRGKWRG----------------------------
--------EEVAVKIFSSRE-----------------------------E
RSWFREAEIYQTVMLR----------------HENILGFIAADNKD----
--------------------------------------NGTWTQLWLVSD
YHEH----------------------------------------------
--GSLFDYLNRYTV------------------------------------
--------------------------------------------------
--------------------------------------TVEGMIKLALST
ASGLAHLHMEIVGT---Q-GKPAIAHRDLKSKNILVKKN-----------
--------GTCCIADLGLAVRHDSATD-----------------------
--------------------------TIDIAPNHRVGTKRYMAPEVLDDS
INMKHF--------------ESF--------KRADIYAMGLVFWEIARRC
SIGG--IHEDYQLPYYDLVPS-------------DPSVEEMRKVVCEQ--
--------------------------------------------------
------------------KLRPNIPNRWQSCEALRVMAKIMRECWY----
ANGAARLTA---------LRIKKTL------------------------
>ALK7
IVLQEIVGKGRFGEVWHGRWCG----------------------------
--------EDVAVKIFSSRD-----------------------------E
RSWFREAEIYQTVMLR----------------HENILGFIAADNKD----
--------------------------------------NGTWTQLWLVSE
YHEQ----------------------------------------------
--GSLYDYLNRNIV------------------------------------
--------------------------------------------------
--------------------------------------TVAGMIKLALSI
ASGLAHLHMEIVGT---Q-GKPAIAHRDIKSKNILVKKC-----------
--------ETCAIADLGLAVKHDSILN-----------------------
--------------------------TIDIPQNPKVGTKRYMAPEMLDDT
MNVNIF--------------ESF--------KRADIYSVGLVYWEIARRC
SVGG--IVEEYQLPYYDMVPS-------------DPSIEEMRKVVCDQ--
--------------------------------------------------
------------------KFRPSIPNQWQSCEALRVMGRIMRECWY----
ANGAARLTA---------LRIKKTI------------------------
>BMPR1A
IQMVRQVGKGRYGEVWMGKWRG----------------------------
--------EKVAVKVFFTTE-----------------------------E
ASWFRETEIYQTVLMR----------------HENILGFIAADIKG----
--------------------------------------TGSWTQLYLITD
YHEN----------------------------------------------
--GSLYDFLKCATL------------------------------------
--------------------------------------------------
--------------------------------------DTRALLKLAYSA
ACGLCHLHTEIYGT---Q-GKPAIAHRDLKSKNILIKKN-----------
--------GSCCIADLGLAVKFNSDTN-----------------------
--------------------------EVDVPLNTRVGTKRYMAPEVLDES
LNKNHF--------------QPY--------IMADIYSFGLIIWEMARRC
ITGG--IVEEYQLPYYNMVPS-------------DPSYEDMREVVCVK--
--------------------------------------------------
------------------RLRPIVSNRWNSDECLRAVLKLMSECWA----
HNPASRLTA---------LRIKKTL------------------------
>BMPR1B
IQMVKQIGKGRYGEVWMGKWRG----------------------------
--------EKVAVKVFFTTE-----------------------------E
ASWFRETEIYQTVLMR----------------HENILGFIAADIKG----
--------------------------------------TGSWTQLYLITD
YHEN----------------------------------------------
--GSLYDYLKSTTL------------------------------------
--------------------------------------------------
--------------------------------------DAKSMLKLAYSS
VSGLCHLHTEIFST---Q-GKPAIAHRDLKSKNILVKKN-----------
--------GTCCIADLGLAVKFISDTN-----------------------
--------------------------EVDIPPNTRVGTKRYMPPEVLDES
LNRNHF--------------QSY--------IMADMYSFGLILWEVARRC
VSGG--IVEEYQLPYHDLVPS-------------DPSYEDMREIVCIK--
--------------------------------------------------
------------------KLRPSFPNRWSSDECLRQMGKLMTECWA----
HNPASRLTA---------LRVKKTL------------------------
>ALK1
VALVECVGKGRYGEVWRGLWHG----------------------------
--------ESVAVKIFSSRD-----------------------------E
QSWFRETEIYNTVLLR----------------HDNILGFIASDMTS----
--------------------------------------RNSSTQLWLITH
YHEH----------------------------------------------
--GSLYDFLQRQTL------------------------------------
--------------------------------------------------
--------------------------------------EPHLALRLAVSA
ACGLAHLHVEIFGT---Q-GKPAIAHRDFKSRNVLVKSN-----------
--------LQCCIADLGLAVMHSQGSD-----------------------
--------------------------YLDIGNNPRVGTKRYMAPEVLDEQ
IRTDCF--------------ESY--------KWTDIWAFGLVLWEIARRT
IVNG--IVEDYRPPFYDVVPN-------------DPSFEDMKKVVCVD--
--------------------------------------------------
------------------QQTPTIPNRLAADPVLSGLAQMMRECWY----
PNPSARLTA---------LRIKKTL------------------------
>ALK2
ITLLECVGKGRYGEVWRGSWQG----------------------------
--------ENVAVKIFSSRD-----------------------------E
KSWFRETELYNTVMLR----------------HENILGFIASDMTS----
--------------------------------------RHSSTQLWLITH
YHEM----------------------------------------------
--GSLYDYLQLTTL------------------------------------
--------------------------------------------------
--------------------------------------DTVSCLRIVLSI
ASGLAHLHIEIFGT---Q-GKPAIAHRDLKSKNILVKKN-----------
--------GQCCIADLGLAVMHSQSTN-----------------------
--------------------------QLDVGNNPRVGTKRYMAPEVLDET
IQVDCF--------------DSY--------KRVDIWAFGLVLWEVARRM
VSNG--IVEDYKPPFYDVVPN-------------DPSFEDMRKVVCVD--
--------------------------------------------------
------------------QQRPNIPNRWFSDPTLTSLAKLMKECWY----
QNPSARLTA---------LRIKKTL------------------------
>ACTR2
LQLLEVKARGRFGCVWKAQLLN----------------------------
--------EYVAVKIFPIQD-----------------------------K
QSWQNEYEVYSLPGMK----------------HENILQFIGAEKRG----
--------------------------------------TSVDVDLWLITA
FHEK----------------------------------------------
--GSLSDFLKANVV------------------------------------
--------------------------------------------------
--------------------------------------SWNELCHIAETM
ARGLAYLHEDIPGLKD-G-HKPAISHRDIKSKNVLLKNN-----------
--------LTACIADFGLALKFEAGKS-----------------------
----------------------------AGDTHGQVGTRRYMAPEVLEGA
INFQR---------------DAF--------LRIDMYAMGLVLWELASRC
TAAD-GPVDEYMLPFEEEIGQ-------------HPSLEDMQEVVVHK--
--------------------------------------------------
------------------KKRPVLRDYWQKHAGMAMLCETIEECWD----
HDAEARLSA----------------------------------------
>ACTR2B
LQLLEIKARGRFGCVWKAQLMN----------------------------
--------DFVAVKIFPLQD-----------------------------K
QSWQSEREIFSTPGMK----------------HENLLQFIAAEKRG----
--------------------------------------SNLEVELWLITA
FHDK----------------------------------------------
--GSLTDYLKGNII------------------------------------
--------------------------------------------------
--------------------------------------TWNELCHVAETM
SRGLSYLHEDVPWCRGEG-HKPSIAHRDFKSKNVLLKSD-----------
--------LTAVLADFGLAVRFEPGKP-----------------------
----------------------------PGDTHGQVGTRRYMAPEVLEGA
INFQR---------------DAF--------LRIDMYAMGLVLWELVSRC
KAAD-GPVDEYMLPFEEEIGQ-------------HPSLEELQEVVVHK--
--------------------------------------------------
------------------KMRPTIKDHWLKHPGLAQLCVTIEECWD----
HDAEARLSA-------GCVEERVSL------------------------
>TGFbR2
IELDTLVGKGRFAEVYKAKLKQNTSE------------------------
------QFETVAVKIFPYEE-----------------------------Y
ASWKTEKDIFSDINLK----------------HENILQFLTAEERK----
--------------------------------------TELGKQYWLITA
FHAK----------------------------------------------
--GNLQEYLTRHVI------------------------------------
--------------------------------------------------
--------------------------------------SWEDLRKLGSSL
ARGIAHLHSDHTPCG--R-PKMPIVHRDLNSSNILVKND-----------
--------LTCCLCDFGLSLRLDPTLS-----------------------
--------------------------VDDLANSGQVGTARYMAPEVLESR
MNLENA--------------ESF--------KQTDVYSMALVLWEMTSRC
NAVG--EVKDYEPPFGSKVRE-------------HPCVESMKDNVLRD--
--------------------------------------------------
------------------RGRPEIPSFWLNHQGIQMVCETLTECWD----
HDPEARLTA-------QCVAERFS-------------------------
>MISR2
LCFSQVIREGGHAVVWAGQLQG----------------------------
--------KLVAIKAFPPRS-----------------------------V
AQFQAERALYELPGLQ----------------HDHIVRFITASRGG----
-------------------------------------PGRLLSGPLLVLE
LHPK----------------------------------------------
--GSLCHYLTQYTS------------------------------------
--------------------------------------------------
--------------------------------------DWGSSLRMALSL
AQGLAFLHEERWQNG--Q-YKPGIAHRDLSSQNVLIRED-----------
--------GSCAIGDLGLALVLPGLTQPPAWTPTQ---------------
--------------------------PQGPAAIMEAGTQRYMAPELLDKT
LDLQDWG-------------MAL--------RRADIYSLALLLWEILSRC
PDL---RPDSSPPPFQLAYEAELGN---------TPTSDELWALAVQE--
--------------------------------------------------
-----------------RRRPYIPSTWRCFATDPDGLRELLEDCWD----
ADPEARLTAECVQQRLAALAHPQE-------------------------
>BMPR2
LKLLELIGRGRYGAVYKGSLDE----------------------------
--------RPVAVKVFSFAN-----------------------------R
QNFINEKNIYRVPLME----------------HDNIARFIVGDERV----
-------------------------------------TADGRMEYLLVME
YYPN----------------------------------------------
--GSLCKYLSLHTS------------------------------------
--------------------------------------------------
--------------------------------------DWVSSCRLAHSV
TRGLAYLHTELPRGD--H-YKPAISHRDLNSRNVLVKND-----------
--------GTCVISDFGLSMRLTGNRLVRPGE------------------
---------------------------EDNAAISEVGTIRYMAPEVLEGA
VNLRDCE-------------SAL--------KQVDMYALGLIYWEIFMRC
TDL---FPGESVPEYQMAFQTEVGN---------HPTFEDMQVLVSRE--
--------------------------------------------------
-----------------KQRPKFPEAWKENSLAVRSLKETIEDCWD----
QDAEARLTAQCAEERMAELMMIWE-------------------------
>ANPa
-------GRGSNYGSLLTTEGQFQVFAKTA--------------------
----YYKGNLVAVKRVNRKRIEL--------------------------T
RKVLFELKHMRDVQ------------------NEHLTRFVGACTD-----
-----------------------------------------PPNICILTE
YCPR----------------------------------------------
--GSLQDILENESITL----------------------------------
--------------------------------------------------
--------------------------------------DWMFRYSLTNDI
VKGMLFLHNGA-----------ICSHGNLKSSNCVVDGR-----------
--------FVLKITDYGLESFR----------------------------
-------------------------DLDPEQGHTVYAKKLWTAPELLRMA
SPP-----------------VRG-------SQAGDVYSFGIILQEIALR-
-----------SGVFHVEGLDLS--------------PKEIIERVTRG--
--------------------------------------------------
-------------------EQPPFRPSLALQSHLEELGLLMQRCWA----
EDPQERPPF----QQIRLTLRK---------------------------
>ANPb
-----LRGSSYGSLMTAHGKYQIFANTG----------------------
----HFKGNVVAIKHVNKKRIEL--------------------------T
RQVLFELKHMRDVQ------------------FNHLTRFIGACID-----
-----------------------------------------PPNICIVTE
YCPR----------------------------------------------
--GSLQDILENDSINL----------------------------------
--------------------------------------------------
--------------------------------------DWMFRYSLINDL
VKGMAFLHNSI-----------ISSHGSLKSSNCVVDSR-----------
--------FVLKITDYGLASFR----------------------------
------------------------STAEPDDSHALYAKKLWTAPELLSGN
PLP-----------------TTG-------MQKADVYSFGIILQEIALR-
-----------SGPFYLEGLDLS--------------PKEIVQKVRNG--
--------------------------------------------------
-------------------QRPYFRPSIDRTQLNEELVLLMERCWA----
QDPAERPDF----GQIKGFIRR---------------------------
>HSER
------------LKIDDDKRRDTIQRLRQC--------------------
----KYDKKRVILKDLKHNDGNF--------------------------T
EKQKIELNKLLQID------------------YYNLTKFYGTVKL-----
-----------------------------------------DTMIFGVIE
YCER----------------------------------------------
--GSLREVLNDTISY-----------------------------------
--------------------------------------------------
--------------------------------PDGTFMDWEFKISVLYDI
AKGMSYLHSSK-----------TEVHGRLKSTNCVVDSR-----------
--------MVVKITDFGCN-------------------------------
-------------------------------SILPPKKDLWTAPEHLRQ-
--------------------ANI-------SQKGDVYSYGIIAQEIILR-
-----------KETFYTLSCRDR--------------NEKIFRVENS---
--------------------------------------------------
---------------NGMKPFRPDLFLETAEEKELEVYLLVKNCWE----
EDPEKRPDFKKI--ETTLAKIFGLFHDQKNESYM---------------
>CYGD
ARSMSDIRSGPSQHLDSPNIGVYEGDRVWL--------------------
--KKFPGDQHIAIRPATKTAFS--------------------------KL
QELRHENVALYLGL------------------FLARGAEGPAALW-----
-----------------------------------------EGNLAVVSE
HCTR----------------------------------------------
--GSLQDLLAQREIK-----------------------------------
--------------------------------------------------
-------------------------------------LDWMFKSSLLLDL
IKGIRYLHHR------------GVAHGRLKSRNCIVDGR-----------
--------FVLKITDHGHGRLLEAQK------------------------
----------------------------VLPEPPRAEDQLWTAPELLRDP
ALE-----------------RRG-------TLAGDVFSLAIIMQEVVCR-
-----------SAPYAMLELT----------------PEEVVQRVRS---
--------------------------------------------------
-------------------PPPLCRPLVSMDQAPVECILLMKQCWA----
EQPELRPSM--------DHTFDLFK------------------------
>CYGF
FQITSEVQSGRSPRLSFSSGSLTPATYENS--------------------
-NIAIYEGDWVWLKKFSLGDF-------------------------GDLK
SIKSRASDVFEMMKDLR---------------HENINPLLGFFYD-----
-----------------------------------------SGMFAIVTE
FCSR----------------------------------------------
--GSLEDILTNQDVK-----------------------------------
--------------------------------------------------
-------------------------------------LDWMFKSSLLLDL
IKGMKYLHHR------------EFVHGRLKSRNCVVDGR-----------
--------FVLKVTDYGFNDILEMLR------------------------
----------------------------LSEEESSMEELLWTAPELLRAP
RGS-----------------RLG-------SFAGDVYSFAIIMQEVMVR-
-----------GTPFCMMDLP----------------AQEIINRLKK---
--------------------------------------------------
-------------------PPPVYRPVVPPEHAPPECLQLMKQCWA----
EAAEQRPTF--------DEIFNQFKT-----------------------
>SgK307
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
-------------------------------------QQRSQFPVLHMEV
IVHLLLQIS------------DALRYLHFQGFIHRSLSS-----------
------YAVHIISPGEARLTNLEYMLESEDRGVQR---------------
---------------------------DLTRVPLPTQLYNWAAPEVILQ-
--------------------KAA-------TVKSDIYSFSMIMQEILTD-
-----------DIPWKGLDG------------------SVVKKAVVSGNY
--------------------------------------------------
---------------LEADVRLPKPYYDIVKSG---IHVKQKDRTM----
NLQDIRYIL---KNDLKASPEVDFT------------------------
>SgK424
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
---------------------------------------------LIC--
--------------------GDM------PTTTSDLYSFCILIQEVFTG-
-----------ELPWAGRGG------------------PEVKAKLEAGE-
--------------------------------------------------
-------------------------SPALEPRVPAPYQALIRAGLG----
LAPADRWG------SL---------------------------------
>NRBP1
-NQRNVPGIDSAYLAMDTEEG-----------------------------
--------VEVVWNEVQFSERK---------------------------N
YKLQEEKVRAVFDNLIQ