>FER
VILGELLGKGNFGEVYKGTLKD-----------------------------
-------KTSVAVKTCKEDLPQEL-------------------------K
IKFLQEAKILKQYD------------------HPNIVKLIGVCTQ-----
-----------------------------------------RQPVYIIME
LVSG----------------------------------------------
--GDFLTFLRRKKDE-----------------------------------
--------------------------------------------------
-------------------------------------LKLKQLVKFSLDA
AAGMLYLESK------------NCIHRDLAARNCLVGEN-----------
--------NVLKISDFGMSRQEDG--------------------------
--------------------------GVYSSSGLKQIPIKWTAPEALNY-
--------------------GRY-------SSESDVWSFGILLWETFSLG
-----------VCPYPGMT------------------NQQAREQVERG--
--------------------------------------------------
---------------------YRMSAPQHCP---EDISKIMMKCWD----
YKPENRPKF---------SELQKELTI----------------------
>FES
LVLGEQIGRGNFGEVFSGRLRAD---------------------------
-------NTLVAVKSCRETLPPDL-------------------------K
AKFLQEARILKQYS------------------HPNIVRLIGVCTQ-----
-----------------------------------------KQPIYIVME
LVQG----------------------------------------------
--GDFLTFLRTEGAR-----------------------------------
--------------------------------------------------
-------------------------------------LRVKTLLQMVGDA
AAGMEYLESK------------CCIHRDLAARNCLVTEK-----------
--------NVLKISDFGMSREEAD--------------------------
-------------------------GVYAASGGSRQVPVKWTAPEALNY-
--------------------GRY-------SSESDVWSFGILLWETFSLG
-----------ASPYPNLS------------------NQQTREFVEKG--
--------------------------------------------------
---------------------GRLPCPELCP---DAVFRLMEQCWA----
YEPGQRPSF---------STIYQELQS----------------------
>abl_1fpu.PDB
ITMKHKLGGGQYGEVYEGVWKKY---------------------------
-------SLTVAVKTLKEDTMEV---------------------------
EEFLKEAAVMKEIK------------------HPNLVQLLGVCTR-----
-----------------------------------------EPPFYIITE
FMTY----------------------------------------------
--GNLLDYLRECNRQE----------------------------------
--------------------------------------------------
-------------------------------------VSAVVLLYMATQI
SSAMEYLEKK------------NFIHRDLAARNCLVGEN-----------
--------HLVKVADFGLSRLMTG--------------------------
--------------------------DTYTAHAGAKFPIKWTAPESLAY-
--------------------NKF-------SIKSDVWAFGVLLWEIATYG
-----------MSPYPGID------------------LSQVYELLEKD--
--------------------------------------------------
---------------------YRMERPEGCP---EKVYELMRACWQ----
WNPSDRPSF---------AEIHQAFETMFQ-------------------
>ABL
ITMKHKLGGGQYGEVYEGVWKKY---------------------------
-------SLTVAVKTLKEDTMEV---------------------------
EEFLKEAAVMKEIK------------------HPNLVQLLGVCTR-----
-----------------------------------------EPPFYIITE
FMTY----------------------------------------------
--GNLLDYLRECNRQE----------------------------------
--------------------------------------------------
-------------------------------------VNAVVLLYMATQI
SSAMEYLEKK------------NFIHRDLAARNCLVGEN-----------
--------HLVKVADFGLSRLMTG--------------------------
--------------------------DTYTAHAGAKFPIKWTAPESLAY-
--------------------NKF-------SIKSDVWAFGVLLWEIATYG
-----------MSPYPGID------------------LSQVYELLEKD--
--------------------------------------------------
---------------------YRMERPEGCP---EKVYELMRACWQ----
WNPSDRPSF---------AEIHQAF------------------------
>ARG
ITMKHKLGGGQYGEVYVGVWKKY---------------------------
-------SLTVAVKTLKEDTMEV---------------------------
EEFLKEAAVMKEIK------------------HPNLVQLLGVCTL-----
-----------------------------------------EPPFYIVTE
YMPY----------------------------------------------
--GNLLDYLRECNREE----------------------------------
--------------------------------------------------
-------------------------------------VTAVVLLYMATQI
SSAMEYLEKK------------NFIHRDLAARNCLVGEN-----------
--------HVVKVADFGLSRLMTG--------------------------
--------------------------DTYTAHAGAKFPIKWTAPESLAY-
--------------------NTF-------SIKSDVWAFGVLLWEIATYG
-----------MSPYPGID------------------LSQVYDLLEKG--
--------------------------------------------------
---------------------YRMEQPEGCP---PKVYELMRACWK----
WSPADRPSF---------AETHQAF------------------------
>csk_1k9a.PDB
LKLLQTIGKGEFGDVMLGDYRG----------------------------
--------NKVAVKCIKNDATA----------------------------
QAFLAEASVMTQLR------------------HSNLVQLLGVIVEE----
-----------------------------------------KGGLYIVTE
YMAK----------------------------------------------
--GSLVDYLRSRGRSV----------------------------------
--------------------------------------------------
-------------------------------------LGGDCLLKFSLDV
CEAMEYLEGN------------NFVHRDLAARNVLVSED-----------
--------NVAKVSDFGLTKEA----------------------------
----------------------------------SKLPVKWTAPEALRE-
--------------------KKF-------STKSDVWSFGILLWEIYSFG
-----------RVPYPRIP------------------LKDVVPRVEKG--
--------------------------------------------------
---------------------YKMDAPDGCP---PAVYDVMKNCWH----
LDAATRPTF---------LQLREQLEHIRTHELH---------------
>CSK
LKLLQTIGKGEFGDVMLGDYRG----------------------------
--------NKVAVKCIKNDATA----------------------------
QAFLAEASVMTQLR------------------HSNLVQLLGVIVEE----
-----------------------------------------KGGLYIVTE
YMAK----------------------------------------------
--GSLVDYLRSRGRSV----------------------------------
--------------------------------------------------
-------------------------------------LGGDCLLKFSLDV
CEAMEYLEGN------------NFVHRDLAARNVLVSED-----------
--------NVAKVSDFGLTKEA----------------------------
----------------------------SSTQDTGKLPVKWTAPEALRE-
--------------------KKF-------STKSDVWSFGILLWEIYSFG
-----------RVPYPRIP------------------LKDVVPRVEKG--
--------------------------------------------------
---------------------YKMDAPDGCP---PAVYEVMKNCWH----
LDAAMRPSF---------LQLREQL------------------------
>CTK
LTLGAQIGEGEFGAVLQGEYLG----------------------------
--------QKVAVKNIKCDVTA----------------------------
QAFLDETAVMTKMQ------------------HENLVRLLGVIL------
-----------------------------------------HQGLYIVME
HVSK----------------------------------------------
--GNLVNFLRTRGRAL----------------------------------
--------------------------------------------------
-------------------------------------VNTAQLLQFSLHV
AEGMEYLESK------------KLVHRDLAARNILVSED-----------
--------LVAKVSDFGLAKAE----------------------------
----------------------------RKGLDSSRLPVKWTAPEALKH-
--------------------GKF-------TSKSDVWSFGVLLWEVFSYG
-----------RAPYPKMS------------------LKEVSEAVEKG--
--------------------------------------------------
---------------------YRMEPPEGCP---GPVHVLMSSCWE----
AEPARRPPF---------RKLAEKL------------------------
>BMX
ITLLKELGSGQFGVVQLGKWKG----------------------------
-------QYDVAVKMIKEGSMSE---------------------------
DEFFQEAQTMMKLS------------------HPKLVKFYGVCSK-----
-----------------------------------------EYPIYIVTE
YISN----------------------------------------------
--GCLLNYLRSHGKG-----------------------------------
--------------------------------------------------
-------------------------------------LEPSQLLEMCYDV
CEGMAFLESH------------QFIHRDLAARNCLVDRD-----------
--------LCVKVSDFGMTRYVLD--------------------------
--------------------------DQYVSSVGTKFPVKWSAPEVFHY-
--------------------FKY-------SSKSDVWAFGILMWEVFSLG
-----------KQPYDLYD------------------NSQVVLKVSQG--
--------------------------------------------------
---------------------HRLYRPHLAS---DTIYQIMYSCWH----
ELPEKRPTF---------QQLLSSIEP----------------------
>BTK
LTFLKELGTGQFGVVKYGKWRG----------------------------
-------QYDVAIKMIKEGSMSE---------------------------
DEFIEEAKVMMNLS------------------HEKLVQLYGVCTK-----
-----------------------------------------QRPIFIITE
YMAN----------------------------------------------
--GCLLNYLREMRHR-----------------------------------
--------------------------------------------------
-------------------------------------FQTQQLLEMCKDV
CEAMEYLESK------------QFLHRDLAARNCLVNDQ-----------
--------GVVKVSDFGLSRYVLD--------------------------
--------------------------DEYTSSVGSKFPVRWSPPEVLMY-
--------------------SKF-------SSKSDIWAFGVLMWEIYSLG
-----------KMPYERFT------------------NSETAEHIAQG--
--------------------------------------------------
---------------------LRLYRPHLAS---EKVYTIMYSCWH----
EKADERPTF---------KILLSNILD----------------------
>TXK
LAFIKEIGSGQFGVVHLGEWRS----------------------------
-------HIQVAIKAINEGSMSE---------------------------
EDFIEEAKVMMKLS------------------HSKLVQLYGVCIQ-----
-----------------------------------------RKPLYIVTE
FMEN----------------------------------------------
--GCLLNYLRENKGK-----------------------------------
--------------------------------------------------
-------------------------------------LRKEMLLSVCQDI
CEGMEYLERN------------GYIHRDLAARNCLVSST-----------
--------CIVKISDFGMTRYVLD--------------------------
--------------------------DEYVSSFGAKFPIKWSPPEVFLF-
--------------------NKY-------SSKSDVWSFGVLMWEVFTEG
-----------KMPFENKS------------------NLQVVEAISEG--
--------------------------------------------------
---------------------FRLYRPHLAP---MSIYEVMYSCWH----
EKPEGRPTF---------AELLRAVTE----------------------
>TEC
LTFMRELGSGLFGVVRLGKWRA----------------------------
-------QYKVAIKAIREGAMCE---------------------------
EDFIEEAKVMMKLT------------------HPKLVQLYGVCTQ-----
-----------------------------------------QKPIYIVTE
FMER----------------------------------------------
--GCLLNFLRQRQGH-----------------------------------
--------------------------------------------------
-------------------------------------FSRDVLLSMCQDV
CEGMEYLERN------------SFIHRDLAARNCLVSEA-----------
--------GVVKVSDFGMARYFLD--------------------------
--------------------------DQYTSSSGAKFPVKWCPPEVFNY-
--------------------SRF-------SSKSDVWSFGVLMWEVFTEG
-----------RMPFEKYT------------------NYEVVTMVTRG--
--------------------------------------------------
---------------------HRLYQPKLAS---NYVYEVMLRCWQ----
EKPEGRPSF---------EDLLRTI------------------------
>ITK
LTFVQEIGSGQFGLVHLGYWLN----------------------------
-------KDKVAIKTIREGAMSE---------------------------
EDFIEEAEVMMKLS------------------HPKLVQLYGVCLE-----
-----------------------------------------QAPICLVFE
FMEH----------------------------------------------
--GCLSDYLRTQRGL-----------------------------------
--------------------------------------------------
-------------------------------------FAAETLLGMCLDV
CEGMAYLEEA------------CVIHRDLAARNCLVGEN-----------
--------QVIKVSDFGMTRFVLD--------------------------
--------------------------DQYTSSTGTKFPVKWASPEVFSF-
--------------------SRY-------SSKSDVWSFGVLMWEVFSEG
-----------KIPYENRS------------------NSEVVEDISTG--
--------------------------------------------------
---------------------FRLYKPRLAS---THVYQIMNHCWK----
ERPEDRPAF---------SRLLRQL------------------------
>BRK
FTLCRKLGSGYFGEVFEGLWKD----------------------------
-------RVQVAIKVISRDNLLHQ--------------------------
QMLQSEIQAMKKLR------------------HKHILALYAVVSV-----
-----------------------------------------GDPVYIITE
LMAK----------------------------------------------
--GSLLELLRDSDEKV----------------------------------
--------------------------------------------------
-------------------------------------LPVSELLDIAWQV
AEGMCYLESQ------------NYIHRDLAARNILVGEN-----------
--------TLCKVGDFGLARLIKE--------------------------
---------------------------DVYLSHDHNIPYKWTAPEALSR-
--------------------GHY-------STKSDVWSFGILLHEMFSRG
-----------QVPYPGMS------------------NHEAFLRVDAG--
--------------------------------------------------
---------------------YRMPCPLECP---PSVHKLMLTCWC----
RDPEQRPCF---------KALRERLSSF---------------------
>SRM
FALGRKLGEGYFGEVWEGLWLG----------------------------
-------SLPVAIKVIKSANMKL---------------------------
TDLAKEIQTLKGLR------------------HERLIRLHAVCSG-----
-----------------------------------------GEPVYIVTE
LMRK----------------------------------------------
--GNLQAFLGTPEGRA----------------------------------
--------------------------------------------------
-------------------------------------LRLPPLLGFACQV
AEGMSYLEEQ------------RVVHRDLAARNVLVDDG-----------
--------LACKVADFGLARLLKD--------------------------
--------------------------DIYSPSSSSKIPVKWTAPEAANY-
--------------------RVF-------SQKSDVWSFGVLLHEVFTYG
-----------QCPYEGMT------------------NHETLQQIMRG--
--------------------------------------------------
---------------------YRLPRPAACP---AEVYVLMLECWR----
SSPEERPSF---------ATLREKL------------------------
>FRK
IQLLKRLGSGQFGEVWEGLWNN----------------------------
-------TTPVAVKTLKPGSMDP---------------------------
NDFLREAQIMKNLR------------------HPKLIQLYAVCTL-----
-----------------------------------------EDPIYIITE
LMRH----------------------------------------------
--GSLQEYLQNDTGSK----------------------------------
--------------------------------------------------
-------------------------------------IHLTQQVDMAAQV
ASGMAYLESR------------NYIHRDLAARNVLVGEH-----------
--------NIYKVADFGLARVFKV--------------------------
-----------------------DNEDIYESRHEIKLPVKWTAPEAIRS-
--------------------NKF-------SIKSDVWSFGILLYEIITYG
-----------KMPYSGMT------------------GAQVIQMLAQN--
--------------------------------------------------
---------------------YRLPQPSNCP---QQFYNIMLECWN----
AEPKERPTF---------ETLRWKLEDYF--------------------
>BLK
LRLVRKLGSGQFGEVWMGYYKN----------------------------
-------NMKVAIKTLKEGTMSP---------------------------
EAFLGEANVMKALQ------------------HERLVRLYAVVT------
-----------------------------------------KEPIYIVTE
YMAR----------------------------------------------
--GCLLDFLKTDEGSR----------------------------------
--------------------------------------------------
-------------------------------------LSLPRLIDMSAQI
AEGMAYIERM------------NSIHRDLRAANILVSEA-----------
--------LCCKIADFGLARIIDS--------------------------
---------------------------EYTAQEGAKFPIKWTAPEAYHF-
--------------------GVF-------TIKADVWSFGVLLMEVVTYG
-----------RVPYPGMS------------------NPEVIRNLERG--
--------------------------------------------------
---------------------YRMPRPDTCP--PELYRGVIAECWR----
SRPEERPTF---------EFLQSVLE-----------------------
>lck_3lck.PDB
LKLVERLGAGQFGEVWMGYYNG----------------------------
-------HTKVAVKSLKQGSMSP---------------------------
DAFLAEANLMKQLQ------------------HQRLVRLYAVVT------
-----------------------------------------QEPIYIITE
YMEN----------------------------------------------
--GSLVDFLKTPSGIK----------------------------------
--------------------------------------------------
-------------------------------------LTINKLLDMAAQI
AEGMAFIEER------------NYIHRDLRAANILVSDT-----------
--------LSCKIADFGLARLIE---------------------------
--------------------------DNETAREGAKFPIKWTAPEAINY-
--------------------GTF-------TIKSDVWSFGILLTEIVTHG
-----------RIPYPGMT------------------NPEVIQNLERG--
--------------------------------------------------
---------------------YRMVRPDNCP---EELYQLMRLCWK----
ERPEDRPTF---------DYLRSVLEDFFTA------------------
>LCK
LKLVERLGAGQFGEVWMGYYNG----------------------------
-------HTKVAVKSLKQGSMSP---------------------------
DAFLAEANLMKQLQ------------------HQRLVRLYAVVT------
-----------------------------------------QEPIYIITE
YMEN----------------------------------------------
--GSLVDFLKTPSGIK----------------------------------
--------------------------------------------------
-------------------------------------LTINKLLDMAAQI
AEGMAFIEER------------NYIHRDLRAANILVSDT-----------
--------LSCKIADFGLARLIE---------------------------
-------------------------DNEYTAREGAKFPIKWTAPEAINY-
--------------------GTF-------TIKSDVWSFGILLTEIVTHG
-----------RIPYPGMT------------------NPEVIQNLERG--
--------------------------------------------------
---------------------YRMVRPDNCP---EELYQLMRLCWK----
ERPEDRPTF---------DYLRSVLE-----------------------
>hck_1ad5.PDB
LKLEKKLGAGQFGEVWMATYNK----------------------------
-------HTKVAVKTMKPGSMSV---------------------------
EAFLAEANVMKTLQ------------------HDKLVKLHAVVT------
-----------------------------------------KEPIYIITE
FMAK----------------------------------------------
--GSLLDFLKSDEGSK----------------------------------
--------------------------------------------------
-------------------------------------QPLPKLIDFSAQI
AEGMAFIEQR------------NYIHRDLRAANILVSAS-----------
--------LVCKIADFGLARV-----------------------------
---------------------------------GAKFPIKWTAPEAINF-
--------------------GSF-------TIKSDVWSFGILLMEIVTYG
-----------RIPYPGMS------------------NPEVIRALERG--
--------------------------------------------------
---------------------YRMPRPENCP---EELYNIMMRCWK----
NRPEERPTF---------EYIQSVLDDFYTATESQ--------------
>HCK
LKLEKKLGAGQFGEVWMATYNK----------------------------
-------HTKVAVKTMKPGSMSV---------------------------
EAFLAEANVMKTLQ------------------HDKLVKLHAVVT------
-----------------------------------------KEPIYIITE
FMAK----------------------------------------------
--GSLLDFLKSDEGSK----------------------------------
--------------------------------------------------
-------------------------------------QPLPKLIDFSAQI
AEGMAFIEQR------------NYIHRDLRAANILVSAS-----------
--------LVCKIADFGLARVIE---------------------------
-------------------------DNEYTAREGAKFPIKWTAPEAINF-
--------------------GSF-------TIKSDVWSFGILLMEIVTYG
-----------RIPYPGMS------------------NPEVIRALERG--
--------------------------------------------------
---------------------YRMPRPENCP---EELYNIMMRCWK----
NRPEERPTF---------EYIQSVLD-----------------------
>LYN
IKLVKRLGAGQFGEVWMGYYNN----------------------------
-------STKVAVKTLKPGTMSV---------------------------
QAFLEEANLMKTLQ------------------HDKLVRLYAVVTR-----
-----------------------------------------EEPIYIITE
YMAK----------------------------------------------
--GSLLDFLKSDEGGK----------------------------------
--------------------------------------------------
-------------------------------------VLLPKLIDFSAQI
AEGMAYIERK------------NYIHRDLRAANVLVSES-----------
--------LMCKIADFGLARVIE---------------------------
-------------------------DNEYTAREGAKFPIKWTAPEAINF-
--------------------GCF-------TIKSDVWSFGILLYEIVTYG
-----------KIPYPGRT------------------NADVMTALSQG--
--------------------------------------------------
---------------------YRMPRVENCP---DELYDIMKMCWK----
EKAEERPTF---------DYLQSVLD-----------------------
>FGR
ITLERRLGTGCFGDVWLGTWNG----------------------------
-------STKVAVKTLKPGTMSP---------------------------
KAFLEEAQVMKLLR------------------HDKLVQLYAVVS------
-----------------------------------------EEPIYIVTE
FMCH----------------------------------------------
--GSLLDFLKNPEGQD----------------------------------
--------------------------------------------------
-------------------------------------LRLPQLVDMAAQV
AEGMAYMERM------------NYIHRDLRAANILVGER-----------
--------LACKIADFGLARLIK---------------------------
-------------------------DDEYNPCQGSKFPIKWTAPEAALF-
--------------------GRF-------TIKSDVWSFGILLTELITKG
-----------RIPYPGMN------------------KREVLEQVEQG--
--------------------------------------------------
---------------------YHMPCPPGCP---ASLYEAMEQTWR----
LDPEERPTF---------EYLQSFL------------------------
>FYN
LQLIKRLGNGQFGEVWMGTWNG----------------------------
-------NTKVAIKTLKPGTMSP---------------------------
ESFLEEAQIMKKLK------------------HDKLVQLYAVVS------
-----------------------------------------EEPIYIVTE
YMNK----------------------------------------------
--GSLLDFLKDGEGRA----------------------------------
--------------------------------------------------
-------------------------------------LKLPNLVDMAAQV
AAGMAYIERM------------NYIHRDLRSANILVGNG-----------
--------LICKIADFGLARLIE---------------------------
-------------------------DNEYTARQGAKFPIKWTAPEAALY-
--------------------GRF-------TIKSDVWSFGILLTELVTKG
-----------RVPYPGMN------------------NREVLEQVERG--
--------------------------------------------------
---------------------YRMPCPQDCP---ISLHELMIHCWK----
KDPEERPTF---------EYLQSFL------------------------
>src_2src.PDB
LRLEVKLGQGCFGEVWMGTWNG----------------------------
-------TTRVAIKTLKPGTMSP---------------------------
EAFLQEAQVMKKLR------------------HEKLVQLYAVVS------
-----------------------------------------EEPIYIVTE
YMSK----------------------------------------------
--GSLLDFLKGETGKY----------------------------------
--------------------------------------------------
-------------------------------------LRLPQLVDMAAQI
ASGMAYVERM------------NYVHRDLRAANILVGEN-----------
--------LVCKVADFGLARLIE---------------------------
-------------------------DNEYTARQGAKFPIKWTAPEAALY-
--------------------GRF-------TIKSDVWSFGILLTELTTKG
-----------RVPYPGMV------------------NREVLDQVERG--
--------------------------------------------------
---------------------YRMPCPPECP---ESLHDLMCQCWR----
KEPEERPTF---------EYLQAFLEDYFTSTEPQQPGEN---------
>SRC
LRLEVKLGQGCFGEVWMGTWNG----------------------------
-------TTRVAIKTLKPGTMSP---------------------------
EAFLQEAQVMKKLR------------------HEKLVQLYAVVS------
-----------------------------------------EEPIYIVTE
YMSK----------------------------------------------
--GSLLDFLKGETGKY----------------------------------
--------------------------------------------------
-------------------------------------LRLPQLVDMAAQI
ASGMAYVERM------------NYVHRDLRAANILVGEN-----------
--------LVCKVADFGLARLIE---------------------------
-------------------------DNEYTARQGAKFPIKWTAPEAALY-
--------------------GRF-------TIKSDVWSFGILLTELTTKG
-----------RVPYPGMV------------------NREVLDQVERG--
--------------------------------------------------
---------------------YRMPCPPECP---ESLHDLMCQCWR----
KEPEERPTF---------EYLQAF-------------------------
>YES
LRLEVKLGQGCFGEVWMGTWNG----------------------------
-------TTKVAIKTLKPGTMMP---------------------------
EAFLQEAQIMKKLR------------------HDKLVPLYAVVS------
-----------------------------------------EEPIYIVTE
FMSK----------------------------------------------
--GSLLDFLKEGDGKY----------------------------------
--------------------------------------------------
-------------------------------------LKLPQLVDMAAQI
ADGMAYIERM------------NYIHRDLRAANILVGEN-----------
--------LVCKIADFGLARLIE---------------------------
-------------------------DNEYTARQGAKFPIKWTAPEAALY-
--------------------GRF-------TIKSDVWSFGILQTELVTKG
-----------RVPYPGMV------------------NREVLEQVERG--
--------------------------------------------------
---------------------YRMPCPQGCP---ESLHELMNLCWK----
KDPDERPTF---------EYIQSFL------------------------
>EphB1
VKIEEVIGAGEFGEVYKGRLKLPG--------------------------
-----KREIYVAIKTLKAGYSEKQ-------------------------R
RDFLSEASIMGQFD------------------HPNIIRLEGVVTK-----
-----------------------------------------SRPVMIITE
FMEN----------------------------------------------
--GALDSFLRQNDGQ-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
AAGMKYLAEM------------NYVHRDLAARNILVNSN-----------
--------LVCKVSDFGLSRYLQD--------------------------
----------------------DTSDPTYTSSLGGKIPVRWTAPEAIAY-
--------------------RKF-------TSASDVWSYGIVMWEVMSFG
-----------ERPYWDMS------------------NQDVINAIEQD--
--------------------------------------------------
---------------------YRLPPPMDCP---AALHQLMLDCWQ----
KDRNSRPRF---------AEIVNTL------------------------
>ephb2_1jpa.PDB
VKIEQVIGAGEFGEVCSGHLKL----------------------------
------REIFVAIKTLKSGYTEKQ-------------------------R
RDFLSEASIMGQFD------------------HPNVIHLEGVVTK-----
-----------------------------------------STPVMIITE
FMEN----------------------------------------------
--GSLDSFLRQNDGQ-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
AAGMKYLADM------------NYVHRDLAARNILVNSN-----------
--------LVCKVSDF----------------------------------
-------------------------------------PIRWTAPEAIQY-
--------------------RKF-------TSASDVWSYGIVMWEVMSYG
-----------ERPYWDMT------------------NQDVINAIEQD--
--------------------------------------------------
---------------------YRLPPPMDCP---SALHQLMLDCWQ----
KDRNHRPKF---------GQIVNTLDKMIRNPNSLK-------------
>EphB2
VKIEQVIGAGEFGEVCSGHLKLPG--------------------------
-----KREIFVAIKTLKSGYTEKQ-------------------------R
RDFLSEASIMGQFD------------------HPNVIHLEGVVTK-----
-----------------------------------------STPVMIITE
FMEN----------------------------------------------
--GSLDSFLRQNDGQ-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
AAGMKYLADM------------NYVHRDLAARNILVNSN-----------
--------LVCKVSDFGLSRFLED--------------------------
----------------------DTSDPTYTSALGGKIPIRWTAPEAIQY-
--------------------RKF-------TSASDVWSYGIVMWEVMSYG
-----------ERPYWDMT------------------NQDVINAIEQD--
--------------------------------------------------
---------------------YRLPPPMDCP---SALHQLMLDCWQ----
KDRNHRPKF---------GQIVNTL------------------------
>EphB3
VKIEEVIGAGEFGEVCRGRLKQPG--------------------------
-----RREVFVAIKTLKVGYTERQ-------------------------R
RDFLSEASIMGQFD------------------HPNIIRLEGVVTK-----
-----------------------------------------SRPVMILTE
FMEN----------------------------------------------
--CALDSFLRLNDGQ-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
AAGMKYLSEM------------NYVHRDLAARNILVNSN-----------
--------LVCKVSDFGLSRFLED--------------------------
----------------------DPSDPTYTSSLGGKIPIRWTAPEAIAY-
--------------------RKF-------TSASDVWSYGIVMWEVMSYG
-----------ERPYWDMS------------------NQDVINAVEQD--
--------------------------------------------------
---------------------YRLPPPMDCP---TALHQLMLDCWV----
RDRNLRPKF---------SQIVNTL------------------------
>EphB4
VKIEEVIGAGEFGEVCRGRLKAPG--------------------------
-----KKESCVAIKTLKGGYTERQ-------------------------R
REFLSEASIMGQFE------------------HPNIIRLEGVVTN-----
-----------------------------------------SMPVMILTE
FMEN----------------------------------------------
--GALDSFLRLNDGQ-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
ASGMRYLAEM------------SYVHRDLAARNILVNSN-----------
--------LVCKVSDFGLSRFLEE--------------------------
----------------------NSSDPTYTSSLGGKIPIRWTAPEAIAF-
--------------------RKF-------TSASDAWSYGIVMWEVMSFG
-----------ERPYWDMS------------------NQDVINAIEQD--
--------------------------------------------------
---------------------YRLPPPPDCP---TSLHQLMLDCWQ----
KDRNARPRF---------PQVVSALDKMIRNPASLKIVARENGGASHPL
>EphB6
IKIEEVIGTGSFGEVRQGRLQPRG--------------------------
-----RREQTVAIQALWAGGAESL-------------------------Q
MTFLGRAAVLGQFQ------------------HPNILRLEGVVTK-----
-----------------------------------------SRPLMVLTE
FMEL----------------------------------------------
--GPLDSFLRQREGQ-----------------------------------
--------------------------------------------------
-------------------------------------FSSLQLVAMQRGV
AAAMQYLSSF------------AFVHRSLSAHSVLVNSH-----------
--------LVCKVARLG---------------------------------
-----------------------------HSPQGPSCLLRWAAPEVIAH-
--------------------GKH-------TTSSDVWSFGILMWEVMSYG
-----------ERPYWDMS------------------EQEVLNAIEQE--
--------------------------------------------------
---------------------FRLPPPPGCP---PGLHLLMLDTWQ----
KDRARRPHF---------DQLVAAF------------------------
>EphA1
LMVDTVIGEGEFGEVYRGTLRLPS--------------------------
-----QDCKTVAIKTLKDTSPGGQ-------------------------W
WNFLREATIMGQFS------------------HPHILHLEGVVTK-----
-----------------------------------------RKPIMIITE
FMEN----------------------------------------------
--AALDAFLREREDQ-----------------------------------
--------------------------------------------------
-------------------------------------LVPGQLVAMLQGI
ASGMNYLSNH------------NYVHRDLAARNILVNQN-----------
--------LCCKVSDFGLTRLLDD--------------------------
-------------------------FDGTYETQGGKIPIRWTAPEAIAH-
--------------------RIF-------TTASDVWSFGIVMWEVLSFG
-----------DKPYGEMS------------------NQEVMKSIEDG--
--------------------------------------------------
---------------------YRLPPPVDCP---APLYELMKNCWA----
YDRARRPHF---------QKLQAHLEQL---------------------
>EphA2
VTRQKVIGAGEFGEVYKGMLKTSSG-------------------------
-----KKEVPVAIKTLKAGYTEKQ-------------------------R
VDFLGEAGIMGQFS------------------HHNIIRLEGVISK-----
-----------------------------------------YKPMMIITE
YMEN----------------------------------------------
--GALDKFLREKDGE-----------------------------------
--------------------------------------------------
-------------------------------------FSVLQLVGMLRGI
AAGMKYLANM------------NYVHRDLAARNILVNSN-----------
--------LVCKVSDFGLSRVLED--------------------------
------------------------DPEATYTTSGGKIPIRWTAPEAISY-
--------------------RKF-------TSASDVWSFGIVMWEVMTYG
-----------ERPYWELS------------------NHEVMKAINDG--
--------------------------------------------------
---------------------FRLPTPMDCP---SAIYQLMMQCWQ----
QERARRPKF---------ADIVSI-------------------------
>EphA3
ISIDKVVGAGEFGEVCSGRLKLPS--------------------------
-----KKEISVAIKTLKVGYTEKQ-------------------------R
RDFLGEASIMGQFD------------------HPNIIRLEGVVTK-----
-----------------------------------------SKPVMIVTE
YMEN----------------------------------------------
--GSLDSFLRKHDAQ-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
ASGMKYLSDM------------GYVHRDLAARNILINSN-----------
--------LVCKVSDFGLSRVLED--------------------------
------------------------DPEAAYTTRGGKIPIRWTSPEAIAY-
--------------------RKF-------TSASDVWSYGIVLWEVMSYG
-----------ERPYWEMS------------------NQDVIKAVDEG--
--------------------------------------------------
---------------------YRLPPPMDCP---AALYQLMLDCWQ----
KDRNNRPKF---------EQIVSI-------------------------
>EphA4
IKIEKVIGVGEFGEVCSGRLKVPG--------------------------
-----KREICVAIKTLKAGYTDKQ-------------------------R
RDFLSEASIMGQFD------------------HPNIIHLEGVVTK-----
-----------------------------------------CKPVMIITE
YMEN----------------------------------------------
--GSLDAFLRKNDGR-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
GSGMKYLSDM------------SYVHRDLAARNILVNSN-----------
--------LVCKVSDFGMSRVLED--------------------------
------------------------DPEAAYTTRGGKIPIRWTAPEAIAY-
--------------------RKF-------TSASDVWSYGIVMWEVMSYG
-----------ERPYWDMS------------------NQDVIKAIEEG--
--------------------------------------------------
---------------------YRLPPPMDCP---IALHQLMLDCWQ----
KERSDRPKF---------GQIVNM-------------------------
>EphA5
ITIERVIGAGEFGEVCSGRLKLPG--------------------------
-----KRELPVAIKTLKVGYTEKQ-------------------------R
RDFLGEASIMGQFD------------------HPNIIHLEGVVTK-----
-----------------------------------------SKPVMIVTE
YMEN----------------------------------------------
--GSLDTFLKKNDGQ-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
SAGMKYLSDM------------GYVHRDLAARNILINSN-----------
--------LVCKVSDFGLSRVLED--------------------------
------------------------DPEAAYTTRGGKIPIRWTAPEAIAF-
--------------------RKF-------TSASDVWSYGIVMWEVVSYG
-----------ERPYWEMT------------------NQDVIKAVEEG--
--------------------------------------------------
---------------------YRLPSPMDCP---AALYQLMLDCWQ----
KERNSRPKF---------DEIVNM-------------------------
>EphA6
IRIERVIGAGEFGEVCSGRLKTPG--------------------------
-----KREIPVAIKTLKGGHMDRQ-------------------------R
RDFLREASIMGQFD------------------HPNIIRLEGVVTKRSFPA
IGVEAFCPSFLRAG----FLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVE
YMEN----------------------------------------------
--GSLDSFLRKHDGH-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
ASGMKYLSDM------------GYVHRDLAARNILVNSN-----------
--------LVCKVSDFGLSRVLED--------------------------
------------------------DPEAAYTTTGGKIPIRWTAPEAIAY-
--------------------RKF-------SSASDAWSYGIVMWEVMSYG
-----------ERPYWEMS------------------NQDVILSIEEG--
--------------------------------------------------
---------------------YRLPAPMGCP---ASLHQLMLHCWQ----
KERNHRPKF---------TDIVSFL------------------------
>EphA7
IKIERVIGAGEFGEVCSGRLKLPG--------------------------
-----KRDVAVAIKTLKVGYTEKQ-------------------------R
RDFLCEASIMGQFD------------------HPNVVHLEGVVTR-----
-----------------------------------------GKPVMIVIE
FMEN----------------------------------------------
--GALDAFLRKHDGQ-----------------------------------
--------------------------------------------------
-------------------------------------FTVIQLVGMLRGI
AAGMRYLADM------------GYVHRDLAARNILVNSN-----------
--------LVCKVSDFGLSRVIED--------------------------
------------------------DPEAVYTTTGGKIPVRWTAPEAIQY-
--------------------RKF-------TSASDVWSYGIVMWEVMSYG
-----------ERPYWDMS------------------NQDVIKAIEEG--
--------------------------------------------------
---------------------YRLPAPMDCP---AGLHQLMLDCWQ----
KERAERPKF---------EQIVGI-------------------------
>EphA8
IHIEKIIGSGDSGEVCYGRLRVPG--------------------------
-----QRDVPVAIKALKAGYTERQ-------------------------R
RDFLSEASIMGQFD------------------HPNIIRLEGVVTR-----
-----------------------------------------GRLAMIVTE
YMEN----------------------------------------------
--GSLDTFLRTHDGQ-----------------------------------
--------------------------------------------------
-------------------------------------FTIMQLVGMLRGV
GAGMRYLSDL------------GYVHRDLAARNVLVDSN-----------
--------LVCKVSDFGLSRVLED--------------------------
------------------------DPDAAYTTTGGKIPIRWTAPEAIAF-
--------------------RTF-------SSASDVWSFGVVMWEVLAYG
-----------ERPYWNMT------------------NRDVISSVEEG--
--------------------------------------------------
---------------------YRLPAPMGCP---HALHQLMLDCWH----
KDRAQRPRF---------SQIVSVL------------------------
>EphA10
VTLERSLGGGRFGELCCGCLQLPG--------------------------
-----RQELLVAVHMLRDSASDSQ-------------------------R
LGFLAEALTLGQFD------------------HSHIVRLEGVVTR-----
-----------------------------------------GSTLMIVTE
YMSH----------------------------------------------
--GALDGFLRRHEGQ-----------------------------------
--------------------------------------------------
-------------------------------------LVAGQLMGLLPGL
ASAMKYLSEM------------GYVHRGLAARHVLVSSD-----------
--------LVCKISGFGRGPRDRS--------------------------
--------------------------EAVYTTMSGRSPALWAAPETLQF-
--------------------GHF-------SSASDVWSFGIIMWEVMAFG
-----------ERPYWDMS------------------GQDVIKAVEDG--
--------------------------------------------------
---------------------FRLPPPRNCP---NLLHRLMLDCWQ----
KDPGERPRF---------SQIHSI-------------------------
>FAK
IELGRCIGEGQFGDVHQGIYMSPE--------------------------
-----NPALAVAIKTCKNCTSDSV-------------------------R
EKFLQEALTMRQFD------------------HPHIVKLIGVIT------
-----------------------------------------ENPVWIIME
LCTL----------------------------------------------
--GELRSFLQVRKYS-----------------------------------
--------------------------------------------------
-------------------------------------LDLASLILYAYQL
STALAYLESK------------RFVHRDIAARNVLVSSN-----------
--------DCVKLGDFGLSRYMEDS-------------------------
---------------------------TYYKASKGKLPIKWMAPESINF-
--------------------RRF-------TSASDVWMFGVCMWEILMHG
-----------VKPFQGVK------------------NNDVIGRIENG--
--------------------------------------------------
---------------------ERLPMPPNCP---PTLYSLMTKCWA----
YDPSRRPRF---------TELKAQL------------------------
>PYK2
VVLNRILGEGLFGEVYEGVYTNHK--------------------------
-----GEKINVAVKTCKKDCTLDN-------------------------K
EKFMSEAVIMKNLD------------------HPHIVKLIGIIE------
-----------------------------------------EEPTWIIME
LYPY----------------------------------------------
--GELGHYLERNKNS-----------------------------------
--------------------------------------------------
-------------------------------------LKVLTLVLYSLQI
CKAMAYLESI------------NCVHRDIAVRNILVASP-----------
--------ECVKLGDFGLSRYIEDE-------------------------
---------------------------DYYKASVTRLPIKWMSPESINF-
--------------------RRF-------TTASDVWMFAVCMWEILSFG
-----------KQPFFWLE------------------NKDVIGVLEKG--
--------------------------------------------------
---------------------DRLPKPDLCP---PVLYTLMTRCWD----
YDPSDRPRF---------TELVCSLSDVYQ-------------------
>SYK
TLEDKELGSGNFGTVKKGYYQMKK--------------------------
------VVKTVAVKILKNEANDPA------------------------LK
DELLAEANVMQQLD------------------NPYIVRMIGICE------
-----------------------------------------AESWMLVME
MAEL----------------------------------------------
--GPLNKYLQQNRH------------------------------------
--------------------------------------------------
-------------------------------------VKDKNIIELVHQV
SMGMKYLEES------------NFVHRDLAARNVLLVTQ-----------
--------HYAKISDFGLSKALRAD-------------------------
-------------------------ENYYKAQTHGKWPVKWYAPECINY-
--------------------YKF-------SSKSDVWSFGVLMWEAFSYG
-----------QKPYRGMK------------------GSEVTAMLEKG--
--------------------------------------------------
---------------------ERMGCPAGCP---REMYDLMNLCWT----
YDVENRPGF----------------------------------------
>ZAP70
LIADIELGCGNFGSVRQGVYRMRK--------------------------
------KQIDVAIKVLKQGTEKA-------------------------DT
EEMMREAQIMHQLD------------------NPYIVRLIGVCQ------
-----------------------------------------AEALMLVME
MAGG----------------------------------------------
--GPLHKFLVGKREE-----------------------------------
--------------------------------------------------
-------------------------------------IPVSNVAELLHQV
SMGMKYLEEK------------NFVHRDLAARNVLLVNR-----------
--------HYAKISDFGLSKALGAD-------------------------
-------------------------DSYYTARSAGKWPLKWYAPECINF-
--------------------RKF-------SSRSDVWSYGVTMWEALSYG
-----------QKPYKKMK------------------GPEVMAFIEQG--
--------------------------------------------------
---------------------KRMECPPECP---PELYALMSDCWI----
YKWEDRPDFL---------------------------------------
>TRKA
IVLKWELGEGAFGKVFLAECHNLLP-------------------------
----EQDKMLVAVKALKEASESA--------------------------R
QDFQREAELLTMLQ------------------HQHIVRFFGVCTE-----
-----------------------------------------GRPLLMVFE
YMRH----------------------------------------------
--GDLNRFLRSHGPDAKLLAGGE---------------------------
--------------------------------------------------
-------------------------------DVAPGPLGLGQLLAVASQV
AAGMVYLAGL------------HFVHRDLATRNCLVGQG-----------
--------LVVKIGDFGMSRDIYST-------------------------
--------------------------DYYRVGGRTMLPIRWMPPESILY-
--------------------RKF-------TTESDVWSFGVVLWEIFTYG
-----------KQPWYQLS------------------NTEAIDCITQG--
--------------------------------------------------
---------------------RELERPRACP---PEVYAIMRGCWQ----
REPQQRHSI---------KDVHARLQAL---------------------
>TRKB
IVLKRELGEGAFGKVFLAECYNLCP-------------------------
----EQDKILVAVKTLKDASDNA--------------------------R
KDFHREAELLTNLQ------------------HEHIVKFYGVCVE-----
-----------------------------------------GDPLIMVFE
YMKH----------------------------------------------
--GDLNKFLRAHGPDAVLMAEGN---------------------------
--------------------------------------------------
---------------------------------PPTELTQSQMLHIAQQI
AAGMVYLASQ------------HFVHRDLATRNCLVGEN-----------
--------LLVKIGDFGMSRDVYST-------------------------
--------------------------DYYRVGGHTMLPIRWMPPESIMY-
--------------------RKF-------TTESDVWSLGVVLWEIFTYG
-----------KQPWYQLS------------------NNEVIECITQG--
--------------------------------------------------
---------------------RVLQRPRTCP---QEVYELMLGCWQ----
REPHMRKNI---------KGIHTLL------------------------
>TRKC
IVLKRELGEGAFGKVFLAECYNLSP-------------------------
----TKDKMLVAVKALKDPTLAA--------------------------R
KDFQREAELLTNLQ------------------HEHIVKFYGVCGD-----
-----------------------------------------GDPLIMVFE
YMKH----------------------------------------------
--GDLNKFLRAHGPNAMILVDGQ---------------------------
--------------------------------------------------
------------------------------PRQAKGELGLSQMLHIASQI
ASGMVYLASQ------------HFVHRDLATRNCLVGAN-----------
--------LLVKIGDFGMSRDVYST-------------------------
--------------------------DYYRVGGHTMLPIRWMPPESIMY-
--------------------RKF-------TTESDVWSFGVILWEIFTYG
-----------KQPWFQLS------------------NTEVIECITQG--
--------------------------------------------------
---------------------RVLERPRVCP---KEVYDVMLGCWQ----
REPQQRLNI---------KEIYKI-------------------------
>musk_1luf.PDB
IEYVRDIGEGAFGRVFQARAPGLLP-------------------------
----YEPFTMVAVKMLKEEASAD-------------------------MQ
ADFQREAALMAEFD------------------NPNIVKLLGVCAV-----
-----------------------------------------GKPMCLLFE
YMAY----------------------------------------------
--GDLNEFLRSMSP------------------------------------
--------------------------------------------------
-----------------------------------PPLSCAEQLCIARQV
AAGMAYLSER------------KFVHRDLATRNCLVGEN-----------
--------MVVKIADFGLSRNIYSA-------------------------
---------------------------DYYK---DAIPIRWMPPESIFY-
--------------------NRY-------TTESDVWAYGVVLWEIFSYG
-----------LQPYYGMA------------------HEEVIYYVRDG--
--------------------------------------------------
---------------------NILACPENCP---LELYNLMRLCWS----
KLPADRPSF---------CSIHRILQRMC--------------------
>MUSK
IEYVRDIGEGAFGRVFQARAPGLLP-------------------------
----YEPFTMVAVKMLKEEASAD-------------------------MQ
ADFQREAALMAEFD------------------NPNIVKLLGVCAV-----
-----------------------------------------GKPMCLLFE
YMAY----------------------------------------------
--GDLNEFLRSMSPHTVCSLSHSDLSMRAQ--------------------
--------------------------------------------------
-----------------------------VSSPGPPPLSCAEQLCIARQV
AAGMAYLSER------------KFVHRDLATRNCLVGEN-----------
--------MVVKIADFGLSRNIYSA-------------------------
--------------------------DYYKANENDAIPIRWMPPESIFY-
--------------------NRY-------TTESDVWAYGVVLWEIFSYG
-----------LQPYYGMA------------------HEEVIYYVRDG--
--------------------------------------------------
---------------------NILSCPENCP---VELYNLMRLCWS----
KLPADRPSF---------TSIHRI-------------------------
>DDR1
LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDF------------------P
LNVRKGHPLLVAVKILRPDATKN-------------------------AR
NDFLKEVKIMSRLK------------------DPNIIRLLGVCVQ-----
-----------------------------------------DDPLCMITD
YMEN----------------------------------------------
--GDLNQFLSAHQLEDKAAEGAPGDGQAAQ--------------------
--------------------------------------------------
----------------------------------GPTISYPMLLHVAAQI
ASGMRYLATL------------NFVHRDLATRNCLVGEN-----------
--------FTIKIADFGMSRNLYAG-------------------------
--------------------------DYYRVQGRAVLPIRWMAWECILM-
--------------------GKF-------TTASDVWAFGVTLWEVLMLC
R----------AQPFGQLT------------------DEQVIENAGEFFR
D-------------------------------------------------
-----------------QGRQVYLSRPPACP---QGLYELMLRCWS----
RESEQRPPF---------SQLHRFL------------------------
>DDR2
LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDF------------------A
LDVSANQPVLVAVKMLRADANKN-------------------------AR
NDFLKEIKIMSRLK------------------DPNIIHLLSVCIT-----
-----------------------------------------DDPLCMITE
YMEN----------------------------------------------
--GDLNQFLSRHEPPNSSSSDVRT--------------------------
--------------------------------------------------
-------------------------------------VSYTNLKFMATQI
ASGMKYLSSL------------NFVHRDLATRNCLVGKN-----------
--------YTIKIADFGMSRNLYSG-------------------------
--------------------------DYYRIQGRAVLPIRWMSWESILL-
--------------------GKF-------TTASDVWAFGVTLWETFTFC
Q----------EQPYSQLS------------------DEQVIENTGEFFR
D-------------------------------------------------
-----------------QGRQTYLPQPAICP---DSVYKLMLSCWR----
RDTKNRPSF---------QEIHLLL------------------------
>ROR1
VRFMEELGECAFGKIYKGHLYLPG--------------------------
----MDHAQLVAIKTLKDYNNPQ-------------------------QW
MEFQQEASLMAELH------------------HPNIVCLLGAVTQ-----
-----------------------------------------EQPVCMLFE
YINQ----------------------------------------------
--GDLHEFLIMRSPHSDVGCSSDEDGTVKSS-------------------
--------------------------------------------------
-------------------------------------LDHGDFLHIAIQI
AAGMEYLSSH------------FFVHKDLAARNILIGEQ-----------
--------LHVKISDLGLSREIYSA-------------------------
--------------------------DYYRVQSKSLLPIRWMPPEAIMY-
--------------------GKF-------SSDSDIWSFGVVLWEIFSFG
-----------LQPYYGFS------------------NQEVIEMVRKR--
--------------------------------------------------
---------------------QLLPCSEDCP---PRMYSLMTECWN----
EIPSRRPRF---------KDIHVRLRSWEGLSSHTSSTTPSGGNATTQT
>ROR2
VRFMEELGEDRFGKVYKGHLFGPAPG------------------------
-----EQTQAVAIKTLKDKAEGP-------------------------LR
EEFRHEAMLRARLQ------------------HPNVVCLLGVVTK-----
-----------------------------------------DQPLSMIFS
YCSH----------------------------------------------
--GDLHEFLVMRSPHSDVGSTDDDRTVKSA--------------------
--------------------------------------------------
-------------------------------------LEPPDFVHLVAQI
AAGMEYLSSH------------HVVHKDLATRNVLVYDK-----------
--------LNVKISDLGLFREVYAA-------------------------
--------------------------DYYKLLGNSLLPIRWMAPEAIMY-
--------------------GKF-------SIDSDIWSYGVVLWEVFSYG
-----------LQPYCGYS------------------NQDVVEMIRNR--
--------------------------------------------------
---------------------QVLPCPDDCP---AWVYALMIECWN----
EFPSRRPRF---------KDIHSRLRAWGNLSNYNSSAQTSGASNTTQT
>IGF1R
ITMSRELGQGSFGMVYEGVAKGVVKD------------------------
-----EPETRVAIKTVNEAASMR-------------------------ER
IEFLNEASVMKEFN------------------CHHVVRLLGVVSQ-----
-----------------------------------------GQPTLVIME
LMTR----------------------------------------------
--GDLKSYLRSLRPEMENNPVLAP--------------------------
--------------------------------------------------
-------------------------------------PSLSKMIQMAGEI
ADGMAYLNAN------------KFVHRDLAARNCMVAED-----------
--------FTVKIGDFGMTRDIYET-------------------------
--------------------------DYYRKGGKGLLPVRWMSPESLKD-
--------------------GVF-------TTYSDVWSFGVVLWEIATLA
-----------EQPYQGLS------------------NEQVLRFVMEG--
--------------------------------------------------
---------------------GLLDKPDNCP---DMLFELMRMCWQ----
YNPKMRPSF---------LEIISSIKE----------------------
>irk_1ir3.PDB
ITLLRELGQGSFGMVYEGNARDIIKG------------------------
-----EAETRVAVKTVNESASLR-------------------------ER
IEFLNEASVMKGFT------------------CHHVVRLLGVVSK-----
-----------------------------------------GQPTLVVME
LMAH----------------------------------------------
--GDLKSYLRSLRPEAENNPGRPP--------------------------
--------------------------------------------------
-------------------------------------PTLQEMIQMAAEI
ADGMAYLNAK------------KFVHRDLAARNCMVAHD-----------
--------FTVKIGDFGMTRDI-ET-------------------------
---------------------------D-RKGGKGLLPVRWMAPESLKD-
--------------------GVF-------TTSSDMWSFGVVLWEITSLA
-----------EQPYQGLS------------------NEQVLKFVMDG--
--------------------------------------------------
---------------------GYLDQPDNCP---ERVTDLMRMCWQ----
FNPKMRPTF---------LEIVNLLKDDLHPSFPEVSFFHSEEN-----
>INSR
ITLLRELGQGSFGMVYEGNARDIIKG------------------------
-----EAETRVAVKTVNESASLR-------------------------ER
IEFLNEASVMKGFT------------------CHHVVRLLGVVSK-----
-----------------------------------------GQPTLVVME
LMAH----------------------------------------------
--GDLKSYLRSLRPEAENNPGRPP--------------------------
--------------------------------------------------
-------------------------------------PTLQEMIQMAAEI
ADGMAYLNAK------------KFVHRDLAARNCMVAHD-----------
--------FTVKIGDFGMTRDIYET-------------------------
--------------------------DYYRKGGKGLLPVRWMAPESLKD-
--------------------GVF-------TTSSDMWSFGVVLWEITSLA
-----------EQPYQGLS------------------NEQVLKFVMDG--
--------------------------------------------------
---------------------GYLDQPDNCP---ERVTDLMRMCWQ----
FNPNMRPTF---------LEIVNLL------------------------
>IRR
ISIIRELGQGSFGMVYEGLARGLEAG------------------------
-----EESTPVALKTVNELASPR-------------------------EC
IEFLKEASVMKAFK------------------CHHVVRLLGVVSQ-----
-----------------------------------------GQPTLVIME
LMTR----------------------------------------------
--GDLKSHLRSLRPEAENNPGLPQ--------------------------
--------------------------------------------------
-------------------------------------PALGEMIQMAGEI
ADGMAYLAAN------------KFVHRDLAARNCMVSQD-----------
--------FTVKIGDFGMTRDVYET-------------------------
--------------------------DYYRKGGKGLLPVRWMAPESLKD-
--------------------GIF-------TTHSDVWSFGVVLWEIVTLA
-----------EQPYQGLS------------------NEQVLKFVMDG--
--------------------------------------------------
---------------------GVLEELEGCP---LQLQELMSRCWQ----
PNPRLRPSF---------THILDSIQE----------------------
>ROS
LTLRLLLGSGAFGEVYEGTAVDILGV------------------------
----GSGEIKVAVKTLKKGSTDQ-------------------------EK
IEFLKEAHLMSKFN------------------HPNILKQLGVCLL-----
-----------------------------------------NEPQYIILE
LMEG----------------------------------------------
--GDLLTYLRKARMATFYGPL-----------------------------
--------------------------------------------------
-------------------------------------LTLVDLVDLCVDI
SKGCVYLERM------------HFIHRDLAARNCLVSVKDYTSP------
--------RIVKIGDFGLARDIYKN-------------------------
--------------------------DYYRKRGEGLLPVRWMAPESLMD-
--------------------GIF-------TTQSDVWSFGILIWEILTLG
-----------HQPYPAHS------------------NLDVLNYVQTG--
--------------------------------------------------
---------------------GRLEPPRNCP---DDLWNLMTQCWA----
QEPDQRPTF---------HRIQNQL------------------------
>ALK
ITLIRGLGHGAFGEVYEGQVSGMPND------------------------
-----PSPLQVAVKTLPEVCSEQ-------------------------DE
LDFLMEALIISKFN------------------HQNIVRCIGVSLQ-----
-----------------------------------------SLPRFILLE
LMAG----------------------------------------------
--GDLKSFLRETRPRPSQPSS-----------------------------
--------------------------------------------------
-------------------------------------LAMLDLLHVARDI
ACGCQYLEEN------------HFIHRDIAARNCLLTCPGPG--------
--------RVAKIGDFGMARDIYRA-------------------------
--------------------------SYYRKGGCAMLPVKWMPPEAFME-
--------------------GIF-------TSKTDTWSFGVLLWEIFSLG
-----------YMPYPSKS------------------NQEVLEFVTSG--
--------------------------------------------------
---------------------GRMDPPKNCP---GPVYRIMTQCWQ----
HQPEDRPNF---------AIILERIEY----------------------
>LTK
VTLLRALGHGAFGEVYEGLVIGLPGD------------------------
-----SSPLQVAIKTLPELCSPQ-------------------------DE
LDFLMEALIISKFR------------------HQNIVRCVGLSLR-----
-----------------------------------------ATPRLILLE
LMSG----------------------------------------------
--GDMKSFLRHSRPHLGQPSP-----------------------------
--------------------------------------------------
-------------------------------------LVMRDLLQLAQDI
AQGCHYLEEN------------HFIHRDIAARNCLLSCAGPS--------
--------RVAKIGDFGMARDIYRA-------------------------
--------------------------SYYRRGDRALLPVKWMPPEAFLE-
--------------------GIF-------TSKTDSWSFGVLLWEIFSLG
-----------YMPYPGRT------------------NQEVLDFVVGG--
--------------------------------------------------
---------------------GRMDPPRGCP---GPVYRIMTQCWQ----
HEPELRPSF---------ASILERLQY----------------------
>CCK4
LQPITTLGKSEFGEVFLAKAQGLEEG------------------------
-----VAETLVLVKSLQSKDEQQ--------------------------Q
LDFRRELEMFGKLN------------------HANVVRLLGLCRE-----
-----------------------------------------AEPHYMVLE
YVDL----------------------------------------------
--GDLKQFLRISKSKDEKLKSQP---------------------------
--------------------------------------------------
-------------------------------------LSTKQKVALCTQV
ALGMEHLSNN------------RFVHKDLAARNCLVSAQ-----------
--------RQVKVSALGLSKDVYNS-------------------------
---------------------------EYYHFRQAWVPLRWMSPEAILE-
--------------------GDF-------STKSDVWAFGVLMWEVFTHG
-----------EMPHGGQA------------------DDEVLADLQAGK-
--------------------------------------------------
---------------------ARLPQPEGCP---SKLYRLMQRCWA----
LSPKDRPSF---------SEIASAL------------------------
>MER
LILGKILGEGEFGSVMEGNLKQEDG-------------------------
------TSLKVAVKTMKLDNSSHR------------------------EI
EEFLSEAACMKDFS------------------HPNVIRLLGVCIEMS---
--------------------------------------SQGIPKPMVILP
FMKY----------------------------------------------
--GDLHTYLLYSRLETGPKH------------------------------
--------------------------------------------------
-------------------------------------IPLQTLLKFMVDI
ALGMEYLSNR------------NFLHRDLAARNCMLRDD-----------
--------MTVCVADFGLSKKIYSG-------------------------
--------------------------DYYRQGRIAKMPVKWIAIESLAD-
--------------------RVY-------TSKSDVWAFGVTMWEIRTRG
-----------MTPYPGVQ------------------NHEMYDYLLHG--
--------------------------------------------------
---------------------HRLKQPEDCL---DELYEIMYSCWR----
TDPLDRPTF---------SVLRL--------------------------
>AXL
VALGKTLGEGEFGAVMEGQLNQDD--------------------------
------SILKVAVKTMKIAICTRS------------------------EL
EDFLSEAVCMKEFD------------------HPNVMRLIGVCFQGSER-
---------------------------------------ESFPAPVVILP
FMKH----------------------------------------------
--GDLHSFLLYSRLGDQPVY------------------------------
--------------------------------------------------
-------------------------------------LPTQMLVKFMADI
ASGMEYLSTK------------RFIHRDLAARNCMLNEN-----------
--------MSVCVADFGLSKKIYNG-------------------------
--------------------------DYYRQGRIAKMPVKWIAIESLAD-
--------------------RVY-------TSKSDVWSFGVTMWEIATRG
-----------QTPYPGVE------------------NSEIYDYLRQG--
--------------------------------------------------
---------------------NRLKQPADCL---DGLYALMSRCWE----
LNPQDRPSF---------TELREDLE-----------------------
>TYRO3
FTLGRMLGKGEFGSVREAQLKQEDG-------------------------
------SFVKVAVKMLKADIIASS------------------------DI
EEFLREAACMKEFD------------------HPHVAKLVGVSLRSRAK-
---------------------------------------GRLPIPMVILP
FMKH----------------------------------------------
--GDLHAFLLASRIGENPFN------------------------------
--------------------------------------------------
-------------------------------------LPLQTLIRFMVDI
ACGMEYLSSR------------NFIHRDLAARNCMLAED-----------
--------MTVCVADFGLSRKIYSG-------------------------
--------------------------DYYRQGCASKLPVKWLALESLAD-
--------------------NLY-------TVQSDVWAFGVTMWEIMTRG
-----------QTPYAGIE------------------NAEIYNYLIGG--
--------------------------------------------------
---------------------NRLKQPPECM---EDVYDLMYQCWS----
ADPKQRPSF----------------------------------------
>MET
VHFNEVIGRGHFGCVYHGTLLDND--------------------------
-----GKKIHCAVKSLNRITDIG-------------------------EV
SQFLTEGIIMKDFS------------------HPNVLSLLGICLRS----
-----------------------------------------EGSPLVVLP
YMKH----------------------------------------------
--GDLRNFIRNETHN-----------------------------------
--------------------------------------------------
-------------------------------------PTVKDLIGFGLQV
AKAMKYLASK------------KFVHRDLAARNCMLDEK-----------
--------FTVKVADFGLARDMYDK-------------------------
------------------------EYYSVHNKTGAKLPVKWMALESLQT-
--------------------QKF-------TTKSDVWSFGVVLWELMTRG
-----------APPYPDVN-----------------TFDITVYLLQG---
--------------------------------------------------
---------------------RRLLQPEYCP---DPLYEVMLKCWH----
PKAEMRPSF---------SELVSRISA----------------------
>RON
THSDRVIGKGHFGVVYHGEYIDQA--------------------------
-----QNRIQCAIKSLSRITEMQ-------------------------QV
EAFLREGLLMRGLN------------------HPNVLALIGIMLPP----
-----------------------------------------EGLPHVLLP
YMCH----------------------------------------------
--GDLLQFIRSPQRN-----------------------------------
--------------------------------------------------
-------------------------------------PTVKDLISFGLQV
ARGMEYLAEQ------------KFVHRDLAARNCMLDES-----------
--------FTVKVADFGLARDILDR-------------------------
------------------------EYYSVQQHRHARLPVKWMALESLQT-
--------------------YRF-------TTKSDVWSFGVLLWELLTRG
-----------APPYRHID-----------------PFDLTHFLAQG---
--------------------------------------------------
---------------------RRLPQPEYCP---DSLYQVMQQCWE----
ADPAVRPTF----------------------------------------
>RYK
ITLKDVLQEGTFGRIFHGILIDEKD-------------------------
----PNKEKQAFVKTVKDQASEI-------------------------QV
TMMLTESCKLRGLH------------------HRNLLPITHVCIEE----
-----------------------------------------GEKPMVILP
YMNW----------------------------------------------
--GNLKLFLRQCKLVEANNPQA----------------------------
--------------------------------------------------
-------------------------------------ISQQDLVHMAIQI
ACGMSYLARR------------EVIHKDLAARNCVIDDT-----------
--------LQVKITDNALSRDLFPM-------------------------
--------------------------DYHCLGDNENRPVRWMALESLVN-
--------------------NEF-------SSASDVWAFGVTLWELMTLG
-----------QTPYVDID-----------------PFEMAAYLKDG---
--------------------------------------------------
---------------------YRIAQPINCP---DELFAVMACCWA----
LDPEERPKF---------QQLVQCL------------------------
>fgfr_1fgk.PDB
LVLGKPLG-----QVVLAEAIGL---------------------------
----PNRVTKVAVKMLKSDATEK-------------------------DL
SDLISEMEMMKMIGK-----------------HKNIINLLGACTQ-----
-----------------------------------------DGPLYVIVE
YASK----------------------------------------------
--GNLREYLQARRPP------------EEQ--------------------
--------------------------------------------------
-------------------------------------LSSKDLVSCAYQV
ARGMEYLASK------------KCIHRDLAARNVLVTED-----------
--------NVMKIADFGLARDIHHI-------------------------
--------------------------DYYKKTTNGRLPVKWMAPEALFD-
--------------------RIY-------THQSDVWSFGVLLWEIFTLG
-----------GSPYPGV------------------PVEELFKLLKEG--
--------------------------------------------------
---------------------HRMDKPSNCT---NELYMMMRDCWH----
AVPSQRPTF---------KQLVEDLDRIVALT-----------------
>FGFR1
LVLGKPLGEGCFGQVVLAEAIGLDKD------------------------
---KPNRVTKVAVKMLKSDATEK-------------------------DL
SDLISEMEMMKMIGK-----------------HKNIINLLGACTQ-----
-----------------------------------------DGPLYVIVE
YASK----------------------------------------------
--GNLREYLQARRPPGLEYCYNPSHNPEEQ--------------------
--------------------------------------------------
-------------------------------------LSSKDLVSCAYQV
ARGMEYLASK------------KCIHRDLAARNVLVTED-----------
--------NVMKIADFGLARDIHHI-------------------------
--------------------------DYYKKTTNGRLPVKWMAPEALFD-
--------------------RIY-------THQSDVWSFGVLLWEIFTLG
-----------GSPYPGV------------------PVEELFKLLKEG--
--------------------------------------------------
---------------------HRMDKPSNCT---NELYMMMRDCWH----
AVPSQRPTF---------KQLVEDL------------------------
>FGFR2
LTLGKPLGEGCFGQVVMAEAVGIDKD------------------------
---KPKEAVTVAVKMLKDDATEK-------------------------DL
SDLVSEMEMMKMIGK-----------------HKNIINLLGACTQ-----
-----------------------------------------DGPLYVIVE
YASK----------------------------------------------
--GNLREYLRARRPPGMEYSYDINRVPEEQ--------------------
--------------------------------------------------
-------------------------------------MTFKDLVSCTYQL
ARGMEYLASQ------------KCIHRDLAARNVLVTEN-----------
--------NVMKIADFGLARDINNI-------------------------
--------------------------DYYKKTTNGRLPVKWMAPEALFD-
--------------------RVY-------THQSDVWSFGVLMWEIFTLG
-----------GSPYPGI------------------PVEELFKLLKEG--
--------------------------------------------------
---------------------HRMDKPANCT---NELYMMMRDCWH----
AVPSQRPTF---------KQLVEDL------------------------
>FGFR3
LTLGKPLGEGCFGQVVMAEAIGIDKD------------------------
---RAAKPVTVAVKMLKDDATDK-------------------------DL
SDLVSEMEMMKMIGK-----------------HKNIINLLGACTQ-----
-----------------------------------------GGPLYVLVE
YAAK----------------------------------------------
--GNLREFLRARRPPGLDYSFDTCKPPEEQ--------------------
--------------------------------------------------
-------------------------------------LTFKDLVSCAYQV
ARGMEYLASQ------------KCIHRDLAARNVLVTED-----------
--------NVMKIADFGLARDVHNL-------------------------
--------------------------DYYKKTTNGRLPVKWMAPEALFD-
--------------------RVY-------THQSDVWSFGVLLWEIFTLG
-----------GSPYPGI------------------PVEELFKLLKEG--
--------------------------------------------------
---------------------HRMDKPANCT---HDLYMIMRECWH----
AAPSQRPTF---------KQLVEDL------------------------
>FGFR4
LVLGKPLGEGCFGQVVRAEAFGMDPA------------------------
---RPDQASTVAVKMLKDNASDK-------------------------DL
ADLVSEMEVMKLIGR-----------------HKNIINLLGVCTQ-----
-----------------------------------------EGPLYVIVE
CAAK----------------------------------------------
--GNLREFLRARRPPGPDLSPDGPRSSEGP--------------------
--------------------------------------------------
-------------------------------------LSFPVLVSCAYQV
ARGMQYLESR------------KCIHRDLAARNVLVTED-----------
--------NVMKIADFGLARGVHHI-------------------------
--------------------------DYYKKTSNGRLPVKWMAPEALFD-
--------------------RVY-------THQSDVWSFGILLWEIFTLG
-----------GSPYPGI------------------PVEELFSLLREG--
--------------------------------------------------
---------------------HRMDRPPHCP---PELYGLMRECWH----
AAPSQRPTF---------KQLVEAL------------------------
>RET
LVLGKTLGEGEFGKVVKATAFHLKG-------------------------
----RAGYTTVAVKMLKENASPS-------------------------EL
RDLLSEFNVLKQVN------------------HPHVIKLYGACSQ-----
-----------------------------------------DGPLLLIVE
YAKY----------------------------------------------
--GSLRGFLRESRKVGPGYLGSGGSRNSSSL-------------------
--------------------------------------------------
------------------------------DHPDERALTMGDLISFAWQI
SQGMQYLAEM------------KLVHRDLAARNILVAEG-----------
--------RKMKISDFGLSRDVYEED------------------------
---------------------------SYVKRSQGRIPVKWMAIESLFD-
--------------------HIY-------TTQSDVWSFGVLLWEIVTLG
-----------GNPYPGI------------------PPERLFNLLKTG--
--------------------------------------------------
---------------------HRMERPDNCS---EEMYRLMLQCWK----
QEPDKRPVF---------ADISKDLEK----------------------
>FLT1
LKLGKSLGRGAFGKVVQASAFGIKK-------------------------
----SPTCRTVAVKMLKEGATAS-------------------------EY
KALMTELKILTHIGH-----------------HLNVVNLLGACTKQ----
-----------------------------------------GGPLMVIVE
YCKY----------------------------------------------
--GNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKP-------
-------------------------------------------------R
LDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQV
ARGMEFLSSR------------KCIHRDLAARNILLSEN-----------
--------NVVKICDFGLARDIYKNP------------------------
---------------------------DYVRKGDTRLPLKWMAPESIFD-
--------------------KIY-------STKSDVWSYGVLLWEIFSLG
-----------GSPYPGVQ-----------------MDEDFCSRLREG--
--------------------------------------------------
---------------------MRMRAPEYST---PEIYQIMLDCWH----
RDPKERPRF---------AELVEKL------------------------
>kdr_1vr2.PDB
LKLGKPLGRGAFGQVIEADAFGIDK-------------------------
----TATCRTVAVKMLKEGATHS-------------------------EH
RALMSELKILIHIGH-----------------HLNVVNLLGACTKP----
-----------------------------------------GGPLMVIVE
FCKF----------------------------------------------
--GNLSTYLRSKRNEFVPYKDF----------------------------
--------------------------------------------------
-------------------------------------LTLEHLICYSFQV
AKGMEFLASR------------KCIHRDLAARNILLSEK-----------
--------NVVKICDF----------------------------------
---------------------------------DARLPLKWMAPETIFD-
--------------------RVY-------TIQSDVWSFGVLLWEIFSLG
-----------ASPYPGVK-----------------IDEEFCRRLKEG--
--------------------------------------------------
---------------------TRMRAPDYTT---PEMYQTMLDCWH----
GEPSQRPTF---------SELVEHLGNLLQAN-----------------
>KDR
LKLGKPLGRGAFGQVIEADAFGIDK-------------------------
----TATCRTVAVKMLKEGATHS-------------------------EH
RALMSELKILIHIGH-----------------HLNVVNLLGACTKP----
-----------------------------------------GGPLMVIVE
FCKF----------------------------------------------
--GNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL------
--------------------------------------------------
-DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQV
AKGMEFLASR------------KCIHRDLAARNILLSEK-----------
--------NVVKICDFGLARDIYKDP------------------------
---------------------------DYVRKGDARLPLKWMAPETIFD-
--------------------RVY-------TIQSDVWSFGVLLWEIFSLG
-----------ASPYPGVK-----------------IDEEFCRRLKEG--
--------------------------------------------------
---------------------TRMRAPDYTT---PEMYQTMLDCWH----
GEPSQRPTF---------SELVEHL------------------------
>FLT4
LHLGRVLGYGAFGKVVEASAFGIHK-------------------------
----GSSCDTVAVKMLKEGATAS-------------------------EH
RALMSELKILIHIGN-----------------HLNVVNLLGACTKP----
-----------------------------------------QGPLMVIVE
FCKY----------------------------------------------
--GNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRP------
--------------------------------------------------
---GSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQV
ARGMEFLASR------------KCIHRDLAARNILLSES-----------
--------DVVKICDFGLARDIYKDP------------------------
---------------------------DYVRKGSARLPLKWMAPESIFD-
--------------------KVY-------TTQSDVWSFGVLLWEIFSLG
-----------ASPYPGVQ-----------------INEEFCQRLRDG--
--------------------------------------------------
---------------------TRMRAPELAT---PAIRRIMLNCWS----
GDPKARPAF---------SELVEIL------------------------
>FMS
LQFGKTLGAGAFGKVVEATAFGLGK-------------------------
----EDAVLKVAVKMLKSTAHAD-------------------------EK
EALMSELKIMSHLGQ-----------------HENIVNLLGACTH-----
-----------------------------------------GGPVLVITE
YCCY----------------------------------------------
--GDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVR------
------------------------------------------------RD
SGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQV
AQGMAFLASK------------NCIHRDVAARNVLLTNG-----------
--------HVAKIGDFGLARDIMNDS------------------------
---------------------------NYIVKGNARLPVKWMAPESIFD-
--------------------CVY-------TVQSDVWSYGILLWEIFSLG
-----------LNPYPGIL-----------------VNSKFYKLVKDG--
--------------------------------------------------
---------------------YQMAQPAFAP---KNIYSIMQACWA----
LEPTHRPTF---------QQICSFL------------------------
>KIT
LSFGKTLGAGAFGKVVEATAYGLIK-------------------------
----SDAAMTVAVKMLKPSAHLT-------------------------ER
EALMSELKVLSYLGN-----------------HMNIVNLLGACTI-----
-----------------------------------------GGPTLVITE
YCCY----------------------------------------------
--GDLLNFLRRKRDSFICSKQEDHAEAAL---YKN---------------
-----LLHSKESSCSDS------------------------TNEYMDMKP
GVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQV
AKGMAFLASK------------NCIHRDLAARNILLTHG-----------
--------RITKICDFGLARDIKNDS------------------------
---------------------------NYVVKGNARLPVKWMAPESIFN-
--------------------CVY-------TFESDVWSYGIFLWELFSLG
-----------SSPYPGMP-----------------VDSKFYKMIKEG--
--------------------------------------------------
---------------------FRMLSPEHAP---AEMYDIMKTCWD----
ADPLKRPTF---------KQIVQLI------------------------
>FLT3
LEFGKVLGSGAFGKVMNATAYGISK-------------------------
----TGVSIQVAVKMLKEKADSS-------------------------ER
EALMSELKMMTQLGS-----------------HENIVNLLGACTL-----
-----------------------------------------SGPIYLIFE
YCCY----------------------------------------------
--GDLLNYLRSKREKFHRTWTEIFKEHNFSF-------------------
------YPTFQSHPNSS------------------------MPGSREVQI
HPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQV
AKGMEFLEFK------------SCVHRDLAARNVLVTHG-----------
--------KVVKICDFGLARDIMSDS------------------------
---------------------------NYVVRGNARLPVKWMAPESLFE-
--------------------GIY-------TIKSDVWSYGILLWEIFSLG
-----------VNPYPGIP-----------------VDANFYKLIQNG--
--------------------------------------------------
---------------------FKMDQPFYAT---EEIYIIMQSCWA----
FDSRKRPSF---------PNLTSFL------------------------
>PDGFRa
LVLGRVLGSGAFGKVVEGTAYGLSR-------------------------
----SQPVMKVAVKMLKPTARSS-------------------------EK
QALMSELKIMTHLGP-----------------HLNIVNLLGACTK-----
-----------------------------------------SGPIYIITE
YCFY----------------------------------------------
--GDLVNYLHKNRDSFLSHHPE-KPKKELDIFGLNPADESTRSYVILSFE
NNGDYMDMKQADTTQYV------------------------PMLERKEVS
KYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQV
ARGMEFLASK------------NCVHRDLAARNVLLAQG-----------
--------KIVKICDFGLARDIMHDS------------------------
---------------------------NYVSKGSTFLPVKWMAPESIFD-
--------------------NLY-------TTLSDVWSYGILLWEIFSLG
-----------GTPYPGMM-----------------VDSTFYNKIKSG--
--------------------------------------------------
---------------------YRMAKPDHAT---SEVYEIMVKCWN----
SEPEKRPSF---------YHLSEIV------------------------
>PDGFRb
LVLGRTLGSGAFGQVVEATAHGLSH-------------------------
----SQATMKVAVKMLKSTARSS-------------------------EK
QALMSELKIMSHLGP-----------------HLNVVNLLGACTK-----
-----------------------------------------GGPIYIITE
YCRY----------------------------------------------
--GDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTG
ESDGGYMDMSKDESVDY------------------------VPMLDMKGD
VKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQV
ANGMEFLASK------------NCVHRDLAARNVLICEG-----------
--------KLVKICDFGLARDIMRDS------------------------
---------------------------NYISKGSTFLPLKWMAPESIFN-
--------------------SLY-------TTLSDVWSFGILLWEIFTLG
-----------GTPYPELP-----------------MNEQFYNAIKRG--
--------------------------------------------------
---------------------YRMAQPAHAS---DEIYEIMQKCWE----
EKFEIRPPF---------SQLVLLL------------------------
>TIE1
ITFEDLIGEGNFGQVIRAMIKKDGL-------------------------
-------KMNAAIKMLKEYASEN-------------------------DH
RDFAGELEVLCKLGH-----------------HPNIINLLGACKN-----
-----------------------------------------RGYLYIAIE
YAPY----------------------------------------------
--GNLLDFLRKSRVLETDPAFAREHGTAST--------------------
--------------------------------------------------
-------------------------------------LSSRQLLRFASDA
ANGMQYLSEK------------QFIHRDLAARNVLVGEN-----------
--------LASKIADFGLSRGEE---------------------------
---------------------------VYVKKTMGRLPVRWMAIESLNY-
--------------------SVY-------TTKSDVWSFGVLLWEIVSLG
-----------GTPYCGMT------------------CAELYEKLPQG--
--------------------------------------------------
---------------------YRMEQPRNCD---DEVYELMRQCWR----
DRPYERPPF---------AQIALQL------------------------
>tie2_1fvr.PDB
IKFQDVIGEGNFGQVLKARIKKDGLR------------------------
--------MDAAIKRMKEYR------------------------------
-DFAGELEVLCKLGH-----------------HPNIINLLGACEH-----
-----------------------------------------RGYLYLAIE
YAPH----------------------------------------------
--GNLLDFLRKSRVLETDPAFAIANSTAST--------------------
--------------------------------------------------
-------------------------------------LSSQQLLHFAADV
ARGMDYLSQK------------QFIHRDLAARNILVGEN-----------
--------YVAKIADFGLSRGQE---------------------------
----------------------------VYVKK---LPVRWMAIESLNY-
--------------------SVY-------TTNSDVWSYGVLLWEIVSLG
-----------GTPYCGMT------------------CAELYEKLPQG--
--------------------------------------------------
---------------------YRLEKPLNCD---DEVYDLMRQCWR----
EKPYERPSF---------AQILVSLNRMLEERKTYVNTTLYEKFTYAGI
>TIE2
IKFQDVIGEGNFGQVLKARIKKDGLR------------------------
--------MDAAIKRMKEYASKD-------------------------DH
RDFAGELEVLCKLGH-----------------HPNIINLLGACEH-----
-----------------------------------------RGYLYLAIE
YAPH----------------------------------------------
--GNLLDFLRKSRVLETDPAFAIANSTAST--------------------
--------------------------------------------------
-------------------------------------LSSQQLLHFAADV
ARGMDYLSQK------------QFIHRDLAARNILVGEN-----------
--------YVAKIADFGLSRGQE---------------------------
---------------------------VYVKKTMGRLPVRWMAIESLNY-
--------------------SVY-------TTNSDVWSYGVLLWEIVSLG
-----------GTPYCGMT------------------CAELYEKLPQG--
--------------------------------------------------
---------------------YRLEKPLNCD---DEVYDLMRQCWR----
EKPYERPSF---------AQILVSL------------------------
>egfr_1m14.PDB
FKKIKVLGSGAFGTVYKGLWIPEGEKV-----------------------
-------KIPVAIKELREATSPK-------------------------AN
KEILDEAYVMASVD------------------NPHVCRLLGICL------
-----------------------------------------TSTVQLITQ
LMPF----------------------------------------------
--GCLLDYVREHKDN-----------------------------------
--------------------------------------------------
-------------------------------------IGSQYLLNWCVQI
AKGMNYLEDR------------RLVHRDLAARNVLVKTP-----------
--------QHVKITDFGLAKLLGAEE------------------------
---------------------------KEYHAEGGKVPIKWMALESILH-
--------------------RIY-------THQSDVWSYGVTVWELMTFG
-----------SKPYDGIP------------------ASEISSILEKG--
--------------------------------------------------
---------------------ERLPQPPICT---IDVYMIMVKCWM----
IDADSRPKF---------RELIIEFSKMARDPQRYLVIQGDDEEDMDDV
>EGFR
FKKIKVLGSGAFGTVYKGLWIPEGEKV-----------------------
-------KIPVAIKELREATSPK-------------------------AN
KEILDEAYVMASVD------------------NPHVCRLLGICL------
-----------------------------------------TSTVQLITQ
LMPF----------------------------------------------
--GCLLDYVREHKDN-----------------------------------
--------------------------------------------------
-------------------------------------IGSQYLLNWCVQI
AKGMNYLEDR------------RLVHRDLAARNVLVKTP-----------
--------QHVKITDFGLAKLLGAEE------------------------
---------------------------KEYHAEGGKVPIKWMALESILH-
--------------------RIY-------THQSDVWSYGVTVWELMTFG
-----------SKPYDGIP------------------ASEISSILEKG--
--------------------------------------------------
---------------------ERLPQPPICT---IDVYMIMVKCWM----
IDADSRPKF---------RELIIEFS-----------------------
>HER2/ErbB2
LRKVKVLGSGAFGTVYKGIWIPDGENV-----------------------
-------KIPVAIKVLRENTSPK-------------------------AN
KEILDEAYVMAGVG------------------SPYVSRLLGICL------
-----------------------------------------TSTVQLVTQ
LMPY----------------------------------------------
--GCLLDHVRENRGR-----------------------------------
--------------------------------------------------
-------------------------------------LGSQDLLNWCMQI
AKGMSYLEDV------------RLVHRDLAARNVLVKSP-----------
--------NHVKITDFGLARLLDIDE------------------------
---------------------------TEYHADGGKVPIKWMALESILR-
--------------------RRF-------THQSDVWSYGVTVWELMTFG
-----------AKPYDGIP------------------AREIPDLLEKG--
--------------------------------------------------
---------------------ERLPQPPICT---IDVYMIMVKCWM----
IDSECRPRF---------RELVSEFS-----------------------
>HER4/ErbB4
LKRVKVLGSGAFGTVYKGIWVPEGETV-----------------------
-------KIPVAIKILNETTGPK-------------------------AN
VEFMDEALIMASMD------------------HPHLVRLLGVCL------
-----------------------------------------SPTIQLVTQ
LMPH----------------------------------------------
--GCLLEYVHEHKDN-----------------------------------
--------------------------------------------------
-------------------------------------IGSQLLLNWCVQI
AKGMMYLEER------------RLVHRDLAARNVLVKSP-----------
--------NHVKITDFGLARLLEGDE------------------------
---------------------------KEYNADGGKMPIKWMALECIHY-
--------------------RKF-------THQSDVWSYGVTIWELMTFG
-----------GKPYDGIP------------------TREIPDLLEKG--
--------------------------------------------------
---------------------ERLPQPPICT---IDVYMVMVKCWM----
IDADSRPKF---------KELAAEFS-----------------------
>HER3/ErbB3
LRKLKVLGSGVFGTVHKGVWIPEGESI-----------------------
-------KIPVCIKVIEDKSGRQ-------------------------SF
QAVTDHMLAIGSLD------------------HAHIVRLLGLCP------
-----------------------------------------GSSLQLVTQ
YLPL----------------------------------------------
--GSLLDHVRQHRGA-----------------------------------
--------------------------------------------------
-------------------------------------LGPQLLLNWGVQI
AKGMYYLEEH------------GMVHRNLAARNVLLKSP-----------
--------SQVQVADFGVADLLPPDD------------------------
---------------------------KQLLYSEAKTPIKWMALESIHF-
--------------------GKY-------THQSDVWSYGVTVWELMTFG
-----------AEPYAGLR------------------LAEVPDLLEKG--
--------------------------------------------------
---------------------ERLAQPQICT---IDVYMVMVKCWM----
IDENIRPTF---------KELANEF------------------------
>TNK1
VCRGELLGSGCFGVVHRGLWTLPSGK------------------------
-------SVPVAVKSLRVGPEGPMG----------------------TEL
GDFLREVSVMMNLE------------------HPHVLRLHGLVL------
-----------------------------------------GQPLQMVME
LAPL----------------------------------------------
--GSLHARLTAPAPTPP---------------------------------
--------------------------------------------------
-------------------------------------LLVALLCLFLRQL
AGAMAYLGAR------------GLVHRDLATRNLQLASP-----------
--------RTIKVADFGLVRPLGGAR------------------------
--------------------------GRYVMGGPRPIPYTWCAPESLRH-
--------------------GAF-------SSASDVWMFGVTLWEMFSGG
-----------EEPWPGVP------------------PYLILQRLEDR--
--------------------------------------------------
---------------------ARLPRPPPSS---RALYSLALRCWA----
PHPADRPSF---------SHLEGLL------------------------
>ACK
LRLLEKLGDGSFGVVRRGEWDAPSGK------------------------
-------TVSVAVKCLKPDVLSQPE-----------------------AM
DDFIREVNAMHSLD------------------HRNLIRLYGVVL------
-----------------------------------------TPPMKMVTE
LAPL----------------------------------------------
--GSLLDRLRKHQGH-----------------------------------
--------------------------------------------------
-------------------------------------FLLGTLSRYAVQV
AEGMGYLESK------------RFIHRDLAARNLLLATR-----------
--------DLVKIGDFGLMRALPQND------------------------
--------------------------DHYVMQEHRKVPFAWCAPESLKT-
--------------------RTF-------SHASDTWMFGVTLWEMFTYG
-----------QEPWIGLN-----------------GSQILHKIDKEG--
--------------------------------------------------
---------------------ERLPRPEDCP---QDIYNVMVQCWA----
HKPEDRPTF---------VALRDFL------------------------
>TYK2
LKKIRDLGEGHFGKVSLYCYDPTNDG------------------------
------TGEMVAVKALKADCGPQ-------------------------HR
SGWKQEIDILRTLY------------------HEHIIKYKGCCEDQ----
----------------------------------------GEKSLQLVME
YVPL----------------------------------------------
--GSLRDYLPRHS-------------------------------------
--------------------------------------------------
-------------------------------------IGLAQLLLFAQQI
CEGMAYLHAH------------DYIHRDLAARNVLLDND-----------
--------RLVKIGDFGLAKAVPEGH------------------------
--------------------------EYYRVREDGDSPVFWYAPECLKE-
--------------------YKF-------YYASDVWSFGVTLYELLTHC
DSS--------QSPPTKFLELIGIAQ-------GQMTVLRLTELLERG--
--------------------------------------------------
---------------------ERLPRPDKCP---CEVYHLMKNCWE----
TEASFRPTF----------------------------------------
>JAK1
LKRIRDLGEGHFGKVELCRYDPEDN-------------------------
------TGEQVAVKSLKPESGGN-------------------------HI
ADLKKEIEILRNLY------------------HENIVKYKGICTED----
----------------------------------------GGNGIKLIME
FLPS----------------------------------------------
--GSLKEYLPKNKNK-----------------------------------
--------------------------------------------------
-------------------------------------INLKQQLKYAVQI
CKGMDYLGSR------------QYVHRDLAARNVLVESE-----------
--------HQVKIGDFGLTKAIETDK------------------------
--------------------------EYYTVKDDRDSPVFWYAPECLMQ-
--------------------SKF-------YIASDVWSFGVTLHELLTYC
DSD--------SSPMALFLKMIGPTH-------GQMTVTRLVNTLKEG--
--------------------------------------------------
---------------------KRLPCPPNCP---DEVYQLMRKCWE----
FQPSNRTSF------QNLIEGFEAL------------------------
>JAK2
LKFLQQLGKGNFGSVEMCRYDPLQDN------------------------
------TGEVVAVKKLQHSTEEH-------------------------LR
-DFEREIEILKSLQ------------------HDNIVKYKGVCYSA----
----------------------------------------GRRNLKLIME
YLPY----------------------------------------------
--GSLRDYLQKHKER-----------------------------------
--------------------------------------------------
-------------------------------------IDHIKLLQYTSQI
CKGMEYLGTK------------RYIHRDLATRNILVENE-----------
--------NRVKIGDFGLTKVLPQDK------------------------
--------------------------EYYKVKEPGESPIFWYAPESLTE-
--------------------SKF-------SVASDVWSFGVVLYELFTYI
EKS--------KSPPAEFMRMIGNDKQ------GQMIVFHLIELLKNN--
--------------------------------------------------
---------------------GRLPRPDGCP---DEIYMIMTECWN----
NNVNQRPSF------RDLALRVDQI------------------------
>JAK3
LKYISQLGKGNFGSVELCRYDPLAHN------------------------
------TGALVAVKQLQHSGPDQ-------------------------QR
-DFQREIQILKAL-------------------HSDFIVKYRGVSYGP---
----------------------------------------GRPELRLVME
YLPS----------------------------------------------
--GCLRDFLQRHRAR-----------------------------------
--------------------------------------------------
-------------------------------------LDASRLLLYSSQI
CKGMEYLGSR------------RCVHRDLAARNILVESE-----------
--------AHVKIADFGLAKLLPLDK------------------------
--------------------------DYYVVREPGQSPIFWYAPESLSD-
--------------------NIF-------SRQSDVWSFGVVLYELFTYC
DKS--------CSPSAEFLRMMGCERDVP-------ALCRLLELLEEG--
--------------------------------------------------
---------------------QRLPAPPACP---AEVHELMKLCWA----
PSPQDRPSF----SALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLS--
>LMR1
LLYLKEIGRGWFGKVFLGEVNSGIS-------------------------
-------SAQVVVKELQASASVQ-------------------------EQ
MQFLEEVQPYRALK------------------HSNLLQCLAQCAE-----
-----------------------------------------VTPYLLVME
FCPL----------------------------------------------
--GDLKGYLRSCRVAESMA-------------------------------
--------------------------------------------------
-------------------------------------PDPRTLQRMACEV
ACGVLHLHRN------------NFVHSDLALRNCLLTAD-----------
--------LTVKIGDYGLAHCKYRE-------------------------
--------------------------DYFVTADQLWVPLRWIAPELVDEV
H-------------------SNL--LVVDQTKSGNVWSLGVTIWELFELG
-----------TQPYPQHSD-----------------QQVLAYTVREQQL
KL------------------------------------------------
---------------------PKPQLQLTLS---DRWYEVMQFCWL----
Q-PEQRPTA------EEVHLLLSYL------------------------
>LMR2
LNYIQEIGNGWFGKVLLGEIYTGTS-------------------------
-------VARVIVKELKASANPK-------------------------EQ
DTFLKNGEPYYILQ------------------HPNILQCVGQCVE-----
-----------------------------------------AIPYLLVFE
FCDL----------------------------------------------
--GDLKAYLRSEQEHMRGD-------------------------------
--------------------------------------------------
-------------------------------------SQTMLLQRMACEV
AAGLAAMHKL------------HFLHSDLALRNCFLTSD-----------
--------LNVKVGDYGIGFSRYKE-------------------------
--------------------------DYIETDDKKVFPLRWTAPELVTSF
Q-------------------DRL--LTADQTKYSNIWSLGVTLWELFDNA
-----------AQPYSNLSN-----------------LDVLNQVIRERDT
KL------------------------------------------------
---------------------PKPQLEQPYS---DRWYEVLQFCWL----
S-PEKRPAA------EDVHRLLTYL------------------------
>LMR3
LSYLQEIGSGWFGKVILGEIFSDYT-------------------------
-------PAQVVVKELRASAGPL-------------------------EQ
RKFISEAQPYRSLQ------------------HPNVLQCLGLCVE-----
-----------------------------------------TLPFLLIME
FCQL----------------------------------------------
--GDLKRYLRAQRPPEGLSPELPP--------------------------
--------------------------------------------------
-------------------------------------RDLRTLQRMGLEI
ARGLAHLHSH------------NYVHSDLALRNCLLTSD-----------
--------LTVRIGDYGLAHSNYKE-------------------------
--------------------------DYYLTPERLWIPLRWAAPELLGEL
H-------------------GTF--MVMDQSRESNIWSLGVTLWELFEFG
-----------AQPYRHLSD-----------------EEVLAFVVRQQHV
KL------------------------------------------------
---------------------ARPKLKLPYA---DYWYDILQSCWR----
P-PAQRPSA----SDLQLQLTYLLSERPPRPPPPPPPPRDGPFPWPWPP
>JAK3-b
LEWHENLGHGSFTKIYRGCRHEVVDGE-----------------------
-----ARKTEVLLKVMDAKHK---------------------------NC
MESFLEAASLMSQVS-----------------YRHLVLLHGVCM------
-----------------------------------------AGDSTMVQE
FVHL----------------------------------------------
--GAIDMYLR----------------------------------------
--------------------------------------------------
------------------------------------KRGHLVPASWKLQV
VKQLAYALN-------------YLEDKGLPHGNVSARKVLLARE------
--GADGSPPFIKLSDPGVSPAVL---------------------------
-----------------------------SLEMLTDRIP-WVAPECLREA
--------------------QTL-------SLEADKWGFGATVWEVFSGV
TMPISA-----LDPA-----------------------KKLQFYEDR---
--------------------------------------------------
---------------------QQLPAPKWT-----ELALLIQQCMA----
YEPVQRPSF----RAVIRDLNSLISSDYELLSDPTP-------------
>JAK2-b
LIFNESLGQGTFTKIFKGVRREVGDYG-----------------------
----QLHETEVLLKVLDKAHR---------------------------NY
SESFFEAASMMSKLS-----------------HKHLVLNYGVCVC-----
-----------------------------------------GDENILVQE
FVKF----------------------------------------------
--GSLDTYLK----------------------------------------
--------------------------------------------------
------------------------------------KNKNCINILWKLEV
AKQLAWAMH-------------FLEENTLIHGNVCAKNILLIREE-----
-DRKTGNPPFIKLSDPGISITVL---------------------------
-----------------------------PKDILQERIP-WVPPECIENP
--------------------KNL-------NLATDKWSFGTTLWEICSGG
-----------DKPLSALDS-----------------QRKLQFYEDR---
--------------------------------------------------
---------------------HQLPAPKWA-----ELANLINNCMD----
YEPDFRPSF----RAIIRDLNSLF-------------------------
>JAK1-b
LVQGEHLGRGTRTHIYSGTLMDYKDDEGTS--------------------
----EEKKIKVILKVLDPSHR---------------------------DI
SLAFFEAASMMRQVS-----------------HKHIVYLYGVCVR-----
-----------------------------------------DVENIMVEE
FVEG----------------------------------------------
--GPLDLFMHRKSDV-----------------------------------
--------------------------------------------------
-------------------------------------LTTPWKFKVAKQL
ASALSYLEDK------------DLVHGNVCTKNLLLAREGIDS-------
-----ECGPFIKLSDPGIPITVL---------------------------
-----------------------------SRQECIERIP-WIAPECVEDS
--------------------KNL-------SVAADKWSFGTTLWEICYNG
-----------EIPLKDKTL-----------------IEKERFYES----
--------------------------------------------------
--------------------RCRPVTPSCK-----ELADLMTRCMN----
YDPNQRPFF--------RAIMRDINK-----------------------
>TYK2-b
ITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDD----------EDPLV
PGRDRGQELRVVLKVLDPSHH---------------------------DI
ALAFYETASLMSQVS-----------------HTHLAFVHGVCVR-----
-----------------------------------------GPENSMVTE
YVEH----------------------------------------------
--GPLDVWLRRERGH-----------------------------------
--------------------------------------------------
-------------------------------------VPMAWKMVVAQQL
ASALSYLENK------------NLVHGNVCGRNILLARLGLAE-------
-----GTSPFIKLSDPGVGLGAL---------------------------
-----------------------------SREERVERIP-WLAPECLPGG
A-------------------NSL-------STAMDKWGFGATLLEICFDG
-----------EAPLQSRSP-----------------SEKEHFYQRQ---
--------------------------------------------------
---------------------HRLPEPSCP-----QLATLTSQCLT----
YEPTQRPSF---------RTILRDL------------------------
>SuRTK106
SEVLEQICSGSCGPIFRANMNTGDPSKP----------------------
--------KSVILKALKEPAGLHEVQ-----------------------D
FLGRIQFHQYLGK-------------------HKNLVQLEGCCTE-----
-----------------------------------------KLPLYMVLE
DVAQ----------------------------------------------
--GDLLGFLWTCRRDVMTMDGLLYD-------------------------
--------------------------------------------------
-------------------------------------LTEKQVYHIGKQV
LLALEFLQEK------------HLFHGDVAARNILMQSD-----------
--------LTAKLCGLGLAYEVY---------------------------
--------------------------TRGAISSTQTIPLKWLAPERLLL-
--------------------RPA-------SIRADVWSFGILLYEMVTLG
-----------APPYPEVPP------------------TSILEHLQRRK-
--------------------------------------------------
---------------------IMKRPSSCTH----TMYSIMKSCWR----
WREADRPSP---------RELRLRL------------------------
>MOS
VCLLQRLGAGGFGSVYKATYRGV---------------------------
---------PVAIKQVNKCTKNRLA-----------------------SR
RSFWAELNVARLR-------------------HDNIVRVVAASTRTP---
--------------------------------------AGSNSLGTIIME
FGGN----------------------------------------------
--VTLHQVIYGAAGHPEGDAGEPHCRTGGQ--------------------
--------------------------------------------------
-------------------------------------LSLGKCLKYSLDV
VNGLLFLHSQ------------SIVHLDLKPANILISEQ-----------
--------DVCKISDFGCSEKLEDLLCF----------------------
----------------------------QTPSYPLGGTYTHRAPELLKG-
--------------------EGV-------TPKADIYSFAITLWQMTTK-
-----------QAPYSGERQ-----------------HILYAVVAYDL--
--------------------------------------------------
-----------------RPSLS--AAVFEDSLPGQRLGDVIQRCWR----
PSAAQRPSA----RLLLVDLTS---------------------------
>SgK496
PKLGQELGRGQYGVVYLCDNWGGHF-------------------------
---------PCALKSVVPPDEK--------------------------HW
NDLALEFHYMRSLPK-----------------HERLVDLHGSVI------
--------------------------------------DYNYGGGSSIAV
LLIM----------------------------------------------
--ERLHRDLYTGLKAG----------------------------------
--------------------------------------------------
-------------------------------------LTLETRLQIALDV
VEGIRFLHSQ------------GLVHRDIKLKNVLLDKQ-----------
--------NRAKITDLGFCKPE----------------------------
----------------------------AMMSGSIVGTPIHMAPELFT--
--------------------GKY-------DNSVDVYAFGILFWYICSGS
V----------KLPEAFERCAS---------------KDHLWNNVRRGA-
--------------------------------------------------
-----------------RPER----LPVFDE----ECWQLMEACWD----
GDPLKRPLL----GIVQPMLQGIMNRLCK--------------------
>PBK
SPFMQKLGFGTGVNVYLMKRSPRGLSHS----------------------
---------PWAVKKINPICNDHYRSV---------------------YQ
KRLMDEAKILKSLH------------------HPNIVGYRAFTE------
---------------------------------------ASDGSLCLAME
YGGE----------------------------------------------
--KSLNDLIEERYKASQDP-------------------------------
--------------------------------------------------
-------------------------------------FPAAIILKVALNM
ARGLKYLHQEK-----------KLLHGDIKSSNVVIKGDF----------
--------ETIKICDVGVSLPLDENMTVT---------------------
-----------------------------DPEACYIGTEPWKPKEAVEEN
--------------------GVI-------TDKADIFAFGLTLWEMMTL-
-----------SIPHINLSNDDDD----EDKTFDESDFDDEAYYAALGT-
--------------------------------------------------
-----------------RPPI--NMEELDESY--QKVIELFSVCTN----
EDPKDRPSA---------AHIVEAL------------------------
>MLKL
LLRENEVSTLYKGEYHRA--------------------------------
---------PVAIKVFKKLQAGSIAIV----------------------R
QTFNKEIKTMKKFE------------------SPNILRIFGICIDE----
--------------------------------------TVTPPQFSIVME
YCEL----------------------------------------------
--GTLRELLDREKD------------------------------------
--------------------------------------------------
-------------------------------------LTLGKRMVLVLGA
ARGLYRLHHSEA----------PELHGKIRSSNFLVTQG-----------
--------YQVKLAGFELRKTQTSMSLGTTRE------------------
------------------------------KTDRVKSTAYLSPQELED--
--------------------VFY---------QYDVKSEIYSFGIVLWEI
ATG--------DIPFQGCNS-----------------EKIRKLVAVKRQQ
--------------------------------------------------
----------------------EPLGEDCPSE----LREIIDECRA----
HDPSVRPSV------DEILKKLSTF------------------------
>IRAK1
FSEELKIGEGGFGCVYRAVMRNT---------------------------
---------VYAVKRLKENADLEWTAV----------------------K
QSFLTEVEQLSRFR------------------HPNIVDFAGYCA------
----------------------------------------QNGFYCLVYG
FLPN----------------------------------------------
--GSLEDRLHCQTQACPP--------------------------------
--------------------------------------------------
-------------------------------------LSWPQRLDILLGT
ARAIQFLHQDSP----------SLIHGDIKSSNVLLDER-----------
--------LTPKLGDFGLARFSRFAGSSPSQSS-----------------
---------------------------MVARTQTVRGT-LAYLPEEYIKT
--------------------GRL-------AVDTDTFSFGVVVLETLAGQ
R----------AVKTHGARTKYLK--------DLVEEEAEEAGVALRSTQ
-------------------------STLQAGLAADAWAAPIAM-------
---------------QIYKKHLDPRPGPCPPELGLGLGQLACCCLH----
RRAKRRPPM----TQVYERLEKL--------------------------
>IRAK2
FNQNRKISQGTFADVYRGHRHGK---------------------------
---------PFVFKKLRETACSSPGSI----------------------E
RFFQAELQICLRCC------------------HPNVLPVLGFCA------
----------------------------------------ARQFHSFIYP
YMAN----------------------------------------------
--GSLQDRLQGQGGSDPLPWPQRVSICSGLL-------------------
--------------------------------------------------
-------------------------CAVEYLHGLEIIHSNVKSSNVLLDQ
NLTPKLAHP----------------MAHLCPVNKRSKYTM----------
--------MKTHLLRTSAAYLPEDFIRVGQ--------------------
---------------------------LTKRVDIFSCG--IVLAEVLTGI
--------------------PAM-----------DNNRSPVYLKDLLLS-
-----------EIPSSTASL------------------------------
--------------------------------------------------
--------------------------CSRKTGVENVMAKEICQKYL----
EKGAGRLPE----DCAEALATA---------------------------
>IRAK3
FHKDFLIGEGEIFEVYRVEIQNL---------------------------
---------TYAVKLFKQEKKMQCKKH----------------------W
KRFLSELEVLLLFH------------------HPNILELAAYFT------
----------------------------------------ETEKFCLIYP
YMRN----------------------------------------------
--GTLFDRLQCVGDTAP---------------------------------
--------------------------------------------------
-------------------------------------LPWHIRIGILIGI
SKAIHYLHNVQPC---------SVICGSISSANILLDDQ-----------
--------FQPKLTDFAMAHFRSHLEHQ----------------------
--------------------------SCTINMTSSSSKHLWYMPEEYIRQ
--------------------GKL-------SIKTDVYSFGIVIMEVLTGC
RVVL-------DDPKHIQLR------------------DLLRELMEKRGL
DSCL----------------------------------------------
-------------------SFLDKKVPPCPRNFSAKLFCLAGRCAA----
TRAKLRPSM---------DEVLNTL------------------------
>IRAK4
SVGGNKMGEGGFGVVYKGYVNNT---------------------------
---------TVAVKKLAAMVDITTEEL----------------------K
QQFDQEIKVMAKCQ------------------HENLVELLGFSS------
----------------------------------------DGDDLCLVYV
YMPN----------------------------------------------
--GSLLDRLSCLDGTPP---------------------------------
--------------------------------------------------
-------------------------------------LSWHMRCKIAQGA
ANGINFLHEN------------HHIHRDIKSANILLDEA-----------
--------FTAKISDFGLARASEKFAQ-----------------------
---------------------------TVMTSRIVGTT-AYMAPEALR--
--------------------GEI-------TPKSDIYSFGVVLLEIITG-
------------LPAVDEHRE----------------PQLLLDIKEEIED
EEKTI---------------------------------------------
------------------EDYIDKKMNDADSTSVEAMYSGASQCRH----
EKKNKSPDI---------KKVHQLL------------------------
>RIPK1
FLESAELDSGGFGKVSLCFHRTQ---------------------------
--------GLMIMKTVYKGPNCIE------------------------HN
EALLEEAKMMNRLR------------------HSRVVKLLGVII------
----------------------------------------EEGKYSLVME
YMEK----------------------------------------------
--GNLMHVLKAEMS------------------------------------
--------------------------------------------------
-------------------------------------TPLSVKGRIILEI
IEGMCYLHGK------------GVIHKDLKPENILVDND-----------
--------FHIKIADLGLASFKMWSKLNNEEHNEL---------------
-------------------------REVDGTAKKNGGTLYYMAPEHLNDV
N-------------------AKP-------TEKSDVYSFAVVLWAIFAN-
-----------KEPYENAIC-----------------EQQLIMCIKSGN-
--------------------------------------------------
-----------------RPDVDDITEYCP-----REIISLMKLCWE----
ANPEARPTF---------PGIEEKF------------------------
>RIPK2
LADLRYLSRGASGTVSSARHADWR--------------------------
--------VQVAVKHLHIHTPLLD-----------------------SER
KDVLREAEIL----------------------HKARFSYILPILGI----
--------------------------------------CNEPEFLGIVTE
YMPN----------------------------------------------
--GSLNELLHRKTEYPD---------------------------------
--------------------------------------------------
-------------------------------------VAWPLRFRILHEI
ALGVNYLHNMTP----------PLLHHDLKTQNILLDNE-----------
--------FHVKIADFGLSKWRMMSLSQS---------------------
---------------------------RSSKSAPEGGTIIYMPPENYEPG
QK------------------SRA-------SIKHDIYSYAVITWEVLSR-
-----------KQPFEDVTN-----------------PLQIMYSVSQGH-
--------------------------------------------------
-----------------RPVINEESLPYDIPHR-ARMISLIESGWA----
QNPDERPSFL---------------------------------------
>RIPK3
LENQELVGKDGFGTVFRAQHRKWG--------------------------
--------YDVAVKIVNSKAISREV----------------------KAM
ASLDNEFVLRLEGVIE----------------KVNWDQDPKP--------
------------------------------------------ALVTKFME
NGSL----------------------------------------------
--SGLLQSQCP---------------------------------------
--------------------------------------------------
-------------------------------------RPWPLLCRLLKEV
VLGMFYLHDQNP----------VLLHRDLKPSNVLPDPE-----------
--------LHVKLADFGLSTFQGGSQS-----------------------
----------------------------GTGSGEPGGTLGYLAPELFVNV
N-------------------RKA-------STASDVYSFGILMWAVLAGR
EV---------ELPTEP--------------------SLVYEAVCNRQN-
--------------------------------------------------
-----------------RPSLAELPQAGPETPGLEGLKELMQLCWS----
SEPKDRPSFQ-----ECLPKTDEVF------------------------
>ANKRD3
FTGWEKVGSGGFGQVYKVRHVHWK--------------------------
--------TWLAIKCSPSLHVDDRERM-------------------ELLE
EAKKMEMAKFRYI-------------------LPVYGICRE---------
-------------------------------------------PVGLVME
YMET----------------------------------------------
--GSLEKLLASEP-------------------------------------
--------------------------------------------------
-------------------------------------LPWDLRFRIIHET
AVGMNFLHCMAP----------PLLHLDLKPANILLDAH-----------
--------YHVKISDFGLAKCNGLSHSH----------------------
----------------------------DLSMDGLFGTIAYLPPERIREK
S-------------------RLF-------DTKHDVYSFAIVIWGVLTQ-
-----------KKPFADEKN-----------------ILHIMVKVVKGH-
--------------------------------------------------
-----------------RPELPPVCRARPRAC--SHLIRLMQRCWQ----
GDPRVRPTFQ-----EITSETED--------------------------
>SgK288
---WRLVASGGFSQVFQARHRRWR--------------------------
--------TEYAIKCAPCLPPDAAS----------------------SDV
NYLIEEAAKMKKIK------------------FQHIVSIYGVCKQ-----
-------------------------------------------PLGIVME
FMAN----------------------------------------------
--GSLEKVLSTHS-------------------------------------
--------------------------------------------------
-------------------------------------LCWKLRFRIIHET
SLAMNFLHSIKP----------PLLHLDLKPGNILLDSN-----------
--------MHVKISDFGLSKWMEQSTRM----------------------
---------------------------QYIERSALRGMLSYIPPEMFLES
N-------------------KAP-------GPKYDVYSFAIVIWELLTQ-
-----------KKPYSGFNM-----------------MMIIIRVAAGM--
--------------------------------------------------
-----------------RPSLQPVSDQWPSEA--QQMVDLMKRCWD----
QDPKKRPCFL---------------------------------------
>LRRK1
EDEGSVLGQGGSGTVIYRARYQG---------------------------
--------QPVAVKRFHIKKFKNFANVPAD-----TMLRHLRATDAMKNF
SEFRQEASMLHALQ------------------HPCIVALIGISIH-----
-------------------------------------------PLCFALE
LAPL----------------------------------------------
--SSLNTVLSENARDSSFIP------------------------------
--------------------------------------------------
-------------------------------------LGHMLTQKIAYQI
ASGLAYLHKK------------NIIFCDLKSDNILVWSLDVK--------
------EHINIKLSDYGISRQSFH--------------------------
-----------------------------EGALGVEGTPGYQAPEIRPR-
--------------------IVY-------DEKVDMFSYGMVLYELLSG-
-----------QRPALGHHQ-----------------LQIAKKLSKGI--
--------------------------------------------------
-----------------RPVLGQPEEVQF-----RRLQALMMECWD----
TKPEKRPLAL----SVVSQMKDPTF------------------------
>LRRK2
TVHGADHGDGSFGSVYRAAYEG----------------------------
--------EEVAVKIFNKHT----------------------------SL
RLLRQELVVLCHLH------------------HPSLISLLAAGIR-----
-------------------------------------------PRMLVME
LASK----------------------------------------------
--GSLDRLLQQDKAS-----------------------------------
--------------------------------------------------
-------------------------------------LTRTLQHRIALHV
ADGLRYLHSA------------MIIYRDLKPHNVLLFTLYPN--------
------AAIIAKIADYGIAQYCCR--------------------------
-----------------------------MGIKTSEGTPGFRAPEVARGN
--------------------VIY-------NQQADVYSFGLLLYDILTTG
GRIVE------GLKFPNEFD------------------ELEIQGKL----
--------------------------------------------------
-----------------PDPVKEYGCAPWPM-----VEKLIKQCLK----
ENPQERPTSA---------QVFDI-------------------------
>LIMK1
LIHGEVLGKGCFGQAIKVTHRETG--------------------------
--------EVMVMKELIRFDEE--------------------------TQ
RTFLKEVKVMRCLE------------------HPNVLKFIGVLYKD----
------------------------------------------KRLNFITE
YIKG----------------------------------------------
--GTLRGIIKSMDSQ-----------------------------------
--------------------------------------------------
-------------------------------------YPWSQRVSFAKDI
ASGMAYLHSM------------NIIHRDLNSHNCLVREN-----------
--------KNVVVADFGLARLMVDEKTQPEGLRSL---------------
-----------------------KKPDRKKRYTVVGNP-YWMAPEMING-
--------------------RSY-------DEKVDVFSFGIVLCEIIGRV
N----------ADPDYLPRTM----------------DFGLNVRGFL---
--------------------------------------------------
----------------------DRYCPPNCPPS---FFPITVRCCD----
LDPEKRPSFV--------KLEHWL-------------------------
>LIMK2
LIHGEVLGKGFFGQAIKVTHKATG--------------------------
--------KVMVMKELIRCDEE--------------------------TQ
KTFLTEVKVMRSLD------------------HPNVLKFIGVLYKD----
------------------------------------------KKLNLLTE
YIEG----------------------------------------------
--GTLKDFLRSMDP------------------------------------
--------------------------------------------------
-------------------------------------FPWQQKVRFAKGI
ASGMAYLHSM------------CIIHRDLNSHNCLIKLD-----------
--------KTVVVADFGLSRLIVEERKRAPMEKAT---------------
------------------TKKRTLRKNDRKKRYTVVGNPYWMAPEMLNG-
--------------------KSY-------DETVDIFSFGIVLCEIIGQV
Y----------ADPDCLPRTL----------------DFGLNVKLFW---
--------------------------------------------------
----------------------EKFVPTDCPPA---FFPLAAICCR----
LEPESRPAFS--------KLEDSF-------------------------
>TESK1
FHCAEKIGAGFFSEVYKVRHRQSG--------------------------
--------QVMVLKMNKLPSN----------------------------R
GNTLREVQLMNRLR------------------HPNILRFMGVCVHQ----
------------------------------------------GQLHALTE
YMNG----------------------------------------------
--GTLEQLLSSPEP------------------------------------
--------------------------------------------------
-------------------------------------LSWPVRLHLALDI
ARGLRYLHSK------------GVFHRDLTSKNCLVRREDRG--------
--------FTAVVGDFGLAEKIPVYRE-----------------------
--------------------------GARKEPLAVVGSPYWMAPEVLRG-
--------------------ELY-------DEKADVFAFGIVLCELIARV
P----------ADPDYLPRTE----------------DFGLDVPAFR---
--------------------------------------------------
-----------------------TLVGDDCPLP---FLLLAIHCCN----
LEPSTRAPFT----EITQHLEWI--------------------------
>TESK2
----EKIGSGFFSEVFKVRHRASG--------------------------
--------QVMALKMNTLSSN----------------------------R
ANMLKEVQLMNRLS------------------HPNILRYIN---------
---------------------------------------------SGNLE
QLL-----------------------------------------------
-----DSNLH----------------------------------------
--------------------------------------------------
-------------------------------------LPWTVRVKLAYDI
AVGLSYLHFK------------GIFHRDLTSKNCLIKRDENG--------
--------YSAVVADFGLAEKIPDV-------------------------
--------------------------SMGSEKLAVVGSPFWMAPEVLRD-
--------------------EPY-------NEKADVFSYGIILCEIIARI
Q----------ADPDYLPRTE----------------NFGLDYDAFQ---
--------------------------------------------------
------------------------HMVGDCPPD---FLQLTFNCCN----
MDPKLRPSFV--------EIGKTL-------------------------
>HH498
IEFHEIIGSGSFGKVYKGRCRN----------------------------
--------KIVAIKRYRANTYCSKS-----------------------DV
DMFCREVSILCQLN------------------HPCVIQFVGACLND----
-----------------------------------------PSQFAIVTQ
YISG----------------------------------------------
--GSLFSLLHEQKRI-----------------------------------
--------------------------------------------------
-------------------------------------LDLQSKLIIAVDV
AKGMEYLHNLTQ----------PIIHRDLNSHNILLYED-----------
--------GHAVVADFGESRFLQS--------------------------
--------------------------LDEDNMTKQPGNLRWMAPEVFTQC
--------------------TRY-------TIKADVFSYALCLWEILTG-
-----------EIPFAHLK--------------PAAAAADMAYHHI----
--------------------------------------------------
--------------------RPPIGYSIPKP-----ISSLLIRGWN----
ACPEGRPEFS----EVVMKLEECL-------------------------
>TAK1
IEVEEVVGRGAFGVVCKAKWRA----------------------------
--------KDVAIKQIES----------------------------ESER
KAFIVELRQLSRVN------------------HPNIVKLYGACLN-----
-------------------------------------------PVCLVME
YAEG----------------------------------------------
--GSLYNVLHGAEPLP----------------------------------
--------------------------------------------------
------------------------------------YYTAAHAMSWCLQC
SQGVAYLHSMQPK---------ALIHRDLKPPNLLLVAG-----------
-------GTVLKICDFGTACDI----------------------------
----------------------------QTHMTNNKGSAAWMAPEVFEG-
--------------------SNY-------SEKCDVFSWGIILWEVITR-
-----------RKPFDEIG--------------GPAFRIMWAVHNGT---
--------------------------------------------------
--------------------RPPLIKNLPKP-----IESLMTRCWS----
KDPSQRPSME---------EIVKI-------------------------
>ILK
LNFLTKLNENHSGELWKGRWQGND--------------------------
-------IVVKVLKVRDW---------------------------STRKS
RDFNEECPRLRIFS------------------HPNVLPVLGACQSP----
----------------------------------------PAPHPTLITH
WMPY----------------------------------------------
--GSLYNVLHEGTNFV----------------------------------
--------------------------------------------------
-------------------------------------VDQSQAVKFALDM
ARGMAFLHTLEP----------LIPRHALNSRSVMIDEDMT---------
--------ARISMADVKFSFQC----------------------------
------------------------------PGRMYA--PAWVAPEALQKK
PE------------------DTN-------RRSADMWSFAVLLWELVTR-
-----------EVPFADLS-------------------NMEIGMKVAL--
--------------------------------------------------
-----------------EGLRPTIPPGISPH-----VCKLMKICMN----
EDPAKRPKFD------MIVPILEKM------------------------
>KSR1
VELGEPIGQGRWGRVHRGRWHG----------------------------
---------EVAIRLLEMDGH------------------------NQDHL
KLFKKEVMNYRQTR------------------HENVVLFMGACMN-----
-----------------------------------------PPHLAIITS
FCKG----------------------------------------------
--RTLHSFVRDPKTS-----------------------------------
--------------------------------------------------
-------------------------------------LDINKTRQIAQEI
IKGMGYLHAK------------GIVHKDLKSKNVFYDN------------
--------GKVVITDFGLFGISGVVREG----------------------
--------------------------RRENQLKLSHDWLCYLAPEIVREM
TPGKDEDQ------------LPF-------SKAADVYAFGTVWYELQAR-
-----------DWPLKNQA------------------AEASIWQIGSG--
--------------------------------------------------
----------------EGMKRVLTSVSLGKE-----VSEILSACWA----
FDLQERPSFS---------LLMDM-------------------------
>KSR2
LEIGELIGKGRFGQVYHGRWHG----------------------------
---------EVAIRLIDIERD------------------------NEDQL
KAFKREVMAYRQTR------------------HENVVLFMGACMS-----
-----------------------------------------PPHLAIITS
LCKG----------------------------------------------
--RTLYSVVRDAKIV-----------------------------------
--------------------------------------------------
-------------------------------------LDVNKTRQIAQEI
VKGMGYLHAK------------GILHKDLKSKNVFYDN------------
--------GKVVITDFGLFSISGVLQAG----------------------
--------------------------RREDKLRIQNGWLCHLAPEIIRQL
SPDTEEDK------------LPF-------SKHSDVFALGTIWYELHAR-
-----------EWPFKTQP------------------AEAIIWQMGTG--
--------------------------------------------------
------------------MKPNLSQIGMGKE-----ISDILLFCWA----
FEQEERPTFT---------KLMDM-------------------------
>ARAF
VQLLKRIGTGSFGTVFRGRWHG----------------------------
---------DVAVKVLKVSQP------------------------TAEQA
QAFKNEMQVLRKTR------------------HVNILLFMGFMT------
-----------------------------------------RPGFAIITQ
WCEG----------------------------------------------
--SSLYHHLHVADTR-----------------------------------
--------------------------------------------------
-------------------------------------FDMVQLIDVARQT
AQGMDYLHAK------------NIIHRDLKSNNIFLHEG-----------
--------LTVKIGDFGLATVKTRWS------------------------
---------------------------GAQPLEQPSGSVLWMAAEVIRMQ
DP------------------NPY-------SFQSDVYAYGVVLYELMTG-
-----------SLPYSHIG-----------------CRDQIIFMVGRG--
--------------------------------------------------
-----------------YLSPDLSKISSNCPKA---MRRLLSDCLK----
FQREERPLFP---------QILATI------------------------
>RAF1
VMLSTRIGSGSFGTVYKGKWHG----------------------------
---------DVAVKILKVVDP------------------------TPEQF
QAFRNEVAVLRKTR------------------HVNILLFMGYMT------
-----------------------------------------KDNLAIVTQ
WCEG----------------------------------------------
--SSLYKHLHVQETK-----------------------------------
--------------------------------------------------
-------------------------------------FQMFQLIDIARQT
AQGMDYLHAK------------NIIHRDMKSNNIFLHEG-----------
--------LTVKIGDFGLATVKSRWS------------------------
---------------------------GSQQVEQPTGSVLWMAPEVIRMQ
DN------------------NPF-------SFQSDVYSYGIVLYELMTG-
-----------ELPYSHIN-----------------NRDQIIFMVGRG--
--------------------------------------------------
-----------------YASPDLSKLYKNCPKA---MKRLVADCVK----
KVKEERPLFP-------QILSSIEL------------------------
>BRAF
ITVGQRIGSGSFGTVYKGKWHG----------------------------
---------DVAVKMLNVTAP------------------------TPQQL
QAFKNEVGVLRKTR------------------HVNILLFMGYST------
-----------------------------------------KPQLAIVTQ
WCEG----------------------------------------------
--SSLYHHLHIIETK-----------------------------------
--------------------------------------------------
-------------------------------------FEMIKLIDIARQT
AQGMDYLHAK------------SIIHRDLKSNNIFLHED-----------
--------LTVKIGDFGLATVKSRWS------------------------
---------------------------GSHQFEQLSGSILWMAPEVIRMQ
DK------------------NPY-------SFQSDVYAFGIVLYELMTG-
-----------QLPYSNIN-----------------NRDQIIFMVGRG--
--------------------------------------------------
-----------------YLSPDLSKVRSNCPKA---MKRLMAECLK----
KKRDERPLFP-------QILASIEL------------------------
>ZAK
LQFFENCGGGSFGSVYRAKWIS----------------------------
------QDKEVAVKKLL---------------------------------
-KIEKEAEILSVLS------------------HRNIIQFYGVILE-----
-----------------------------------------PPNYGIVTE
YASL----------------------------------------------
--GSLYDYINSNRSEE----------------------------------
--------------------------------------------------
-------------------------------------MDMDHIMTWATDV
AKGMHYLHMEAPV---------KVIHRDLKSRNVVIAAD-----------
--------GVLKICDFGASRFHN---------------------------
----------------------------HTTHMSLVGTFPWMAPEVIQS-
--------------------LPV-------SETCDTYSYGVVLWEMLTR-
-----------EVPFKGL--------------------EGLQVAWLVVEK
--------------------------------------------------
--------------------NERLTIPSSCPRS---FAELLHQCWE----
ADAKKRPSFK---------QIISI-------------------------
>LZK
ISELQWLGSGAQGAVFLGKFRA----------------------------
--------EEVAIKKV----------------------------------
-REQNETDIKHLRKLK----------------HPNIIAFKGVCTQ-----
-----------------------------------------APCYCIIME
YCAH----------------------------------------------
--GQLYEVLRAGRK------------------------------------
--------------------------------------------------
-------------------------------------ITPRLLVDWSTGI
ASGMNYLHLH------------KIIHRDLKSPNVLVTHT-----------
--------DAVKISDFGTSKELSD--------------------------
----------------------------KSTKMSFAGTVAWMAPEVIRN-
--------------------EPV-------SEKVDIWSFGVVLWELLTG-
-----------EIPYKDV--------------------DSSAIIWGVGSN
--------------------------------------------------
--------------------SLHLPVPSTCPDG---FKILMKQTWQ----
SKPRNRPSFR---------QTLMHL------------------------
>DLK
ILDLQWVGSGAQGAVFLGRFHG----------------------------
--------EEVAVKKV----------------------------------
-RDLKETDIKHLRKLK----------------HPNIITFKGVCTQ-----
-----------------------------------------APCYCILME
FCAQ----------------------------------------------
--GQLYEVLRAGRP------------------------------------
--------------------------------------------------
-------------------------------------VTPSLLVDWSMGI
AGGMNYLHLH------------KIIHRDLKSPNMLITYD-----------
--------DVVKISDFGTSKELSD--------------------------
----------------------------KSTKMSFAGTVAWMAPEVIRN-
--------------------EPV-------SEKVDIWSFGVVLWELLTG-
-----------EIPYKDV--------------------DSSAIIWGVGSN
--------------------------------------------------
--------------------SLHLPVPSSCPDG---FKILLRQCWN----
SKPRNRPSFR---------QILLHL------------------------
>MLK1
LTLEEIIGIGGFGKVYRAFWIG----------------------------
--------DEVAVKAARHDPDED----------------------ISQTI
ENVRQEAKLFAMLK------------------HPNIIALRGVCLK-----
-----------------------------------------EPNLCLVME
FARG----------------------------------------------
--GPLNRVLSGKRI------------------------------------
--------------------------------------------------
--------------------------------------PPDILVNWAVQI
ARGMNYLHDEAIV---------PIIHRDLKSSNILILQKVENG-------
----DLSNKILKITDFGLAREWH---------------------------
----------------------------RTTKMSAAGTYAWMAPEVIRA-
--------------------SMF-------SKGSDVWSYGVLLWELLTG-
-----------EVPFRGI--------------------DGLAVAYGVAMN
--------------------------------------------------
--------------------KLALPIPSTCPEP---FAKLMEDCWN----
PDPHSRPSFT---------NILDQL------------------------
>MLK2
LQLEEIIGVGGFGKVYRALWRG----------------------------
--------EEVAVKAARLDPEKD----------------------PAVTA
EQVCQEARLFGALQ------------------HPNIIALRGACLN-----
-----------------------------------------PPHLCLVME
YARG----------------------------------------------
--GALSRVLAGRRV------------------------------------
--------------------------------------------------
--------------------------------------PPHVLVNWAVQV
ARGMNYLHNDAPV---------PIIHRDLKSINILILEAIENH-------
----NLADTVLKITDFGLAREWH---------------------------
----------------------------KTTKMSAAGTYAWMAPEVIRL-
--------------------SLF-------SKSSDVWSFGVLLWELLTG-
-----------EVPYREI--------------------DALAVAYGVAMN
--------------------------------------------------
--------------------KLTLPIPSTCPEP---FARLLEECWD----
PDPHGRPDFG------SILKRLEVI------------------------
>MLK3
LRLEEVIGIGGFGKVYRGSWRG----------------------------
--------ELVAVKAARQDPDED----------------------ISVTA
ESVRQEARLFAMLA------------------HPNIIALKAVCLE-----
-----------------------------------------EPNLCLVME
YAAG----------------------------------------------
--GPLSRALAGRRV------------------------------------
--------------------------------------------------
--------------------------------------PPHVLVNWAVQI
ARGMHYLHCEALV---------PVIHRDLKSNNILLLQPIESD-------
----DMEHKTLKITDFGLAREWH---------------------------
----------------------------KTTQMSAAGTYAWMAPEVIKA-
--------------------STF-------SKGSDVWSFGVLLWELLTG-
-----------EVPYRGI--------------------DCLAVAYGVAVN
--------------------------------------------------
--------------------KLTLPIPSTCPEP---FAQLMADCWA----
QDPHRRPDF---------ASILQQL------------------------
>MLK4
LELKELIGAGGFGQVYRATWQG----------------------------
--------QEVAVKAARQDPEQD----------------------AAAAA
ESVRREARLFAMLR------------------HPNIIELRGVCLQ-----
-----------------------------------------QPHLCLVLE
FARG----------------------------------------------
--GALNRALAAANAAPDPRAP-----------------------------
--------------------------------------------------
------------------------------GPRRARRIPPHVLVNWAVQI
ARGMLYLHEEAFV---------PILHRDLKSSNILLLEKIEHD-------
----DICNKTLKITDFGLAREWH---------------------------
----------------------------RTTKMSTAGTYAWMAPEVIKS-
--------------------SLF-------SKGSDIWSYGVLLWELLTG-
-----------EVPYRGI--------------------DGLAVAYGVAVN
--------------------------------------------------
--------------------KLTLPIPSTCPEP---FAKLMKECWQ----
QDPHIRPSF---------ALILEQL------------------------
>ALK4
IVLQEIIGKGRFGEVWRGRWRG----------------------------
--------GDVAVKIFSSRE-----------------------------E
RSWFREAEIYQTVMLR----------------HENILGFIAADNKD----
--------------------------------------NGTWTQLWLVSD
YHEH----------------------------------------------
--GSLFDYLNRYTV------------------------------------
--------------------------------------------------
--------------------------------------TIEGMIKLALSA
ASGLAHLHMEIVGT---Q-GKPGIAHRDLKSKNILVKKN-----------
--------GMCAIADLGLAVRHDAVTD-----------------------
--------------------------TIDIAPNQRVGTKRYMAPEVLDET
INMKHF--------------DSF--------KCADIYALGLVYWEIARRC
NSGG--VHEEYQLPYYDLVPS-------------DPSIEEMRKVVCDQ--
--------------------------------------------------
------------------KLRPNIPNWWQSYEALRVMGKMMRECWY----
ANGAARLTA---------LRIKKTL------------------------
>TGFbR1
IVLQESIGKGRFGEVWRGKWRG----------------------------
--------EEVAVKIFSSRE-----------------------------E
RSWFREAEIYQTVMLR----------------HENILGFIAADNKD----
--------------------------------------NGTWTQLWLVSD
YHEH----------------------------------------------
--GSLFDYLNRYTV------------------------------------
--------------------------------------------------
--------------------------------------TVEGMIKLALST
ASGLAHLHMEIVGT---Q-GKPAIAHRDLKSKNILVKKN-----------
--------GTCCIADLGLAVRHDSATD-----------------------
--------------------------TIDIAPNHRVGTKRYMAPEVLDDS
INMKHF--------------ESF--------KRADIYAMGLVFWEIARRC
SIGG--IHEDYQLPYYDLVPS-------------DPSVEEMRKVVCEQ--
--------------------------------------------------
------------------KLRPNIPNRWQSCEALRVMAKIMRECWY----
ANGAARLTA---------LRIKKTL------------------------
>ALK7
IVLQEIVGKGRFGEVWHGRWCG----------------------------
--------EDVAVKIFSSRD-----------------------------E
RSWFREAEIYQTVMLR----------------HENILGFIAADNKD----
--------------------------------------NGTWTQLWLVSE
YHEQ----------------------------------------------
--GSLYDYLNRNIV------------------------------------
--------------------------------------------------
--------------------------------------TVAGMIKLALSI
ASGLAHLHMEIVGT---Q-GKPAIAHRDIKSKNILVKKC-----------
--------ETCAIADLGLAVKHDSILN-----------------------
--------------------------TIDIPQNPKVGTKRYMAPEMLDDT
MNVNIF--------------ESF--------KRADIYSVGLVYWEIARRC
SVGG--IVEEYQLPYYDMVPS-------------DPSIEEMRKVVCDQ--
--------------------------------------------------
------------------KFRPSIPNQWQSCEALRVMGRIMRECWY----
ANGAARLTA---------LRIKKTI------------------------
>BMPR1A
IQMVRQVGKGRYGEVWMGKWRG----------------------------
--------EKVAVKVFFTTE-----------------------------E
ASWFRETEIYQTVLMR----------------HENILGFIAADIKG----
--------------------------------------TGSWTQLYLITD
YHEN----------------------------------------------
--GSLYDFLKCATL------------------------------------
--------------------------------------------------
--------------------------------------DTRALLKLAYSA
ACGLCHLHTEIYGT---Q-GKPAIAHRDLKSKNILIKKN-----------
--------GSCCIADLGLAVKFNSDTN-----------------------
--------------------------EVDVPLNTRVGTKRYMAPEVLDES
LNKNHF--------------QPY--------IMADIYSFGLIIWEMARRC
ITGG--IVEEYQLPYYNMVPS-------------DPSYEDMREVVCVK--
--------------------------------------------------
------------------RLRPIVSNRWNSDECLRAVLKLMSECWA----
HNPASRLTA---------LRIKKTL------------------------
>BMPR1B
IQMVKQIGKGRYGEVWMGKWRG----------------------------
--------EKVAVKVFFTTE-----------------------------E
ASWFRETEIYQTVLMR----------------HENILGFIAADIKG----
--------------------------------------TGSWTQLYLITD
YHEN----------------------------------------------
--GSLYDYLKSTTL------------------------------------
--------------------------------------------------
--------------------------------------DAKSMLKLAYSS
VSGLCHLHTEIFST---Q-GKPAIAHRDLKSKNILVKKN-----------
--------GTCCIADLGLAVKFISDTN-----------------------
--------------------------EVDIPPNTRVGTKRYMPPEVLDES
LNRNHF--------------QSY--------IMADMYSFGLILWEVARRC
VSGG--IVEEYQLPYHDLVPS-------------DPSYEDMREIVCIK--
--------------------------------------------------
------------------KLRPSFPNRWSSDECLRQMGKLMTECWA----
HNPASRLTA---------LRVKKTL------------------------
>ALK1
VALVECVGKGRYGEVWRGLWHG----------------------------
--------ESVAVKIFSSRD-----------------------------E
QSWFRETEIYNTVLLR----------------HDNILGFIASDMTS----
--------------------------------------RNSSTQLWLITH
YHEH----------------------------------------------
--GSLYDFLQRQTL------------------------------------
--------------------------------------------------
--------------------------------------EPHLALRLAVSA
ACGLAHLHVEIFGT---Q-GKPAIAHRDFKSRNVLVKSN-----------
--------LQCCIADLGLAVMHSQGSD-----------------------
--------------------------YLDIGNNPRVGTKRYMAPEVLDEQ
IRTDCF--------------ESY--------KWTDIWAFGLVLWEIARRT
IVNG--IVEDYRPPFYDVVPN-------------DPSFEDMKKVVCVD--
--------------------------------------------------
------------------QQTPTIPNRLAADPVLSGLAQMMRECWY----
PNPSARLTA---------LRIKKTL------------------------
>ALK2
ITLLECVGKGRYGEVWRGSWQG----------------------------
--------ENVAVKIFSSRD-----------------------------E
KSWFRETELYNTVMLR----------------HENILGFIASDMTS----
--------------------------------------RHSSTQLWLITH
YHEM----------------------------------------------
--GSLYDYLQLTTL------------------------------------
--------------------------------------------------
--------------------------------------DTVSCLRIVLSI
ASGLAHLHIEIFGT---Q-GKPAIAHRDLKSKNILVKKN-----------
--------GQCCIADLGLAVMHSQSTN-----------------------
--------------------------QLDVGNNPRVGTKRYMAPEVLDET
IQVDCF--------------DSY--------KRVDIWAFGLVLWEVARRM
VSNG--IVEDYKPPFYDVVPN-------------DPSFEDMRKVVCVD--
--------------------------------------------------
------------------QQRPNIPNRWFSDPTLTSLAKLMKECWY----
QNPSARLTA---------LRIKKTL------------------------
>ACTR2
LQLLEVKARGRFGCVWKAQLLN----------------------------
--------EYVAVKIFPIQD-----------------------------K
QSWQNEYEVYSLPGMK----------------HENILQFIGAEKRG----
--------------------------------------TSVDVDLWLITA
FHEK----------------------------------------------
--GSLSDFLKANVV------------------------------------
--------------------------------------------------
--------------------------------------SWNELCHIAETM
ARGLAYLHEDIPGLKD-G-HKPAISHRDIKSKNVLLKNN-----------
--------LTACIADFGLALKFEAGKS-----------------------
----------------------------AGDTHGQVGTRRYMAPEVLEGA
INFQR---------------DAF--------LRIDMYAMGLVLWELASRC
TAAD-GPVDEYMLPFEEEIGQ-------------HPSLEDMQEVVVHK--
--------------------------------------------------
------------------KKRPVLRDYWQKHAGMAMLCETIEECWD----
HDAEARLSA----------------------------------------
>ACTR2B
LQLLEIKARGRFGCVWKAQLMN----------------------------
--------DFVAVKIFPLQD-----------------------------K
QSWQSEREIFSTPGMK----------------HENLLQFIAAEKRG----
--------------------------------------SNLEVELWLITA
FHDK----------------------------------------------
--GSLTDYLKGNII------------------------------------
--------------------------------------------------
--------------------------------------TWNELCHVAETM
SRGLSYLHEDVPWCRGEG-HKPSIAHRDFKSKNVLLKSD-----------
--------LTAVLADFGLAVRFEPGKP-----------------------
----------------------------PGDTHGQVGTRRYMAPEVLEGA
INFQR---------------DAF--------LRIDMYAMGLVLWELVSRC
KAAD-GPVDEYMLPFEEEIGQ-------------HPSLEELQEVVVHK--
--------------------------------------------------
------------------KMRPTIKDHWLKHPGLAQLCVTIEECWD----
HDAEARLSA-------GCVEERVSL------------------------
>TGFbR2
IELDTLVGKGRFAEVYKAKLKQNTSE------------------------
------QFETVAVKIFPYEE-----------------------------Y
ASWKTEKDIFSDINLK----------------HENILQFLTAEERK----
--------------------------------------TELGKQYWLITA
FHAK----------------------------------------------
--GNLQEYLTRHVI------------------------------------
--------------------------------------------------
--------------------------------------SWEDLRKLGSSL
ARGIAHLHSDHTPCG--R-PKMPIVHRDLNSSNILVKND-----------
--------LTCCLCDFGLSLRLDPTLS-----------------------
--------------------------VDDLANSGQVGTARYMAPEVLESR
MNLENA--------------ESF--------KQTDVYSMALVLWEMTSRC
NAVG--EVKDYEPPFGSKVRE-------------HPCVESMKDNVLRD--
--------------------------------------------------
------------------RGRPEIPSFWLNHQGIQMVCETLTECWD----
HDPEARLTA-------QCVAERFS-------------------------
>MISR2
LCFSQVIREGGHAVVWAGQLQG----------------------------
--------KLVAIKAFPPRS-----------------------------V
AQFQAERALYELPGLQ----------------HDHIVRFITASRGG----
-------------------------------------PGRLLSGPLLVLE
LHPK----------------------------------------------
--GSLCHYLTQYTS------------------------------------
--------------------------------------------------
--------------------------------------DWGSSLRMALSL
AQGLAFLHEERWQNG--Q-YKPGIAHRDLSSQNVLIRED-----------
--------GSCAIGDLGLALVLPGLTQPPAWTPTQ---------------
--------------------------PQGPAAIMEAGTQRYMAPELLDKT
LDLQDWG-------------MAL--------RRADIYSLALLLWEILSRC
PDL---RPDSSPPPFQLAYEAELGN---------TPTSDELWALAVQE--
--------------------------------------------------
-----------------RRRPYIPSTWRCFATDPDGLRELLEDCWD----
ADPEARLTAECVQQRLAALAHPQE-------------------------
>BMPR2
LKLLELIGRGRYGAVYKGSLDE----------------------------
--------RPVAVKVFSFAN-----------------------------R
QNFINEKNIYRVPLME----------------HDNIARFIVGDERV----
-------------------------------------TADGRMEYLLVME
YYPN----------------------------------------------
--GSLCKYLSLHTS------------------------------------
--------------------------------------------------
--------------------------------------DWVSSCRLAHSV
TRGLAYLHTELPRGD--H-YKPAISHRDLNSRNVLVKND-----------
--------GTCVISDFGLSMRLTGNRLVRPGE------------------
---------------------------EDNAAISEVGTIRYMAPEVLEGA
VNLRDCE-------------SAL--------KQVDMYALGLIYWEIFMRC
TDL---FPGESVPEYQMAFQTEVGN---------HPTFEDMQVLVSRE--
--------------------------------------------------
-----------------KQRPKFPEAWKENSLAVRSLKETIEDCWD----
QDAEARLTAQCAEERMAELMMIWE-------------------------
>ANPa
-------GRGSNYGSLLTTEGQFQVFAKTA--------------------
----YYKGNLVAVKRVNRKRIEL--------------------------T
RKVLFELKHMRDVQ------------------NEHLTRFVGACTD-----
-----------------------------------------PPNICILTE
YCPR----------------------------------------------
--GSLQDILENESITL----------------------------------
--------------------------------------------------
--------------------------------------DWMFRYSLTNDI
VKGMLFLHNGA-----------ICSHGNLKSSNCVVDGR-----------
--------FVLKITDYGLESFR----------------------------
-------------------------DLDPEQGHTVYAKKLWTAPELLRMA
SPP-----------------VRG-------SQAGDVYSFGIILQEIALR-
-----------SGVFHVEGLDLS--------------PKEIIERVTRG--
--------------------------------------------------
-------------------EQPPFRPSLALQSHLEELGLLMQRCWA----
EDPQERPPF----QQIRLTLRK---------------------------
>ANPb
-----LRGSSYGSLMTAHGKYQIFANTG----------------------
----HFKGNVVAIKHVNKKRIEL--------------------------T
RQVLFELKHMRDVQ------------------FNHLTRFIGACID-----
-----------------------------------------PPNICIVTE
YCPR----------------------------------------------
--GSLQDILENDSINL----------------------------------
--------------------------------------------------
--------------------------------------DWMFRYSLINDL
VKGMAFLHNSI-----------ISSHGSLKSSNCVVDSR-----------
--------FVLKITDYGLASFR----------------------------
------------------------STAEPDDSHALYAKKLWTAPELLSGN
PLP-----------------TTG-------MQKADVYSFGIILQEIALR-
-----------SGPFYLEGLDLS--------------PKEIVQKVRNG--
--------------------------------------------------
-------------------QRPYFRPSIDRTQLNEELVLLMERCWA----
QDPAERPDF----GQIKGFIRR---------------------------
>HSER
------------LKIDDDKRRDTIQRLRQC--------------------
----KYDKKRVILKDLKHNDGNF--------------------------T
EKQKIELNKLLQID------------------YYNLTKFYGTVKL-----
-----------------------------------------DTMIFGVIE
YCER----------------------------------------------
--GSLREVLNDTISY-----------------------------------
--------------------------------------------------
--------------------------------PDGTFMDWEFKISVLYDI
AKGMSYLHSSK-----------TEVHGRLKSTNCVVDSR-----------
--------MVVKITDFGCN-------------------------------
-------------------------------SILPPKKDLWTAPEHLRQ-
--------------------ANI-------SQKGDVYSYGIIAQEIILR-
-----------KETFYTLSCRDR--------------NEKIFRVENS---
--------------------------------------------------
---------------NGMKPFRPDLFLETAEEKELEVYLLVKNCWE----
EDPEKRPDFKKI--ETTLAKIFGLFHDQKNESYM---------------
>CYGD
ARSMSDIRSGPSQHLDSPNIGVYEGDRVWL--------------------
--KKFPGDQHIAIRPATKTAFS--------------------------KL
QELRHENVALYLGL------------------FLARGAEGPAALW-----
-----------------------------------------EGNLAVVSE
HCTR----------------------------------------------
--GSLQDLLAQREIK-----------------------------------
--------------------------------------------------
-------------------------------------LDWMFKSSLLLDL
IKGIRYLHHR------------GVAHGRLKSRNCIVDGR-----------
--------FVLKITDHGHGRLLEAQK------------------------
----------------------------VLPEPPRAEDQLWTAPELLRDP
ALE-----------------RRG-------TLAGDVFSLAIIMQEVVCR-
-----------SAPYAMLELT----------------PEEVVQRVRS---
--------------------------------------------------
-------------------PPPLCRPLVSMDQAPVECILLMKQCWA----
EQPELRPSM--------DHTFDLFK------------------------
>CYGF
FQITSEVQSGRSPRLSFSSGSLTPATYENS--------------------
-NIAIYEGDWVWLKKFSLGDF-------------------------GDLK
SIKSRASDVFEMMKDLR---------------HENINPLLGFFYD-----
-----------------------------------------SGMFAIVTE
FCSR----------------------------------------------
--GSLEDILTNQDVK-----------------------------------
--------------------------------------------------
-------------------------------------LDWMFKSSLLLDL
IKGMKYLHHR------------EFVHGRLKSRNCVVDGR-----------
--------FVLKVTDYGFNDILEMLR------------------------
----------------------------LSEEESSMEELLWTAPELLRAP
RGS-----------------RLG-------SFAGDVYSFAIIMQEVMVR-
-----------GTPFCMMDLP----------------AQEIINRLKK---
--------------------------------------------------
-------------------PPPVYRPVVPPEHAPPECLQLMKQCWA----
EAAEQRPTF--------DEIFNQFKT-----------------------
>SgK307
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
-------------------------------------QQRSQFPVLHMEV
IVHLLLQIS------------DALRYLHFQGFIHRSLSS-----------
------YAVHIISPGEARLTNLEYMLESEDRGVQR---------------
---------------------------DLTRVPLPTQLYNWAAPEVILQ-
--------------------KAA-------TVKSDIYSFSMIMQEILTD-
-----------DIPWKGLDG------------------SVVKKAVVSGNY
--------------------------------------------------
---------------LEADVRLPKPYYDIVKSG---IHVKQKDRTM----
NLQDIRYIL---KNDLKASPEVDFT------------------------
>SgK424
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
---------------------------------------------LIC--
--------------------GDM------PTTTSDLYSFCILIQEVFTG-
-----------ELPWAGRGG------------------PEVKAKLEAGE-
--------------------------------------------------
-------------------------SPALEPRVPAPYQALIRAGLG----
LAPADRWG------SL---------------------------------
>NRBP1
-NQRNVPGIDSAYLAMDTEEG-----------------------------
--------VEVVWNEVQFSERK---------------------------N
YKLQEEKVRAVFDNLIQ-------------LEHLNIVKFHKYWADIK---
---------------------------------------ENKARVIFITE
YMSS----------------------------------------------
--GSLKQFLKKTKKNHKTMN------------------------------
--------------------------------------------------
---------------------------------------EKAWKRWCTQI
LSALSYLHSCDP----------PIIHGNLTCDTIFIQHN-----------
--------GLIKIGSVAPDTINN---------------------------
---------------------------HVKTCREEQKNLHFFAPEYGEV-
--------------------TNV-------TTAVDIYSFGMCALEMAVL-
-----------EIQGNGES------------------SYVPQEAISSA--
--------------------------------------------------
-------------------------IQLLEDPL---QREFIQKCLQ----
SEPARRP------TARELLFHPALF------------------------
>NRBP2
-NQGNMPGLQSTFLAMDTEEG-----------------------------
--------VEVVWNELHFGDRK---------------------------A
FAAHEEKIQTVFEQLVL-------------VDHPNIVKLHKYWLDTS---
---------------------------------------EACARVIFITE
YVSS----------------------------------------------
--GSLKQFLKKTKKNHKAMN------------------------------
--------------------------------------------------
---------------------------------------ARAWKRWCTQI
LSALSFLHACSP----------PIIHGNLTSDTIFIQHN-----------
--------GLIKIGSVWHRIFSNALRPPTALPDDL---------------
-------------------------RSPIRAEREELRNLHFFPPEYGE--
--------------------VAD-------GTAVDIFSFGMCALEMAVL-
-----------EIQTNGD-------------------TRVTEEAIARA--
--------------------------------------------------
-------------------------RHSLSDPN---MREFILCCLA----
RDPARRP------SAHSLLFHRVLF------------------------
>Wnk1
LKFDIEIGRGSFKTVYKGLDTET---------------------------
-------TVEVAWCELQDRKLTKS-------------------------E
RQRFKEEAEMLKGLQ-----------------HPNIVRFYDSWESTV---
---------------------------------------KGKKCIVLVTE
LMTS----------------------------------------------
--GTLKTYLKRFKVMK----------------------------------
--------------------------------------------------
---------------------------------------IKVLRSWCRQI
LKGLQFLHTRTP----------PIIHRDLKCDNIFITGPT----------
--------GSVKIGDLGLATLK----------------------------
---------------------------RASFAKSVIGTPEFMAPEMYE--
--------------------EKY-------DESVDVYAFGMCMLEMATS-
-----------EYPYSECQN-----------------AAQIYRRVTSGV-
--------------------------------------------------
---------------------KPASFDKVAIPE---VKEIIEGCIR----
QNKDERY-------SIKDLLNHAFF------------------------
>Wnk2
LKFDIELGRGSFKTVYKGLDTET---------------------------
-------WVEVAWCELQDRKLTKL-------------------------E
RQRFKEEAEMLKGLQ-----------------HPNIVRFYDFWESSA---
---------------------------------------KGKRCIVLVTE
LMTS----------------------------------------------
--GTLKTYLKRFKVMK----------------------------------
--------------------------------------------------
---------------------------------------PKVLRSWCRQI
LKGLLFLHTRTP----------PIIHRDLKCDNIFITGPT----------
--------GSVKIGDLGLATLK----------------------------
---------------------------RASFAKSVIGTPEFMAPEMYE--
--------------------EHY-------DESVDVYAFGMCMLEMATS-
-----------EYPYSECQN-----------------AAQIYRKVTCGI-
--------------------------------------------------
---------------------KPASFEKVHDPE---IKEIIGECIC----
KNKEERY-------EIKDLLSHAFF------------------------
>Wnk3
LKFDIELGRGAFKTVYKGLDTET---------------------------
-------WVEVAWCELQDRKLTKA-------------------------E
QQRFKEEAEMLKGLQ-----------------HPNIVRFYDSWESIL---
---------------------------------------KGKKCIVLVTE
LMTS----------------------------------------------
--GTLKTYLKRFKVMK----------------------------------
--------------------------------------------------
---------------------------------------PKVLRSWCRQI
LKGLQFLHTRTP----------PIIHRDLKCDNIFITGPT----------
--------GSVKIGDLGLATLM----------------------------
---------------------------RTSFAKSVIGTPEFMAPEMYE--
--------------------EHY-------DESVDVYAFGMCMLEMATS-
-----------EYPYSECQN-----------------AAQIYRKVTSGI-
--------------------------------------------------
---------------------KPASFNKVTDPE---VKEIIEGCIR----
QNKSERL-------SIRDLLNHAFF------------------------
>Wnk4
LKFDIEIGRGSFKTVYRGLDTDT---------------------------
-------TVEVAWCELQTRKLSRA-------------------------E
RQRFSEEVEMLKGLQ-----------------HPNIVRFYDSWKSVL---
---------------------------------------RGQVCIVLVTE
LMTS----------------------------------------------
--GTLKTYLRRFREMK----------------------------------
--------------------------------------------------
---------------------------------------PRVLQRWSRQI
LRGLHFLHSRVP----------PILHRDLKCDNVFITGPT----------
--------GSVKIGDLGLATLK----------------------------
---------------------------RASFAKSVIGTPEFMAPEMYE--
--------------------EKY-------DEAVDVYAFGMCMLEMATS-
-----------EYPYSECQN-----------------AAQIYRKVTSGR-
--------------------------------------------------
---------------------KPNSFHKVKIPE---VKEIIEGCIR----
TDKNERF-------TIQDLLAHAFF------------------------
>NIK
ATHQLRLGRGSFGEVHRMEDKQ----------------------------
------TGFQCAVKKVRL-------------------------------E
VFRAEELMACAGLT------------------SPRIVPLYGAVRE-----
-----------------------------------------GPWVNIFME
LLEG----------------------------------------------
--GSLGQLVKEQGC------------------------------------
--------------------------------------------------
-------------------------------------LPEDRALYYLGQA
LEGLEYLHSR------------RILHGDVKADNVLLSSDG----------
--------SHAALCDFGHAVCLQPDGLGK---------------------
---------------------------SLLTGDYIPGTETHMAPEVVLG-
--------------------RSC-------DAKVDVWSSCCMMLHMLNG-
-----------CHPWTQFFR----------------GPLCLKIASE----
--------------------------------------------------
-------PPPVREIPPSCAPLTAQAIQEGLRKE---PIHRVSAAEL----
GGKVNRA-------LQQVGGLKSPWR-----------------------
>GCN2-b
----VHKGKCIGSDEQLG--------------------------------
---------KLVYNALETATG----------------------------G
FVLLYEWVLQWQKKM-----------------GPFLTSQEKEKIDK----
-----------------------------------------CKKQIQGTE
TEF-----------------------------------------------
--NSLVKLSHPNVVRYLAMNLKEQDDS-----------------------
--------------------------------------------------
-------------------------------------IVVDILVEHISGV
SLAAHLSHSGP-----------IPVHQLRRYTAQLL--------------
--------SGLDYLHSNSVVHKVLS-------------------------
---------------------------ASNVLVDAEGTVKITDYSISKR-
--------------------LAD-------ICKEDVFEQTRVRFSDN---
-----------ALPYKTGKKG------------DRLGLLLLSLSQG----
--------------------------------------------------
----------------QECGEYPVTIPSDLPAD---FQDFLKKCVC----
LDDKERW-------SPQQLLKHSFI------------------------
>COT
NIGSDFIPRGAFGKVYLAQDIK----------------------------
------TKKRMACKLIPVDQ-----------------------------F
KPSDVEIQACFR--------------------HENIAELYGAVLW-----
-----------------------------------------GETVHLFME
AGEG----------------------------------------------
--GSVLEKLESCGP------------------------------------
--------------------------------------------------
-------------------------------------MREFEIIWVTKHV
LKGLDFLHSK------------KVIHHDIKPSNIVFMS------------
--------TKAVLVDFGLSVQMTED-------------------------
----------------------------VYFPKDLRGTEIYMSPEVILC-
--------------------RGH-------STKADIYSLGATLIHMQTG-
-----------TPPWVKRYPR-------------SAYPSYLYIIHKQ---
--------------------------------------------------
-------------------APPLEDIADDCSPG---MRELIEASLE----
RNPNHRP-------RAADLLKHEAL------------------------
>MAP2K1
FEKISELGAGNGGVVFKVSHKPS---------------------------
-------GLVMARKLIHLEIKP-------------------------AIR
NQIIRELQVLHECN------------------SPYIVGFYGAFYS-----
-----------------------------------------DGEISICME
HMDG----------------------------------------------
--GSLDQVLKKAGRI-----------------------------------
--------------------------------------------------
--------------------------------------PEQILGKVSIAV
IKGLTYLREKH-----------KIMHRDVKPSNILVNSR-----------
--------GEIKLCDFGVSGQLID--------------------------
-----------------------------SMANSFVGTRSYMSPERLQG-
--------------------THY-------SVQSDIWSMGLSLVEMAVG-
-----------RYPIPPPDA------------------KELELMFGCQVE
G------DAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEP---
---------------------PPKLPSGVFSLE---FQDFVNKCLI----
KNPAERA-------DLKQLMVHAFI------------------------
>MAP2K2
FERISELGAGNGGVVTKVQHRPS---------------------------
-------GLIMARKLIHLEIKP-------------------------AIR
NQIIRELQVLHECN------------------SPYIVGFYGAFYS-----
-----------------------------------------DGEISICME
HMDG----------------------------------------------
--GSLDQVLKEAKRI-----------------------------------
--------------------------------------------------
--------------------------------------PEEILGKVSIAV
LRGLAYLREKH-----------QIMHRDVKPSNILVNSR-----------
--------GEIKLCDFGVSGQLID--------------------------
-----------------------------SMANSFVGTRSYMAPERLQG-
--------------------THY-------SVQSDIWSMGLSLVELAVG-
-----------RYPIPPPDA------------------KELEAIFGRPVV
DGEEG--EPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEP---
---------------------PPKLPNGVFTPD---FQEFVNKCLI----
KNPAERA-------DLKMLTNHTFI------------------------
>MAP2K3
LVTISELGRGAYGVVEKVRHAQS---------------------------
-------GTIMAVKRIRATVNS-------------------------QEQ
KRLLMDLDINMRTVD-----------------CFYTVTFYGALFR-----
-----------------------------------------EGDVWICME
LMD-----------------------------------------------
--TSLDKFYRKVLDKNMTI-------------------------------
--------------------------------------------------
--------------------------------------PEDILGEIAVSI
VRALEHLHSKL-----------SVIHRDVKPSNVLINKE-----------
--------GHVKMCDFGISGYLVD--------------------------
----------------------------SVAKTMDAGCKPYMAPERINPE
LNQ-----------------KGY-------NVKSDVWSLGITMIEMAIL-
-----------RFPYESWG----------------TPFQQLKQVVEE---
--------------------------------------------------
--------------------PSPQLPADRFSPE---FVDFTAQCLR----
KNPAERM-------SYLELMEHPFF------------------------
>MAP2K4
LKDLGEIGRGAYGSVNKMVHKPS---------------------------
-------GQIMAVKRIRSTVDE-------------------------KEQ
KQLLMDLDVVMRSSD-----------------CPYIVQFYGALFR-----
-----------------------------------------EGDCWICME
LMS-----------------------------------------------
--TSFDKFYKYVYSVLDDVI------------------------------
--------------------------------------------------
--------------------------------------PEEILGKITLAT
VKALNHLKENL-----------KIIHRDIKPSNILLDRS-----------
--------GNIKLCDFGISGQLVD--------------------------
----------------------------SIAKTRDAGCRPYMAPERIDPS
ASR-----------------QGY-------DVRSDVWSLGITLYELATG-
-----------RFPYPKWN----------------SVFDQLTQVVKG---
--------------------------------------------------
------------------DPPQLSNSEEREFSP---SFINFVNLCL----
TKDESKRP------KYKELLKHPFI------------------------
>MAP2K5
IRYRDTLGHGNGGTVYKAYHVPS---------------------------
-------GKILAVKVILLDITL-------------------------ELQ
KQIMSELEILYKCD------------------SSYIIGFYGAFFV-----
-----------------------------------------ENRISICTE
FMDG----------------------------------------------
--GSLDVYRKM---------------------------------------
--------------------------------------------------
--------------------------------------PEHVLGRIAVAV
VKGLTYLWSL------------KILHRDVKPSNMLVNTR-----------
--------GQVKLCDFGVSTQLVN--------------------------
-----------------------------SIAKTYVGTNAYMAPERISG-
--------------------EQY-------GIHSDVWSLGISFMEIQKNQ
GS---------LMPL-----------------------QLLQCIVDEDS-
--------------------------------------------------
----------------------PVLPVGEFSEP---FVHFITQCMR----
KQPKERP-------APEELMGHPFI------------------------
>MAP2K6
LEPIMELGRGAYGVVEKMRHVPS---------------------------
-------GQIMAVKRIRATVNS-------------------------QEQ
KRLLMDLDISMRTVD-----------------CPFTVTFYGALFR-----
-----------------------------------------EGDVWICME
LMD-----------------------------------------------
--TSLDKFYKQVIDKGQTI-------------------------------
--------------------------------------------------
--------------------------------------PEDILGKIAVSI
VKALEHLHSKL-----------SVIHRDVKPSNVLINAL-----------
--------GQVKMCDFGISGYLVD--------------------------
----------------------------SVAKTIDAGCKPYMAPERINPE
LNQ-----------------KGY-------SVKSDIWSLGITMIELAIL-
-----------RFPYDSWGT----------------PFQQLKQVVEE---
--------------------------------------------------
--------------------PSPQLPADKFSAE---FVDFTSQCLK----
KNSKERP-------TYPELMQHPFF------------------------
>MAP2K7
LENLGEMGSGTCGQVWKMRFRKT---------------------------
-------GHVIAVKQMRRSGNK-------------------------EEN
KRILMDLDVVLKSHD-----------------CPYIVQCFGTFIT-----
-----------------------------------------NTDVFIAME
LMG-----------------------------------------------
--TCAEKLKKRMQGPI----------------------------------
--------------------------------------------------
--------------------------------------PERILGKMTVAI
VKALYYLKEKH-----------GVIHRDVKPSNILLDER-----------
--------GQIKLCDFGISGRLVD--------------------------
----------------------------SKAKTRSAGCAAYMAPERIDPP
DPTK----------------PDY-------DIRADVWSLGISLVELATG-
-----------QFPYKNCKT----------------DFEVLTKVLQEE--
--------------------------------------------------
--------------------PPLLPGHMGFSGD---FQSFVKDCLT----
KDHRKRP-------KYNKLLEHSFI------------------------
>MAP3K1
WLKGQQIGLGAFSSCYQAQDVGT---------------------------
-------GTLMAVKQVTYVRNTSS---------------------EQEEV
VEALREEIRMMSHLN-----------------HPNIIRMLGATCE-----
-----------------------------------------KSNYNLFIE
WMAG----------------------------------------------
--GSVAHLLSKYGA------------------------------------
--------------------------------------------------
-------------------------------------FKESVVINYTEQL
LRGLSYLHEN------------QIIHRDVKGANLLIDST-----------
-------GQRLRIADFGAAARLASKGTG----------------------
---------------------------AGEFQGQLLGTIAFMAPEVLRG-
--------------------QQY-------GRSCDVWSVGCAIIEMACA-
-----------KPPWNAEKH---------------SNHLALIFKIASATT
A-------------------------------------------------
-----------------------PSIPSHLSPG---LRDVALRCLE----
LQPQDRP-------PSRELLKHPVF------------------------
>MAP3K2
WRLGKLLGQGAFGRVYLCYDVDT---------------------------
-------GRELAVKQVQFDPDSPE---------------------TSKEV
NALECEIQLLKNFL------------------HERIVQYYGCLRD-----
---------------------------------------PQEKTLSIFME
YMPG----------------------------------------------
--GSIKDQLKAYGA------------------------------------
--------------------------------------------------
-------------------------------------LTENGTRKYTRQI
LEGVHYLHSN------------MILHRDIKGANILRDST-----------
--------GNVKLGDFGASKRLQTICL-----------------------
---------------------------SGTGMKSVTGTPYWMSPEVISG-
--------------------QGY-------GRKADIWSVACTVVEMLTE-
-----------KPPWAEF---------------------EAMAAIFKIAT
Q-------------------------------------------------
---------------------PTNPKLPPHVSD---YTRDFLKRIF----
VEAKLRP-------SADELLRHMFV------------------------
>MAP3K3
WRRGKLLGQGAFGRVYLCYDVDT---------------------------
-------GRELASKQVQFDPDSPE---------------------TSKEV
SALECEIQLLKNLQ------------------HERIVQYYGCLRD-----
---------------------------------------RAEKTLTIFME
YMPG----------------------------------------------
--GSVKDQLKAYGA------------------------------------
--------------------------------------------------
-------------------------------------LTESVTRKYTRQI
LEGMSYLHSN------------MIVHRDIKGANILRDSA-----------
--------GNVKLGDFGASKRLQTICM-----------------------
---------------------------SGTGMRSVTGTPYWMSPEVISG-
--------------------EGY-------GRKADVWSLGCTVVEMLTE-
-----------KPPWAEY---------------------EAMAAIFKIAT
Q-------------------------------------------------
---------------------PTNPQLPSHISE---HGRDFLRRIF----
VEARQRP-------SAEELLTHHFA------------------------
>MAP3K4
WQRGNKIGEGQYGKVYTCISVDT---------------------------
-------GELMAMKEIRFQPN------------------------DHKTI
KETADELKIFEGIK------------------HPNLVRYFGVELH-----
-----------------------------------------REEMYIFME
YCDE----------------------------------------------
--GTLEEVSRLG--------------------------------------
--------------------------------------------------
-------------------------------------LQEHVIRLYSKQI
TIAINVLHEH------------GIVHRDIKGANIFLTSS-----------
--------GLIKLGDFGCSVKLKNNAQTM---------------------
----------------------------PGEVNSTLGTAAYMAPEVITRA
KG------------------EGH-------GRAADIWSLGCVVIEMVTG-
-----------KRPWHEYEH-------------------NFQIMYKVGMG
HK------------------------------------------------
-----------------------PPIPERLSPE---GKDFLSHCLE----
SDPKMRW-------TASQLLDHSFV------------------------
>MAP3K5
NGDRVVLGKGTYGIVYAGRDLSN---------------------------
-------QVRIAIKEIPERDS--------------------------RYS
QPLHEEIALHKHLK------------------HKNIVQYLGSFSE-----
-----------------------------------------NGFIKIFME
QVPG----------------------------------------------
--GSLSALLRSKWGPLK---------------------------------
--------------------------------------------------
-------------------------------------DNEQTIGFYTKQI
LEGLKYLHDN------------QIVHRDIKGDNVLINTYS----------
--------GVLKISDFGTSKRLAGIN------------------------
-----------------------------PCTETFTGTLQYMAPEIIDKG
P-------------------RGY-------GKAADIWSLGCTIIEMATG-
-----------KPPFYELGE-------------------PQAAMFKVGMF
KVH-----------------------------------------------
-----------------------PEIPESMSAE---AKAFILKCFE----
PDPDKRA-------CANDLLVDEFL------------------------
>MAP3K6
-----VLGKGTYGVVYAGRDRHT---------------------------
-------RVRIAIKEIPERDS--------------------------RFS
QPLHEEIALHRRLR------------------HKNIVRYLGSASQ-----
-----------------------------------------GGYLKIFME
EVPG----------------------------------------------
--GSLSSLLRSVWGPLK---------------------------------
--------------------------------------------------
-------------------------------------DNESTISFYTRQI
LQGLGYLHDN------------HIVHRDIKGDNVLINTFS----------
--------GLLKISDFGTSKRLAGIT------------------------
-----------------------------PCTETFTGTLQYMAPEIIDQG
P-------------------RGY-------GKAADIWSLGCTVIEMATG-
-----------RPPFHELGS-------------------PQAAMFQVGMY
KVH-----------------------------------------------
-----------------------PPMPSSLSAE---AQAFLLRTFE----
PDPRLRA-------SAQTLLGDPFL------------------------
>MAP3K7
E--RVVLGKGTYGIVYAGRDLSN---------------------------
-------QVRIAIKEIPERDS--------------------------RYS
QPLHEEIALHKYLK------------------HRNIVQYLGSVSE-----
-----------------------------------------NGYIKIFME
QVPG----------------------------------------------
--GSLSALLRSKWGP-----------------------------------
--------------------------------------------------
-------------------------------------MKEPTIKFYTKQI
LEGLKYLHEN------------QIVHRDIKGDNVLVNTYS----------
--------GVVKISDFGTSKRLAGVN------------------------
-----------------------------PCTETFTGTLQYMAPEIIDQG
P-------------------RGY-------GAPADIWSLGCTIIEMATS-
-----------KPPFHELGE-------------------PQAAMFKVGMF
KIH-----------------------------------------------
-----------------------PEIPEALSAE---ARAFILSCFE----
PDPHKRA-------TTAELLREGFL------------------------
>MAP3K8
WTKGEILGKGAYGTVYCGLTSQ----------------------------
-------GQLIAVKQVALDTSNKL--------------------AAEKEY
RKLQEEVDLLKALK------------------HVNIVAYLGTCLQ-----
-----------------------------------------ENTVSIFME
FVPG----------------------------------------------
--GSISSIINRFGP------------------------------------
--------------------------------------------------
-------------------------------------LPEMVFCKYTKQI
LQGVAYLHEN------------CVVHRDIKGNNVMLMPT-----------
--------GIIKLIDFGCARRLAWAGLN----------------------
-------------------------GTHSDMLKSMHGTPYWMAPEVINE-
--------------------SGY-------GRKSDIWSIGCTVFEMATG-
-----------KPPLASMD--------------------RMAAMFYIGAH
RGLM----------------------------------------------
-----------------------PPLPDHFSEN---AADFVRMCLT----
RDQHERP-------SALQLLKHSFL------------------------
>OSR1
YELQEVIGSGATAVVQAAYCAPK---------------------------
-------KEKVAIKRINLEKC-------------------------QTSM
DELLKEIQAMSQCH------------------HPNIVSYYTSFVV-----
-----------------------------------------KDELWLVMK
LLSG----------------------------------------------
--GSVLDIIKHIVAKGEHKSGV----------------------------
--------------------------------------------------
-------------------------------------LDESTIATILREV
LEGLEYLHKN------------GQIHRDVKAGNILLGED-----------
--------GSVQIADFGVSAFLATGGDI----------------------
--------------------------TRNKVRKTFVGTPCWMAPEVMEQV
--------------------RGY-------DFKADIWSFGITAIELATG-
-----------AAPYHKY--------------------PPMKVLMLTLQN
D-------------------------------------------------
-------------PPSLETGVQDKEMLKKYGKS---FRKMISLCLQ----
KDPEKRP-------TAAELLRHKFF------------------------
>STLK3
YELQEVIGSGATAVVQAALCKPR---------------------------
-------QERVAIKRINLEKC-------------------------QTSM
DELLKEIQAMSQCS------------------HPNVVTYYTSFVV-----
-----------------------------------------KDELWLVMK
LLSG----------------------------------------------
--GSMLDIIKYIVNRGEHKNGV----------------------------
--------------------------------------------------
-------------------------------------LEEAIIATILKEV
LEGLDYLHRN------------GQIHRDLKAGNILLGED-----------
--------GSVQIADFGVSAFLATGGDV----------------------
--------------------------TRNKVRKTFVGTPCWMAPEVMEQV
--------------------RGY-------DFKADMWSFGITAIELATG-
-----------AAPYHKY--------------------PPMKVLMLTLQN
D-------------------------------------------------
-------------PPTLETGVEDKEMMKKYGKS---FRKLLSLCLQ----
KDPSKRP-------TAAELLKCKFF------------------------
>STLK5
YELLTVIGKGFEDLMTVNLARYKP--------------------------
------TGEYVTVRRINLECS-------------------------NEMV
TFLQGELHVSKLFN------------------HPNIVPYRATFIA-----
-----------------------------------------DNELWVVTS
FMAY----------------------------------------------
--GSAKDLICTHFMDG----------------------------------
--------------------------------------------------
-------------------------------------MNELAIAYILQGV
LKALDYIHHM------------GYVHRSVKASHILISVD-----------
--------GKVYLSGLRSNLSMISHGQ-----------------------
-----------------------RQRVVHDFPKYSVKVLPWLSPEVLQQN
L-------------------QGY-------DAKSDIYSVGITACELANG-
-----------HVPFKDM--------------------PATQMLLEKLNG
T---------VPCLLDTSTIPAEELTMSPSRSVANSGLSDSLT-------
------------TSTPRPSNGDSPSHPYHRTFS---PHFHHFVEQC----
RNPDARP-------SASTLLNHSFF------------------------
>STLK6
YELQVEIGRGFDNLTSVHLARHTP--------------------------
------TGTLVTIKITNLENC--------------------------NEE
RLKALQKAVILSHFFR----------------HPNITTYWTVFTV-----
-----------------------------------------GSWLWVISP
FMAY----------------------------------------------
--GSASQLLRTYFPEG----------------------------------
--------------------------------------------------
-------------------------------------MSETLIRNILFGA
VRGLNYLHQN------------GCIHRSIKASHILIS-------------
--------GDGLVTLSGLSHLHSLVKHG----------------------
----------------------QRHRAVYDFPQFSTSVQPWLSPELLRQD
L-------------------HGY-------NVKSDIYSVGITACELASG-
-----------QVPFQDM--------------------HRTQMLLQKLKG
--------PPYSPLDISIFPQSESRMKNSQSGVDSGIGESVLV-------
------------SSGTHTVNSDRLHTPSSKTFS---PAFFSLVQLQ----
QDPEKRP-------SASSLLSHVFF------------------------
>PAK1
YTRFEKIGQGASGTVYTAMDVAT---------------------------
-------GQEVAIKQMNLQQQP--------------------------KK
ELIINEILVMRENK------------------NPNIVNYLDSYLV-----
-----------------------------------------GDELWVVME
YLAG----------------------------------------------
--GSLTDVVTETC-------------------------------------
--------------------------------------------------
-------------------------------------MDEGQIAAVCREC
LQALEFLHSN------------QVIHRDIKSDNILLGMD-----------
--------GSVKLTDFGFCAQITPE-------------------------
----------------------------QSKRSTMVGTPYWMAPEVVTR-
--------------------KAY-------GPKVDIWSLGIMAIEMIEG-
-----------EPPYLNE--------------------NPLRALYLIATN
--------------------------------------------------
-------------------GTPELQNPEKLSAI---FRDFLNRCLD----
MDVEKRG-------SAKELLQHQFL------------------------
>PAK2
YTRYEKIGQGASGTVFTATDVAL---------------------------
-------GQEVAIKQINLQKQP--------------------------KK
ELIINEILVMKELK------------------NPNIVNFLDSYLV-----
-----------------------------------------GDELFVVME
YLAG----------------------------------------------
--GSLTDVVTETAC------------------------------------
--------------------------------------------------
-------------------------------------MDEAQIAAVCREC
LQALEFLHAN------------QVIHRDIKSDNVLLGME-----------
--------GSVKLTDFGFCAQITPE-------------------------
----------------------------QSKRSTMVGTPYWMAPEVVTR-
--------------------KAY-------GPKVDIWSLGIMAIEMVEG-
-----------EPPYLNE--------------------NPLRALYLIATN
--------------------------------------------------
-------------------GTPELQNPEKLSPI---FRDFLNRCLE----
MDVEKRG-------SAKELLQHPFL------------------------
>PAK3
YTRFEKIGQGASGTVYTALDIAT---------------------------
-------GQEVAIKQMNLQQQP--------------------------KK
ELIINEILVMRENK------------------NPNIVNYLDSYLV-----
-----------------------------------------GDELWVVME
YLAG----------------------------------------------
--GSLTDVVTETC-------------------------------------
--------------------------------------------------
-------------------------------------MDEGQIAAVCREC
LQALDFLHSN------------QVIHRDIKSDNILLGMD-----------
--------GSVKLTDFGFCAQITPE-------------------------
----------------------------QSKRSTMVGTPYWMAPEVVTR-
--------------------KAY-------GPKVDIWSLGIMAIEMVEG-
-----------EPPYLNE--------------------NPLRALYLIATN
--------------------------------------------------
-------------------GTPELQNPERLSAV---FRDFLNRCLE----
MDVDRRG-------SAKELLQHPFL------------------------
>PAK4
LDNFIKIGEGSTGIVCIATVRSS---------------------------
-------GKLVAVKKMDLRKQQ--------------------------RR
ELLFNEVVIMRDYQ------------------HENVVEMYNSYLV-----
-----------------------------------------GDELWVVME
FLEG----------------------------------------------
--GALTDIVTHTR-------------------------------------
--------------------------------------------------
-------------------------------------MNEEQIAAVCLAV
LQALSVLHAQ------------GVIHRDIKSDSILLTHD-----------
--------GRVKLSDFGFCAQVSKE-------------------------
----------------------------VPRRKSLVGTPYWMAPELISR-
--------------------LPY-------GPEVDIWSLGIMVIEMVDG-
-----------EPPYFNE--------------------PPLKAMKMIRDN
--------------------------------------------------
-------------------LPPRLKNLHKVSPS---LKGFLDRLLV----
RDPAQRA-------TAAELLKHPFL------------------------
>PAK5
LANFIKIGEGSTGIVCIATEKHT---------------------------
-------GKQVAVKKMDLRKQQ--------------------------RR
ELLFNEVVIMRDYH------------------HDNVVDMYSSYLV-----
-----------------------------------------GDELWVVME
FLEG----------------------------------------------
--GALTDIVTHTR-------------------------------------
--------------------------------------------------
-------------------------------------MNEEQIATVCLSV
LRALSYLHNQ------------GVIHRDIKSDSILLTSD-----------
--------GRIKLSDFGFCAQVSKE-------------------------
----------------------------VPKRKSLVGTPYWMAPEVISR-
--------------------LPY-------GTEVDIWSLGIMVIEMIDG-
-----------EPPYFNE--------------------PPLQAMRRIRDS
--------------------------------------------------
-------------------LPPRVKDLHKVSSV---LRGFLDLMLV----
REPSQRA-------TAQELLGHPFL------------------------
>PAK6
LDSYVKIGEGSTGIVCLAREKHS---------------------------
-------GRQVAVKMMDLRKQQ--------------------------RR
ELLFNEVVIMRDYQ------------------HFNVVEMYKSYLV-----
-----------------------------------------GEELWVLME
FLQG----------------------------------------------
--GALTDIVSQVR-------------------------------------
--------------------------------------------------
-------------------------------------LNEEQIATVCEAV
LQALAYLHAQ------------GVIHRDIKSDSILLTLD-----------
--------GRVKLSDFGFCAQISKD-------------------------
----------------------------VPKRKSLVGTPYWMAPEVISR-
--------------------SLY-------ATEVDIWSLGIMVIEMVDG-
-----------EPPYFSD--------------------SPVQAMKRLRDS
--------------------------------------------------
-------------------PPPKLKNSHKVSPV---LRDFLERMLV----
RDPQERA-------TAQELLDHPFL------------------------
>TAO1
FTDLREIGHGSFGAVYFARDVRT---------------------------
-------NEVVAIKKMSYSGKQST-----------------------EKW
QDIIKEVKFLQRIK------------------HPNSIEYKGCYLR-----
-----------------------------------------EHTAWLVME
YCLG----------------------------------------------
--SASDLLEVHKKP------------------------------------
--------------------------------------------------
-------------------------------------LQEVEIAAITHGA
LQGLAYLHSH------------TMIHRDIKAGNILLTEP-----------
--------GQVKLADFGSASMA----------------------------
-----------------------------SPANSFVGTPYWMAPEVILAM
DE------------------GQY-------DGKVDVWSLGITCIELAER-
-----------KPPLFNM--------------------NAMSALYHIAQN
--------------------------------------------------
--------------------ESPTLQSNEWSDY---FRNFVDSCLQ----
KIPQDRP-------TSEELLKHIFV------------------------
>TAO2
FSDLREIGHGSFGAVYFARDVRN---------------------------
-------SEVVAIKKMSYSGKQSN-----------------------EKW
QDIIKEVRFLQKLR------------------HPNTIQYRGCYLR-----
-----------------------------------------EHTAWLVME
YCLG----------------------------------------------
--SASDLLEVHKKP------------------------------------
--------------------------------------------------
-------------------------------------LQEVEIAAVTHGA
LQGLAYLHSH------------NMIHRDVKAGNILLSEP-----------
--------GLVKLGDFGSASIM----------------------------
-----------------------------APANSFVGTPYWMAPEVILAM
DE------------------GQY-------DGKVDVWSLGITCIELAER-
-----------KPPLFNM--------------------NAMSALYHIAQN
--------------------------------------------------
--------------------ESPVLQSGHWSEY---FRNFVDSCLQ----
KIPQDRP-------TSEVLLKHRFV------------------------
>TAO3
FIGLHEIGHGSFGAVYFATNAHT---------------------------
-------NEVVAIKKMSYSGKQTH-----------------------EKW
QDILKEVKFLRQLK------------------HPNTIEYKGCYLK-----
-----------------------------------------EHTAWLVME
YCLG----------------------------------------------
--SASDLLEVHKKP------------------------------------
--------------------------------------------------
-------------------------------------LQEVEIAAITHGA
LHGLAYLHSH------------ALIHRDIKAGNILLTEP-----------
--------GQVKLADFGSASMA----------------------------
-----------------------------SPANSFVGTPYWMAPEVILAM
DE------------------GQY-------DGKVDIWSLGITCIELAER-
-----------KPPLFNM--------------------NAMSALYHIAQN
--------------------------------------------------
--------------------DSPTLQSNEWTDS---FRRFVDYCLQ----
KIPQERP-------TSAELLRHDFV------------------------
>LOK
WEIVGELGDGAFGKVYKAKNKET---------------------------
-------GALAAAKVIETKSE--------------------------EEL
EDYIVEIEILATCD------------------HPYIVKLLGAYYH-----
-----------------------------------------DGKLWIMIE
FCPG----------------------------------------------
--GAVDAIMLELDRG-----------------------------------
--------------------------------------------------
-------------------------------------LTEPQIQVVCRQM
LEALNFLHSK------------RIIHRDLKAGNVLMTLE-----------
--------GDIRLADFGVSAKNLKT-------------------------
----------------------------LQKRDSFIGTPYWMAPEVVMCE
TMKD----------------TPY-------DYKADIWSLGITLIEMAQI-
-----------EPPHHEL--------------------NPMRVLLKIAKS
--------------------------------------------------
-------------------DPPTLLTPSKWSVE---FRDFLKIALD----
KNPETRP-------SAAQLLEHPFV------------------------
>SLK
WEIIGELGDGAFGKVYKAQNKET---------------------------
-------SVLAAAKVIDTKSE--------------------------EEL
EDYMVEIDILASCD------------------HPNIVKLLDAFYY-----
-----------------------------------------ENNLWILIE
FCAG----------------------------------------------
--GAVDAVMLELERP-----------------------------------
--------------------------------------------------
-------------------------------------LTESQIQVVCKQT
LDALNYLHDN------------KIIHRDLKAGNILFTLD-----------
--------GDIKLADFGVSAKNTRT-------------------------
----------------------------IQRRDSFIGTPYWMAPEVVMCE
TSKD----------------RPY-------DYKADVWSLGITLIEMAEI-
-----------EPPHHEL--------------------NPMRVLLKIAKS
--------------------------------------------------
-------------------EPPTLAQPSRWSSN---FKDFLKKCLE----
KNVDARW-------TTSQLLQHPFV------------------------
>HPK1
YDLLQRLGGGTYGEVFKARDKVS---------------------------
-------GDLVALKMVKMEPD--------------------------DDV
STLQKEILILKTCR------------------HANIVAYHGSYLW-----
-----------------------------------------LQKLWICME
FCGA----------------------------------------------
--GSLQDIYQVTGS------------------------------------
--------------------------------------------------
-------------------------------------LSELQISYVCREV
LQGLAYLHSQ------------KKIHRDIKGANILINDA-----------
--------GEVRLADFGISAQIGAT-------------------------
----------------------------LARRLSFIGTPYWMAPEVAAVA
LK------------------GGY-------NELCDIWSLGITAIELAEL-
-----------QPPLFDV--------------------HPLRVLFLMTKS
GY------------------------------------------------
-------------------QPPRLKEKGKWSAA---FHNFIKVTLT----
KSPKKRP-------SATKMLSHQLV------------------------
>KHS1
YELVQRVGSGTYGDVYKARNVHT---------------------------
-------GELAAVKIIKLEPG--------------------------DDF
SLIQQEIFMVKECK------------------HCNIVAYFGSYLS-----
-----------------------------------------REKLWICME
YCGG----------------------------------------------
--GSLQDIYHVTGP------------------------------------
--------------------------------------------------
-------------------------------------LSELQIAYVCRET
LQGLAYLHTK------------GKMHRDIKGANILLTDH-----------
--------GDVKLADFGVAAKITAT-------------------------
----------------------------IAKRKSFIGTPYWMAPEVAAVE
KN------------------GGY-------NQLCDIWAVGITAIELGEL-
-----------QPPMFDL--------------------HPMRALFLMSKS
NF------------------------------------------------
-------------------QPPKLKDKTKWSST---FHNFVKIALT----
KNPKKRP-------TAERLLTHTFV------------------------
>KHS2
FELIQRIGSGTYGDVYKARNVNT---------------------------
-------GELAAIKVIKLEPG--------------------------EDF
AVVQQEIIMMKDCK------------------HPNIVAYFGSYLR-----
-----------------------------------------RDKLWICME
FCGG----------------------------------------------
--GSLQDIYHVTGP------------------------------------
--------------------------------------------------
-------------------------------------LSELQIAYVSRET
LQGLYYLHSK------------GKMHRDIKGANILLTDN-----------
--------GHVKLADFGVSAQITAT-------------------------
----------------------------IAKRKSFIGTPYWMAPEVAAVE
RK------------------GGY-------NQLCDLWAVGITAIELAEL-
-----------QPPMFDL--------------------HPMRALFLMTKS
NF------------------------------------------------
-------------------QPPKLKDKMKWSNS---FHHFVKMALT----
KNPKKRP-------TAEKLLQHPFV------------------------
>GCK
FELLQRVGAGTYGDVYKARDTVT---------------------------
-------SELAAVKIVKLDPG--------------------------DDI
SSLQQEITILRECR------------------HPNVVAYIGSYLR-----
-----------------------------------------NDRLWICME
FCGG----------------------------------------------
--GSLQEIYHATGP------------------------------------
--------------------------------------------------
-------------------------------------LEERQIAYVCRER
LKGLHHLHSQ------------GKIHRDIKGANLLLTLQ-----------
--------GDVKLADFGVSGELTAS-------------------------
----------------------------VAKRRSFIGTPYWMAPEVAAVE
RK------------------GGY-------NELCDVWALGITAIELGEL-
-----------QPPLFHL--------------------HPMRALMLMSKS
SF------------------------------------------------
-------------------QPPKLRDKTRWTQN---FHHFLKLALT----
KNPKKRP-------TAEKLLQHPFT------------------------
>MST1
FDVLEKLGEGSYGSVYKAIHKET---------------------------
-------GQIVAIKQVPVE----------------------------SDL
QEIIKEISIMQQCD------------------SPHVVKYYGSYFK-----
-----------------------------------------NTDLWIVME
YCGA----------------------------------------------
--GSVSDIIRLRNKT-----------------------------------
--------------------------------------------------
-------------------------------------LTEDEIATILQST
LKGLEYLHFM------------RKIHRDIKAGNILLNTE-----------
--------GHAKLADFGVAGQLTDT-------------------------
----------------------------MAKRNTVIGTPFWMAPEVIQE-
--------------------IGY-------NCVADIWSLGITAIEMAEG-
-----------KPPYADI--------------------HPMRAIFMIP--
--------------------------------------------------
-----------------TNPPPTFRKPELWSDN---FTDFVKQCLV----
KSPEQRA-------TATQLLQHPFV------------------------
>MST2
FDVLEKLGEGSYGSVFKAIHKES---------------------------
-------GQVVAIKQVPVE----------------------------SDL
QEIIKEISIMQQCD------------------SPYVVKYYGSYFK-----
-----------------------------------------NTDLWIVME
YCGA----------------------------------------------
--GSVSDIIRLRNKT-----------------------------------
--------------------------------------------------
-------------------------------------LIEDEIATILKST
LKGLEYLHFM------------RKIHRDIKAGNILLNTE-----------
--------GHAKLADFGVAGQLTDT-------------------------
----------------------------MAKRNTVIGTPFWMAPEVIQE-
--------------------IGY-------NCVADIWSLGITSIEMAEG-
-----------KPPYADI--------------------HPMRAIFMIP--
--------------------------------------------------
-----------------TNPPPTFRKPELWSDD---FTDFVKKCLV----
KNPEQRA-------TATQLLQHPFI------------------------
>MST3
FTKLEKIGKGSFGEVFKGIDNRT---------------------------
-------QKVVAIKIIDLEEA-------------------------EDEI
EDIQQEITVLSQCD------------------SPYVTKYYGSYLK-----
-----------------------------------------DTKLWIIME
YLGG----------------------------------------------
--GSALDLLEPGP-------------------------------------
--------------------------------------------------
-------------------------------------LDETQIATILREI
LKGLDYLHSE------------KKIHRDIKAANVLLSEH-----------
--------GEVKLADFGVAGQLTDT-------------------------
----------------------------QIKRNTFVGTPFWMAPEVIKQ-
--------------------SAY-------DSKADIWSLGITAIELARG-
-----------EPPHSEL--------------------HPMKVLFLIP--
--------------------------------------------------
-------------------KNNPPTLEGNYSKP---LKEFVEACLN----
KEPSFRP-------TAKELLKHKFI------------------------
>YSK1
FTKLDRIGKGSFGEVYKGIDNHT---------------------------
-------KEVVAIKIIDLEEA-------------------------EDEI
EDIQQEITVLSQCD------------------SPYITRYFGSYLK-----
-----------------------------------------STKLWIIME
YLGG----------------------------------------------
--GSALDLLKPGP-------------------------------------
--------------------------------------------------
-------------------------------------LEETYIATILREI
LKGLDYLHSE------------RKIHRDIKAANVLLSEQ-----------
--------GDVKLADFGVAGQLTDT-------------------------
----------------------------QIKRNTFVGTPFWMAPEVIKQ-
--------------------SAY-------DFKADIWSLGITAIELAKG-
-----------EPPNSDL--------------------HPMRVLFLIP--
--------------------------------------------------
-------------------KNSPPTLEGQHSKP---FKEFVEACLN----
KDPRFRP-------TAKELLKHKFI------------------------
>MST4
FTKLQRIGKGSFGEVFKGIDNRT---------------------------
-------QQVVAIKIIDLEEA-------------------------EDEI
EDIQQEITVLSQCD------------------SSYVTKYYGSYLK-----
-----------------------------------------GSKLWIIME
YLGG----------------------------------------------
--GSALDLLRAGP-------------------------------------
--------------------------------------------------
-------------------------------------FDEFQIATMLKEI
LKGLDYLHSE------------KKIHRDIKAANVLLSEQ-----------
--------GDVKLADFGVAGQLTDT-------------------------
----------------------------QIKRNTFVGTPFWMAPEVIQQ-
--------------------SAY-------DSKADIWSLGITAIELAKG-
-----------EPPNSDM--------------------HPMRVLFLIP--
--------------------------------------------------
-------------------KNNPPTLVGDFTKS---FKEFIDACLN----
KDPSFRP-------TAKELLKHKFI------------------------
>MYO3A
WEITETIGKGTYGKVFKVLNKKN---------------------------
-------GQKAAVKILDPIH---------------------------DID
EEIEAEYNILKALSD-----------------HPNVVRFYGIYFKKD---
--------------------------------------KVNGDKLWLVLE
LCSG----------------------------------------------
--GSVTDLVKGFLKRGER--------------------------------
--------------------------------------------------
-------------------------------------MSEPLIAYILHEA
LMGLQHLHNN------------KTIHRDVKGNNILLTTE-----------
--------GGVKLVDFGVSAQLTST-------------------------
----------------------------RHRRNTSVGTPFWMAPEVIACE
QQLD----------------TTY-------DARCDTWSLGITAIELGDG-
-----------DPPLADL--------------------HPMRALFKIP--
--------------------------------------------------
-----------------RNPPPKLRQPELWSAE---FNDFISKCLT----
KDYEKRP-------TVSELLQHKFI------------------------
>MYO3B
WEIIETIGKGTYGKVYKVTNKRD---------------------------
------GSLA-AVKILDPVS---------------------------DMD
EEIEAEYNILQFLPN-----------------HPNVVKFYGMFYKAD---
--------------------------------------HCVGGQLWLVLE
LCNG----------------------------------------------
--GSVTELVKGLLRCGQR--------------------------------
--------------------------------------------------
-------------------------------------LDEAMISYILYGA
LLGLQHLHNN------------RIIHRDVKGNNILLTTE-----------
--------GGVKLVDFGVSAQLTST-------------------------
----------------------------RLRRNTSVGTPFWMAPEVIACE
QQYD----------------SSY-------DARCDVWSLGITAIELGDG-
-----------DPPLFDM--------------------HPVKTLFKIP--
--------------------------------------------------
-----------------RNPPPTLLHPEKWCEE---FNHFISQCLI----
KDFERRP-------SVTHLLDHPFI------------------------
>ZC1/HGK
FELVEVVGNGTYGQVYKGRHVKT---------------------------
-------GQLAAIKVMDVTE---------------------------DEE
EEIKLEINMLKKYSH-----------------HRNIATYYGAFIKKS---
-------------------------------------PPGHDDQLWLVME
FCGA----------------------------------------------
--GSITDLVKNTKGNT----------------------------------
--------------------------------------------------
-------------------------------------LKEDWIAYISREI
LRGLAHLHIH------------HVIHRDIKGQNVLLTEN-----------
--------AEVKLVDFGVSAQLDRT-------------------------
----------------------------VGRRNTFIGTPYWMAPEVIACD
ENPD----------------ATY-------DYRSDLWSCGITAIEMAEG-
-----------APPLCDM--------------------HPMRALFLIP--
--------------------------------------------------
------------------RNPPPRLKSKKWSKK---FFSFIEGCLV----
KNYMQRP-------STEQLLKHPFI------------------------
>ZC2/TNIK
FELVELVGNGTYGQVYKGRHVKT---------------------------
-------GQLAAIKVMDVTG---------------------------DEE
EEIKQEINMLKKYSH-----------------HRNIATYYGAFIKKN---
-------------------------------------PPGMDDQLWLVME
FCGA----------------------------------------------
--GSVTDLIKNTKGNT----------------------------------
--------------------------------------------------
-------------------------------------LKEEWIAYICREI
LRGLSHLHQH------------KVIHRDIKGQNVLLTEN-----------
--------AEVKLVDFGVSAQLDRT-------------------------
----------------------------VGRRNTFIGTPYWMAPEVIACD
ENPD----------------ATY-------DFKSDLWSLGITAIEMAEG-
-----------APPLCDM--------------------HPMRALFLIP--
--------------------------------------------------
------------------RNPAPRLKSKKWSKK---FQSFIESCLV----
KNHSQRP-------ATEQLMKHPFI------------------------
>ZC3/MINK
FELVEVVGNGTYGQVYKGRHVKT---------------------------
-------GQLAAIKVMDVTE---------------------------DEE
EEIKQEINMLKKYSH-----------------HRNIATYYGAFIKKS---
-------------------------------------PPGNDDQLWLVME
FCGA----------------------------------------------
--GSVTDLVKNTKGNA----------------------------------
--------------------------------------------------
-------------------------------------LKEDCIAYICREI
LRGLAHLHAH------------KVIHRDIKGQNVLLTEN-----------
--------AEVKLVDFGVSAQLDRT-------------------------
----------------------------VGRRNTFIGTPYWMAPEVIACD
ENPD----------------ATY-------DYRSDIWSLGITAIEMAEG-
-----------APPLCDM--------------------HPMRALFLIP--
--------------------------------------------------
------------------RNPPPRLKSKKWSKK---FIDFIDTCLI----
KTYLSRP-------PTEQLLKFPFI------------------------
>ZC4/NRK
FSLDKTIGLGTYGRIYLGLHEKT---------------------------
-------GAFTAVKVMNARKTPLPEIGRRVR---VNKYQKSVGWRYSDEE
EDLRTELNLLRKYSF-----------------HKNIVSFYGAFFKLS---
-------------------------------------PPGQRHQLWMVME
LCAA----------------------------------------------
--GSVTDVVRMTSNQS----------------------------------
--------------------------------------------------
-------------------------------------LKEDWIAYICREI
LQGLAHLHAH------------RVIHRDIKGQNVLLTHN-----------
--------AEVKLVDFGVSAQVSRT-------------------------
----------------------------NGRRNSFIGTPYWMAPEVIDCD
EDPR----------------RSY-------DYRSDVWSVGITAIEMAEG-
-----------APPLCNL--------------------QPLEALFVIL--
--------------------------------------------------
------------------RESAPTVKSSGWSRK---FHNFMEKCTI----
KNFLFRP-------TSANMLQHPFV------------------------
>MYT1
FQRLSRLGHGSYGEVFKVRSKED---------------------------
-------GRLYAVKRSMSPFRGP------------------------KDR
ARKLAEVGSHEKVGQ-----------------HPCCVRLEQAWE------
----------------------------------------EGGILYLQTE
LCG-----------------------------------------------
--PSLQQHCEAWGAS-----------------------------------
--------------------------------------------------
-------------------------------------LPEAQVWGYLRDT
LLALAHLHSQ------------GLVHLDVKPANIFLGPR-----------
--------GRCKLGDFGLLVELGT--------------------------
----------------------------AGAGEVQEGDPRYMAPELLQ--
--------------------GSY-------GTAADVFSLGLTILEVACNM
-----------ELPHGGE----------------------GWQQLRQGYL
--------------------------------------------------
----------------------PPEFTAGLSSE---LRSVLVMMLE----
PDPKLRA-------TAEALLALPVL------------------------
>Wee1
FHELEKIGSGEFGSVFKCVKRLD---------------------------
-------GCIYAIKRSKKPLAGS------------------------VDE
QNALREVYAHAVLGQ-----------------HSHVVRYFSAWA------
----------------------------------------EDDHMLIQNE
YCNG----------------------------------------------
--GSLADAISENYRIMSY--------------------------------
--------------------------------------------------
-------------------------------------FKEAELKDLLLQV
GRGLRYIHSM------------SLVHMDIKPSNIFISRTSIPNAASEEGD
EDDWASNKVMFKIGDLGHVTRIS---------------------------
------------------------------SPQVEEGDSRFLANEVLQ--
--------------------ENY-----THLPKADIFALALTVVCAAG--
-----------AEPLPRNG--------------------DQWHEIRQGRL
--------------------------------------------------
-----------------------PRIPQVLSQE---FTELLKVMIH----
PDPERRP-------SAMALVKHSVL------------------------
>Wee1B
FLEVEKIGVGEFGTVYKCIKRLD---------------------------
-------GCVYAIKRSMKTFTEL------------------------SNE
NSALHEVYAHAVLGH-----------------HPHVVRYYSSWA------
----------------------------------------EDDHMIIQNE
YCNG----------------------------------------------
--GSLQAAISENTKSGNH--------------------------------
--------------------------------------------------
-------------------------------------FEEPKLKDILLQI
SLGLNYIHNS------------SMVHLDIKPSNIFICHKMQSES------
---SGVIEEVENEADWFLSANVMYKIGDLG--------------------
------------------------HATSINKPKVEEGDSRFLANEILQ--
--------------------EDY-----RHLPKADIFALGLTIAVAAGAE
-----------SLPTNG----------------------AAWHHIRKGNF
--------------------------------------------------
-----------------------PDVPQELSES---FSSLLKNMIQ----
PDAEQRP-------SAAALARNTVL------------------------
>VRK1
WKVGLPIGQGGFGCIYLADMNSSESV------------------------
-----GSDAPCVVKVEPSDNGPLFTE-------------------LKFYQ
RAAKPEQIQKWIRTR-----------------KLKYLGVPKYWGS-----
----------------------------------GLHDKNGKSYRFMIMD
RFG-----------------------------------------------
--SDLQKIYEANAKR-----------------------------------
--------------------------------------------------
-------------------------------------FSRKTVLQLSLRI
LDILEYIHEH------------EYVHGDIKASNLLLNYKNP---------
--------DQVYLVDYGLAYRYCPEGVH----------------------
------------------------KEYKEDPKRCHDGTIEFTSIDAHNG-
--------------------VAP-------SRRGDLEILGYCMIQWLTG-
-----------HLPWEDNLKD------------------PKYVRDSK---
--------------------------------------------------
-------------------------------------IRYRENIAS----
LMDKCFPEK------NKPGEIAKYM------------------------
>VRK2
WVLGKKIGSGGFGLIYLAFPTNKP--------------------------
-----EKDARHVVKVEYQENGPLFSE-------------------LKFYQ
RVAKKDCIKKWIERK-----------------QLDYLGIPLFYGS-----
----------------------------------GLTEFKGRSYRFMVME
RLG-----------------------------------------------
--IDLQKISGQNGT------------------------------------
--------------------------------------------------
-------------------------------------FKKSTVLQLGIRM
LDVLEYIHEN------------EYVHGDVKAANLLLGYKNP---------
--------DQVYLADYGLSYRYCPNGNH----------------------
------------------------KQYQENPRKGHNGTIEFTSLDAHKG-
--------------------VAL-------SRRSDVEILGYCMLRWLCG-
-----------KLPWEQNLKD------------------PVAVQTAK---
--------------------------------------------------
-------------------------------------TNLLDELPQ----
SVLKWAPSG------SSCCEIAQFL------------------------
>VRK3
--------------------------------------------------
--------------------------------------------------
AAKPLQVNKWKKLYSTP---------------LLAIPTCMGFGVHQD---
------------------------------------------KYRFLVLP
SLG-----------------------------------------------
--RSLQSALDVSPKHV----------------------------------
--------------------------------------------------
-------------------------------------LSERSVLQVACRL
LDALEFLHEN------------EYVHGNVTAENIFVDPEDQ---------
--------SQVTLAGYGFAFRYCPSGKH----------------------
------------------------VAYVEGSRSPHEGDLEFISMDLHKG-
--------------------CGP-------SRRSDLQSLGYCMLKWLYG-
-----------FLPWTNCLPNT---------------EDIMKQKQKFVDK
PGP-----------------------------------------------
------------FVGPCGHWIRPSETLQKYLKV---VMALTYEEKP----
PYAMLRNNL--------EALLQDL-------------------------
>CK1g1
FRVGKKIGCGNFGELRLGKNLYT---------------------------
-------NEYVAIKLEPIKSRA----------------------------
PQLHLEYRFYKQLGSA---------------GEGLPQVYYFGPC------
-----------------------------------------GKYNAMVLE
LLG-----------------------------------------------
--PSLEDLFDLCDRT-----------------------------------
--------------------------------------------------
-------------------------------------FTLKTVLMIAIQL
LSRMEYVHSK------------NLIYRDVKPENFLIGRQGNKKE------
--------HVIHIIDFGLAKEYIDPETKK---------------------
-------------------------HIPYREHKSLTGTARYMSINTHLG-
--------------------KEQ-------SRRDDLEALGHMFMYFLRG-
-----------SLPWQGLKADT---------------LKERYQKIGDTK-
--------------------------------------------------
---------------------RNTPIEALCENFPEEMATYLRYVRR----
---LDFF----------EKPDYEYL------------------------
>CK1g2
FRVGKKIGCGNFGELRLGKNLYT---------------------------
-------NEYVAIKLEPIKSRA----------------------------
PQLHLEYRFYKQLSAT---------------EGVPQVYYFGPCGK-----
-------------------------------------------YNAMVLE
LLG-----------------------------------------------
--PSLEDLFDLCDRT-----------------------------------
--------------------------------------------------
-------------------------------------FTLKTVLMIAIQL
ITRMEYVHTK------------SLIYRDVKPENFLVGRPGTKRQ------
--------HAIHIIDFGLAKEYIDPETKK---------------------
-------------------------HIPYREHKSLTGTARYMSINTHLG-
--------------------KEQ-------SRRDDLEALGHMFMYFLRG-
-----------SLPWQGLKADT---------------LKERYQKIGDTK-
--------------------------------------------------
---------------------RATPIEVLCENFPEEMATYLRYVRR----
---LDFF----------EKPDYDYL------------------------
>CK1g3
FRVGKKIGCGNFGELRLGKNLYT---------------------------
-------NEYVAIKLEPMKSRA----------------------------
PQLHLEYRFYKQLGSG---------------DGIPQVYYFGPCGK-----
-------------------------------------------YNAMVLE
LLG-----------------------------------------------
--PSLEDLFDLCDRT-----------------------------------
--------------------------------------------------
-------------------------------------FSLKTVLMIAIQL
ISRMEYVHSK------------NLIYRDVKPENFLIGRPRNKTQ------
--------QVIHIIDFGLAKEYIDPETKK---------------------
-------------------------HIPYREHKSLTGTARYMSINTHLG-
--------------------KEQ-------SRRDDLEALGHMFMYFLRG-
-----------SLPWQGLKADT---------------LKERYQKIGDTK-
--------------------------------------------------
---------------------RATPIEVLCENFP-EMATYLRYVRR----
---LDFF----------EKPDYEYL------------------------
>TTBK1
WKVLKKIGGGGFGEIYEAMDLLT---------------------------
-------RENVALKVESAQQP----------------------------K
QVLKMEVAVLKKLQGK---------------DHVCRFIGCGRNEK-----
-------------------------------------------FNYVVMQ
LQG-----------------------------------------------
--RNLADLRRSQPRGT----------------------------------
--------------------------------------------------
-------------------------------------FTLSTTLRLGKQI
LESIEAIHSV------------GFLHRDIKPSNFAMGRLPSTY-------
--------RKCYMLDFGLARQYTNTTGD----------------------
-------------------------VRPPRNVAGFRGTVRYASVNAHKN-
--------------------REM-------GRHDDLWSLFYMLVEFAVG-
-----------QLPWRKIKDK--------------------EQVGMIK--
--------------------------------------------------
---------------------EKYEHRMLLKHMPSEFHLFLDHIAS----
---LDYF----------TKPDYQLI------------------------
>TTBK2
WKVLRKIGGGGFGEIYDALDMLT---------------------------
-------RENVALKVESAQQP----------------------------K
QVLKMEVAVLKKLQGK---------------DHVCRFIGCGRNDR-----
-------------------------------------------FNYVVMQ
LQG-----------------------------------------------
--RNLADLRRSQSRGT----------------------------------
--------------------------------------------------
-------------------------------------FTISTTLRLGRQI
LESIESIHSV------------GFLHRDIKPSNFAMGRFPSTC-------
--------RKCYMLDFGLARQFTNSCGD----------------------
-------------------------VRPPRAVAGFRGTVRYASINAHRN-
--------------------REM-------GRHDDLWSLFYMLVEFVVG-
-----------QLPWRKIKDK--------------------EQVGSIK--
--------------------------------------------------
---------------------ERYDHRLMLKHLPPEFSIFLDHISS----
---LDYF----------TKPDYQLL------------------------
>CK1a
YKLVRKIGSGSFGDIYLAINITN---------------------------
-------GEEVAVKLESQKARHP---------------------------
-QLLYESKLYKILQGG---------------VGIPHIRWYGQEKD-----
-------------------------------------------YNVLVMD
LLG-----------------------------------------------
--PSLEDLFNFCSRR-----------------------------------
--------------------------------------------------
-------------------------------------FTMKTVLMLADQM
ISRIEYVHTK------------NFIHRDIKPDNFLMGIGRHC--------
--------NKLFLIDFGLAKKYRDNRTRQ---------------------
-------------------------HIPYREDKNLTGTARYASINAHLG-
--------------------IEQ-------SRRDDMESLGYVLMYFNRT-
-----------SLPWQGLKAAT-K--------------KQKYEKISEKK-
--------------------------------------------------
---------------------MSTPVEVLCKGFPAEFAMYLNYCRG----
---LRFE----------EAPDYMYL------------------------
>CK1a2
YKLVRKIGSGSFGDVYLGITTTN---------------------------
-------GEDVAVKLESQKVKHP---------------------------
-QLLYESKLYTILQGG---------------VGIPHMHWYGQEKD-----
-------------------------------------------NNVLVMD
LLG-----------------------------------------------
--PSLEDLFNFCSRR-----------------------------------
--------------------------------------------------
-------------------------------------FTMKTVLMLADQM
ISRIEYVHTK------------NFLHRDIKPDNFLMGTGRHC--------
--------NKLFLIDFGLAKKYRDNRTRQ---------------------
-------------------------HIPYREDKHLIGTVRYASINAHLG-
--------------------IEQ-------SRRDDMESLGYVFMYFNRT-
-----------SLPWQGLRAMT-K--------------KQKYEKISEKK-
--------------------------------------------------
---------------------MSTPVEVLCKGFPAEFAMYLNYCRG----
---LRFE----------EVPDYMYL------------------------
>cki_1cki.PDB
YRLGRKIGSGSFGDIYLGTDIAA---------------------------
-------GEEVAIKLECVKTKHP---------------------------
-QLHIESKIYKMMQGG---------------VGIPTIRWCGAEGD-----
-------------------------------------------YNVMVME
LLG-----------------------------------------------
--PSLEDLFNFCSRK-----------------------------------
--------------------------------------------------
-------------------------------------FSLKTVLLLADQM
ISRIEYIHSK------------NFIHRDVKPDNFLMGLGKKG--------
--------NLVYIIDFGLAKKYRDARTHQ---------------------
-------------------------HIPYRENKNLTGTARYASINTHLG-
--------------------IEQ-------SRRDDLESLGYVLMYFNLG-
-----------SLPWQGLK----------------------YERISEKK-
--------------------------------------------------
---------------------MSTPIEVLCKGYPSEFATYLNFCRS----
---LRFD----------DKPDYSYLRQLFRNLFHRQGFSYDYVFDWNML
>CK1d
YRLGRKIGSGSFGDIYLGTDIAA---------------------------
-------GEEVAIKLECVKTKHP---------------------------
-QLHIESKIYKMMQGG---------------VGIPTIRWCGAEGD-----
-------------------------------------------YNVMVME
LLG-----------------------------------------------
--PSLEDLFNFCSRK-----------------------------------
--------------------------------------------------
-------------------------------------FSLKTVLLLADQM
ISRIEYIHSK------------NFIHRDVKPDNFLMGLGKKG--------
--------NLVYIIDFGLAKKYRDARTHQ---------------------
-------------------------HIPYRENKNLTGTARYASINTHLG-
--------------------IEQ-------SRRDDLESLGYVLMYFNLG-
-----------SLPWQGLKAAT-K--------------RQKYERISEKK-
--------------------------------------------------
---------------------MSTPIEVLCKGYPSEFATYLNFCRS----
---LRFD----------DKPDYSYL------------------------
>CK1e
YRLGRKIGSGSFGDIYLGANIAS---------------------------
-------GEEVAIKLECVKTKHP---------------------------
-QLHIESKFYKMMQGG---------------VGIPSIKWCGAEGD-----
-------------------------------------------YNVMVME
LLG-----------------------------------------------
--PSLEDLFNFCSRK-----------------------------------
--------------------------------------------------
-------------------------------------FSLKTVLLLADQM
ISRIEYIHSK------------NFIHRDVKPDNFLMGLGKKG--------
--------NLVYIIDFGLAKKYRDARTHQ---------------------
-------------------------HIPYRENKNLTGTARYASINTHLG-
--------------------IEQ-------SRRDDLESLGYVLMYFNLG-
-----------SLPWQGLKAATK--------------RQKYERISEKK--
--------------------------------------------------
--------------------MSTPIEVLCKGYPSEFSTYLNFCRS-----
--LRFD----------DKPDYSYL-------------------------
>SgK196
VRQLKRVGEGAVKRVFLSEWK-----------------------------
-------EHKVALSQLTSLEMK----------------------------
DDFLHGLQMLKSLQGT---------------HVVTLLGYCED--------
-------------------------------------------DNTMLTE
YHPL----------------------------------------------
--GSLSNLEETLNL------------------------------------
--------------------------------------------------
-------------------------------------SKYQNVNTWQHRL
ELAMDYVSII------------NYLHHSPVGTRVMCDSND----------
--------LPKTLSQYLLTSNFSILANDL---------------------
----------------DALPLVNHSSGMLVKCGHRELHGDFVAPEQLWP-
--------------------YG------------------ED--------
------------VPFHDDLMPS-YDEKIDI---------WKIPDISSF--
--------------------------------------------------
-------------------LLGHIEGSDMVRFH---LFDIHKACKS----
QTPSERPTAQ--------DVLETY-------------------------
>PRPK
LSGLELVKQGAEARVFRGRF------------------------------
------QGRAAVIKHRFPKGYR----------------------------
-HPALEARLGRRRT------------------VQEARALLRCRRAGISAP
V-----------------------------------VFFVDYASNCLYME
EIE-----------------------------------------------
--GSVTVRDYIQSTMETE--------------------------------
--------------------------------------------------
-------------------------------------KTPQGLSNLAKTI
GQVLARMHDE------------DLIHGDLTTSNMLLKPPLEQ--------
--------LNIVLIDFGLSFI-----------------------------
-----------------------------------------------SAL
P---------------------E-------DKGVDLYVLEKAFLSTHPN-
------------TETVFE--------------------------------
--------------------------------------------------
--------------------------------------AFLKSYST----
SSKKARP-------VLKKLDEVRLRGRKRSMV-----------------
>Haspin
LQRCEKIGEGVFGEVFQTIA------------------------------
------DHTPVAIKIIAIEGPDLVNGSHQKTFE------------EILPE
IIISKELSLLSGEVCN----------------RTEGFIGLNSVHCVQGSY
PPLLLKAWDHYN---------------STKGSANDRPDFFKDDQLFIVLE
FEFG----------------------------------------------
--GIDLEQMRTKLS------------------------------------
--------------------------------------------------
--------------------------------------SLATAKSILHQL
TASLAVAEASL-----------RFEHRDLHWGNVLLKKTSLKKLHYT---
--------LNGKSSTIPSCGLQVSII------------------------
--------------------------DYTLSRLERDGIVVFCDVSMDEDL
FTGD----------------GDY---------QFDIYRLMKKENNNRWGE
Y-----------HPYSNVL--------------------WLHYLTDKMLK
QMTFKTKCNT----------------------------------------
-------------------------------------PAMKQIKRK----
IQEFHRT-------MLNFSSATDLLCQHSLF------------------
>BUB1
VYVHHLLGEGAFAQVYEATQGDLNDAKN----------------------
-------KQKFVLKVQKPAN------------------------------
---PWEFYIGTQLMERL---------------KPSMQHMFMKFY------
------------------------------------SAHLFQNGSVLVGE
LYSY----------------------------------------------
--GTLLNAINLYKNTPEKV-------------------------------
--------------------------------------------------
-------------------------------------MPQGLVISFAMRM
LYMIEQVHDC------------EIIHGDIKPDNFILGNGFLEQDDEDDLS
--------AGLALIDLGQSIDMKLFP------------------------
---------------------------KGTIFTAKCETSGFQCVEMLSNK
P-------------------WNY---------QIDYFGVAATVYCMLFG-
---------------------------------------TYMKVKNEGGE
--------------------------------------------------
-------------------------CKPEGLFRRLPHLDMWNEFFH----
VMLNIPD-------CHHLPSLDLLRQKL---------------------
>BUBR1
LEIEKEIELGNEDYCIKREYLICEDYKLFW--------------------
-VAPRNSAELTVIKVSSQPV------------------------------
---PWDFYINLKLKERL---------------NEDFDHFCSCY-------
----------------------------------------QYQDGCIVWH
QYIN----------------------------------------------
-CFTLQDLLQHSEYIT----------------------------------
--------------------------------------------------
---------------------------------------HEITVLIIYNL
LTIVEMLHKA------------EIVHGDLSPRCLILRNRIHDPYDCNKNN
--------QALKIVDFSYSVDLRVQ-------------------------
---------------------------LDVFTLSGFRT--VQILEGQKIL
ANCS----------------SPY---------QVDLFGIADLAHLLLFK-
---------------------------------------EHLQVFWDG--
--------------------------------------------------
----------------------------SFWKLSQNISELKDGELW----
NKFFVRI-------LNANDEATVSVLGELAA------------------
>Slob
VEPLKDIGWRIRKKYFLMKIKNQ---------------------------
-----PKERLVLSWADLGP-----------------------------DK
YLSDKDFQCLIKLLPSCL--------------HPYIYRVTF---------
---------------------------------------ATANESSALLI
RMFNEK--------------------------------------------
--GTLKDLIYKAKPKDPFLKKYC---------------------------
--------------------------------------------------
-----------------------------NPKKIQGLELQQ-IKTYGRQI
LEVLKFLHDK------------GFPYGHLHASNVMLDG------------
--------DTCRLLDLENSLLGLPSFYR----------------------
---------------------------SYFSQFRKINT------------
------------------------------LESVDVHCFGHLLYEMTYGR
------------PPDSVPVDSF-PPA------------PSMAVVAVLEST
--------------------------------------------------
-------------------------------------LSCEACKNG----
MPTISRL-------LQM-----PLF------------------------
>SgK396
AEPMKELSSKRPLVRSEVN-------------------------------
-------GQIILLKGYSVDVDTEAKVI-----------------ERAATY
HRAWREAEGDSGL-------------------LPLIFLFLCKSD------
----------------------------------------PMAYLMVPYY
P-------------------------------------------------
--RANLNAVQANM-------------------------------------
--------------------------------------------------
-------------------------------------PLNSEETLKVMKG
VAQGLHTLHK-----------ADIIHGSLHQNNVFALNREQ---------
--------GIVGDFDFTKSVSQRAS-------------------------
-----------------------------VNMMVGDLS--LMSPELKMGK
P---------------------A-------SPGSDLYAYGCLLLWLSVQN
Q------------EFEINKDGI----------------------------
--------------------------------------------------
-----------------------------PKVDQFHLDDKVKSLLC----
SLICYRS-------SMTAEQVLNAECF----------------------
>SgK493
---AQYMGSGYTKAVYRVRLPG----------------------------
-------GAAVALKAVDFSGHDLGSCVREF---------GVRRGCYRLAA
HKLLKEMVLLERLR------------------HPNVLQLYGYCY------
--------------------------------------------------
-------------------------------------------------Q
DSEDIPDTLT----------------------------------------
--------------------------------------------------
---------------------------------------TITELGAPVEM
IQLLQTSWEDR-----------FRICLSLGRLLHHLAHSPL---------
--------GSVTLLDFRPRQFVLVD-------------------------
--------------------------------GELKVT-DLDDARVEET-
------------------------P----CAGSTDCILEFPAR-------
--------------------------------------------------
--------------------------------------------------
---------------------------------NFTLPCSAQGWCE----
GMNEKRN-------LYNAYRFFFTYLLPHSAPPSLRPLLDSIV------
>PIK3R4
FEYDKSLGSTRFFKVARAKH------------------------------
------REGLVVVKVFAIQDPTLPLT-----------------------S
YKQELEELKIRLNSAQNC--------------LPFQKASEKASE------
----------------------------------------KAAMLFRQYV
RDNLYDRISTR---------------------------------------
--PFLNNIE-----------------------------------------
--------------------------------------------------
------------------------------------------KRWIAFQI
LTAVDQAHKS------------GVRHGDIKTENVMVTSW-----------
--------NWVLLTDFASFKPTYLPEDNPADFNY----------------
-----------------------------FFDTSRRRT-CYIAPERFVDG
GMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEG
------------VPLFDLS--------------------QL-LAYRNG--
--------------------------------------------------
---------------------HFFPEQVLNKIEDHSIRELVTQMIH----
REPDKRL-------EAEDYLK----------------------------
>SCYL1
LHRGRKKATGSPVSIFVYDVK-----------------------------
---PGAEEQTQVAKAAFK--------------------------------
----RFKTLR----------------------HPNILAYIDGLE------
----------------------------------------TEKCLHVVTE
AVTPLG--------------------------------------------
---IYLKARVEAGGL-----------------------------------
--------------------------------------------------
--------------------------------------KELEISWGLHQI
VKALSFLVNDC-----------SLIHNNVCMAAVFVDRA-----------
--------GEWKLGGLDYMYSAQGNGGGPPRKGIPE--------------
-------------------------------------LEQYDPPELADSS
GRVVR---------------EKW---------SADMWRLGCLIWEVFNG-
-------------PLPRAA--------------------ALRNPGKI---
--------------------------------------------------
---------------------------------PKTLVPHYCELVG----
ANPKVRP-------NPARFLQ----------------------------
>SCYL2
FDVGRHIASGGNGLAWKIFNG-----------------------------
--TKKSTKQEVAVFVFDKKLI----------------------------D
KYQKFEKDQIIDSLKRGVQQLTRLR-------HPRLLTVQHPLE------
----------------------------------------ESRDCLAFCT
EPVF----------------------------------------------
--ASLANVLGNWENLPSPISPDI---------------------------
--------------------------------------------------
---------------------------------KDYKLYDVETKYGLLQV
SEGLSFLHSSV-----------KMVHGNITPENIILNKS-----------
--------GAWKIMGFDFCVSSTNPSEQEPKFPCKEWDPNLPSLCLP---
-------------------------------------NPEYLAPEYILS-
--------------------VSC-------ETASDMYSLGTVMYAVFNKG
K------------PIFEVN--------------------KQDIYKSFSRQ
LDQLS---------------------------------------------
-----------------------RLGSSSLTNIPEEVREHVKLLLN----
VTPTVRP-------DADQMTKIPFF------------------------
>SCYL3
AVYPAVLQDGKFASVFVYKRE-----------------------------
----NEDKVNKAAKHLKTLRHPCLL-----------------------RF
LSCTVEADGI----------------------HLVTERVQPL--------
--------------------------------------------------
--------------------------------------------------
--------------E-----------------------------------
--------------------------------------------------
--------------------------------VALETLSSAEVCAGIYDI
LLALIFLHDRG-----------HLTHNNVCLSSVFVSED-----------
--------GHWKLGGMETVCKVSQATPEFLRSI-----------------
----------------------QSIRDPASIPPEEMSPEFTTLPECHGH-
--------------------------------ARDAFSFGTLVESLLT--
-------------ILNEQV--------------------SADVLSSF---
--------------------------------------------------
------------------------------------QQTLHSTLLN----
PIPKCRP-------ALCTLLSHDFF------------------------
>TBCK
ALPHDVCGSNGLPLTPNSIKIL----------------------------
-------GRFQILKTIT---------------------------------
--------------------------------HPRLCQYVDISRGKHERL
----------------------------------------------VVVA
EHCE----------------------------------------------
--RSLEDLLRERKP------------------------------------
--------------------------------------------------
-------------------------------------VSCSTVLCIAFEV
LQGLQYMNKH------------GIVHRALSPHNILLDRK-----------
--------GHIKLAKFGLYHMTAHGDDVDFPIGY----------------
--------------------------------------PSYLAPEVIAQ-
--------------------GIF--------KTTDHMPSKK---------
-------------PLPSGP---------------------KSDVWSLGII
LFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLA-------------
---------------------EEHGCLDIIKELPETVIDLLNKCLT----
FHPSKRP-------TPDELMKDKVF------------------------
>HRI
FEELVILGKGGYGRVYKVRNKL----------------------------
------DGQYYAIKKILIKGATK------------------------TVC
MKVLREVKVLAGL------------------QHPNIVGYHTAWIEHVHVI
QPRADRAAIELPS-------------LEVLSDQEEDREQCGVKNDESSSS
SIIFAEPTPEKEKRFG---------------------------ESDTENQ
NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSH
LEESFTSTEESSEENVN------------------------FLGQTEAQY
HLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVATKIFQEL
VEGVFYIHNM------------GIVHRDLKPRNIFLHGPD----------
--------QQVKIGDFGLACTDILQKNTDWTNRN----------------
-------------------------GKRTPTHTSRVGTCLYASPEQLEG-
--------------------SEY-------DAKSDMYSLGVVLLELFQ--
-------------PFGTEM--------------------ERAEVLTGLRT
GQL-----------------------------------------------
--------------------------PESLRKRCPVQAKYIQHLTR----
RNSSQRP-------SAIQLLQSELF------------------------
>GCN2
FEELQLLGKGAFGAVIKVQNKL----------------------------
------DGCCYAVKRIPINPA-------------------------SRQF
RRIKGEVTLLSRLH------------------HENIVRYYNAWIERHERP
AGPGTPPPDSGPLAKD----------DRAARGQPASDTDGLDSVEAAAPP
PILSSSVEWSTSGERS---------------------------ASARFPA
TGPGSSDDEDDDEDEHGGVFSQSF10NQDEDCNEKNGCHESEPSVTTEAV
HYLYIQMEYCEKSTLRD------------------------TIDQGLY--
-------------------------------------RDTVRLWRLFREI
LDGLAYIHEK------------GMIHRDLKPVNIFLDSD-----------
--------DHVKIGDFGLATDHLAFSADSKQDDQTGD-------------
----------------------LIKSDPSGHLTGMVGTALYVSPEVQGST
K-------------------SAY-------NQKVDLFSLGIIFFEMSYH-
-------------PMVTAS--------------------ERIFVLNQLRD
--------------------------------------------------
-------------------PTSPKFPEDFDDGEHAKQKSVISWLLN----
HDPAKRP-------TATELLKSELL------------------------
>PEK
FEPIQCLGRGGFGVVFEAKNKV----------------------------
------DDCNYAIKRIRLPNR-------------------------ELAR
EKVMREVKALAKLE-----------HPGIVRYFNAWLEAPPEKWQEKMDE
IWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKEHIEIIAPSPQRSRSF
SVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVE
D-GTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEE
PKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNT
TEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQI
AEAVEFLHSK-----------GLMHRDLKPSNIFFTMD------------
-------DVVKVGDFGLVTAMDQDEEEQTVL-------------------
----------------------TPMPAYARHTGQVGTKLYMSPEQIHG--
--------------------NSY------SHKVDIFSLGLILFELLY---
------------PFSTQM--------------------ERVRTLTDVRNL
KF------------------------------------------------
-------------------------PPLFTQKYPCEYVMVQDMLS----P
SPMERP-------EAINIIENAVF-------------------------
>PKR
FKEIELIGSGGFGQVFKAKHRI----------------------------
------DGKTYVIKRVKYNN------------------------------
EKAEREVKALAKLD------------------HVNIVHYNGCWDGFDYDP
ETSDDSLES-----------------SDYDPENSKNSSRSKTKCLFIQME
FCDK----------------------------------------------
--GTLEQWIEKRRGEK----------------------------------
--------------------------------------------------
-------------------------------------LDKVLALELFEQI
TKGVDYIHSK------------KLIHRDLKPSNIFLVDT-----------
--------KQVKIGDFGLVTSLKND-------------------------
-----------------------------GKRTRSKGT-LRYMPEQISS-
--------------------QDY-------GKEVDLYALGLILAELLHVC
D------------TAFETS--------------------KFFTDLRDGII
SDIFD---------------------------------------------
----------------------------------KKEKTLLQKLLS----
KKPEDRP-------NTSEILRTL--------------------------
>CLIK1
YSLLAEIGRGSYGVVYEAVAGR----------------------------
----SGARVAVKKIRCDAP--------------------------ENVEL
ALAEFWALTSLKRR------------------HQNVVQFEECVLQRNGLA
QRMSHGNKSSQLYLRLV-------ETSLKGERILGYAEEPCYLWFVMEFC
EG------------------------------------------------
--GDLNQYVLSRR-------------------------------------
--------------------------------------------------
-------------------------------------PDPATNKSFMLQL
TSAIAFLHKN------------HIVHRDLKPDNILITERSGT--------
--------PILKVADFGLSKVCAGLAPRGKEGNQDNK-------------
-----------------------NVNVNKYWLSSACGSDFYMAPEVWE--
--------------------GHY-------TAKADIFALGIIIWAMIERI
-------------TFIDSETKK-----------------ELLGTYIKQGT
EIV-------PVGEALLENPKMELHI------------------------
-------------------------PQKRRTSMSEGIKQLLKDMLA----
ANPQDRP-------DAFELETRMDQV-----------------------
>CLIK1L
YDLIREVGRGSYGVVYEAVIRK----------------------------
------TSARVAVKKIRCHAP--------------------------ENV
ELALREFWALSSIKSQ----------------HPNVIHLEECILQKDGMV
QKMSHGSNSS-LYLQLV---------ETSLKGE-IAFDPRSAYYLWFVMD
FCDG----------------------------------------------
--GDMNEYLLSRK-------------------------------------
--------------------------------------------------
-------------------------------------PNRKTNTSFMLQL
SSALAFLHKN------------QIIHRDLKPDNILISQTRLDTSDLE---
--------PTLKVADFGLSKVCSASGQNPEEPV-----------------
-------------------------SVNKCFLSTACGTDFYMAPEVWE--
--------------------GHY-------TAKADIFALGIIIWAMLERI
-------------TFIDTETKK-----------------ELLGSYVKQGT
EIV-------PVGEALLENPKMELLI------------------------
--------------------------PVKKKSMNGRMKQLIKEMLA----
ANPQDRP-------DAFELELRLVQIAFKDSSWE---------------
>IRE1
FCPKDVLGHGAEGTIVYR--------------------------------
---GMFDNRDVAVKRILPECF-----------------------------
SFADREVQLLRESDE-----------------HPNVIRYFCTEKD-----
-----------------------------------------RQFQYIAIE
LCA-----------------------------------------------
--ATLQEYVEQKDFA-----------------------------------
--------------------------------------------------
-------------------------------------HLGLEPITLLQQT
TSGLAHLHSL------------NIVHRDLKPHNILISMPNAHGK------
--------IKAMISDFGLCKKLAVG-------------------------
-------------------------RHSFSRRSGVPGTEGWIAPEMLSED
CKEN----------------PTY---------TVDIFSAGCVFYYVVSEG
SH-----------PFGKSL--------------------QRQANILLG--
--------------------------------------------------
--------------------ACSLDCLHPEKHEDVIARELIEKMIA----
MDPQKRP-------SANDVLKHPFF------------------------
>IRE2
FNPKDVLGRGAGGTFVFR--------------------------------
---GQFEGRAVAVKRLLRECF-----------------------------
GLVRREVQLLQESDR-----------------HPNVLRYFCTERG-----
-----------------------------------------PQFHYIALE
LCR-----------------------------------------------
--ASLQEYVENPDLD-----------------------------------
--------------------------------------------------
-------------------------------------RGGLEPEVVLQQL
MSGLAHLHSL------------HIVHRDLKPGNILITGPDSQGL------
--------GRVVLSDFGLCKKLPAG-------------------------
-------------------------RCSFSLHSGIPGTEGWMAPELLQLL
PPDS----------------PTS---------AVDIFSAGCVFYYVLSGG
SH-----------PFGDSL--------------------YRQANILTG--
--------------------------------------------------
--------------------APCLAHLEEEVHDKVVARDLVGAMLS----
PLPQPRP-------SAPQVLAHPFF------------------------
>RNAseL
----YKIADTSEGGIYLGFY------------------------------
------EKQEVAVKTFCEGS------------------------------
PRAQREVSCLQSSRE-----------------NSHLVTFYGSESH-----
-----------------------------------------RGHLFVCVT
LCE-----------------------------------------------
--QTLEACLDVHRGEDVEN-------------------------------
--------------------------------------------------
-------------------------------------EEDEFARNVLSSI
FKAVQELHLSC-----------GYTHQDLQPQNILIDSK-----------
--------KAAHLADFDKSIKWAG--------------------------
-----------------------------------------DPQEV----
--------------------------------KRDLEDLGRLVLYVVKKG
SI-----------SFEDLK--------------------AQSNEEVVQL-
--------------------------------------------------
-------------------------------SPDEETKDLIHRLFH----
PGEHVRD-------CLSDLLGHPFF------------------------
>SgK071
YQVLYQLNPGALGVNLVVEEME----------------------------
------TKVKHVIKQVECMDD---------------------------HY
ASQALEELMPLLKLR-----------------HAHISVYQELFIT-----
-----------------------------------------WNGEISSLY
LCLVME--------------------------------------------
-----FNELSFQEVIEDKRKA-----------------------------
--------------------------------------------------
----------------------------------KKIIDSEWMQNVLGQV
LDALEYLHHLD------------IIHRNLKPSNIILISS-----------
--------DHCKLQDLSSNVLMTDKAKWNIRAEED---------------
----------------------------------PF-RKSWMAPEALN--
--------------------FSF-------SQKSDIWSLGCIILDMTSC-
-------------SFMDGT--------------------EAMHLRKSLRQ
---------SPGSLKAVLKTMEEKQIPDV---------------------
----------------------------------ETFRNLLPLMLQ----
IDPSDR--------ITIKDVVHITF------------------------
>TTK
YSILKQIGSGGSSKVFQVLNEK----------------------------
-------KQIYAIKYVNLEEADNQ------------------------TL
DSYRNEIAYLNKLQQ-----------------HSDKIIRLYDYEI-----
-----------------------------------------TDQYIYMVM
ECGN----------------------------------------------
--IDLNSWLKKKKS------------------------------------
--------------------------------------------------
-------------------------------------IDPWERKSYWKNM
LEAVHTIHQH------------GIVHSDLKPANFLIVD------------
--------GMLKLIDFGIANQMQPDTT-----------------------
----------------------------SVVKDSQVGTVNYMPPEAIKDM
SSSR----------------ENG-KSKSKISPKSDVWSLGCILYYMTYGK
T------------PFQQII--------------------NQISKLHAIID
----------PNHEIEFPDIPE----------------------------
----------------------------------KDLQDVLKCCLK----
RDPKQRI-------SIPELLAHPYV------------------------
>KIS
WQVQSRLGSGSSASVYRVRCCGN---------------------------
-----PGSPPGALKQFLPPGTTGAAASAA--------------------E
YGFRKERAALEQLQG-----------------HRNIVTLYGVFTIHFS--
---------------------------------------PNVPSRCLLLE
LLD-----------------------------------------------
--VSVSELLLYSSHQG----------------------------------
--------------------------------------------------
-------------------------------------CSMWMIQHCARDV
LEALAFLHHE------------GYVHADLKPRNILWSAEN----------
--------ECFKLIDFGLSFKEG---------------------------
-----------------------------NQDVKYIQTDGYRAPEAELQN
CLAQA---------------GLQ--SDTECTSAVDLWSLGIILLEMFSGM
KLKHTV----RSQEWKANS--------------------SAIIDHIF---
--------------------------------------------------
---------------ASKAVVNAAIPA-------YHLRDLIKSMLH----
DDPSRRI-------PAEMALCSPFF------------------------
>CK2a1
YQLVRKLGRGKYSEVFEAINITN---------------------------
-------NEKVVVKILKPVK-----------------------------K
KKIKREIKILENLRG-----------------GPNIITLADIVKDP----
----------------------------------------VSRTPALVFE
HVN-----------------------------------------------
-----NTDFKQLYQT-----------------------------------
--------------------------------------------------
-------------------------------------LTDYDIRFYMYEI
LKALDYCHSM------------GIMHRDVKPHNVMIDHEH----------
--------RKLRLIDWGLAEFYHPG-------------------------
-----------------------------QEYNVRVASRYFKGPELLVDY
--------------------QMY-------DYSLDMWSLGCMLASMIFR-
-----------KEPFFHGHDNY----------------DQLVRIAKVLGT
---------EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFV-------
-----------------------HSENQHLVS--PEALDFLDKLLR----
YDHQSRL-------TAREAMEHPYF------------------------
>CK2a2
YQLVRKLGRGKYSEVFEAINITN---------------------------
-------NERVVVKILKPVK-----------------------------K
KKIKREVKILENLRG-----------------GTNIIKLIDTVKDP----
----------------------------------------VSKTPALVFE
YIN-----------------------------------------------
-----NTDFKQLYQI-----------------------------------
--------------------------------------------------
-------------------------------------LTDFDIRFYMYEL
LKALDYCHSK------------GIMHRDVKPHNVMIDHQQ----------
--------KKLRLIDWGLAEFYHPA-------------------------
-----------------------------QEYNVRVASRYFKGPELLVDY
--------------------QMY-------DYSLDMWSLGCMLASMIFR-
-----------REPFFHGQDNY----------------DQLVRIAKVLGT
---------EELYGYLKKYHIDLDPHFNDILGQHSRKRWENFI-------
-----------------------HSENRHLVS--PEALDLLDKLLR----
YDHQQRL-------TAKEAMEHPYF------------------------
>CDC7
FKIEDKIGEGTFSSVYLATAQLQV--------------------------
-----GPEEKIALKHLIPTSHPI---------------------------
-RIAAELQCLTVAGG-----------------QDNVMGVKYCFRK-----
-----------------------------------------NDHVVIAMP
YL------------------------------------------------
---EHESFLDILNS------------------------------------
--------------------------------------------------
-------------------------------------LSFQEVREYMLNL
FKALKRIHQF------------GIVHRDVKPSNFLYNRRL----------
--------KKYALVDFGLAQGTHDT-------------------------
----------------150KVCSICLSRRQQVAPRAGTPGFRAPEVLTKC
--------------------PNQ-------TTAIDMWSAGVIFLSLLSG-
-----------RYPFYKASDDL----------------TALAQIMTIRGS
RETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHA
SHQPAISEKTDHKASCLVQT20YNTNLEGWNEVPDEAYDLLDKLLD----
LNPASRI-------TAEEALLHPFF------------------------
>PRP4
YNVYGYTGQGVFSNVVRARDNAR---------------------------
------ANQEVAVKIIRNNELM---------------------------Q
KTGLKELEFLKKLNDA---------------DPDDKFHCLRLFRHFY---
----------------------------------------HKQHLCLVFE
PLS-----------------------------------------------
--MNLREVLKKYGKDVG---------------------------------
--------------------------------------------------
-------------------------------------LHIKAVRSYSQQL
FLALKLLKRC------------NILHADIKPDNILVNESK----------
--------TILKLCDFGSASH-----------------------------
--------------------------VADNDITPYLVSRFYRAPEIIIG-
--------------------KSY-------DYGIDMWSVGCTLYELYTG-
-----------KILFPGKTN-----------------NHMLKLAMDLKGK
---------MPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMST
INPTKDLLADLIGCQRL-------PEDQRKKV--HQLKDLLDQILM----
LDPAKRI-------SINQALQ----------------------------
>DYRK1A
YEIDSLIGKGSFGQVVKAYDRVE---------------------------
-------QEWVAIKIIKNKKAF---------------------------L
NQAQIEVRLLELMNKH---------------DTEMKYYIVHLKRHFM---
----------------------------------------FRNHLCLVFE
MLS-----------------------------------------------
--YNLYDLLRNTNFRG----------------------------------
--------------------------------------------------
-------------------------------------VSLNLTRKFAQQM
CTALLFLATPEL----------SIIHCDLKPENILLCNPKR---------
--------SAIKIVDFGSSC------------------------------
--------------------------QLGQRIYQYIQSRFYRSPEVLLG-
--------------------MPY-------DLAIDMWSLGCILVEMHTG-
-----------EPLFSGANE-----------------VDQMNKIVEVLGI
---------PPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT
RKLHNILGVETGGPGGR---RAGESGHTVADY--LKFKDLILRMLD----
YDPKTRI-------QPYYALQHSFF------------------------
>DYRK1B
YEIDSLIGKGSFGQVVKAYDHQT---------------------------
-------QELVAIKIIKNKKAF---------------------------L
NQAQIELRLLELMNQH---------------DTEMKYYIVHLKRHFM---
----------------------------------------FRNHLCLVFE
LLS-----------------------------------------------
--YNLYDLLRNTHFRG----------------------------------
--------------------------------------------------
-------------------------------------VSLNLTRKLAQQL
CTALLFLATPEL----------SIIHCDLKPENILLCNPKR---------
--------SAIKIVDFGSSC------------------------------
--------------------------QLGQRIYQYIQSRFYRSPEVLLG-
--------------------TPY-------DLAIDMWSLGCILVEMHTG-
-----------EPLFSGSNE-----------------VDQMNRIVEVLGI
---------PPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGT
RRLQEVLGVQTGGPGGR---RAGEPGHSPADY--LRFQDLVLRMLE----
YEPAARI-------SPLGALQHGFF------------------------
>DYRK2
YEVLKVIGKGSFGQVVKAYDHKV---------------------------
-------HQHVALKMVRNEKRF---------------------------H
RQAAEEIRILEHLRKQD-------------KDNTMNVIHMLENFTF----
-----------------------------------------RNHICMTFE
LLS-----------------------------------------------
--MNLYELIKKNKFQG----------------------------------
--------------------------------------------------
-------------------------------------FSLPLVRKFAHSI
LQCLDALHKN------------RIIHCDLKPENILLKQQGR---------
--------SGIKVIDFGSSC------------------------------
--------------------------YEHQRVYTYIQSRFYRAPEVILG-
--------------------ARY-------GMPIDMWSLGCILAELLTG-
-----------YPLLPGEDE-----------------GDQLACMIELLGM
---------PSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGR
SRRGKLRGPPESR--------EWGNALKGCDD--PLFLDFLKQCLE----
WDPAVRM-------TPGQALRHPWL------------------------
>DYRK3
YEVLKIIGKGSFGQVARVYDHKL---------------------------
-------RQYVALKMVRNEKRF---------------------------H
RQAAEEIRILEHLKKQD-------------KTGSMNVIHMLESFTF----
-----------------------------------------RNHVCMAFE
LLS-----------------------------------------------
--IDLYELIKKNKFQG----------------------------------
--------------------------------------------------
-------------------------------------FSVQLVRKFAQSI
LQSLDALHKN------------KIIHCDLKPENILLKHHGR---------
--------SSTKVIDFGSSC------------------------------
--------------------------FEYQKLYTYIQSRFYRAPEIILG-
--------------------SRY-------STPIDIWSFRCILAELLTG-
-----------QPLFPGEDE-----------------GDQLACMMELLGM
---------PPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGR
SRRGKKRGPPGSK--------DWGTALKGCDD--YLFIEFLKRCLH----
WDPSARL-------TPAQALRHPWI------------------------
>DYRK4
YEVLETIGKGSFGQVAKCLDHKN---------------------------
-------NELVALKIIRNKKRF---------------------------H
QQALMELKILEALRKKD-------------KDNTYNVVHMKDFFYF----
-----------------------------------------RNHFCITFE
LLG-----------------------------------------------
--INLYELMKNNNFQG----------------------------------
--------------------------------------------------
-------------------------------------FSLSIVRRFTLSV
LKCLQMLSVE------------KIIHCDLKPENIVLYQKGQ---------
--------ASVKVIDFGSSC------------------------------
--------------------------YEHQKVYTYIQSRFYRSPEVILG-
--------------------HPY-------DVAIDMWSLGCITAELYTG-
-----------YPLFPGENE-----------------VEQLACIMEVLGL
---------PPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRY-------
------------------PDSKDLTMVLKTYD--TSFLDFLRRCLV----
WEPSLRM-------TPDQALKHAWI------------------------
>CLK1
YEIVDTLGEGAFGKVVECIDHKA---------------------------
------GGRHVAVKIVKNVDRY---------------------------C
EAARSEIQVLEHLNTTDP------------NSTFRCVQMLEWFEH-----
-----------------------------------------HGHICIVFE
LLG-----------------------------------------------
--LSTYDFIKENGFLP----------------------------------
--------------------------------------------------
-------------------------------------FRLDHIRKMAYQI
CKSVNFLHSN------------KLTHTDLKPENILFVQSDYTEAYNPKIK
RDERTLINPDIKVVDFGSAT------------------------------
--------------------------YDDEHHSTLVSTRHYRAPEVILA-
--------------------LGW-------SQPCDVWSIGCILIEYYLG-
-----------FTVFPTHDS-----------------KEHLAMMERILGP
---------LPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACK----
-------------------PLKEFMLSQDVEH--ERLFDLIQKMLE----
YDPAKRI-------TLREALKHPFF------------------------
>CLK2
YEIVSTLGEGTFGRVVQCVDHRR---------------------------
------GGARVALKIIKNVEKY---------------------------K
EAARLEINVLEKINEKDP------------DNKNLCVQMFDWFDY-----
-----------------------------------------HGHMCISFE
LLG-----------------------------------------------
--LSTFDFLKDNNYLP----------------------------------
--------------------------------------------------
-------------------------------------YPIHQVRHMAFQL
CQAVKFLHDN------------KLTHTDLKPENILFVNSDYELTYNLEKK
RDERSVKSTAVRVVDFGSAT------------------------------
--------------------------FDHEHHSTIVSTRHYRAPEVILE-
--------------------LGW-------SQPCDVWSIGCIIFEYYVG-
-----------FTLFQTHDN-----------------REHLAMMERILGP
---------IPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCK----
-------------------PLRRYLTSEAEEH--HQLFDLIESMLE----
YEPAKRL-------TLGEALQHPFF------------------------
>CLK3
YEIVGNLGEGTFGKVVECLDHAR---------------------------
------GKSQVALKIIRNVGKY---------------------------R
EAARLEINVLKKIKEKDK------------ENKFLCVLMSDWFNF-----
-----------------------------------------HGHMCIAFE
LLG-----------------------------------------------
--KNTFEFLKENNFQP----------------------------------
--------------------------------------------------
-------------------------------------YPLPHVRHMAYQL
CHALRFLHEN------------QLTHTDLKPENILFVNSEFETLYNEHKS
CEEKSVKNTSIRVADFGSAT------------------------------
--------------------------FDHEHHTTIVATRHYRPPEVILE-
--------------------LGW-------AQPCDVWSIGCILFEYYRG-
-----------FTLFQTHEN-----------------REHLVMMEKILGP
---------IPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCK----
-------------------PLKSYMLQDSLEH--VQLFDLMRRMLE----
FDPAQRI-------TLAEALLHPFF------------------------
>CLK4
E-IVDTLGEGAFGKVVECIDHGM---------------------------
------DGMHVAVKIVKNVGRY---------------------------R
EAARSEIQVLEHLNSTDP------------NSVFRCVQMLEWFDH-----
-----------------------------------------HGHVCIVFE
LLG-----------------------------------------------
--LSTYDFIKENSFLP----------------------------------
--------------------------------------------------
-------------------------------------FQIDHIRQMAYQI
CQSINFLHHN------------KLTHTDLKPENILFVKSDYVVKYNSKMK
RDERTLKNTDIKVVDFGSAT------------------------------
--------------------------YDDEHHSTLVSTRHYRAPEVILA-
--------------------LGW-------SQPCDVWSIGCILIEYYLG-
-----------FTVFQTHDS-----------------KEHLAMMERILGP
---------IPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCK----
-------------------PLKEFMLCHDEEH--EKLFDLVRRMLE----
YDPTQRI-------TLDEALQHPFF------------------------
>HIPK1
YEVLEFLGRGTFGQVAKCWKRST---------------------------
-------KEIVAIKILKNHPSY---------------------------A
RQGQIEVSILSRLSSEN-------------ADEYNLVRSYECFQH-----
-----------------------------------------KNHTCLVFE
MLE-----------------------------------------------
--QNLYDFLKQNKFSP----------------------------------
--------------------------------------------------
-------------------------------------LPLKYIRPILQQV
ATALMKLKSL------------GLIHADLKPENIMLVDPVRQ--------
-------PYRVKVIDFGSASH-----------------------------
--------------------------VSKAVCSTYLQSRYYRAPEIILG-
--------------------LPF-------CEAIDMWSLGCVIAELFLG-
-----------WPLYPGASE-----------------YDQIRYISQTQGL
PAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYI
FNCLDDMAQVNMST----DLEGTDMLAEKADR--REYIDLLKKMLT----
IDADKRI-------TPLKTLNHQFV------------------------
>HIPK2
YEVLEFLGRGTFGQVVKCWKRGT---------------------------
-------NEIVAIKILKNHPSY---------------------------A
RQGQIEVSILARLSTES-------------ADDYNFVRAYECFQH-----
-----------------------------------------KNHTCLVFE
MLE-----------------------------------------------
--QNLYDFLKQNKFSP----------------------------------
--------------------------------------------------
-------------------------------------LPLKYIRPVLQQV
ATALMKLKSL------------GLIHADLKPENIMLVDPSRQ--------
-------PYRVKVIDFGSASH-----------------------------
--------------------------VSKAVCSTYLQSRYYRAPEIILG-
--------------------LPF-------CEAIDMWSLGCVIAELFLG-
-----------WPLYPGDSE-----------------YDQIRYISQTQGL
PAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYI
FNCLDDMAQVNMTT----DLEGSDMLVEKADR--REFIDLLKKMLT----
IDADKRI-------TPIETLNHPFV------------------------
>HIPK3
YEVLDFLGRGTFGQVVKCWKRGT---------------------------
-------NEIVAIKILKNHPSY---------------------------A
RQGQIEVSILARLSTEN-------------ADEYNFVRAYECFQH-----
-----------------------------------------RNHTCLVFE
MLE-----------------------------------------------
--QNLYDFLKQNKFSP----------------------------------
--------------------------------------------------
-------------------------------------LPLKVIRPILQQV
ATALKKLKSL------------GLIHADLKPENIMLVDPVRQ--------
-------PYRVKVIDFGSASH-----------------------------
--------------------------VSKTVCSTYLQSRYYRAPEIILG-
--------------------LPF-------CEAIDMWSLGCVIAELFLG-
-----------WPLYPGALE-----------------YDQIRYISQTQGL
PGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYI
FNSLDDVAHVNTVM----DLEGSDLLAEKADR--REFVSLLKKMLL----
IDADLRI-------TPAETLNHPFV------------------------
>HIPK4
YDIIEVLGKGTFGEVAKGWRRST---------------------------
-------GEMVAIKILKNDAYR---------------------------N
RIIKNELKLLHCMRGL----------------DPEEAHVIRFLEFF----
---------------------------------------HDALKFYLVFE
LLE-----------------------------------------------
--QNLFEFQKENNFAP----------------------------------
--------------------------------------------------
-------------------------------------LPARHIRTVTLQV
LTALARLKEL------------AIIHADLKPENIMLVDQTRC--------
-------PFRVKVIDFGSASIFS---------------------------
--------------------------EVRYVKEPYIQSRFYRAPEILLG-
--------------------LPF-------CEKVDVWSLGCVMAELHLG-
-----------WPLYPGNNE-----------------YDQVRYICETQGL
--------------------------------------------------
-----------------------PKPHLLHAA--CKAHHFFKRMLT----
WESHERI-------SPSAALRHPFV------------------------
>MSSK1
YHVVRKLGWGHFSTVWLCWDIQR---------------------------
-------KRFVALKVVKSAGHY---------------------------T
ETAVDEIKLLKCVRDSDPS-------------DPKRETIVQLIDDFRI--
-------------------------------------SGVNGVHVCMVLE
VLGH----------------------------------------------
--QLLKWIIKSNYQG-----------------------------------
--------------------------------------------------
-------------------------------------LPVPCVKSIVRQV
LHGLDYLHTKC-----------KIIHTDIKPENILLCVGDA--------1
00PQNADKIKIKIADLGNACW-----------------------------
---------------------------VHKHFTEDIQTRQYRAVEVLIG-
--------------------AEY-------GPPADIWSTACMAFELATG-
--------DYLFEPHSGEDYSR--------------DEDHIAHIVELLGD
---------IPPAFALSGRYSREFFNRRGELRHIHNLKHWGLYEVLMEKY
EWP--------------------LEQATQFS------AFLLPMMEY----
-IPEKRA-------SAADCLQHPWL------------------------
>SRPK1
YHVIRKLGWGHFSTVWLSWDIQG---------------------------
-------KKFVAMKVVKSAEHY---------------------------T
ETALDEIRLLKSVRNSDPN-------------DPNREMVVQLLDDFKI--
-------------------------------------SGVNGTHICMVFE
VLGH----------------------------------------------
--HLLKWIIKSNYQG-----------------------------------
--------------------------------------------------
-------------------------------------LPLPCVKKIIQQV
LQGLDYLHTKC-----------RIIHTDIKPENILLSVNEQ--------1
25PKNAEKLKVKIADLGNACW-----------------------------
---------------------------VHKHFTEDIQTRQYRSLEVLIG-
--------------------SGY-------NTPADIWSTACMAFELATG-
--------DYLFEPHSGEEYTR--------------DEDHIALIIELLGK
---------VPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKY
EWS--------------------QEEAAGFT------DFLLPMLEL----
-IPEKRA-------TAAECLRHPWL------------------------
>SRPK2
YHVIRKLGWGHFSTVWLCWDMQG---------------------------
-------KRFVAMKVVKSAQHY---------------------------T
ETALDEIKLLKCVRESDPS-------------DPNKDMVVQLIDDFKI--
-------------------------------------SGMNGIHVCMVFE
VLGH----------------------------------------------
--HLLKWIIKSNYQG-----------------------------------
--------------------------------------------------
-------------------------------------LPVRCVKSIIRQV
LQGLDYLHSKC-----------KIIHTDIKPENILMCVDDA--------1
30PRNADKIRVKIADLGNACW-----------------------------
---------------------------VHKHFTEDIQTRQYRSIEVLIG-
--------------------AGY-------STPADIWSTACMAFELATG-
--------DYLFEPHSGEDYSR--------------DEDHIAHIIELLGS
---------IPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKY
GWP--------------------HEDAAQFT------DFLIPMLEM----
-VPEKRA-------SAGECLRHPWL------------------------
>MOK
YKAIGKIGEGTFSEVMKMQSLRD---------------------------
-------GNYYACKQMKQRFESI-------------------------EQ
VNNLREIQALRRLNP-----------------HPNILMLHEVVFDR----
----------------------------------------KSGSLALICE
LMD-----------------------------------------------
--MNIYELIRGRRYP-----------------------------------
--------------------------------------------------
-------------------------------------LSEKKIMHYMYQL
CKSLDHIHRN------------GIFHRDVKPENILIKQ------------
--------DVLKLGDFGSCRSVYS--------------------------
----------------------------KQPYTEYISTRWYRAPECLLTD
--------------------GFY-------TYKMDLWSAGCVFYEIASL-
-----------QPLFPGVNE-----------------LDQISKIHDVIGT
---------PAQKILTKFKQSRAMNFDFPFKKGSGIPLLTT---------
----------------------------NLSP---QCLSLLHAMVA----
YDPDERIA-------AHQALQHPYF------------------------
>ICK
YTTIRQLGDGTYGSVLLGRSIES---------------------------
-------GELIAIKKMKRKFYSW-------------------------EE
CMNLREVKSLKKLN------------------HANVVKLKEVIRE-----
-----------------------------------------NDHLYFIFE
YMK-----------------------------------------------
--ENLYQLIKERNKL-----------------------------------
--------------------------------------------------
-------------------------------------FPESAIRNIMYQI
LQGLAFIHKH------------GFFHRDLKPENLLCMGP-----------
--------ELVKIADFGLAREIRS--------------------------
----------------------------KPPYTDYVSTRWYRAPEVLLRS
--------------------TNY-------SSPIDVWAVGCIMAEVYTL-
-----------RPLFPGASE-----------------IDTIFKICQVLGT
---------PKKTDWPEGYQLSSAMNFRWPQCVPNNLKTLI---------
---------------------------PNASS---EAVQLLRDMLQ----
WDPKKRPT-------ASQALRYPYF------------------------
>MAK
YTTMRQLGDGTYGSVLMGKSNES---------------------------
-------GELVAIKRMKRKFYSW-------------------------DE
CMNLREVKSLKKLN------------------HANVIKLKEVIRE-----
-----------------------------------------NDHLYFIFE
YMK-----------------------------------------------
--ENLYQLMKDRNKL-----------------------------------
--------------------------------------------------
-------------------------------------FPESVIRNIMYQI
LQGLAFIHKH------------GFFHRDMKPENLLCMGP-----------
--------ELVKIADFGLARELRS--------------------------
----------------------------QPPYTDYVSTRWYRAPEVLLRS
--------------------SVY-------SSPIDVWAVGSIMAELYML-
-----------RPLFPGTSE-----------------VDEIFKICQVLGT
---------PKKSDWPEGYQLASSMNFRFPQCVPINLKTLI---------
---------------------------PNASN---EAIQLMTEMLN----
WDPKKRPT-------ASQALKHPYF------------------------
>GSK3A
YTDIKVIGNGSFGVVYQARLAET---------------------------
-------RELVAIKKVLQDK------------------------------
RFKNRELQIMRKLD------------------HCNIVRLRYFFYSSGE--
--------------------------------------KKDELYLNLVLE
YVP-----------------------------------------------
--ETVYRVARHFTKAK----------------------------------
--------------------------------------------------
-----------------------------------LTIPILYVKVYMYQL
FRSLAYIHSQ------------GVCHRDIKPQNLLVDPD-----------
-------TAVLKLCDFGSAKQLVRG-------------------------
-----------------------------EPNVSYICSRYYRAPELIFGA
--------------------TDY-------TSSIDVWSAGCVLAELLLG-
-----------QPIFPGDSG-----------------VDQLVEIIKVLGT
---------PTREQIREMNPNYTEFKFPQIKAHPWTKVFKSR--------
-----------------------------TPP---EAIALCSSLLE----
YTPSSRLS-------PLEACAHSFF------------------------
>GSK3B
YTDTKVIGNGSFGVVYQAKLCDS---------------------------
-------GELVAIKKVLQDK------------------------------
RFKNRELQIMRKLD------------------HCNIVRLRYFFYSSGE--
--------------------------------------KKDEVYLNLVLD
YVP-----------------------------------------------
--ETVYRVARHYSRAK----------------------------------
--------------------------------------------------
-----------------------------------QTLPVIYVKLYMYQL
FRSLAYIHSF------------GICHRDIKPQNLLLDPD-----------
-------TAVLKLCDFGSAKQLVRG-------------------------
-----------------------------EPNVSYICSRYYRAPELIFGA
--------------------TDY-------TSSIDVWSAGCVLAELLLG-
-----------QPIFPGDSG-----------------VDQLVEIIKVLGT
---------PTREQIREMNPNYTEFKFPQIKAHPWTKVFRPR--------
-----------------------------TPP---EAIALCSRLLE----
YTPTARLT-------PLEACAHSFF------------------------
>CDKL1
YEKIGKIGEGSYGVVFKCRNRDT---------------------------
-------GQIVAIKKFLESEDDP------------------------VIK
KIALREIRMLKQLK------------------HPNLVNLLEVFRR-----
-----------------------------------------KRRLHLVFE
YCD-----------------------------------------------
--HTVLHELDRYQRG-----------------------------------
--------------------------------------------------
-------------------------------------VPEHLVKSITWQT
LQAVNFCHKH------------NCIHRDVKPENILITKH-----------
--------SVIKLCDFGFARLLTGP-------------------------
----------------------------SDYYTDYVATRWYRSPELLVGD
--------------------TQY-------GPPVDVWAIGCVFAELLSG-
-----------VPLWPGKSD-----------------VDQLYLIRKTLGD
---------LIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKF--------
---------------------------PNISY---PALGLLKGCLH----
MDPTERLT-------CEQLLHHPYF------------------------
>CDKL2
YENLGLVGEGSYGMVMKCRNKDT---------------------------
-------GRIVAIKKFLESDDDK------------------------MVK
KIAMREIKLLKQLR------------------HENLVNLLEVCKK-----
-----------------------------------------KKRWYLVFE
FVD-----------------------------------------------
--HTILDDLELFPNG-----------------------------------
--------------------------------------------------
-------------------------------------LDYQVVQKYLFQI
INGIGFCHSH------------NIIHRDIKPENILVSQS-----------
--------GVVKLCDFGFARTLAAP-------------------------
----------------------------GEVYTDYVATRWYRAPELLVGD
--------------------VKY-------GKAVDVWAIGCLVTEMFMG-
-----------EPLFPGDSD-----------------IDQLYHIMMCLGN
---------LIPRHQELFNKNPVFAGVRLPEIKEREPLERRY--------
---------------------------PKLSE---VVIDLAKKCLH----
IDPDKRPF-------CAELLHHDFF------------------------
>CDKL3
YETLGKVGEGSYGTVMKCKHKNT---------------------------
-------GQIVAIKIFYERPEQ-------------------------SVN
KIAMREIKFLKQFH------------------HENLVNLIEVFRQ-----
-----------------------------------------KKKIHLVFE
FID-----------------------------------------------
--HTVLDELQHYCHG-----------------------------------
--------------------------------------------------
-------------------------------------LESKRLRKYLFQI
LRAIDYLHSN------------NIIHRDIKPENILVSQS-----------
--------GITKLCDFGFARTLAAP-------------------------
----------------------------GDIYTDYVATRWYRAPELVLKD
--------------------TSY-------GKPVDIWALGCMIIEMATG-
-----------NPYLPSSSD-----------------LDLLHKIVLKVGN
---------LSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKY--------
---------------------------PKLNG---LLADIVHACLQ----
IDPADRIS-------SSDLLHHEYF------------------------
>CDKL4
YEKLAKTGEGSYGVVFKCRNKTS---------------------------
-------GQVVAVKKFVESEDDP------------------------VVK
KIALREIRMLKQLK------------------HPNLVNLIEVFRR-----
-----------------------------------------KRKMHLVFE
YCD-----------------------------------------------
--HTLLNELERNPNG-----------------------------------
--------------------------------------------------
-------------------------------------VADGVIKSVLWQT
LQALNFCHIH------------NCIHRDIKPENILITKQ-----------
--------GIIKICDFGFA-QILIP-------------------------
----------------------------GDAYTDYVATRWYRAPELLVGD
--------------------TQY-------GSSVDIWAIGCVFAELLTG-
-----------QPLWPGKSD-----------------VDQLYLIIRTLGK
---------LIPRHQSIFKSNGFFHGISIPEPEDMETLE-----------
------------------------EKFSDVHP---VALNFMKGCLK----
MNPDDRLT-------CSQLLESSYF------------------------
>CDKL5
FEILGVVGEGAYGVVLKCRHKET---------------------------
-------HEIVAIKKFKDSEENE------------------------EVK
ETTLRELKMLRTLK------------------QENIVELKEAFRR-----
-----------------------------------------RGKLYLVFE
YVE-----------------------------------------------
--KNMLELLEEMPNG-----------------------------------
--------------------------------------------------
-------------------------------------VPPEKVKSYIYQL
IKAIHWCHKN------------DIVHRDIKPENLLISHN-----------
--------DVLKLCDFGFARNLSEGN------------------------
----------------------------NANYTEYVATRWYRSPELLLG-
--------------------APY-------GKSVDMWSVGCILGELSDG-
-----------QPLFPGESE-----------------IDQLFTIQKVLGP
---------LPSEQMKLFYSNPRFHGLRFPAVNHPQSLE-----------
----------------------RRYLGILNSV----LLDLMKNLLK----
LDPADRYL-------TEQCLNHPTF------------------------
>Erk1
YTQLQYIGEGAYGMVSSAYDHVR---------------------------
-------KTRVAIKKISPFEH-------------------------QTYC
QRTLREIQILLRFR------------------HENVIGIRDILRAST---
--------------------------------------LEAMRDVYIVQD
LME-----------------------------------------------
--TDLYKLLKSQQ-------------------------------------
--------------------------------------------------
-------------------------------------LSNDHICYFLYQI
LRGLKYIHSA------------NVLHRDLKPSNLLSNTT-----------
--------CDLKICDFGLARIADPEHDH----------------------
----------------------------TGFLTEYVATRWYRAPEIMLNS
--------------------KGY-------TKSIDIWSVGCILAEMLSN-
-----------RPIFPGKHY-----------------LDQLNHILGILGS
---------PSQEDLNCIINMKARNYLQSLPSKTKVA-------------
---------------------WAKLFPKSDSK----ALDLLDRMLT----
FNPNKRIT-------VEEALAHPYL------------------------
>erk2_2erk.PDB
YTNLSYIGEGAYGMVCSAYDNLN---------------------------
-------KVRVAIKKISPFEH-------------------------QTYC
QRTLREIKILLRFR------------------HENIIGINDIIRAPT---
--------------------------------------IEQMKDVYIVQD
LME-----------------------------------------------
--TDLYKLLKTQH-------------------------------------
--------------------------------------------------
-------------------------------------LSNDHICYFLYQI
LRGLKYIHSA------------NVLHRDLKPSNLLLNTT-----------
--------CDLKICDFGLARVADPDHDHT---------------------
-----------------------------GFL-E-VATRWYRAPEIMLNS
--------------------KGY-------TKSIDIWSVGCILAEMLSN-
-----------RPIFPGKHY-----------------LDQLNHILGILGS
---------PSQEDLNCIINLKARNYLLSLPHKNKVP-------------
---------------------WNRLFPNADSK----ALDLLDKMLT----
FNPHKRIE-------VEQALAHPYLEQYYDPSDEPIAE-----------
>Erk2
YTNLSYIGEGAYGMVCSAYDNVN---------------------------
-------KVRVAIKKISPFEH-------------------------QTYC
QRTLREIKILLRFR------------------HENIIGINDIIRAPT---
--------------------------------------IEQMKDVYIVQD
LME-----------------------------------------------
--TDLYKLLKTQH-------------------------------------
--------------------------------------------------
-------------------------------------LSNDHICYFLYQI
LRGLKYIHSA------------NVLHRDLKPSNLLLNTT-----------
--------CDLKICDFGLARVADPDHDHT---------------------
-----------------------------GFLTEYVATRWYRAPEIMLNS
--------------------KGY-------TKSIDIWSVGCILAEMLSN-
-----------RPIFPGKHY-----------------LDQLNHILGILGS
---------PSQEDLNCIINLKARNYLLSLPHKNKVP-------------
---------------------WNRLFPNADSK----ALDLLDKMLT----
FNPHKRIE-------VEQALAHPYL------------------------
>Erk3
YMDLKPLGCGGNGLVFSAVDNDC---------------------------
-------DKRVAIKKIVLTDP--------------------------QSV
KHALREIKIIRRLD------------------HDNIVKVFEILGPSGSQL
T--------------------------------DDVGSLTELNSVYIVQE
YME-----------------------------------------------
--TDLANVLEQGP-------------------------------------
--------------------------------------------------
-------------------------------------LLEEHARLFMYQL
LRGLKYIHSA------------NVLHRDLKPANLFINTED----------
--------LVLKIGDFGLARIMDPHYSHK---------------------
-----------------------------GHLSEGLVTKWYRSPRLLLSP
--------------------NNY-------TKAIDMWAAGCIFAEMLTG-
-----------KTLFAGAHE-----------------LEQMQLILESIPV
---------VHEEDRQELLSVIPVYIRNDMTEPHK---------------
---------------------PLTQLLPGISR---EALDFLEQILT----
FSPMDRLT-------AEEALSHPYM------------------------
>Erk4
FVDFQPLGFGVNGLVLSAVDSRA---------------------------
-------CRKVAVKKIALSDA--------------------------RSM
KHALREIKIIRRLD------------------HDNIVKVYEVLGPKGTD-
----------------------------------LQGELFKFSVAYIVQE
YME-----------------------------------------------
--TDLARLLEQGT-------------------------------------
--------------------------------------------------
-------------------------------------LAEEHAKLFMYQL
LRGLKYIHSA------------NVLHRDLKPANIFISTED----------
--------LVLKIGDFGLARIVDQHYSHK---------------------
-----------------------------GYLSEGLVTKWYRSPRLLLSP
--------------------NNY-------TKAIDMWAAGCILAEMLTG-
-----------RMLFAGAHE-----------------LEQMQLILETIPV
---------IREEDKDELLRVMPSFVSSTWEVKRP---------------
----------------------LRKLLPEVNS---EAIDFLEKILT----
FNPMDRLT-------AEMGLQHPYM------------------------
>Erk5
YEIIETIGNGAYGVVSSARRRLT---------------------------
-------GQQVAIKKIPNAFD------------------------VVTNA
KRTLRELKILKHFK------------------HDNIIAIKDILRPTVP--
--------------------------------------YGEFKSVYVVLD
LME-----------------------------------------------
--SDLHQIIHSSQP------------------------------------
--------------------------------------------------
-------------------------------------LTLEHVRYFLYQL
LRGLKYMHSA------------QVIHRDLKPSNLLVNEN-----------
--------CELKIGDFGMARGLCTSPAEH---------------------
----------------------------QYFMTEYVATRWYRAPELMLSL
--------------------HEY-------TQAIDLWSVGCIFGEMLAR-
-----------RQLFPGKNY-----------------VHQLQLIMMVLGT
---------PSPAVIQAVGAERVRAYIQSLPPRQPVP-------------
----------------------WETVYPGADR---QALSLLGRMLR----
FEPSARIS-------AAAALRHPFL------------------------
>Erk7
YLLRRQLGQGAYGIVWKAVDRRT---------------------------
-------GEVVAIKKIFDAFRDKTDAQDMG-----FLLAPPTHTPVFLSL
QRTFREITLLQEFGD-----------------HPNIISLLDVIRA-----
---------------------------------------ENDRDIYLVFE
FMD-----------------------------------------------
--TDLNAVIRKGGL------------------------------------
--------------------------------------------------
-------------------------------------LQDVHVRSIFYQL
LRATRFLHSG------------HVVHRDQKPSNVLLDAN-----------
--------CTVKLCDFGLARSLGDLPEGPE--------------------
----------------------------DQAVTEYVATRWYRAPEVLLSS
--------------------HRY-------TLGVDMWSLGCILGEMLRG-
-----------RPLFPGTST-----------------LHQLELILETI--
-------PPPSEEDLLALGSGCRASVLHQLGSRPRQTLDA----------
-----------------------LL-PPDTSP---EALDLLRRLLV----
FAPDKRLS-------ATQALQHPYV------------------------
>NLK
IEPDRPIGYGAFGVVWSVTDPRD---------------------------
-------GKRVALKKMPNVFQ------------------------NLVSC
KRVFRELKMLCFFK------------------HDNVLSALDILQPPH---
--------------------------------------IDYFEEIYVVTE
LMQ-----------------------------------------------
--SDLHKIIVSPQP------------------------------------
--------------------------------------------------
-------------------------------------LSSDHVKVFLYQI
LRGLKYLHSA------------GILHRDIKPGNLLVNSN-----------
--------CVLKICDFGLARVEELDES-----------------------
-----------------------------RHMTQEVVTQYYRAPEILMGS
--------------------RHY-------SNAIDIWSVGCIFAELLGR-
-----------RILFQAQSP-----------------IQQLDLITDLLGT
---------PSLEAMRTACEGAKAHILRGPHKQPSLPVL-----------
-----------------------YTLSSQATH---EAVHLLCRMLV----
FDPSKRIS-------AKDALAHPYL------------------------
>p38a
YQNLSPVGSGAYGSVCAAFDTKT---------------------------
-------GLRVAVKKLSRPFQ------------------------SIIHA
KRTYRELRLLKHMK------------------HENVIGLLDVFTPAR---
-------------------------------------SLEEFNDVYLVTH
LMG-----------------------------------------------
--ADLNNIVKCQK-------------------------------------
--------------------------------------------------
-------------------------------------LTDDHVQFLIYQI
LRGLKYIHSA------------DIIHRDLKPSNLAVNED-----------
--------CELKILDFGLARHTD---------------------------
-----------------------------DEMTGYVATRWYRAPEIMLNW
--------------------MHY-------NQTVDIWSVGCIMAELLTG-
-----------RTLFPGTDH-----------------INQLQQIMRLTGT
---------PPAYLINRMPSHEARNYIQSLTQMPKMNFA-----------
------------------------NVFIGANP---LAVDLLEKMLV----
LDSDKRIT-------AAQALAHAYF------------------------
>p38b
LQGLRPVGSGAYGSVCSAYDARL---------------------------
-------RQKVAVKKLSRPFQ------------------------SLIHA
RRTYRELRLLKHLK------------------HENVIGLLDVFTPAT---
-------------------------------------SIEDFSEVYLVTT
LMG-----------------------------------------------
--ADLNNIVKCQAGAHQGARL-----------------------------
--------------------------------------------------
-------------------------------------ALDEHVQFLVYQL
LRGLKYIHSA------------GIIHRDLKPSNVAVNED-----------
--------CELRILDFGLARQAD---------------------------
-----------------------------EEMTGYVATRWYRAPEIMLNW
--------------------MHY-------NQTVDIWSVGCIMAELLQG-
-----------KALFPGSDY-----------------IDQLKRIMEVVGT
---------PSPEVLAKISSEHARTYIQSLPPMPQKDLS-----------
------------------------SIFRGANP---LAIDLLGRMLV----
LDSDQRVS-------AAEALAHAYF------------------------
>p38g_1cm8.PDB
YRDLQPVA------VCSAVDGRT---------------------------
-------GAKVAIKKLYRPFQ------------------------SELFA
KRAYRELRLLKHMR------------------HENVIGLLDVFTPDE---
-------------------------------------TLDDFTDFYLVMP
FMG-----------------------------------------------
--TDLGKLMKHEK-------------------------------------
--------------------------------------------------
-------------------------------------LGEDRIQFLVYQM
LKGLRYIHAA------------GIIHRDLKPGNLAVNED-----------
--------CELKILDFGLARQAD---------------------------
-----------------------------SEM-GVV-TRWYRAPEVILNW
--------------------MRY-------TQTVDIWSVGCIMAEMITG-
-----------KTLFKGSDH-----------------LDQLKEIMKVTGT
---------PPAEFVQRLQSDEAKNYMKGLPELEKKDFA-----------
------------------------SILTNASP---LAVNLLEKMLV----
LDAEQRVT-------AGEALAHPYFESLHQVQKYDDSRTLDEWKRVTY-
>p38g
YRDLQPVGSGAYGAVCSAVDGRT---------------------------
-------GAKVAIKKLYRPFQ------------------------SELFA
KRAYRELRLLKHMR------------------HENVIGLLDVFTPDE---
-------------------------------------TLDDFTDFYLVMP
FMG-----------------------------------------------
--TDLGKLMKHEK-------------------------------------
--------------------------------------------------
-------------------------------------LGEDRIQFLVYQM
LKGLRYIHAA------------GIIHRDLKPGNLAVNED-----------
--------CELKILDFGLARQAD---------------------------
-----------------------------SEMTGYVVTRWYRAPEVILNW
--------------------MRY-------TQTVDIWSVGCIMAEMITG-
-----------KTLFKGSDH-----------------LDQLKEIMKVTGT
---------PPAEFVQRLQSDEAKNYMKGLPELEKKDFA-----------
------------------------SILTNASP---LAVNLLEKMLV----
LDAEQRVT-------AGEALAHPYF------------------------
>p38d
YVSPTHVGSGAYGSVCSAIDKRS---------------------------
-------GEKVAIKKLSRPFQ------------------------SEIFA
KRAYRELLLLKHMQ------------------HENVIGLLDVFTPAS---
-------------------------------------SLRNFYDFYLVMP
FMQ-----------------------------------------------
--TDLQKIMGME--------------------------------------
--------------------------------------------------
-------------------------------------FSEEKIQYLVYQM
LKGLKYIHSA------------GVVHRDLKPGNLAVNED-----------
--------CELKILDFGLARHAD---------------------------
-----------------------------AEMTGYVVTRWYRAPEVILSW
--------------------MHY-------NQTVDIWSVGCIMAEMLTG-
-----------KTLFKGKDY-----------------LDQLTQILKVTGV
---------PGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFP-------
----------------------------RASP---QAADLLEKMLE----
LDVDKRLT-------AAQALTHPFF------------------------
>JNK1
YQNLKPIGSGAQGIVCAAYDAIL---------------------------
-------ERNVAIKKLSRPFQ------------------------NQTHA
KRAYRELVLMKCVN------------------HKNIIGLLNVFTPQK---
-------------------------------------SLEEFQDVYIVME
LMD-----------------------------------------------
--ANLCQVIQME--------------------------------------
--------------------------------------------------
-------------------------------------LDHERMSYLLYQM
LCGIKHLHSA------------GIIHRDLKPSNIVVKSD-----------
--------CTLKILDFGLARTAGTS-------------------------
-----------------------------FMMTPYVVTRYYRAPEVILG-
--------------------MGY-------KENVDLWSVGCIMGEMVCH-
-----------KILFPGRDY-----------------IDQWNKVIEQLGT
---------PCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFP--------
---------------DVLFPADSEHNKLKASQ----ARDLLSKMLV----
IDASKRIS-------VDEALQHPYI------------------------
>JNK2
YQQLKPIGSGAQGIVCAAFDTVL---------------------------
-------GINVAVKKLSRPFQ------------------------NQTHA
KRAYRELVLLKCVN------------------HKNIISLLNVFTPQK---
-------------------------------------TLEEFQDVYLVME
LMD-----------------------------------------------
--ANLCQVIHME--------------------------------------
--------------------------------------------------
-------------------------------------LDHERMSYLLYQM
LCGIKHLHSA------------GIIHRDLKPSNIVVKSD-----------
--------CTLKILDFGLARTACTN-------------------------
-----------------------------FMMTPYVVTRYYRAPEVILG-
--------------------MGY-------KENVDIWSVGCIMGELVKG-
-----------CVIFQGTDH-----------------IDQWNKVIEQLGT
---------PSAEFMKKLQPTVRNYVENRPKYPGIKFEELFP--------
---------------DWIFPSESERDKIKTSQ----ARDLLSKMLV----
IDPDKRIS-------VDEALRHPYI------------------------
>jnk3_1jnk.PDB
YQNLKPIGSGAQGIVCAAYDAVL---------------------------
-------DRNVAIKKLSRPFQ------------------------NQTHA
KRAYRELVLMKCVN------------------HKNIISLLNVFTPQK---
-------------------------------------TLEEFQDVYLVME
LMD-----------------------------------------------
--ANLCQVIQME--------------------------------------
--------------------------------------------------
-------------------------------------LDHERMSYLLYQM
LCGIKHLHSA------------GIIHRDLKPSNIVVKSD-----------
--------CTLKILDFGLA-----S-------------------------
-----------------------------FMMTPYVVTRYYRAPEVILG-
--------------------MGY-------KENVDIWSVGCIMGEMVRH-
-----------KILFPGRDY-----------------IDQWNKVIEQLGT
---------PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFP--------
---------------DSLFPADSEHNKLKASQ----ARDLLSKMLV----
IDPAKRIS-------VDDALQHPYINVWYDPAEV---------------
>JNK3
YQNLKPIGSGAQGIVCAAYDAVL---------------------------
-------DRNVAIKKLSRPFQ------------------------NQTHA
KRAYRELVLMKCVN------------------HKNIISLLNVFTPQK---
-------------------------------------TLEEFQDVYLVME
LMD-----------------------------------------------
--ANLCQVIQME--------------------------------------
--------------------------------------------------
-------------------------------------LDHERMSYLLYQM
LCGIKHLHSA------------GIIHRDLKPSNIVVKSD-----------
--------CTLKILDFGLARTAGTS-------------------------
-----------------------------FMMTPYVVTRYYRAPEVILG-
--------------------MGY-------KENVDIWSVGCIMGEMVRH-
-----------KILFPGRDY-----------------IDQWNKVIEQLGT
---------PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFP--------
---------------DSLFPADSEHNKLKASQ----ARDLLSKMLV----
IDPAKRIS-------VDDALQHPYI------------------------
>CDC2
YTKIEKIGEGTYGVVYKGRHKTT---------------------------
-------GQVVAMKKIRLESE------------------------EEGVP
STAIREISLLKELR------------------HPNIVSLQDVLMQ-----
-----------------------------------------DSRLYLIFE
FLS-----------------------------------------------
--MDLKKYLDSIPPGQY---------------------------------
--------------------------------------------------
-------------------------------------MDSSLVKSYLYQI
LQGIVFCHSR------------RVLHRDLKPQNLLIDDK-----------
--------GTIKLADFGLARAFGIP-------------------------
----------------------------IRVYTHEVVTLWYRSPEVLLGS
--------------------ARY-------STPVDIWSIGTIFAELATK-
-----------KPLFHGDSE-----------------IDQLFRIFRALGT
---------PNNEVWPEVESLQDYKNTFPKWKPGSLA-------------
------------------------SHVKNLDE---NGLDLLSKMLI----
YDPAKRIS-------GKMALNHPYF------------------------
>cdk2_1gy3.PDB
FQKVEKIGEGTYGVVYKARNKLT---------------------------
-------GEVVALKKIRLDTE------------------------TEGVP
STAIREISLLKELN------------------HPNIVKLLDVIHT-----
-----------------------------------------ENKLYLVFE
FLH-----------------------------------------------
--QDLKKFMDASALTG----------------------------------
--------------------------------------------------
-------------------------------------IPLPLIKSYLFQL
LQGLAFCHSH------------RVLHRDLKPQNLLINTE-----------
--------GAIKLADFGLARAFGVP-------------------------
----------------------------VRTY-HEVVTLWYRAPEILLGC
--------------------KYY-------STAVDIWSLGCIFAEMVTR-
-----------RALFPGDSE-----------------IDQLFRIFRTLGT
---------PDEVVWPGVTSMPDYKPSFPKWARQDFS-------------
------------------------KVVPPLDE---DGRSLLSQMLH----
YDPNKRIS-------AKAALAHPFFQDVTKPVPH---------------
>CDK2
FQKVEKIGEGTYGVVYKARNKLT---------------------------
-------GEVVALKKIRLDTE------------------------TEGVP
STAIREISLLKELN------------------HPNIVKLLDVIHT-----
-----------------------------------------ENKLYLVFE
FLH-----------------------------------------------
--QDLKKFMDASALTG----------------------------------
--------------------------------------------------
-------------------------------------IPLPLIKSYLFQL
LQGLAFCHSH------------RVLHRDLKPQNLLINTE-----------
--------GAIKLADFGLARAFGVP-------------------------
----------------------------VRTYTHEVVTLWYRAPEILLGC
--------------------KYY-------STAVDIWSLGCIFAEMVTR-
-----------RALFPGDSE-----------------IDQLFRIFRTLGT
---------PDEVVWPGVTSMPDYKPSFPKWARQDFS-------------
------------------------KVVPPLDE---DGRSLLSQMLH----
YDPNKRIS-------AKAALAHPFF------------------------
>CDK3
FQKVEKIGEGTYGVVYKAKNRET---------------------------
-------GQLVALKKIRLDLE------------------------MEGVP
STAIREISLLKELK------------------HPNIVRLLDVVHN-----
-----------------------------------------ERKLYLVFE
FLS-----------------------------------------------
--QDLKKYMDSTPGSE----------------------------------
--------------------------------------------------
-------------------------------------LPLHLIKSYLFQL
LQGVSFCHSH------------RVIHRDLKPQNLLINEL-----------
--------GAIKLADFGLARAFGVP-------------------------
----------------------------LRTYTHEVVTLWYRAPEILLGS
--------------------KFY-------TTAVDIWSIGCIFAEMVTR-
-----------KALFPGDSE-----------------IDQLFRIFRMLGT
---------PSEDTWPGVTQLPDYKGSFPKWTRKGLE-------------
------------------------EIVPNLEP---EGRDLLMQLLQ----
YDPSQRIT-------AKTALAHPYF------------------------
>CDK4
YEPVAEIGVGAYGTVYKARDPHS---------------------------
-------GHFVALKSVRVPNGGG---------------------GGGGLP
ISTVREVALLRRLEAF---------------EHPNVVRLMDVCATSRT--
---------------------------------------DREIKVTLVFE
HVD-----------------------------------------------
--QDLRTYLDKAPPPG----------------------------------
--------------------------------------------------
-------------------------------------LPAETIKDLMRQF
LRGLDFLHAN------------CIVHRDLKPENILVTSG-----------
--------GTVKLADFGLARIYSY--------------------------
----------------------------QMALTPVVVTLWYRAPEVLLQ-
--------------------STY-------ATPVDMWSVGCIFAEMFRR-
-----------KPLFCGNSE-----------------ADQLGKIFDLIGL
---------PPEDDWPRDVSLPRGAFPPRGPRPVQ---------------
------------------------SVVPEMEE---SGAQLLLEMLT----
FNPHKRIS-------AFRALQHSYL------------------------
>cdk5_1h4l.PDB
YEKLEKI----YGTVFKAKNRET---------------------------
-------HEIVALKRVRLD----------------------------GVP
SSALREICLLKELK------------------HKNIVRLHDVLHS-----
-----------------------------------------DKKLTLVFE
FCD-----------------------------------------------
--QDLKKYFDSCNGD-----------------------------------
--------------------------------------------------
-------------------------------------LDPEIVKSFLFQL
LKGLGFCHSR------------NVLHRDLKPQNLLINRN-----------
--------GELKLADFGLARAFGIPVR-----------------------
------------------------------CYSAEVVTLWYRPPDVLFGA
--------------------KLY-------STSIDMWSAGCIFAELANAA
-----------RPLFPGNDV-----------------DDQLKRIFRLLGT
---------PTEEQWPSMTKLPDYKPYPMYPATTSLV-------------
------------------------NVVPKLNA---TGRDLLQNLLK----
CNPVQRIS-------AEEALQHPYF------------------------
>CDK5
YEKLEKIGEGTYGTVFKAKNRET---------------------------
-------HEIVALKRVRLDDDD------------------------EGVP
SSALREICLLKELK------------------HKNIVRLHDVLHS-----
-----------------------------------------DKKLTLVFE
FCD-----------------------------------------------
--QDLKKYFDSCNGD-----------------------------------
--------------------------------------------------
-------------------------------------LDPEIVKSFLFQL
LKGLGFCHSR------------NVLHRDLKPQNLLINRN-----------
--------GELKLADFGLARAFGIPVR-----------------------
------------------------------CYSAEVVTLWYRPPDVLFGA
--------------------KLY-------STSIDMWSAGCIFAELANAG
-----------RPLFPGNDV-----------------DDQLKRIFRLLGT
---------PTEEQWPSMTKLPDYKPYPMYPATTSLV-------------
------------------------NVVPKLNA---TGRDLLQNLLK----
CNPVQRIS-------AEEALQHPYF------------------------
>cdk6_1jow.PDB
YECV-------YGKVFKARDLKN---------------------------
------GGRFVALKRVRVQTGE------------------------EGMP
LSTIREVAVLRHLETF---------------EHPNVVRLFDVCTVSRT--
---------------------------------------DRETKLTLVFE
HVD-----------------------------------------------
--QDLTTYLDKVPEPG----------------------------------
--------------------------------------------------
-------------------------------------VPTETIKDMMFQL
LRGLDFLHSH------------RVVHRDLKPQNILVTSS-----------
--------GQIKLADFGLARIYSF--------------------------
----------------------------QMALTSVVVTLWYRAPEVLLQ-
--------------------SSY-------ATPVDLWSVGCIFAEMFRR-
-----------KPLFRGSSD-----------------VDQLGKILDVIGL
---------PGEEDWPQAFHSKSAQPIE----------------------
------------------------KFVTDIDE---LGKDLLLKCLT----
FNPAKRIS-------AYSALSHPY-------------------------
>CDK6
YECVAEIGEGAYGKVFKARDLKN---------------------------
------GGRFVALKRVRVQTGE------------------------EGMP
LSTIREVAVLRHLETF---------------EHPNVVRLFDVCTVSRT--
---------------------------------------DRETKLTLVFE
HVD-----------------------------------------------
--QDLTTYLDKVPEPG----------------------------------
--------------------------------------------------
-------------------------------------VPTETIKDMMFQL
LRGLDFLHSH------------RVVHRDLKPQNILVTSS-----------
--------GQIKLADFGLARIYSF--------------------------
----------------------------QMALTSVVVTLWYRAPEVLLQ-
--------------------SSY-------ATPVDLWSVGCIFAEMFRR-
-----------KPLFRGSSD-----------------VDQLGKILDVIGL
---------PGEEDWPRDVALPRQAFHSKSAQPIE---------------
------------------------KFVTDIDE---LGKDLLLKCLT----
FNPAKRIS-------AYSALSHPYF------------------------
>CDK7
YEKLDFLGEGQFATVYKARDKNT---------------------------
-------NQIVAIKKIKLGHRSE---------------------AKDGIN
RTALREIKLLQELS------------------HPNIIGLLDAFGH-----
-----------------------------------------KSNISLVFD
FME-----------------------------------------------
--TDLEVIIKDNSLVL----------------------------------
--------------------------------------------------
--------------------------------------TPSHIKAYMLMT
LQGLEYLHQH------------WILHRDLKPNNLLLDEN-----------
--------GVLKLADFGLAKSFGSP-------------------------
----------------------------NRAYTHQVVTRWYRAPELLFGA
--------------------RMY-------GVGVDMWAVGCILAELLLR-
-----------VPFLPGDSD-----------------LDQLTRIFETLGT
---------PTEEQWPDMCSLPDYVTFKSFPGIPLH--------------
-----------------------HIFSAAGDD----LLDLIQGLFL----
FNPCARIT-------ATQALKMKYF------------------------
>CDK8
EYEGCKVGRGTYGHVYKAKRKDGK--------------------------
------DDKDYALKQIEGT----------------------------GIS
MSACREIALLRELK------------------HPNVISLQKVFLSH----
----------------------------------------ADRKVWLLFD
YAE-----------------------------------------------
--HDLWHIIKFHRASKAN--------------------------------
--------------------------------------------------
--------------------------------KKPVQLPRGMVKSLLYQI
LDGIHYLHAN------------WVLHRDLKPANILVMGEGP---------
------ERGRVKIADMGFARLFNSPLK-----------------------
---------------------------PLADLDPVVVTFWYRAPELLLGA
--------------------RHY-------TKAIDIWAIGCIFAELLTS-
-----------EPIFHCRQEDIKTSNP--------YHHDQLDRIFNVMGF
---------PADKDWEDIKKMPEHSTLMKDFRRNTYTNC-SL--------
------------------IKYMEKHKVKPDSK----AFHLLQKLLT----
MDPIKRIT-------SEQAMQDPYF------------------------
>CDK9
YEKLAKIGQGTFGEVFKARHRK----------------------------
------TGQKVALKKVLMENE------------------------KEGFP
ITALREIKILQLLK------------------HENVVNLIEICRTKAS--
------------------------------------PYNRCKGSIYLVFD
FCE-----------------------------------------------
--HDLAGLLSNVLVK-----------------------------------
--------------------------------------------------
-------------------------------------FTLSEIKRVMQML
LNGLYYIHRN------------KILHRDMKAANVLITRD-----------
--------GVLKLADFGLARAFSLAKNS----------------------
---------------------------QPNRYTNRVVTLWYRPPELLLGE
--------------------RDY-------GPPIDLWGAGCIMAEMWTR-
-----------SPIMQANTE-----------------QHQLALISQLCGS
---------ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLK--------
---------------------------AYVRD--PYALDLIDKLLV----
LDPAQRID-------SDDALNHDFF------------------------
>CDK10
FEKLNRIGEGTYGIVYRARDTQ----------------------------
------TDEIVALKKVRMDKE------------------------KDGIP
ISSLREITLLLRLR------------------HPNIVELKEVVVGN----
----------------------------------------HLESIFLVMG
YCE-----------------------------------------------
--QDLASLLENMPTPFS---------------------------------
--------------------------------------------------
---------------------------------------EAQVKCIVLQV
LRGLQYLHRN------------FIIHRDLKVSNLLMTDK-----------
--------GCVKTADFGLARAYGVPVKP----------------------
-------------------------------MTPKVVTLWYRAPELLLGT
--------------------TTQ-------TTSIDMWAVGCILAELLAH-
-----------RPLLPGTSE-----------------IHQIDLIVQLLGT
---------PSENIWPGFSKLPLVGQYSLRKQP-----------------
-------------------YNNLKHKFPWLSE---AGLRLLHFLFM----
YDPKKRAT-------AGDCLESSYF------------------------
>CDK11
EYEGCKVGRGTYGHVYKARRKDGK--------------------------
------DEKEYALKQIEGT----------------------------GIS
MSACREIALLRELK------------------HPNVIALQKVFLSH----
----------------------------------------SDRKVWLLFD
YAE-----------------------------------------------
--HDLWHIIKFHRASKAN--------------------------------
--------------------------------------------------
--------------------------------KKPMQLPRSMVKSLLYQI
LDGIHYLHAN------------WVLHRDLKPANILVMGEGP---------
------ERGRVKIADMGFARLFNSPLKP----------------------
----------------------------LADLDPVVVTFWYRAPELLLGA
--------------------RHY-------TKAIDIWAIGCIFAELLTS-
-----------EPIFHCRQEDIKTSNP--------FHHDQLDRIFSVMGF
---------PADKDWEDIRKMPEYPTLQKDFRRTTYANSSLI--------
-------------------KYMEKHKVKPDSK----VFLLLQKLLT----
MDPTKRIT-------SEQALQDPYF------------------------
>PFTAIRE1
YEKLEKLGEGSYATVYKGKSKVN---------------------------
-------GKLVALKVIRLQEE-------------------------EGTP
FTAIREASLLKGLK------------------HANIVLLHDIIHT-----
-----------------------------------------KETLTLVFE
YVH-----------------------------------------------
--TDLCQYMDKHPGGL----------------------------------
--------------------------------------------------
--------------------------------------HPDNVKLFLFQL
LRGLSYIHQR------------YILHRDLKPQNLLISDT-----------
--------GELKLADFGLARAKSVP-------------------------
----------------------------SHTYSNEVVTLWYRPPDVLLGS
--------------------TEY-------STCLDMWGVGCIFVEMIQG-
-----------VAAFPGMKDI----------------QDQLERIFLVLGT
---------PNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWN--------
-------------------------KLSYVNH----AEDLASKLLQ----
CSPKNRLS-------AQAALSHEYF------------------------
>PFTAIRE2
YLNLEKLGEGSYATVYKGISRIN---------------------------
-------GQLVALKVISMNAE-------------------------EGVP
FTAIREASLLKGLK------------------HANIVLLHDIIHT-----
-----------------------------------------KETLTFVFE
YMH-----------------------------------------------
--TDLAQYMSQHPGGL----------------------------------
--------------------------------------------------
--------------------------------------HPHNVRLFMFQL
LRGLAYIHHQ------------HVLHRDLKPQNLLISHL-----------
--------GELKLADFGLARAKSIP-------------------------
----------------------------SQTYSSEVVTLWYRPPDALLGA
--------------------TEY-------SSELDIWGAGCIFIEMFQG-
-----------QPLFPGVSNI----------------LEQLEKIWEVLGV
---------PTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWN--------
-------------------------RLGRVPE----AEDLASQMLK----
GFPRDRVS-------AQEALVHDYF------------------------
>PCTAIRE1
YIKLDKLGEGTYATVYKGKSKLT---------------------------
-------DNLVALKEIRLEHE-------------------------EGAP
CTAIREVSLLKDLK------------------HANIVTLHDIIHT-----
-----------------------------------------EKSLTLVFE
YLD-----------------------------------------------
--KDLKQYLDDCGNI-----------------------------------
--------------------------------------------------
-------------------------------------INMHNVKLFLFQL
LRGLAYCHRQ------------KVLHRDLKPQNLLINER-----------
--------GELKLADFGLARAKSIP-------------------------
----------------------------TKTYSNEVVTLWYRPPDILLGS
--------------------TDY-------STQIDMWGVGCIFYEMATG-
-----------RPLFPGS-TV----------------EEQLHFIFRILGT
---------PTEETWPGILSNEEFKTYNYPKYRAEALLSHA---------
--------------------------PRLDSD----GADLLTKLLQ----
FEGRNRIS-------AEDAMKHPFF------------------------
>PCTAIRE2
YIKLEKLGEGTYATVYKGRSKLT---------------------------
-------ENLVALKEIRLEHE-------------------------EGAP
CTAIREVSLLKDLK------------------HANIVTLHDIVHT-----
-----------------------------------------DKSLTLVFE
YLD-----------------------------------------------
--KDLKQYMDDCGNI-----------------------------------
--------------------------------------------------
-------------------------------------MSMHNVKLFLYQI
LRGLAYCHRR------------KVLHRDLKPQNLLINEK-----------
--------GELKLADFGLARAKSVP-------------------------
----------------------------TKTYSNEVVTLWYRPPDVLLGS
--------------------SEY-------LTQIDMWGVGCIFFEMASG-
-----------RPLFPGS-TV----------------EDELHLIFRLLGT
---------PSQETWPGISSNEEFKNYNFPKYKPEPLINHA---------
--------------------------PRLDSE----GIELIRKFLQ----
YESKKRVS-------AEEAMKHVYF------------------------
>PCTAIRE3
YVKLDKLGEGTYATVFKGRSKLT---------------------------
-------ENLVALKEIRLEHE-------------------------EGAP
CTAIREVSLLKNLK------------------HANIVTLHDLIHT-----
-----------------------------------------DRSLTLVFE
YLD-----------------------------------------------
--SDLKQYLDHCGNL-----------------------------------
--------------------------------------------------
-------------------------------------MSMHNVKIFMFQL
LRGLAYCHHR------------KILHRDLKPQNLLINER-----------
--------GELKLADFGLARAKSVP-------------------------
----------------------------TKTYSNEVVTLWYRPPDVLLGS
--------------------TEY-------STPIDMWGVGCIHYEMATG-
-----------RPLFPGS-TV----------------KEELHLIFRLLGT
---------PTEETWPGVTAFSEFRTYSFPCYLPQPLINHA---------
--------------------------PRLDTD----GIHLLSSLLL----
YESKSRMS-------AEAALSHSYF------------------------
>PITSLRE
FQCLNRIEEGTYGVVYRAKDKKT---------------------------
-------DEIVALKRLKMEKE------------------------KEGFP
ITSLREINTILKAQ------------------HPNIVTVREIVVGS----
----------------------------------------NMDKIYIVMN
YVE-----------------------------------------------
--HDLKSLMETMKQP-----------------------------------
--------------------------------------------------
-------------------------------------FLPGEVKTLMIQL
LRGVKHLHDN------------WILHRDLKTSNLLLSHA-----------
--------GILKVGDFGLAREYGSP-------------------------
----------------------------LKAYTPVVVTLWYRAPELLLGA
--------------------KEY-------STAVDMWSVGCIFGELLTQ-
-----------KPLFPGK-SE----------------IDQINKVFKDLGT
---------PSEKIWPGYSELPAVKKMTFSEHPYNNLRKRF---------
--------------------------GALLSD---QGFDLMNKFLT----
YFPGRRIS-------AEDGLKHEYF------------------------
>CCRK
YCILGRIGEGAHGIVFKAKHVET---------------------------
-------GEIVALKKVALRRL------------------------EDGFP
NQALREIKALQEM-------------------EDNQYVVQLKAVFP----
----------------------------------------HGGGFVLAFE
FML-----------------------------------------------
--SDLAEVVRHAQRPL----------------------------------
--------------------------------------------------
--------------------------------------AQAQVKSYLQML
LKGVAFCHAN------------NIVHRDLKPANLLISAS-----------
--------GQLKIADFGLARVFSPDG------------------------
----------------------------SRLYTHQVATRWYRAPELLYGA
--------------------RQY-------DQGVDLWSVGCIMGELLNG-
-----------SPLFPGK-ND----------------IEQLCYVLRILGT
---------PNPQVWPELTELPDYNKISFKEQVPMPLEEVL---------
---------------------------PDVSP---QALDLLGQFLL----
YPPHQRIA-------ASKALLHQYF------------------------
>CHED
FDIIGIIGEGTYGQVYKARDKDT---------------------------
-------GEMVALKKVRLDNE------------------------KEGFP
ITAIREIKILRQLT------------------HQSIINMKEIVTDKEDAL
D------------------------------------FKKDKGAFYLVFE
YMD-----------------------------------------------
--HDLMGLLESGLVHFY---------------------------------
--------------------------------------------------
---------------------------------------ENHIKSFMRQL
MEGLDYCHKK------------NFLHRDIKCSNILLNNR-----------
--------GQIKLADFGLARLYSSEE------------------------
----------------------------SRPYTNKVITLWYRPPELLLGE
--------------------ERY-------TPAIDVWSCGCILGELFTK-
-----------KPIFQANQ-----------------ELAQLELISRICGS
---------PCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFV--------
---------------------------FIPAA----ALDLFDYMLA----
LDPSKRCT-------AEQALQCEFL------------------------
>CRK7
FDIIGIIGEGTYGQVYKARDKDT---------------------------
-------GELVALKKVRLDNE------------------------KEGFP
ITAIREIKILRQLI------------------HRSVVNMKEIVTDKQDAL
D------------------------------------FKKDKGAFYLVFE
YMD-----------------------------------------------
--HDLMGLLESGLVHFS---------------------------------
--------------------------------------------------
---------------------------------------EDHIKSFMKQL
MEGLEYCHKK------------NFLHRDIKCSNILLNNS-----------
--------GQIKLADFGLARLYNSEE------------------------
----------------------------SRPYTNKVITLWYRPPELLLGE
--------------------ERY-------TPAIDVWSCGCILGELFTK-
-----------KPIFQANL-----------------ELAQLELISRLCGS
---------PCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFS--------
---------------------------FIPSA----ALDLLDHMLT----
LDPSKRCT-------AEQTLQSDFL------------------------
>PINK1
YLIGQSIGKGCSAAVYEATMPTLPQNLEVTKSTGLLPGRGPGTSAPGEGQ
ERAPGAPAFPLAIKMMWNISAGSSSE------------AILNTMSQELVP
ASRVALAGEYGAVTYRKSKR-----GPKQLAPHPNIIRVLRAFTSSVP--
------------------------------------------LLPGALVD
YPDVLPSRLH------------------------PEGLGHGRTLFLVMKN
YPCTLRQYLCVNTPS-----------------------------------
--------------------------------------------------
---------------------------------------PRLAAMMLLQL
LEGVDHLVQQ------------GIAHRDLKSDNILVELDPDGC-------
--------PWLVIADFGCCLADESIGLQLPF-------------------
----------------------------SSWYVDRGGNGCLMAPEVSTAR
PGPRAV--------------IDY--------SKADAWAVGAIAYEIFGL-
-----------VNPFYGQGKA---------------HLESRSYQEAQL--
--------------------------------------------------
-------------------PALPESVPPDVRQL---VRALLQREAS----
KRPSARVA-------------ANVL------------------------
>SgK269
LTSDKPCCEAGDAVYYTASYAKD---------------------------
------PLNNYAVKICKSKAKESQ----------------------QYYH
SLAVRQSLAV----------------------HFNIKENQGVMSK-----
-----------------------------------------KQRSHVVVI
TREVPCLTV--------------------------------------ADF
VRDSLAQHGKSPDL------------------------------------
--------------------------------------------------
--------------------------------------YERQVCLLLLQL
CSGLEHLKPY------------HVTHCDLRLENLLLVHYQ----------
--------PGGTAQGFGPAEPSPTSSYPTRLIVSNFSQAKQ---------
--------------------------KSHLVDPEILRDQSRLAPEIITA-
--------------------TQY--------KKCDEFQTGILIYEMLHL-
-----------PNPFDENPEL---------------KEREYTRADL----
--------------------------------------------------
---------------------PRIPFRSPYSRG---LQQLASCLLN----
PNPSERILI------SDAKGILQCL------------------------
>SgK223
--------------------------------------------------
-------GSTYAVKICKAPEPKTVSYCSPSV------PVHFNIQQDCGHF
VASVPSSMLSSPDAP-----------------KDPVPALPTHPPA-----
-----------------------------------------QEQDCVVVI
TREVPHQTA--------------------------------------SDF
VRDSAASHQAEPEA------------------------------------
--------------------------------------------------
--------------------------------------YERRVCFLLLQL
CNGLEHLKEH------------GIIHRDLCLENLLLVHCTLQ--------
--------AGPGPAPAPAPAPAAAAPPCSSAAPPAGGTLSPAAGPASPEG
PREKQLP------RLIISNFLKAKQKPGGTPNLQQKKSQARLAPEIVSA-
--------------------SQY--------RKFDEFQTGILIYELLHQ-
-----------PNPFEVRAQL---------------RERDYRQEDL----
--------------------------------------------------
---------------------PPLPALSLYSPG---LQQLAHLLLE----
ADPIKRIR---------IGEAKRVL------------------------
>SgK110
YHLIRKLGSGSYGRVLLAQPHQ----------------------------
------GGPAVALKLLRRDLVLR---------------------------
STFLREFCVGRCVSA-----------------HPGLLQTLAGPLQT----
-----------------------------------------PRYFAFAQE
YAPC----------------------------------------------
--GDLSGMLQERGLP-----------------------------------
--------------------------------------------------
---------------------------------------ELLVKRVVAQL
AGALDFLHSR------------GLVHADVKPDNVLVFDPVC---------
--------SRVALGDLGLTR------------------------------
--------------------------PEGSPTPAPPVPLPTAPPELCLLL
PPDT----------------LPL-------RPAVDSWGLGVLLFCAATA-
-----------CFPWDVALAP--------------NPEFEAFAGWVTTK-
--------------------------------------------------
-----------------PQPPQPPPPWDQFAPP---ALALLQGLLD----
LDPETRSP---------PLAVLDFL------------------------
>SgK069
YEEVRPLGQGRYGRVLLVTHRQ----------------------------
------KGTPLALKQLPKPRTS---------------------------L
RGFLYEFCVGLSLGA-----------------HSAIVTAYGIGIES----
-----------------------------------------AHSYSFLTE
PVLH----------------------------------------------
--GDLMAFIQPKVGLP----------------------------------
--------------------------------------------------
---------------------------------------QPAVHRCAAQL
ASALEYIHAR------------GLVYRDLKPENVLVCDPAC---------
--------RRFKLTDFGHTR------------------------------
--------------------------PRGTLLRLAGPPIPYTAPELCAPP
PLPEG---------------LPI-------QPALDAWALGVLLFCLLTG-
-----------YFPWDRPLAE----------------ADPFYEDFLIWQA
SGQ-----------------------------------------------
-------------------PRDRPQPWFGLAAA---ADALLRGLLD----
PHPRRRSA---------VIAIREHL------------------------
>SBK
YELVRELGKGTYGKVDLVVYKG----------------------------
------TGTKMALKFVNKSKTK---------------------------L
KNFLREVSITNSLSS-----------------SPFIIKVFDVVFET----
-----------------------------------------EDCYVFAQE
YAPA----------------------------------------------
--GDLFDIIPPQVGLP----------------------------------
--------------------------------------------------
---------------------------------------EDTVKRCVQQL
GLALDFMHGR------------QLVHRDIKPENVLLFDREC---------
--------RRVKLADFGMTRR-----------------------------
---------------------------VGCRVKRVSGTIPYTAPEVCQAG
RADG----------------LAV-------DTGVDVWAFGVLIFCVLTG-
-----------NFPWEAASG-----------------ADAFFEEFVRWQR
GRL-----------------------------------------------
--------------------PGLPSQWRRFTEP---ALRMFQRLLA----
LEPERRGP---------AKEVFRFL------------------------
>IKKa
WEMRERLGTGGFGNVCLYQHRE----------------------------
------LDLKIAIKSCRLELSTK-------------------------NR
ERWCHEIQIMKKLN------------------HANVVKACDVPEELNI--
---------------------------------------LIHDVPLLAME
YCSG----------------------------------------------
--GDLRKLLNKPENCCG---------------------------------
--------------------------------------------------
-------------------------------------LKESQILSLLSDI
GSGIRYLHEN------------KIIHRDLKPENIVLQDVGGK--------
--------IIHKIIDLGYAKDVD---------------------------
---------------------------QGSLCTSFVGTLQYLAPELFEN-
--------------------KPY-------TATVDYWSFGTMVFECIAG-
-----------YRPFLHHLQP----FTWHEKIKKKD-PKCIFACEEMSG-
--------------------------------------------------
------------EVRFSSHLPQPNSLCSLIVEP---MENWLQLMLN----
WDPQQRG------------------------------------------
>IKKb
WEMKERLGTGGFGNVIRWHNQE----------------------------
------TGEQIAIKQCRQELSPR-------------------------NR
ERWCLEIQIMRRLT------------------HPNVVAARDVPEGMQN--
--------------------------------------LAPNDLPLLAME
YCQG----------------------------------------------
--GDLRKYLNQFENCCG---------------------------------
--------------------------------------------------
-------------------------------------LREGAILTLLSDI
ASALRYLHEN------------RIIHRDLKPENIVLQQGEQR--------
--------LIHKIIDLGYAKELD---------------------------
---------------------------QGSLCTSFVGTLQYLAPELLEQ-
--------------------QKY-------TVTVDYWSFGTLAFECITG-
-----------FRPFLPNWQP----VQWHSKVRQKS-EVDIVVSEDLNGT
--------------------------------------------------
-------------VKFSSSLPYPNNLNSVLAER---LEKWLQLMLM----
WHPRQRG------------------------------------------
>IKKe
WHTDDLLGQGATASVYKARNKK----------------------------
------SGELVAVKVFNTTSYLR-------------------------PR
EVQVREFEVLRKLN------------------HQNIVKLFAVEETGG---
-----------------------------------------SRQKVLVME
YCSS----------------------------------------------
--GSLLSVLESPENAFG---------------------------------
--------------------------------------------------
-------------------------------------LPEDEFLVVLRCV
VAGMNHLREN------------GIVHRDIKPGNIMRLVGEEGQ-------
--------SIYKLTDFGAARELD---------------------------
---------------------------DDEKFVSVYGTEEYLHPDMYERA
VLRKPQQ-------------KAF-------GVTVDLWSIGVTLYHAATG-
-----------SLPFIPFGGPRR--------------NKEIMYRITTEK-
----------------------------------------PAGAIAGAQR
RENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFAE
TSDILQRVVVHVFSLSQAVLHHIYI------------------------
>TBK1
WLLSDILGQGATANVFRGRHKK----------------------------
------TGDLFAIKVFNNISFLR-------------------------PV
DVQMREFEVLKKLN------------------HKNIVKLFAIEEETT---
-----------------------------------------TRHKVLIME
FCPC----------------------------------------------
--GSLYTVLEEPSNAYG---------------------------------
--------------------------------------------------
-------------------------------------LPESEFLIVLRDV
VGGMNHLREN------------GIVHRDIKPGNIMRVIGEDGQ-------
--------SVYKLTDFGAARELE---------------------------
---------------------------DDEQFVSLYGTEEYLHPDMYERA
VLRKDHQ-------------KKY-------GATVDLWSIGVTFYHAATG-
-----------SLPFRPFEGPRR--------------NKEVMYKIITGK-
----------------------------------------PSGAISGVQK
AENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE
T------------------------------------------------
>AAK1
VTVDEVLAEGGFAIVFLVRTSN----------------------------
-------GMKCALKRMFVNNEH--------------------------DL
QVCKREIQIMRDLSG-----------------HKNIVGYIDSSINNVS--
--------------------------------------SGDVWEVLILMD
FCRG----------------------------------------------
--GQVVNLMNQRLQTG----------------------------------
--------------------------------------------------
-------------------------------------FTENEVLQIFCDT
CEAVARLHQCKT----------PIIHRDLKVENILLHDR-----------
--------GHYVLCDFGSATNKFQNPQTEGV-------------------
--------------------------NAVEDEIKKYTTLSYRAPEMVNLY
SG------------------KII-------TTKADIWALGCLLYKLCYF-
-----------TLPFG-----------------------ESQVAICDGNF
TI------------------------------------------------
------------------------PDNSRYSQD---MHCLIRYMLE----
PDPDKRPD-----IYQVSYFSFKLLKKECP-------------------
>BIKE
VTLEESLAEGGFSTVFLVRTHG----------------------------
-------GIRCALKRMYVNNMP--------------------------DL
NVCKREITIMKELSG-----------------HKNIVGYLDCAVNSIS--
---------------------------------------DNVWEVLILME
YCRA----------------------------------------------
--GQVVNQMNKKLQTG----------------------------------
--------------------------------------------------
-------------------------------------FTEPEVLQIFCDT
CEAVARLHQCKT----------PIIHRDLKVENILLNDG-----------
--------GNYVLCDFGSATNKFLNPQKDGV-------------------
--------------------------NVVEEEIKKYTTLSYRAPEMINLY
GG------------------KPI-------TTKADIWALGCLLYKLCFF-
-----------TLPFG-----------------------ESQVAICDGNF
TI------------------------------------------------
------------------------PDNSRYSRN---IHCLIRFMLE----
PDPEHRPD-----IFQVSYFAFKFAKKDCPVSNINKCCKQLLRHGAL--
>GAK
LRVRRVLAEGGFAFVYEAQDVG----------------------------
------SGREYALKRLLSNEEE--------------------------KN
RAIIQEVCFMKKLSG-----------------HPNIVQFCSAASIGKE--
------------------------------------ESDTGQAEFLLLTE
LCK-----------------------------------------------
--GQLVEFLKKMESRGP---------------------------------
--------------------------------------------------
-------------------------------------LSCDTVLKIFYQT
CRAVQHMHRQKP----------PIIHRDLKVENLLLSNQ-----------
--------GTIKLCDFGSATTISHYPDYSWSAQRR---------------
---------------------------ALVEEEITRNTTPMYRTPEIIDL
YSN-----------------FPI-------GEKQDIWALGCILYLLCFR-
-----------QHPFE-----------------------DGAKLRIVNGK
YSI-----------------------------------------------
------------------------PPHDTQYTV---FHSLIRAMLQ----
VNPEERLS---------IAEVVHQL------------------------
>MPSK1
YLFIQKLGEGGFSYVDLVEGLH----------------------------
------DGHFYALKRILCHEQQ--------------------------DR
EEAQREADMHRLFN------------------HPNILRLVAYCLRERG--
----------------------------------------AKHEAWLLLP
FFKR----------------------------------------------
--GTLWNEIERLKDKGNF--------------------------------
--------------------------------------------------
-------------------------------------LTEDQILWLLLGI
CRGLEAIHAK------------GYAHRDLKPTNILLGDE-----------
--------GQPVLMDLGSMNQACIHVEGSRQAL-----------------
---------------------------TLQDWAAQRCTISYRAPELFSVQ
SH------------------CVI-------DERTDVWSFGCVLYAMMFG-
-----------EGPYDMVFQ------------------KGDSVALAVQ--
--------------------------------------------------
-------------------NQLSIPQSPRHSSA---LRQLLNSMMT----
VDPHQRPH---------IPLLLSQL------------------------
>PLK1
YVRGRLLSKGGFAKCFEISDAD----------------------------
------TKEVFAGKIVPKSLLLKP-----------------------HQR
EKMSMEISIHRSLA------------------HQHVVGFHGFFEDN----
------------------------------------------DFVFVVLE
LCRR----------------------------------------------
--RSLLELHKRRKA------------------------------------
--------------------------------------------------
-------------------------------------LTEPEARYYLRQI
VLGCQYLHRN------------RVIHRDLKLGNLFLNED-----------
--------LEVKIGDFGLATKVEY--------------------------
---------------------------DGERKKTLCGTPNYIAPEVLSK-
--------------------KGH-------SFEVDVWSIGCIMYTLLVG-
-----------KPPFETSCL------------------KETYLRIKKN--
--------------------------------------------------
----------------------EYSIPKHINPV---AASLIQKMLQ----
TDPTARP-------TINELLNDEFF------------------------
>PLK2
YCRGKVLGKGGFAKCYEMTDLT----------------------------
------NNKVYAAKIIPHSRVAKP-----------------------HQR
EKIDKEIELHRILH------------------HKHVVQFYHYFEDK----
------------------------------------------ENIYILLE
YCSR----------------------------------------------
--RSMAHILKARKV------------------------------------
--------------------------------------------------
-------------------------------------LTEPEVRYYLRQI
VSGLKYLHEQ------------EILHRDLKLGNFFINEA-----------
--------MELKVGDFGLAARLEP--------------------------
---------------------------LEHRRRTICGTPNYLSPEVLNK-
--------------------QGH-------GCESDIWALGCVMYTMLLG-
-----------RPPFETTNL------------------KETYRCIREA--
--------------------------------------------------
----------------------RYTMPSSLLAP---AKHLIASMLS----
KNPEDRP-------SLDDIIRHDFF------------------------
>PLK3
YLKGRLLGKGGFARCYEATDTE----------------------------
------TGSAYAVKVIPQSRVAKP-----------------------HQR
EKILNEIELHRDLQ------------------HRHIVRFSHHFEDA----
------------------------------------------DNIYIFLE
LCSR----------------------------------------------
--KSLAHIWKARHT------------------------------------
--------------------------------------------------
-------------------------------------LLEPEVRYYLRQI
LSGLKYLHQR------------GILHRDLKLGNFFITEN-----------
--------MELKVGDFGLAARLEP--------------------------
---------------------------PEQRKKTICGTPNYVAPEVLLR-
--------------------QGH-------GPEADVWSLGCVMYTLLCG-
-----------SPPFETADL------------------KETYRCIKQV--
--------------------------------------------------
----------------------HYTLPASLSLP---ARQLLAAILR----
ASPRDRP-------SIDQILRHDFF------------------------
>PLK4
FKVGNLLGKGSFAGVYRAESIH----------------------------
------TGLEVAIKMIDKKAMYKA-----------------------GMV
QRVKNEVKIHCQLK------------------HPSILELYNYFEDS----
------------------------------------------NYVYLVLE
MCHN----------------------------------------------
--GEMNRYLKNRVKP-----------------------------------
--------------------------------------------------
-------------------------------------FSENEARHFMHQI
ITGMLYLHSH------------GILHRDLTLSNLLLTRN-----------
--------MNIKIADFGLATQLKM--------------------------
---------------------------PHEKHYTLCGTPNYISPEIATR-
--------------------SAH-------GLESDVWSLGCMFYTLLIG-
-----------RPPFDTDTV------------------KNTLNKVVLA--
--------------------------------------------------
----------------------DYEMPTFLSIE---AKDLIHQLLR----
RNPADRL-------SLSSVLDHPFM------------------------
>CaMKK1
VGLTDAYLQGAYGVVRLAYNES----------------------------
------EDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPAKQLLPL
ERVYQEIAILKKLD------------------HVNVVKLIEVLDDP----
-----------------------------------------AEDNLYLVD
LLRK----------------------------------------------
--GPVMEV--PCDKP-----------------------------------
--------------------------------------------------
-------------------------------------FSEEQARLYLRDV
ILGLEYLHCQ------------KIVHRDIKPSNLLLGDD-----------
--------GHVKIADFGVSNQFEG--------------------------
---------------------------NDAQLSSTAGTPAFMAPEAISDS
G-------------------QSF------SGKALDVWATGVTLYCFVYG-
-----------KCPFID-------------------DFILALHRKIKNE-
--------------------------------------------------
--------------------PVVFPEEPEISEE---LKDLILKMLD----
KNPETRI-------GVPDIKLHPWV------------------------
>CaMKK2
YTLKDEIGKGSYGVVKLAYNEN----------------------------
------DNTYYAMKVLSKKKLIRQAAFPRRPPPRGTRPAPGGCIQPRGPI
EQVYQEIAILKKLD------------------HPNVVKLVEVLDDP----
----------------------------------------NEDHLYMVFE
LVNQ----------------------------------------------
--GPVMEV--PTLKP-----------------------------------
--------------------------------------------------
-------------------------------------LSEDQARFYFQDL
IKGIEYLHYQ------------KIIHRDIKPSNLLVGED-----------
--------GHIKIADFGVSNEFKG--------------------------
---------------------------SDALLSNYVGTPAFMAPESLSET
R-------------------KIF------SGKAKDVWAMGVTLYCFVFG-
-----------QCPFMDERIM---------------CLHSKIKSQALEF-
--------------------------------------------------
------------------------PDQPDIAED---LKDLITRMLD----
KNPESRI-------VVPEIKLHPWV------------------------
>TLK1
YLLLHLLGRGGFSEVYKAFDLY----------------------------
------EQRYAAVKIHQLNKSWRDEKK-------------------ENYH
KHACREYRIHKELD------------------HPRIVKLYDYFSLD----
-----------------------------------------TDTFCTVLE
YCEG----------------------------------------------
--NDLDFYLKQHKL------------------------------------
--------------------------------------------------
-------------------------------------MSEKEARSIVMQI
VNALRYLNEIKP----------PIIHYDLKPGNILLVDGTAC--------
--------GEIKITDFGLSKIMDDDSY-----------------------
------------------------GVDGMDLTSQGAGTYWYLPPECFVVG
KEP-----------------PKI-------SNKVDVWSVGVIFFQCLYG-
-----------RKPFGHNQSQ---------------QDILQENTILKATE
V-------------------------------------------------
----------------------QFPVKPVVSSE---AKAFIRRCLA----
YRKEDRF-------DVHQLANDPYL------------------------
>TLK2
YLLLHLLGRGGFSEVYKAFDLT----------------------------
------EQRYVAVKIHQLNKNWRDEKK-------------------ENYH
KHACREYRIHKELD------------------HPRIVKLYDYFSLD----
-----------------------------------------TDSFCTVLE
YCEG----------------------------------------------
--NDLDFYLKQHKL------------------------------------
--------------------------------------------------
-------------------------------------MSEKEARSIIMQI
VNALKYLNEIKP----------PIIHYDLKPGNILLVNGTAC--------
--------GEIKITDFGLSKIMDDDSYN----------------------
------------------------SVDGMELTSQGAGTYWYLPPECFVVG
KEP-----------------PKI-------SNKVDVWSVGVIFYQCLYG-
-----------RKPFGHNQSQ---------------QDILQENTILKATE
V-------------------------------------------------
----------------------QFPPKPVVTPE---AKAFIRRCLA----
YRKRDRI-------DVQQLACDPYL------------------------
>ULK1
FSRKDLIGHGAFAVVFKGRHREK---------------------------
------HDLEVAVKCINKKNLAKS-------------------------Q
TLLGKEIKILKELK------------------HENIVALYDFQEM-----
-----------------------------------------ANSVYLVME
YCNG----------------------------------------------
--GDLADYLHAMRT------------------------------------
--------------------------------------------------
-------------------------------------LSEDTIRLFLQQI
AGAMRLLHSK------------GIIHRDLKPQNILLSNPAGRRANPNS--
--------IRVKIADFGFARYLQS--------------------------
----------------------------NMMAATLCGSPMYMAPEVIMS-
--------------------QHY-------DGKADLWSIGTIVYQCLTG-
-----------KAPFQASSPQ---------------DLRLFYEKNKTLV-
--------------------------------------------------
-----------------------PTIPRETSAP---LRQLLLALLQ----
RNHKDRM-------DFDEFFHHPFL------------------------
>ULK2
YSKRDLVGHGAFAVVFRGRHRQK---------------------------
------TDWEVAIKSINKKNLSKS-------------------------Q
ILLGKEIKILKELQ------------------HENIVALYDVQEL-----
-----------------------------------------PNSVFLVME
YCNG----------------------------------------------
--GDLADYLQAKGT------------------------------------
--------------------------------------------------
-------------------------------------LSEDTIRVFLHQI
AAAMRILHSK------------GIIHRDLKPQNILLSYANRRKSSVSG--
--------IRIKIADFGFARYLHS--------------------------
----------------------------NMMAATLCGSPMYMAPEVIMS-
--------------------QHY-------DAKADLWSIGTVIYQCLVG-
-----------KPPFQANSPQ---------------DLRMFYEKNRSLM-
--------------------------------------------------
-----------------------PSIPRETSPY---LANLLLGLLQ----
RNQKDRM-------DFEAFFSHPFL------------------------
>ULK3
FILTERLGSGTYATVYKAYAKKD---------------------------
------TREVVAIKCVAKKSLNKAS------------------------V
ENLLTEIEILKGIR------------------HPHIVQLKDFQWD-----
-----------------------------------------SDNIYLIME
FCAG----------------------------------------------
--GDLSRFIHTRRI------------------------------------
--------------------------------------------------
-------------------------------------LPEKVARVFMQQL
ASALQFLHER------------NISHLDLKPQNILLSSLEK---------
--------PHLKLADFGFAQHMSP--------------------------
----------------------------WDEKHVLRGSPLYMAPEMVCQ-
--------------------RQY-------DARVDLWSMGVILYEALFG-
-----------QPPFASRSFS---------------ELEEKIRSNRVIEL
--------------------------------------------------
------------------------PLRPLLSRD---CRDLLQRLLE----
RDPSRRI-------SFQDFFAHPWV------------------------
>ULK4
FILYEEIGRGSKTVVYKGRRKG----------------------------
------TINFVAILCTDKCRRPEIT-----------------------NW
VRLTREIKHKNIV-------------------TFHEWYETSNHLW-----
-----------------------------------------VENLPEDVV
REFG----------------------------------------------
--IDLISGLHHLHKL-----------------------------------
--------------------------------------------------
-------------------------------------GILFCDISPRKIL
LEGPGTLKFS------------NFCLAKVEGENLEEFFALVA--------
--------AEEGGGDNGENVLK----------------------------
----------------------------KSMKSRVKGSPVYTAPEVVRG-
--------------------ADF-------SISSDLWSLGCLLYEMFSG-
-----------KPPFFSESVS---------------ELTEKILCED----
--------------------------------------------------
----------------PLPPIPKDSSRPKASSD---FINLLDGLLQ----
RDPQKRL-------TWTRLLQHSFW------------------------
>Fused
YHVLEMIGEGSFGRVYKGRRKY----------------------------
------SAQVVALKFIPKLGRSE------------------------KEL
RNLQREIEIMRGLR------------------HPNIVHMLDSFET-----
-----------------------------------------DKEVVVVTD
YAE-----------------------------------------------
--GELFQILEDDGK------------------------------------
--------------------------------------------------
-------------------------------------LPEDQVQAIAAQL
VSALYYLHSH------------RILHRDMKPQNILLAKG-----------
--------GGIKLCDFGFARAMST--------------------------
---------------------------NTMVLTSIKGTPLYMSPELVEE-
--------------------RPY-------DHTADLWSVGCILYELAVG-
-----------TPPFYATSIF---------------QLVSLILKD-----
--------------------------------------------------
----------------------PVRWPSTISPC---FKNFLQGLLT----
KDPRQRL-------SWPDLLYHPFI------------------------
>AurA
FEIGRPLGKGKFGNVYLAREKQ----------------------------
------SKFILALKVLFKAQLEKA-----------------------GVE
HQLRREVEIQSHLR------------------HPNILRLYGYFHD-----
-----------------------------------------ATRVYLILE
YAPL----------------------------------------------
--GTVYRELQKLSK------------------------------------
--------------------------------------------------
-------------------------------------FDEQRTATYITEL
ANALSYCHSK------------RVIHRDIKPENLLLGSA-----------
--------GELKIADFGWSVHAP---------------------------
----------------------------SSRRTTLCGTLDYLPPEMIEG-
--------------------RMH-------DEKVDLWSLGVLCYEFLVG-
-----------KPPFEANTYQ------------------ETYKRISRV--
--------------------------------------------------
----------------------EFTFPDFVTEG---ARDLISRLLK----
HNPSQRP-------MLREVLEHPWI------------------------
>AurB
FEIGRPLGKGKFGNVYLAREKK----------------------------
------SHFIVALKVLFKSQIEKE-----------------------GVE
HQLRREIEIQAHLH------------------HPNILRLYNYFYD-----
-----------------------------------------RRRIYLILE
YAPR----------------------------------------------
--GELYKELQKSCT------------------------------------
--------------------------------------------------
-------------------------------------FDEQRTATIMEEL
ADALMYCHGK------------KVIHRDIKPENLLLGLK-----------
--------GELKIADFGWSVHAP---------------------------
----------------------------SLRRKTMCGTLDYLPPEMIEG-
--------------------RMH-------NEKVDLWCIGVLCYELLVG-
-----------NPPFESASHN------------------ETYRRIVKV--
--------------------------------------------------
----------------------DLKFPASVPTG---AQDLISKLLR----
HNPSERL-------PLAQVSAHPWV------------------------
>AurC
FEIGRPLGKGKFGNVYLARLKE----------------------------
------SHFIVALKVLFKSQIEKE-----------------------GLE
HQLRREIEIQAHLQ------------------HPNILRLYNYFHD-----
-----------------------------------------ARRVYLILE
YAPR----------------------------------------------
--GELYKELQKSEK------------------------------------
--------------------------------------------------
-------------------------------------LDEQRTATIIEEV
ADALTYCHDK------------KVIHRDIKPENLLLGFR-----------
--------GEVKIADFGWSVHTP---------------------------
----------------------------LPERKTMCGTLDYLPPEMIEG-
--------------------RTY-------DEKVDLWCIGVLCYELLVG-
-----------YPPFESASHS------------------ETYRRILKV--
--------------------------------------------------
----------------------DVRFPLSMPLG---ARDLISRLLR----
YQPLERL-------PLAQILKHPWV------------------------
>SgK494
LKILGLVAKGSFGTVLKVLDCT----------------------------
------QKAVFAVKVVPKVKVLQR-----------------------DTV
RQCKEEVSIQRQIN------------------HPFVHSLGDSWQG-----
-----------------------------------------KRHLFIMCS
YCS-----------------------------------------------
--TDLYSLWSAVGC------------------------------------
--------------------------------------------------
-------------------------------------FPEASIRLFAAEL
VLVLCYLHDL------------GIMHRDVKMENILLDER-----------
--------GHLKLTDFGLSRHVP---------------------------
---------------------------QGAQAYTICGTLQYMAPEVLSG-
--------------------GPY-------NHAADWWSLGVLLFSLATG-
-----------KFPVAAE-----------------RDHVAMLASVTHS--
--------------------------------------------------
----------------------DSEIPASLNQG---LSLLLHELLC----
QNPLHRL------RYLHHFQVHPFF------------------------
>PDK1
FKFGKILGEGSFSTVVLARELA----------------------------
------TSREYAIKILEKRHIIKE-----------------------NKV
PYVTRERDVMSRLD------------------HPFFVKLYFTFQD-----
-----------------------------------------DEKLYFGLS
YAKN----------------------------------------------
--GELLKYIRKIGS------------------------------------
--------------------------------------------------
-------------------------------------FDETCTRFYTAEI
VSALEYLHGK------------GIIHRDLKPENILLNED-----------
--------MHIQITDFGTAKVLSP--------------------------
-------------------------ESKQARANSFVGTAQYVSPELLTE-
--------------------KSA-------CKSSDLWALGCIIYQLVAG-
-----------LPPFRAG-----------------NEYLIFQKIIKLE--
--------------------------------------------------
-----------------------YDFPEKFFPK---ARDLVEKLLV----
LDATKRLGCE-EMEGYGPLKAHPFF------------------------
>BARK1
FSVHRIIGRGGFGEVYGCRKAD----------------------------
------TGKMYAMKCLDKKRIKMK-----------------------QGE
TLALNERIMLSLVSTG---------------DCPFIVCMSYAFHT-----
-----------------------------------------PDKLSFILD
LMNG----------------------------------------------
--GDLHYHLSQHGV------------------------------------
--------------------------------------------------
-------------------------------------FSEADMRFYAAEI
ILGLEHMHNR------------FVVYRDLKPANILLDEH-----------
--------GHVRISDLGLACDF----------------------------
---------------------------SKKKPHASVGTHGYMAPEVLQKG
--------------------VAY-------DSSADWFSLGCMLFKLLRG-
-----------HSPFRQHKT---------------KDKHEIDRMTLTM--
--------------------------------------------------
----------------------AVELPDSFSPE---LRSLLEGLLQ----
RDVNRRLGC--LGRGAQEVKESPFF------------------------
>BARK2
FSVHRIIGRGGFGEVYGCRKAD----------------------------
------TGKMYAMKCLDKKRIKMK-----------------------QGE
TLALNERIMLSLVSTG---------------DCPFIVCMTYAFHT-----
-----------------------------------------PDKLCFILD
LMNG----------------------------------------------
--GDLHYHLSQHGV------------------------------------
--------------------------------------------------
-------------------------------------FSEKEMRFYATEI
ILGLEHVHNR------------FVVYRDLKPANILLDEH-----------
--------GHARISDLGLACDF----------------------------
---------------------------SKKKPHASVGTHGYMAPEVLQKG
--------------------TAY-------DSSADWFSLGCMLFKLLRG-
-----------HSPFRQHKT---------------KDKHEIDRMTLTV--
--------------------------------------------------
----------------------NVELPDTFSPE---LKSLLEGLLQ----
RDVSKRLGC--HGGGSQEVKEHSFF------------------------
>GPRK7
FTEFRVLGKGGFGEVCAVQVKN----------------------------
------TGKMYACKKLDKKRLKKK-----------------------GGE
KMALLEKEILEKVS------------------SPFIVSLAYAFES-----
-----------------------------------------KTHLCLVMS
LMNG----------------------------------------------
--GDLKFHIYNVGTRG----------------------------------
--------------------------------------------------
-------------------------------------LDMSRVIFYSAQI
ACGMLHLHEL------------GIVYRDMKPENGLLDDL-----------
--------GNCRLSDLGLAVEM----------------------------
--------------------------KGGKPITQRAGTNGYMAPEILMEK
--------------------VSY-------SYPVDWFAMGCSIYEMVAG-
-----------RTPFKDYKE--------------KVSKEDLKQRTLQD--
--------------------------------------------------
---------------------EVKFQHDNFTEE---AKDICRLFLA----
KKPEQRLR---SREKSDDPRKHHFF------------------------
>RHOK
FLDFRVLGKGGFGEVSACQMKA----------------------------
------TGKLYACKKLNKKRLKKR-----------------------KGY
QGAMVEKKILMKVH------------------SRFIVSLAYAFET-----
-----------------------------------------KADLCLVMT
IMNG----------------------------------------------
--GDIRYHIYNVNEENPG--------------------------------
--------------------------------------------------
-------------------------------------FPEPRALFYTAQI
ICGLEHLHQR------------RIVYRDLKPENVLLDND-----------
--------GNVRISDLGLAVELL---------------------------
--------------------------DGQSKTKGYAGTPGFMAPELLQG-
--------------------EEY-------DFSVDYFALGVTLYEMIAA-
-----------RGPFRARGE--------------KVENKELKHRIISE--
--------------------------------------------------
----------------------PVKYPDKFSQA---SKDFCEALLE----
KDPEKRLGF--RDETCDKLRAHPLF------------------------
>GPRK4
FRHYRVLGKGGFGEVCACQVRA----------------------------
------TGKMYACKKLQKKRIKKR-----------------------KGE
AMALNEKRILEKVQ------------------SRFVVSLAYAYET-----
-----------------------------------------KDALCLVLT
IMNG----------------------------------------------
--GDLKFHIYNLGNPG----------------------------------
--------------------------------------------------
-------------------------------------FDEQRAVFYAAEL
CCGLEDLQRE------------RIVYRDLKPENILLDDR-----------
--------GHIRISDLGLATEI----------------------------
--------------------------PEGQRVRGRVGTVGYMAPEVVNN-
--------------------EKY-------TFSPDWWGLGCLIYEMIQG-
-----------HSPFKKYKE--------------KVKWEEVDQRIKND--
--------------------------------------------------
----------------------TEEYSEKFSED---AKSICRMLLT----
KNPSKRLGC--RGEGAAGVKQHPVF------------------------
>GPRK5
FRQYRVLGKGGFGEVCACQVRA----------------------------
------TGKMYACKRLEKKRIKKR-----------------------KGE
SMALNEKQILEKVN------------------SQFVVNLAYAYET-----
-----------------------------------------KDALCLVLT
IMNG----------------------------------------------
--GDLKFHIYNMGNPG----------------------------------
--------------------------------------------------
-------------------------------------FEEERALFYAAEI
LCGLEDLHRE------------NTVYRDLKPENILLDDY-----------
--------GHIRISDLGLAVKI----------------------------
--------------------------PEGDLIRGRVGTVGYMAPEVLNN-
--------------------QRY-------GLSPDYWGLGCLIYEMIEG-
-----------QSPFRGRKE--------------KVKREEVDRRVLET--
--------------------------------------------------
----------------------EEVYSHKFSEE---AKSICKMLLT----
KDAKQRLGC--QEEGAAEVKRHPFF------------------------
>GPRK6
FRQYRVLGKGGFGEVCACQVRA----------------------------
------TGKMYACKKLEKKRIKKR-----------------------KGE
AMALNEKQILEKVN------------------SRFVVSLAYAYET-----
-----------------------------------------KDALCLVLT
LMNG----------------------------------------------
--GDLKFHIYHMGQAG----------------------------------
--------------------------------------------------
-------------------------------------FPEARAVFYAAEI
CCGLEDLHRE------------RIVYRDLKPENILLDDH-----------
--------GHIRISDLGLAVHV----------------------------
--------------------------PEGQTIKGRVGTVGYMAPEVVKN-
--------------------ERY-------TFSPDWWALGCLLYEMIAG-
-----------QSPFQQRKK--------------KIKREEVERLVKEV--
--------------------------------------------------
----------------------PEEYSERFSPQ---ARSLCSQLLC----
KDPAERLGC--RGGSAREVKEHPLF------------------------
>RSKL1
--------------------------------------------------
------CSPLSGANEYIASTDTLK-----------------------TEE
VLLFTDQTDDLAKE------------------EPTSLFQRDSET------
-----------------------------------------KGESGLVLE
GDKEI---------------------------------------------
--HQIFEDLDKKLALASRFY------------------------------
--------------------------------------------------
-------------------------------------IPEGCIQRWAAEM
VVALDALHRE------------GIVCRDLNPNNILLNDR-----------
--------GHIQLTYFSRWSEV----------------------------
----------------------------EDSCDSDAIERMYCAPEVGAI-
--------------------TEE-------TEACDWWSLGAVLFELLTG-
-----------KTLVECHPA-----------------GINTH--------
--------------------------------------------------
---------------------TTLNMPECVSEE---ARSLIQQLLQ----
FNPLERLGA--GVAGVEDIKSHPFF------------------------
>RSKL2
CRVVGVIEKVQLVQDPATGG------------------------------
---------TFVVKSLPRCHMV----------------------------
---SRERLTIIPHG------------------VPYMTKLLRYFVS-----
-----------------------------------------EDSIFLHLE
HVQG----------------------------------------------
--GTLWSHLLSQAHSRHSGLSSGSTQERMKAQLNPHLNLLTPARLPSGHA
PGQDRIALEPPRTSPNLLLAGEAPSTRPQREA-EGEPTARTSTSGSRGLT
WVPEGAGPVLGGCGRGMDQSCLSADGAGRGCGRATWSVREEQVKQWAAEM
LVALEALHEQ------------GVLCRDLHPGNLLLDQA-----------
--------GHIRLTYFGQWSEV----------------------------
----------------------------EPQCCGEAVDNLYSAPEVGGI-
--------------------SEL-------TEACDWWSFGSLLYELLTG-
-----------MALSQSHPS-----------------GIQAH--------
--------------------------------------------------
---------------------TQLQLPEWLSRP---AASLLTELLQ----
FEPTRRLGM--GEGGVSKLKSHPFF------------------------
>MSK1
FELLKVLGTGAYGKVFLVRKISG---------------------------
----HDTGKLYAMKVLKKATIVQK----------------------AKTT
EHTRTERQVLEHIRQ-----------------SPFLVTLHYAFQT-----
-----------------------------------------ETKLHLILD
YING----------------------------------------------
--GELFTHLSQRER------------------------------------
--------------------------------------------------
-------------------------------------FTEHEVQIYVGEI
VLALEHLHKL------------GIIYRDIKLENILLDSN-----------
--------GHVVLTDFGLSKEFVA--------------------------
--------------------------DETERAYSFCGTIEYMAPDIVRGG
D-------------------SGH-------DKAVDWWSLGVLMYELLTG-
-----------ASPFTVDG------------------EKNSQAEISR---
--------------------------------------------------
-----------------RILKSEPPYPQEMSAL---AKDLIQRLLM----
KDPKKRLGC--GPRDADEIKEHLFF------------------------
>MSK2
FELLKVLGTGAYGKVFLVRKAGG---------------------------
----HDAGKLYAMKVLRKAALVQR----------------------AKTQ
EHTRTERSVLELVRQ-----------------APFLVTLHYAFQT-----
-----------------------------------------DAKLHLILD
YVSG----------------------------------------------
--GEMFTHLYQRQY------------------------------------
--------------------------------------------------
-------------------------------------FKEAEVRVYGGEI
VLALEHLHKL------------GIIYRDLKLENVLLDSE-----------
--------GHIVLTDFGLSKEFLT--------------------------
--------------------------EEKERTFSFCGTIEYMAPEIIRSK
--------------------TGH-------GKAVDWWSLGILLFELLTG-
-----------ASPFTLEG------------------ERNTQAEVSR---
--------------------------------------------------
-----------------RILKCSPPFPPRIGPV---AQDLLQRLLC----
KDPKKRLGA--GPQGAQEVRNHPFF------------------------
>p70S6K
FELLRVLGKGGYGKVFQVRKVTG---------------------------
----ANTGKIFAMKVLKKAMIVRN----------------------AKDT
AHTKAERNILEEVK------------------HPFIVDLIYAFQT-----
-----------------------------------------GGKLYLILE
YLSG----------------------------------------------
--GELFMQLEREGI------------------------------------
--------------------------------------------------
-------------------------------------FMEDTACFYLAEI
SMALGHLHQK------------GIIYRDLKPENIMLNHQ-----------
--------GHVKLTDFGLCKESIH--------------------------
---------------------------DGTVTHTFCGTIEYMAPEILMR-
--------------------SGH-------NRAVDWWSLGALMYDMLTG-
-----------APPFTGEN------------------RKKTIDKILK---
--------------------------------------------------
---------------------CKLNLPPYLTQE---ARDLLKKLLK----
RNAASRLGA--GPGDAGEVQAHPFF------------------------
>p70S6Kb
FELLRVLGKGGYGKVFQVRKVQG---------------------------
----TNLGKIYAMKVLRKAKIVRN----------------------AKDT
AHTRAERNILESVK------------------HPFIVELAYAFQT-----
-----------------------------------------GGKLYLILE
CLSG----------------------------------------------
--GELFTHLEREGI------------------------------------
--------------------------------------------------
-------------------------------------FLEDTACFYLAEI
TLALGHLHSQ------------GIIYRDLKPENIMLSSQ-----------
--------GHIKLTDFGLCKESIH--------------------------
---------------------------EGAVTHTFCGTIEYMAPEILVR-
--------------------SGH-------NRAVDWWSLGALMYDMLTG-
-----------SPPFTAEN------------------RKKTMDKIIR---
--------------------------------------------------
---------------------GKLALPPYLTPD---ARDLVKKFLK----
RNPSQRIGG--GPGDAADVQRHPFF------------------------
>RSK1
FELLKVLGQGSYGKVFLVRKVKG---------------------------
----SDAGQLYAMKVLKKATLKVR------------------------DR
VRSKMERDILAEVN------------------HPFIVKLHYAFQT-----
-----------------------------------------EGKLYLILD
FLRG----------------------------------------------
--GDLFTRLSKEVM------------------------------------
--------------------------------------------------
-------------------------------------FTEEDVKFYLAEL
ALALDHLHSL------------GIIYRDLKPENILLDEE-----------
--------GHIKITDFGLSKEAID--------------------------
---------------------------HDKRAYSFCGTIEYMAPEVVNR-
--------------------RGH-------TQSADWWSFGVLMFEMLTG-
-----------SLPFQGKD------------------RKETMALILK---
--------------------------------------------------
---------------------AKLGMPQFLSGE---AQSLLRALFK----
RNPCNRLGA--GIDGVEEIKRHPFF------------------------
>RSK2
FELLKVLGQGSFGKVFLVKKISG---------------------------
----SDARQLYAMKVLKKATLKVR------------------------DR
VRTKMERDILVEVN------------------HPFIVKLHYAFQT-----
-----------------------------------------EGKLYLILD
FLRG----------------------------------------------
--GDLFTRLSKEVM------------------------------------
--------------------------------------------------
-------------------------------------FTEEDVKFYLAEL
ALALDHLHSL------------GIIYRDLKPENILLDEE-----------
--------GHIKLTDFGLSKESID--------------------------
---------------------------HEKKAYSFCGTVEYMAPEVVNR-
--------------------RGH-------TQSADWWSFGVLMFEMLTG-
-----------TLPFQGKD------------------RKETMTMILK---
--------------------------------------------------
---------------------AKLGMPQFLSPE---AQSLLRMLFK----
RNPANRLGA--GPDGVEEIKRHSFF------------------------
>RSK3
FELLKVLGQGSFGKVFLVRKVTR---------------------------
----PDSGHLYAMKVLKKATLKVR------------------------DR
VRTKMERDILADVN------------------HPFVVKLHYAFQT-----
-----------------------------------------EGKLYLILD
FLRG----------------------------------------------
--GDLFTRLSKEVM------------------------------------
--------------------------------------------------
-------------------------------------FTEEDVKFYLAEL
ALGLDHLHSL------------GIIYRDLKPENILLDEE-----------
--------GHIKLTDFGLSKEAID--------------------------
---------------------------HEKKAYSFCGTVEYMAPEVVNR-
--------------------QGH-------SHSADWWSYGVLMFEMLTG-
-----------SLPFQGKD------------------RKETMTLILK---
--------------------------------------------------
---------------------AKLGMPQFLSTE---AQSLLRALFK----
RNPANRLGS--GPDGAEEIKRHVFY------------------------
>RSK4
FELLKVLGQGSFGKVFLVRKKTG---------------------------
----PDAGQLYAMKVLKKASLKVR------------------------DR
VRTKMERDILVEVN------------------HPFIVKLHYAFQT-----
-----------------------------------------EGKLYLILD
FLRG----------------------------------------------
--GDVFTRLSKEVL------------------------------------
--------------------------------------------------
-------------------------------------FTEEDVKFYLAEL
ALALDHLHQL------------GIVYRDLKPENILLDEI-----------
--------GHIKLTDFGLSKESVD--------------------------
---------------------------QEKKAYSFCGTVEYMAPEVVNR-
--------------------RGH-------SQSADWWSYGVLMFEMLTG-
-----------TLPFQGKD------------------RNETMNMILK---
--------------------------------------------------
---------------------AKLGMPQFLSAE---AQSLLRMLFK----
RNPANRLGS----EGVEEIKRHLFF------------------------
>AKT1
FEYLKLLGKGTFGKVILVKEKA----------------------------
------TGRYYAMKILKKEVIVAK-----------------------DEV
AHTLTENRVLQNSR------------------HPFLTALKYSFQT-----
-----------------------------------------HDRLCFVME
YANG----------------------------------------------
--GELFFHLSRERV------------------------------------
--------------------------------------------------
-------------------------------------FSEDRARFYGAEI
VSALDYLHSEK-----------NVVYRDLKLENLMLDKD-----------
--------GHIKITDFGLCKEGIK--------------------------
---------------------------DGATMKTFCGTPEYLAPEVLED-
--------------------NDY-------GRAVDWWGLGVVMYEMMCG-
-----------RLPFYNQD------------------HEKLFELILM---
--------------------------------------------------
---------------------EEIRFPRTLGPE---AKSLLSGLLK----
KDPKQRLGG--GSEDAKEIMQHRFF------------------------
>AKT2
FDYLKLLGKGTFGKVILVREKA----------------------------
------TGRYYAMKILRKEVIIAK-----------------------DEV
AHTVTESRVLQNTR------------------HPFLTALKYAFQT-----
-----------------------------------------HDRLCFVME
YANG----------------------------------------------
--GELFFHLSRERV------------------------------------
--------------------------------------------------
-------------------------------------FTEERARFYGAEI
VSALEYLHSR------------DVVYRDIKLENLMLDKD-----------
--------GHIKITDFGLCKEGIS--------------------------
---------------------------DGATMKTFCGTPEYLAPEVLED-
--------------------NDY-------GRAVDWWGLGVVMYEMMCG-
-----------RLPFYNQD------------------HERLFELILM---
--------------------------------------------------
---------------------EEIRFPRTLSPE---AKSLLAGLLK----
KDPKQRLGG--GPSDAKEVMEHRFF------------------------
>AKT3
FDYLKLLGKGTFGKVILVREKA----------------------------
------SGKYYAMKILKKEVIIAK-----------------------DEV
AHTLTESRVLKNTR------------------HPFLTSLKYSFQT-----
-----------------------------------------KDRLCFVME
YVNG----------------------------------------------
--GELFFHLSRERV------------------------------------
--------------------------------------------------
-------------------------------------FSEDRTRFYGAEI
VSALDYLHSG------------KIVYRDLKLENLMLDKD-----------
--------GHIKITDFGLCKEGIT--------------------------
---------------------------DAATMKTFCGTPEYLAPEVLED-
--------------------NDY-------GRAVDWWGLGVVMYEMMCG-
-----------RLPFYNQD------------------HEKLFELILM---
--------------------------------------------------
---------------------EDIKFPRTLSSD---AKSLLSGLLI----
KDPNKRLGG--GPDDAKEIMRHSFF------------------------
>SGK
FHFLKVIGKGSFGKVLLARHKA----------------------------
------EEVFYAVKVLQKKAILKK-----------------------KEE
KHIMSERNVLLKNVK-----------------HPFLVGLHFSFQT-----
-----------------------------------------ADKLYFVLD
YING----------------------------------------------
--GELFYHLQRERC------------------------------------
--------------------------------------------------
-------------------------------------FLEPRARFYAAEI
ASALGYLHSL------------NIVYRDLKPENILLDSQ-----------
--------GHIVLTDFGLCKENIE--------------------------
---------------------------HNSTTSTFCGTPEYLAPEVLHK-
--------------------QPY-------DRTVDWWCLGAVLYEMLYG-
-----------LPPFYSRN------------------TAEMYDNILN---
--------------------------------------------------
---------------------KPLQLKPNITNS---ARHLLEGLLQ----
KDRTKRLGA---KDDFMEIKSHVFF------------------------
>SGK2
FDFLKVIGKGNYGKVLLAKRKS----------------------------
------DGAFYAVKVLQKKSILKK-----------------------KEQ
SHIMAERSVLLKNVR-----------------HPFLVGLRYSFQT-----
-----------------------------------------PEKLYFVLD
YVNG----------------------------------------------
--GELFFHLQRERR------------------------------------
--------------------------------------------------
-------------------------------------FLEPRARFYAAEV
ASAIGYLHSL------------NIIYRDLKPENILLDCQ-----------
--------GHVVLTDFGLCKEGVE--------------------------
---------------------------PEDTTSTFCGTPEYLAPEVLRK-
--------------------EPY-------DRAVDWWCLGAVLYEMLHG-
-----------LPPFYSQD------------------VSQMYENILH---
--------------------------------------------------
---------------------QPLQIPGGRTVA---ACDLLQSLLH----
KDQRQRLGS---KADFLEIKNHVFF------------------------
>SGK3
FDFLKVIGKGSFGKVLLAKRKL----------------------------
------DGKFYAVKVLQKKIVLNRK-----------------------EQ
KHIMAERNVLLKNVK-----------------HPFLVGLHYSFQT-----
-----------------------------------------TEKLYFVLD
FVNG----------------------------------------------
--GELFFHLQRERS------------------------------------
--------------------------------------------------
-------------------------------------FPEHRARFYAAEI
ASALGYLHSI------------KIVYRDLKPENILLDSV-----------
--------GHVVLTDFGLCKEGIAI-------------------------
----------------------------SDTTTTFCGTPEYLAPEVIRK-
--------------------QPY-------DNTVDWWCLGAVLYEMLYG-
-----------LPPFYCRD------------------VAEMYDNILH---
--------------------------------------------------
---------------------KPLSLRPGVSLT---AWSILEELLE----
KDRQNRLGA---KEDFLEIQNHPFF------------------------
>YANK1
FEILRAIGKGSFGKVCIVQKND----------------------------
------TKKMYAMKYMNKQKCVERN-----------------------EV
RNVFKELQIMQGLE------------------HPFLVNLWYSFQD-----
-----------------------------------------EEDMFMVVD
LLLG----------------------------------------------
--GDLRYHLQQNVH------------------------------------
--------------------------------------------------
-------------------------------------FKEETVKLFICEL
VMALDYLQNQ------------RIIHRDMKPDNILLDEH-----------
--------GHVHITDFNIAAMLPR--------------------------
----------------------------ETQITTMAGTKPYMAPEMFSSR
KG------------------AGY-------SFAVDWWSLGVTAYELLRG-
-----------RRPYHIRS------------------STSSKEIVHTFE-
--------------------------------------------------
--------------------TTVVTYPSAWSQE---MVSLLKKLLE----
PNPDQRFS------QLSDVQNFPYM------------------------
>YANK2
FQILRAIGKGSFGKVCIVQKRD----------------------------
------TKKMYAMKYMNKQKCIERD-----------------------EV
RNVFRELQIMQGLE------------------HPFLVNLWYSFQD-----
-----------------------------------------EEDMFMVVD
LLLG----------------------------------------------
--GDLRYHLQQNVH------------------------------------
--------------------------------------------------
-------------------------------------FTEGTVKLYICEL
ALALEYLQRY------------HIIHRDIKPDNILLDEH-----------
--------GHVHITDFNIATVVKG--------------------------
----------------------------AERASSMAGTKPYMAPEVFQVY
MDRG----------------PGY-------SYPVDWWSLGITAYELLRG-
-----------WRPYEIHS------------------VTPIDEILNMFK-
--------------------------------------------------
--------------------VERVHYSSTWCKG---MVALLRKLLT----
KDPESRVS------SLHDIQSVPYL------------------------
>YANK3
FQILRAIGKGSFGKVCIVQKRD----------------------------
------TEKMYAMKYMNKQQCIERD-----------------------EV
RNVFRELEILQEIE------------------HVFLVNLWYSFQD-----
-----------------------------------------EEDMFMVVD
LLLG----------------------------------------------
--GDLRYHLQQNVQ------------------------------------
--------------------------------------------------
-------------------------------------FSEDTVRLYICEM
ALALDYLRGQ------------HIIHRDVKPDNILLDER-----------
--------GHAHLTDFNIATIIKD--------------------------
----------------------------GERATALAGTKPYMAPEIFHSF
VNGG----------------TGY-------SFEVDWWSVGVMAYELLRG-
-----------WRPYDIHS------------------SNAVESLVQLFS-
--------------------------------------------------
--------------------TVSVQYVPTWSKE---MVALLRKLLT----
VNPEHRLS------SLQDVQAAPAL------------------------
>MAST1
FDTIKLISNGAYGAVYLVRHRD----------------------------
------TRQRFAMKKINKQNLILRN-----------------------QI
QQAFVERDILTFAE------------------NPFVVGMFCSFET-----
-----------------------------------------RRHLCMVME
YVEG----------------------------------------------
--GDCATLLKNIGA------------------------------------
--------------------------------------------------
-------------------------------------LPVEMARMYFAET
VLALEYLHNY------------GIVHRDLKPDNLLITSM-----------
--------GHIKLTDFGLSKMGLMSLTTNLYEGHIEKDA-----------
---------------------------REFLDKQVCGTPEYIAPEVILR-
--------------------QGY-------GKPVDWWAMGIILYEFLVG-
-----------CVPFFGDT------------------PEELFGQVISD--
--------------------------------------------------
-------------------DILWPEGDEALPTE---AQLLISSLLQ----
TNPLVRLGA----GGAFEVKQHSFF------------------------
>MAST2
FETIKLISNGAYGAVFLVRHKS----------------------------
------TRQRFAMKKINKQNLILRN-----------------------QI
QQAFVERDILTFAE------------------NPFVVSMFCSFDT-----
-----------------------------------------KRHLCMVME
YVEG----------------------------------------------
--GDCATLLKNIGA------------------------------------
--------------------------------------------------
-------------------------------------LPVDMVRLYFAET
VLALEYLHNY------------GIVHRDLKPDNLLITSM-----------
--------GHIKLTDFGLSKIGLMSLTTNLYEGHIEKDA-----------
---------------------------REFLDKQVCGTPEYIAPEVILR-
--------------------QGY-------GKPVDWWAMGIILYEFLVG-
-----------CVPFFGDT------------------PEELFGQVISD--
--------------------------------------------------
-------------------EIVWPEGDEALPPD---AQDLTSKLLH----
QNPLERLGT----GSAYEVKQHPFF------------------------
>MAST3
FETIKLISNGAYGAVYLVRHRD----------------------------
------TRQRFAIKKINKQNLILRN-----------------------QI
QQVFVERDILTFAE------------------NPFVVSMFCSFET-----
-----------------------------------------RRHLCMVME
YVEG----------------------------------------------
--GDCATLLKNMGP------------------------------------
--------------------------------------------------
-------------------------------------LPVDMARLYFAET
VLALEYLHNY------------GIVHRDLKPDNLLITSL-----------
--------GHIKLTDFGLSKIGLMSMATNLYEGHIEKDA-----------
---------------------------REFIDKQVCGTPEYIAPEVIFR-
--------------------QGY-------GKPVDWWAMGVVLYEFLVG-
-----------CVPFFGDT------------------PEELFGQVVSD--
--------------------------------------------------
-------------------EIMWPEGDEALPAD---AQDLITRLLR----
QSPLDRLGT----GGTHEVKQHPFF------------------------
>MAST4
FETIKLISNGAYGAVYFVRHKE----------------------------
------SRQRFAMKKINKQNLILRN-----------------------QI
QQAFVERDILTFAE------------------NPFVVSMYCSFET-----
-----------------------------------------RRHLCMVME
YVEG----------------------------------------------
--GDCATLMKNMGP------------------------------------
--------------------------------------------------
-------------------------------------LPVDMARMYFAET
VLALEYLHNY------------GIVHRDLKPDNLLVTSM-----------
--------GHIKLTDFGLSKVGLMSMTTNLYEGHIEKDA-----------
---------------------------REFLDKQVCGTPEYIAPEVILR-
--------------------QGY-------GKPVDWWAMGIILYEFLVG-
-----------CVPFFGDT------------------PEELFGQVISD--
--------------------------------------------------
-------------------EINWPEKDE----------------------
-------------------------------------------------
>MASTL
FSIVKPISRGAFGKVYLGQKGG----------------------------
--------KLYAVKVVKKADMINKN-----------------------MT
HQVQAERDALALSK------------------SPFIVHLYYSLQS-----
-----------------------------------------ANNVYLVME
YLIG----------------------------------------------
--GDVKSLLHIYGY------------------------------------
--------------------------------------------------
-------------------------------------FDEEMAVKYISEV
ALALDYLHRH------------GIIHRDLKPDNMLISNE-----------
--------GHIKLTDFGLSKVTL-NRDINMMDILTTPSM-----------
-------------------------AKPRQDYSRTPGQVLSLISSLGFNT
PIAEKN--------------Q-D-----PANILSACLSETSQLSQGLVC-
----------PMSVDQKDT-------------------TPYSSKLLK---
--------------------------------------------------
-------------------SCLETVASNPGMP------VKCLTSNL----
LQSRKRLAT-----SSASSQSHTFI------------------------
>LATS1
FVKIKTLGIGAFGEVCLARKVD----------------------------
------TKALYATKTLRKKDVLLRN-----------------------QV
AHVKAERDILAEAD------------------NEWVVRLYYSFQD-----
-----------------------------------------KDNLYFVMD
YIPG----------------------------------------------
--GDMMSLLIRMGI------------------------------------
--------------------------------------------------
-------------------------------------FPESLARFYIAEL
TCAVESVHKM------------GFIHRDIKPDNILIDRD-----------
--------GHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGD
PSSCRCG------DRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLR-
--------------------TGY-------TQLCDWWSVGVILFEMLVG-
-----------QPPFLAQT------------------PLETQMKVIN---
--------------------------------------------------
------------------WQTSLHIPPQAKLS---PEASDLIIKLC----
RGPEDRLGKN----GADEIKAHPFF------------------------
>LATS2
FVKIKTLGIGAFGEVCLACKVD----------------------------
------THALYAMKTLRKKDVLNRN-----------------------QV
AHVKAERDILAEAD------------------NEWVVKLYYSFQD-----
-----------------------------------------KDSLYFVMD
YIPG----------------------------------------------
--GDMMSLLIRMEV------------------------------------
--------------------------------------------------
-------------------------------------FPEHLARFYIAEL
TLAIESVHKM------------GFIHRDIKPDNILIDLD-----------
--------GHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDD
VSNCRCG------DRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLR-
--------------------KGY-------TQLCDWWSVGVILFEMLVG-
-----------QPPFLAPT------------------PTETQLKVIN---
--------------------------------------------------
------------------WENTLHIPAQVKLS---PEARDLITKLC----
CSADHRLGRN----GADDLKAHPFF------------------------
>NDR1
FESLKVIGRGAFGEVRLVQKKD----------------------------
------TGHVYAMKILRKADMLEKE-----------------------QV
GHIRAERDILVEAD------------------SLWVVKMFYSFQD-----
-----------------------------------------KLNLYLIME
FLPG----------------------------------------------
--GDMMTLLMKKDT------------------------------------
--------------------------------------------------
-------------------------------------LTEEETQFYIAET
VLAIDSIHQL------------GFIHRDIKPDNLLLDSK-----------
--------GHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSK
RKAETWK------------------RNRRQLAFSTVGTPDYIAPEVFMQ-
--------------------TGY-------NKLCDWWSLGVIMYEMLIG-
-----------YPPFCSET------------------PQETYKKVMN---
--------------------------------------------------
------------------WKETLTFPPEVPIS---EKAKDLILRFC----
CEWEHRIGAP----GVEEIKSNSFF------------------------
>NDR2
FESLKVIGRGAFGEVRLVQKKD----------------------------
------TGHIYAMKILRKSDMLEKE-----------------------QV
AHIRAERDILVEAD------------------GAWVVKMFYSFQD-----
-----------------------------------------KRNLYLIME
FLPG----------------------------------------------
--GDMMTLLMKKDT------------------------------------
--------------------------------------------------
-------------------------------------LTEEETQFYISET
VLAIDAIHQL------------GFIHRDIKPDNLLLDAK-----------
--------GHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSK
RKAETWK------------------KNRRQLAYSTVGTPDYIAPEVFMQ-
--------------------TGY-------NKLCDWWSLGVIMYEMLIG-
-----------YPPFCSET------------------PQETYRKVMN---
--------------------------------------------------
------------------WKETLVFPPEVPIS---EKAKDLILRFC----
IDSENRIGNS----GVEEIKGHPFF------------------------
>CRIK
FEVRSLVGCGHFAEVQVVREKA----------------------------
------TGDIYAMKVMKKKALLAQE-----------------------QV
SFFEEERNILSRST------------------SPWIPQLQYAFQD-----
-----------------------------------------KNHLYLVME
YQPG----------------------------------------------
--GDLLSLLNRYEDQ-----------------------------------
--------------------------------------------------
-------------------------------------LDENLIQFYLAEL
ILAVHSVHLM------------GYVHRDIKPENILVDRT-----------
--------GHIKLVDFGSAAKMNSN-------------------------
---------------------------KMVNAKLPIGTPDYMAPEVLTVM
NGDGK---------------GTY-------GLDCDWWSVGVIAYEMIYG-
-----------RSPFAEGT------------------SARTFNNIMN---
--------------------------------------------------
------------------FQRFLKFPDDPKVS---SDFLDLIQSLL----
CGQKERLKF-------EGLCCHPFF------------------------
>ROCK1
YEVVKVIGRGAFGEVQLVRHKS----------------------------
------TRKVYAMKLLSKFEMIKRS-----------------------DS
AFFWEERDIMAFAN------------------SPWVVQLFYAFQD-----
-----------------------------------------DRYLYMVME
YMPG----------------------------------------------
--GDLVNLMSNYD-------------------------------------
--------------------------------------------------
-------------------------------------VPEKWARFYTAEV
VLALDAIHSM------------GFIHRDVKPDNMLLDKS-----------
--------GHLKLADFGTCMKMNKE-------------------------
---------------------------GMVRCDTAVGTPDYISPEVLKSQ
GGD-----------------GYY-------GRECDWWSVGVFLYEMLVG-
-----------DTPFYADS------------------LVGTYSKIMN---
--------------------------------------------------
--------------------HKNSLTFP-DDN---DISKEAKNLIC----
AFLTDREVRLGRN-GVEEIKRHLFF------------------------
>ROCK2
YDVVKVIGRGAFGEVQLVRHKA----------------------------
------SQKVYAMKLLSKFEMIKRS-----------------------DS
AFFWEERDIMAFAN------------------SPWVVQLFYAFQD-----
-----------------------------------------DRYLYMVME
YMPG----------------------------------------------
--GDLVNLMSNYD-------------------------------------
--------------------------------------------------
-------------------------------------VPEKWAKFYTAEV
VLALDAIHSM------------GLIHRDVKPDNMLLDKH-----------
--------GHLKLADFGTCMKMDET-------------------------
---------------------------GMVHCDTAVGTPDYISPEVLKSQ
GGD-----------------GFY-------GRECDWWSVGVFLYEMLVG-
-----------DTPFYADS------------------LVGTYSKIMD---
--------------------------------------------------
--------------------HKNSLCFP-EDA---EISKHAKNLIC----
AFLTDREVRLGRN-GVEEIRQHPFF------------------------
>DMPK1
FEILKVIGRGAFSEVAVVKMKQ----------------------------
------TGQVYAMKIMNKWDMLKRG-----------------------EV
SCFREERDVLVNGD------------------RRWITQLHFAFQD-----
-----------------------------------------ENYLYLVME
YYVG----------------------------------------------
--GDLLTLLSKFGER-----------------------------------
--------------------------------------------------
-------------------------------------IPAEMARFYLAEI
VMAIDSVHRL------------GYVHRDIKPDNILLDRC-----------
--------GHIRLADFGSCLKLRAD-------------------------
---------------------------GTVRSLVAVGTPDYLSPEILQAV
GGGPGT--------------GSY-------GPECDWWALGVFAYEMFYG-
-----------QTPFYADS------------------TAETYGKIVH---
--------------------------------------------------
-----------------YKEHLSLPLVDEGVP---EEARDFIQRLL----
CPPETRLGRG----GAGDFRTHPFF------------------------
>DMPK2
FEILKVIGRGAFGEVTVVRQRD----------------------------
------TGQIFAMKMLHKWEMLKRA-----------------------ET
ACFREERDVLVKGD------------------SRWVTTLHYAFQD-----
-----------------------------------------EEYLYLVMD
YYAG----------------------------------------------
--GDLLTLLSRFEDR-----------------------------------
--------------------------------------------------
-------------------------------------LPPELAQFYLAEM
VLAIHSLHQL------------GYVHRDVKPDNVLLDVN-----------
--------GHIRLADFGSCLRLNTN-------------------------
---------------------------GMVDSSVAVGTPDYISPEILQAM
EEGK----------------GHY-------GPQCDWWSLGVCAYELLFG-
-----------ETPFYAES------------------LVETYGKIMN---
--------------------------------------------------
-----------------HEDHLQFPPDVPDVP---ASAQDLIRQLL----
CRQEERLGRG----GLDDFRNHPFF------------------------
>MRCKa
FEILKVIGRGAFGEVAVVKLKN----------------------------
------ADKVFAMKILNKWEMLKRA-----------------------ET
ACFREERDVLVNGD------------------NKWITTLHYAFQD-----
-----------------------------------------DNNLYLVMD
YYVG----------------------------------------------
--GDLLTLLSKFEDR-----------------------------------
--------------------------------------------------
-------------------------------------LPEDMARFYLAEM
VIAIDSVHQL------------HYVHRDIKPDNILMDMN-----------
--------GHIRLADFGSCLKLMED-------------------------
---------------------------GTVQSSVAVGTPDYISPEILQAM
EDGK----------------GRY-------GPECDWWSLGVCMYEMLYG-
-----------ETPFYAES------------------LVETYGKIMN---
--------------------------------------------------
-----------------HKERFQFPAQVTDVS---ENAKDLIRRLI----
CSREHRLGQN----GIEDFKKHPFF------------------------
>MRCKb
FEIIKVIGRGAFGEVAVVKMKN----------------------------
------TERIYAMKILNKWEMLKRA-----------------------ET
ACFREERDVLVNGD------------------CQWITALHYAFQD-----
-----------------------------------------ENHLYLVMD
YYVG----------------------------------------------
--GDLLTLLSKFEDK-----------------------------------
--------------------------------------------------
-------------------------------------LPEDMARFYIGEM
VLAIDSIHQL------------HYVHRDIKPDNVLLDVN-----------
--------GHIRLADFGSCLKMNDD-------------------------
---------------------------GTVQSSVAVGTPDYISPEILQAM
EDGM----------------GKY-------GPECDWWSLGVCMYEMLYG-
-----------ETPFYAES------------------LVETYGKIMN---
--------------------------------------------------
-----------------HEERFQFPSHVTDVS---EEAKDLIQRLI----
CSRERRLGQN----GIEDFKKHAFF------------------------
>pka-Ca_1atp.PDB
FDRIKTLGTGSFGRVMLVKHKE----------------------------
------SGNHYAMKILDKQKVVKLK-----------------------QI
EHTLNEKRILQAVN------------------FPFLVKLEFSFKD-----
-----------------------------------------NSNLYMVME
YVAG----------------------------------------------
--GEMFSHLRRIGR------------------------------------
--------------------------------------------------
-------------------------------------FSEPHARFYAAQI
VLTFEYLHSL------------DLIYRDLKPENLLIDQQ-----------
--------GYIQVTDFGFAKRVK---------------------------
-----------------------------GRTWTLCGTPEYLAPEIILS-
--------------------KGY-------NKAVDWWALGVLIYEMAAG-
-----------YPPFFADQ------------------PIQIYEKIVSG--
--------------------------------------------------
----------------------KVRFPSHFSS---DLKDLLRNLLQ----
VDLTKRFGNLKN--GVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGP
>PKACa
FERIKTLGTGSFGRVMLVKHKE----------------------------
------TGNHYAMKILDKQKVVKLK-----------------------QI
EHTLNEKRILQAVN------------------FPFLVKLEFSFKD-----
-----------------------------------------NSNLYMVME
YVPG----------------------------------------------
--GEMFSHLRRIGR------------------------------------
--------------------------------------------------
-------------------------------------FSEPHARFYAAQI
VLTFEYLHSL------------DLIYRDLKPENLLIDQQ-----------
--------GYIQVTDFGFAKRVK---------------------------
-----------------------------GRTWTLCGTPEYLAPEIILS-
--------------------KGY-------NKAVDWWALGVLIYEMAAG-
-----------YPPFFADQ------------------PIQIYEKIVSG--
--------------------------------------------------
----------------------KVRFPSHFSS---DLKDLLRNLLQ----
VDLTKRFGNLKN--GVNDIKNHKWF------------------------
>PKACb
FERKKTLGTGSFGRVMLVKHKA----------------------------
------TEQYYAMKILDKQKVVKLK-----------------------QI
EHTLNEKRILQAVN------------------FPFLVRLEYAFKD-----
-----------------------------------------NSNLYMVME
YVPG----------------------------------------------
--GEMFSHLRRIGR------------------------------------
--------------------------------------------------
-------------------------------------FSEPHARFYAAQI
VLTFEYLHSL------------DLIYRDLKPENLLIDHQ-----------
--------GYIQVTDFGFAKRVK---------------------------
-----------------------------GRTWTLCGTPEYLAPEIILS-
--------------------KGY-------NKAVDWWALGVLIYEMAAG-
-----------YPPFFADQ------------------PIQIYEKIVSG--
--------------------------------------------------
----------------------KVRFPSHFSS---DLKDLLRNLLQ----
VDLTKRFGNLKN--GVSDIKTHKWF------------------------
>PKACg
FERLRTLGMGSFGRVMLVRHQE----------------------------
------TGGHYAMKILNKQKVVKMK-----------------------QV
EHILNEKRILQAID------------------FPFLVKLQFSFKD-----
-----------------------------------------NSYLYLVME
YVPG----------------------------------------------
--GEMFSRLQRVGR------------------------------------
--------------------------------------------------
-------------------------------------FSEPHACFYAAQV
VLAVQYLHSL------------DLIHRDLKPENLLIDQQ-----------
--------GYLQVTDFGFAKRVK---------------------------
-----------------------------GRTWTLCGTPEYLAPEIILS-
--------------------KGY-------NKAVDWWALGVLIYEMAVG-
-----------FPPFYADQ------------------PIQIYEKIVSG--
--------------------------------------------------
----------------------RVRFPSKLSS---DLKDLLRSLLQ----
VDLTKRFGNLRN--GVGDIKNHKWF------------------------
>PKG1
FNIIDTLGVGGFGRVELVQLKS----------------------------
-----EESKTFAMKILKKRHIVDTR-----------------------QQ
EHIRSEKQIMQGAH------------------SDFIVRLYRTFKD-----
-----------------------------------------SKYLYMLME
ACLG----------------------------------------------
--GELWTILRDRGS------------------------------------
--------------------------------------------------
-------------------------------------FEDSTTRFYTACV
VEAFAYLHSK------------GIIYRDLKPENLILDHR-----------
--------GYAKLVDFGFAKKIGFG-------------------------
-----------------------------KKTWTFCGTPEYVAPEIILN-
--------------------KGH-------DISADYWSLGILMYELLTG-
-----------SPPFSGPD------------------PMKTYNIILRG--
--------------------------------------------------
--------------------IDMIEFPKKIAK---NAANLIKKLCR----
DNPSERLGNLKN--GVKDIQKHKWF------------------------
>PKG2
LEIIATLGVGGFGRVELVKVKN----------------------------
------ENVAFAMKCIRKKHIVDTK-----------------------QQ
EHVYSEKRILEELC------------------SPFIVKLYRTFKD-----
-----------------------------------------NKYVYMLLE
ACLG----------------------------------------------
--GELWSILRDRGS------------------------------------
--------------------------------------------------
-------------------------------------FDEPTSKFCVACV
TEAFDYLHRL------------GIIYRDLKPENLILDAE-----------
--------GYLKLVDFGFAKKIGSG-------------------------
-----------------------------QKTWTFCGTPEYVAPEVILN-
--------------------KGH-------DFSVDFWSLGILVYELLTG-
-----------NPPFSGVD------------------QMMTYNLILKG--
--------------------------------------------------
--------------------IEKMDFPRKITR---RPEDLIRRLCR----
QNPTERLGNLKN--GINDIKKHRWL------------------------
>PRKX
FDTLATVGTGTFGRVHLVKEKT----------------------------
------AKHFFALKVMSIPDVIRLK-----------------------QE
QHVHNEKSVLKEVS------------------HPFLIRLFWTWHD-----
-----------------------------------------ERFLYMLME
YVPG----------------------------------------------
--GELFSYLRNRGR------------------------------------
--------------------------------------------------
-------------------------------------FSSTTGLFYSAEI
ICAIEYLHSK------------EIVYRDLKPENILLDRD-----------
--------GHIKLTDFGFAKKLV---------------------------
-----------------------------DRTWTLCGTPEYLAPEVIQS-
--------------------KGH-------GRAVDWWALGILIFEMLSG-
-----------FPPFFDDN------------------PFGIYQKILAG--
--------------------------------------------------
----------------------KIDFPRHLDF---HVKDLIKKLLV----
VDRTRRLGNMKN--GANDVKHHRWF------------------------
>PRKY
CDALVTMGTGTFGRVHLVKEKT----------------------------
------AKHFFALKVMSIPDVIRRK-----------------------QE
QHVHNEKSVLKEVS------------------HPFLIRLFWTWHE-----
-----------------------------------------ERFLYMLME
YVPG----------------------------------------------
--GELFSYLRNRGH------------------------------------
--------------------------------------------------
-------------------------------------FSSTTGLFYSAEI
ICAIEYLHSK------------EIVYRDLKPENILLDRD-----------
--------GHIKLTDFGFAKKLV---------------------------
-----------------------------DRTWTLCGTPEYLAPEVIQS-
--------------------KGH-------GRAVDWWALGILIFEMLSG-
-----------FPPFFDDN------------------PFGIYQKILAG--
--------------------------------------------------
----------------------KLYFPR----------------------
-------------------------------------------------
>PKN1
FKFLAVLGRGHFGKVLLSEFRP----------------------------
------SGELFAIKALKKGDIVARD-----------------------EV
ESLMCEKRILAAVTSA---------------GHPFLVNLFGCFQT-----
-----------------------------------------PEHVCFVME
YSAG----------------------------------------------
--GDLMLHIHSDV-------------------------------------
--------------------------------------------------
-------------------------------------FSEPRAIFYSACV
VLGLQFLHEH------------KIVYRDLKLDNLLLDTE-----------
--------GYVKIADFGLCKEGMGY-------------------------
----------------------------GDRTSTFCGTPEFLAPEVLTD-
--------------------TSY-------TRAVDWWGLGVLLYEMLVG-
-----------ESPFPGDD------------------EEEVFDSIVN---
--------------------------------------------------
---------------------DEVRYPRFLSAE---AIGIMRRLLR----
RNPERRLGS--SERDAEDVKKQPFF------------------------
>PKN2
FRCCAVLGRGHFGKVLLAEYKN----------------------------
------TNEMFAIKALKKGDIVARD-----------------------EV
DSLMCEKRIFETVNSV---------------RHPFLVNLFACFQT-----
-----------------------------------------KEHVCFVME
YAAG----------------------------------------------
--GDLMMHIHTDV-------------------------------------
--------------------------------------------------
-------------------------------------FSEPRAVFYAACV
VLGLQYLHEH------------KIVYRDLKLDNLLLDTE-----------
--------GFVKIADFGLCKEGMGY-------------------------
----------------------------GDRTSTFCGTPEFLAPEVLTE-
--------------------TSY-------TRAVDWWGLGVLIYEMLVG-
-----------ESPFPGDD------------------EEEVFDSIVN---
--------------------------------------------------
---------------------DEVRYPRFLSTE---AISIMRRLLR----
RNPERRLGA--SEKDAEDVKKHPFF------------------------
>PKN3
FRCLAVLGRGHFGKVLLVQFKG----------------------------
------TGKYYAIKALKKQEVLSRD-----------------------EI
ESLYCEKRILEAVGCT---------------GHPFLLSLLVCFQT-----
-----------------------------------------SSHARFVTE
FVPG----------------------------------------------
--GDLMMQIHEDV-------------------------------------
--------------------------------------------------
-------------------------------------FPEPQARFYVACV
VLGLQFLHEK------------KIIYRDLKLDNLLLDAQ-----------
--------GFLKIADFGLCKEGIGF-------------------------
----------------------------GDRTSTFCGTPEFLAPEVLTQ-
--------------------EAY-------TQAVDWWALGVLLYEMLVG-
-----------ECPFPGDT------------------EEEVFDCIVN---
--------------------------------------------------
---------------------MDAPYPGFLSVQ---GLEFIQKLLQ----
KCPEKRLGA--GEQDAEEIKVQPFF------------------------
>PKCa
FNFLMVLGKGSFGKVMLADRKG----------------------------
------TEELYAIKILKKDVVIQDD-----------------------DV
ECTMVEKRVLALLDK-----------------PPFLTQLHSCFQT-----
-----------------------------------------VDRLYFVME
YVNG----------------------------------------------
--GDLMYHIQQVGK------------------------------------
--------------------------------------------------
-------------------------------------FKEPQAVFYAAEI
SIGLFFLHKR------------GIIYRDLKLDNVMLDSE-----------
--------GHIKIADFGMCKEHMMD-------------------------
----------------------------GVTTRTFCGTPDYIAPEIIAY-
--------------------QPY-------GKSVDWWAYGVLLYEMLAG-
-----------QPPFDGED------------------EDELFQSIME---
--------------------------------------------------
---------------------HNVSYPKSLSKE---AVSICKGLMT----
KHPAKRLGC--GPEGERDVREHAFF------------------------
>PKCb
FNFLMVLGKGSFGKVMLSERKG----------------------------
------TDELYAVKILKKDVVIQDD-----------------------DV
ECTMVEKRVLALPGK-----------------PPFLTQLHSCFQT-----
-----------------------------------------MDRLYFVME
YVNG----------------------------------------------
--GDLMYHIQQVGR------------------------------------
--------------------------------------------------
-------------------------------------FKEPHAVFYAAEI
AIGLFFLQSK------------GIIYRDLKLDNVMLDSE-----------
--------GHIKIADFGMCKENIWD-------------------------
----------------------------GVTTKTFCGTPDYIAPEIIAY-
--------------------QPY-------GKSVDWWAFGVLLYEMLAG-
-----------QAPFEGED------------------EDELFQSIME---
--------------------------------------------------
---------------------HNVAYPKSMSKE---AVAICKGLMT----
KHPGKRLGC--GPEGERDIKEHAFF------------------------
>PKCg
FSFLMVLGKGSFGKVMLAERRG----------------------------
------SDELYAIKILKKDVIVQDD-----------------------DV
DCTLVEKRVLALGGRG---------------PGGRPHFLTQLHST-----
--------------------------------------FQTPDRLYFVME
YVTG----------------------------------------------
--GDLMYHIQQLGK------------------------------------
--------------------------------------------------
-------------------------------------FKEPHAAFYAAEI
AIGLFFLHNQ------------GIIYRDLKLDNVMLDAE-----------
--------GHIKITDFGMCKENVFP-------------------------
----------------------------GTTTRTFCGTPDYIAPEIIAY-
--------------------QPY-------GKSVDWWSFGVLLYEMLAG-
-----------QPPFDGED------------------EEELFQAIME---
--------------------------------------------------
---------------------QTVTYPKSLSRE---AVAICKGFLT----
KHPGKRLGS--GPDGEPTIRAHGFF------------------------
>PKCd
FIFHKVLGKGSFGKVLLGELKG----------------------------
------RGEYFAIKALKKDVVLIDD-----------------------DV
ECTMVEKRVLTLAAE-----------------NPFLTHLICTFQT-----
-----------------------------------------KDHLFFVME
FLNG----------------------------------------------
--GDLMYHIQDKGR------------------------------------
--------------------------------------------------
-------------------------------------FELYRATFYAAEI
MCGLQFLHSK------------GIIYRDLKLDNVLLDRD-----------
--------GHIKIADFGMCKENIFG-------------------------
----------------------------ESRASTFCGTPDYIAPEILQG-
--------------------LKY-------TFSVDWWSFGVLLYEMLIG-
-----------QSPFHGDD------------------EDELFESIRV---
--------------------------------------------------
---------------------DTPHYPRWITKE---SKDILEKLFE----
REPTKRLG------VTGNIKIHPFF------------------------
>PKCe
FNFIKVLGKGSFGKVMLAELKG----------------------------
------KDEVYAVKVLKKDVILQDD-----------------------DV
DCTMTEKRILALARK-----------------HPYLTQLYCCFQT-----
-----------------------------------------KDRLFFVME
YVNG----------------------------------------------
--GDLMFQIQRSRK------------------------------------
--------------------------------------------------
-------------------------------------FDEPRSRFYAAEV
TSALMFLHQH------------GVIYRDLKLDNILLDAE-----------
--------GHCKLADFGMCKEGILN-------------------------
----------------------------GVTTTTFCGTPDYIAPEILQE-
--------------------LEY-------GPSVDWWALGVLMYEMMAG-
-----------QPPFEADN------------------EDDLFESILH---
--------------------------------------------------
---------------------DDVLYPVWLSKE---AVSILKAFMT----
KNPHKRLGCVASQNGEDAIKQHPFF------------------------
>PKCi
FDLLRVIGRGSYAKVLLVRLKK----------------------------
------TDRIYAMKVVKKELVNDDE-----------------------DI
DWVQTEKHVFEQASN-----------------HPFLVGLHSCFQT-----
-----------------------------------------ESRLFFVIE
YVNG----------------------------------------------
--GDLMFHMQRQRK------------------------------------
--------------------------------------------------
-------------------------------------LPEEHARFYSAEI
SLALNYLHER------------GIIYRDLKLDNVLLDSE-----------
--------GHIKLTDYGMCKEGLRP-------------------------
----------------------------GDTTSTFCGTPNYIAPEILRG-
--------------------EDY-------GFSVDWWALGVLMFEMMAG-
-----------RSPFDIVGSS---------DNPDQNTEDYLFQVILE---
--------------------------------------------------
---------------------KQIRIPRSLSVK---AASVLKSFLN----
KDPKERLGCH-PQTGFADIQGHPFF------------------------
>PKCh
FEFIRVLGKGSFGKVMLARVKE----------------------------
------TGDLYAVKVLKKDVILQDD-----------------------DV
ECTMTEKRILSLARN-----------------HPFLTQLFCCFQT-----
-----------------------------------------PDRLFFVME
FVNG----------------------------------------------
--GDLMFHIQKSRR------------------------------------
--------------------------------------------------
-------------------------------------FDEARARFYAAEI
ISALMFLHDK------------GIIYRDLKLDNVLLDHE-----------
--------GHCKLADFGMCKEGICN-------------------------
----------------------------GVTTATFCGTPDYIAPEILQE-
--------------------MLY-------GPAVDWWAMGVLLYEMLCG-
-----------HAPFEAEN------------------EDDLFEAILN---
--------------------------------------------------
---------------------DEVVYPTWLHED---ATGILKSFMT----
KNPTMRLGSL-TQGGEHAILRHPFF------------------------
>PKCz
FDLIRVIGRGSYAKVLLVRLKK----------------------------
------NDQIYAMKVVKKELVHDDE-----------------------DI
DWVQTEKHVFEQASS-----------------NPFLVGLHSCFQT-----
-----------------------------------------TSRLFLVIE
YVNG----------------------------------------------
--GDLMFHMQRQRK------------------------------------
--------------------------------------------------
-------------------------------------LPEEHARFYAAEI
CIALNFLHER------------GIIYRDLKLDNVLLDAD-----------
--------GHIKLTDYGMCKEGLGP-------------------------
----------------------------GDTTSTFCGTPNYIAPEILRG-
--------------------EEY-------GFSVDWWALGVLMFEMMAG-
-----------RSPFDIITDNP-----------DMNTEDYLFQVILE---
--------------------------------------------------
---------------------KPIRIPRFLSVK---ASHVLKGFLN----
KDPKERLGCR-PQTGFSDIKSHAFF------------------------
>PKCt
FILHKMLGKGSFGKVFLAEFKK----------------------------
------TNQFFAIKALKKDVVLMDD-----------------------DV
ECTMVEKRVLSLAWE-----------------HPFLTHMFCTFQT-----
-----------------------------------------KENLFFVME
YLNG----------------------------------------------
--GDLMYHIQSCHK------------------------------------
--------------------------------------------------
-------------------------------------FDLSRATFYAAEI
ILGLQFLHSK------------GIVYRDLKLDNILLDKD-----------
--------GHIKIADFGMCKENMLG-------------------------
----------------------------DAKTNTFCGTPDYIAPEILLG-
--------------------QKY-------NHSVDWWSFGVLLYEMLIG-
-----------QSPFHGQD------------------EEELFHSIRM---
--------------------------------------------------
---------------------DNPFYPRWLEKE---AKDLLVKLFV----
REPEKRLGV------RGDIRQHPLF------------------------
>NEK1
YVRLQKIGEGSFGKAILVKSTED---------------------------
-------GRQYVIKEINISRMSSKE------------------------R
EESRREVAVLANMK------------------HPNIVQYRESFEE-----
-----------------------------------------NGSLYIVMD
YCEG----------------------------------------------
--GDLFKRINAQKGVL----------------------------------
--------------------------------------------------
-------------------------------------FQEDQILDWFVQI
CLALKHVHDR------------KILHRDIKSQNIFLTKD-----------
--------GTVQLGDFGIARVLNST-------------------------
----------------------------VELARTCIGTPYYLSPEICEN-
--------------------KPY-------NNKSDIWALGCVLYELCTL-
-----------KHAFEAGS------------------MKNLVLKIISG--
--------------------------------------------------
---------------------SFPPVSLHYSYD---LRSLVSQLFK----
RNPRDRPSV-------NSILEKGFI------------------------
>NEK2
YEVLYTIGTGSYGRCQKIRRKSD---------------------------
-------GKILVWKELDYGSMTEAE------------------------K
QMLVSEVNLLRELK------------------HPNIVRYYDRIIDR----
----------------------------------------TNTTLYIVME
YCEG----------------------------------------------
--GDLASVITKGTKERQYL-------------------------------
--------------------------------------------------
--------------------------------------DEEFVLRVMTQL
TLALKECHRRSD-------GGHTVLHRDLKPANVFLDGK-----------
--------QNVKLGDFGLARILNHD-------------------------
----------------------------TSFAKTFVGTPYYMSPEQMNR-
--------------------MSY-------NEKSDIWSLGCLLYELCAL-
-----------MPPFTAFS------------------QKELAGKIREG--
--------------------------------------------------
---------------------KFRRIPYRYSDE---LNEIITRMLN----
LKDYHRPSV-------EEILENPLI------------------------
>NEK3
YMVLRMIGEGSFGRALLVQHESS---------------------------
-------NQMFAMKEIRLPKSFSN-------------------------T
QNSRKEAVLLAKMK------------------HPNIVAFKESFEA-----
-----------------------------------------EGHLYIVME
YCDG----------------------------------------------
--GDLMQKIKQQKGKL----------------------------------
--------------------------------------------------
-------------------------------------FPEDMILNWFTQM
CLGVNHIHKK------------RVLHRDIKSKNIFLTQN-----------
--------GKVKLGDFGSARLLSNP-------------------------
----------------------------MAFACTYVGTPYYVPPEIWEN-
--------------------LPY-------NNKSDIWSLGCILYELCTL-
-----------KHPFQANS------------------WKNLILKVCQG--
--------------------------------------------------
---------------------CISPLPSHYSYE---LQFLVKQMFK----
RNPSHRPSA-------TTLLSRGIV------------------------
>NEK4
YCYLRVVGKGSYGEVTLVKHRRD---------------------------
-------GKQYVIKKLNLRNASSRE------------------------R
RAAEQEAQLLSQLK------------------HPNIVTYKESWEGG----
-----------------------------------------DGLLYIVMG
FCEG----------------------------------------------
--GDLYRKLKEQKGQL----------------------------------
--------------------------------------------------
-------------------------------------LPENQVVEWFVQI
AMALQYLHEK------------HILHRDLKTQNVFLTRT-----------
--------NIIKVGDLGIARVLENH-------------------------
----------------------------CDMASTLIGTPYYMSPELFSN-
--------------------KPY-------NYKSDVWALGCCVYEMATL-
-----------KHAFNAKD------------------MNSLVYRIIEG--
--------------------------------------------------
---------------------KLPAMPRDYSPE---LAELIRTMLS----
KRPEERPSV-------RSILRQPYI------------------------
>NEK5
YDVIKAIGQGAFGKAYLAKGKSD---------------------------
-------SKHCVIKEINFEKMPIQE------------------------K
EASKKEVILLEKMK------------------HPNIVAFFNSFQE-----
-----------------------------------------NGRLFIVME
YCDG----------------------------------------------
--GDLMKRINRQRGVL----------------------------------
--------------------------------------------------
-------------------------------------FSEDQILGWFVQI
SLGLKHIHDR------------KILHRDIKAQNIFLSKNG----------
--------MVAKLGDFGIARVLNNS-------------------------
----------------------------MELARTCIGTPYYLSPEICQN-
--------------------KPY-------NNKTDIWSLGCVLYELCTL-
-----------KHPFEGNN------------------LQQLVLKICQA--
--------------------------------------------------
---------------------HFAPISPGFSRE---LHSLISQLFQ----
VSPRDRPSI-------NSILKRPFL------------------------
>NEK6
FQIEKKIGRGQFSEVYKATCLLD---------------------------
-------RKTVALKKVQIFEMMDAKA-----------------------R
QDCVKEIGLLKQLN------------------HPNIIKYLDSFIE-----
-----------------------------------------DNELNIVLE
LADA----------------------------------------------
--GDLSQMIKYFKKQKRL--------------------------------
--------------------------------------------------
-------------------------------------IPERTVWKYFVQL
CSAVEHMHSR------------RVMHRDIKPANVFITAT-----------
--------GVVKLGDLGLGRFFSSE-------------------------
----------------------------TTAAHSLVGTPYYMSPERIHE-
--------------------NGY-------NFKSDIWSLGCLLYEMAAL-
-----------QSPFYGDK------------------MNLFSLCQKIE--
--------------------------------------------------
------------------QCDYPPLPGEHYSEK---LRELVSMCIC----
PDPHQRPGSLEQLRPQGSAGSPKGCPALQQM------------------
>NEK7
FRIEKKIGRGQFSEVYRAACLLDG--------------------------
--------VPVALKKVQIFDLMDAKA-----------------------R
ADCIKEIDLLKQLN------------------HPNVIKYYASFIE-----
-----------------------------------------DNELNIVLE
LADA----------------------------------------------
--GDLSRMIKHFKKQKRL--------------------------------
--------------------------------------------------
-------------------------------------IPERTVWKYFVQL
CSALEHMHSR------------RVMHRDIKPANVFITAT-----------
--------GVVKLGDLGLGRFFSSK-------------------------
----------------------------TTAAHSLVGTPYYMSPERIHE-
--------------------NGY-------NFKSDIWSLGCLLYEMAAL-
-----------QSPFYGDK------------------MNLYSLCKKIE--
--------------------------------------------------
------------------QCDYPPLPSDHYSEE---LRQLVNMCIN----
PDPEKRPDV----------------------------------------
>NEK8
YERIRVVGRGAFGIVHLCLRKADQ--------------------------
--------KLVIIKQIPVEQMTKEE------------------------R
QAAQNECQVLKLLN------------------HPNVIEYYENFLE-----
-----------------------------------------DKALMIAME
YAPG----------------------------------------------
--GTLAEFIQKRCNSL----------------------------------
--------------------------------------------------
-------------------------------------LEEETILHFFVQI
LLALHHVHTH------------LILHRDLKTQNILLDKHR----------
--------MVVKIGDFGISKILSSK-------------------------
------------------------------------STPCYISPELCEG-
--------------------KPY-------NQKSDIWALGCVLYELASL-
-----------KRAFEAAN------------------LPALVLKIMSG--
--------------------------------------------------
---------------------TFAPISDRYSPE---LRQLVLSLLS----
LEPAQRPPL-------SHIMAQPLC------------------------
>NEK9
YIPIRVLGRGAFGEATLYRRTEDD--------------------------
--------SLVVWKEVDLTRLSEKE------------------------R
RDALNEIVILALLQ------------------HDNIIAYYNHFMD-----
-----------------------------------------NTTLLIELE
YCNG----------------------------------------------
--GNLYDKILRQKDKL----------------------------------
--------------------------------------------------
-------------------------------------FEEEMVVWYLFQI
VSAVSCIHKA------------GILHRDIKTLNIFLTKA-----------
--------NLIKLGDYGLAKKLNSE-------------------------
----------------------------YSMAETLVGTPYYMSPELCQG-
--------------------VKY-------NFKSDIWAVGCVIFELLTL-
-----------KRTFDATN------------------PLNLCVKIVQG--
--------------------------------------------------
-------------------IRAMEVDSSQYSLE---LIQMVHSCLD----
QDPEQRPTA-------DELLDRPLL------------------------
>NEK10
YAILDHLGSGAFGCVYKVRKHSGQ--------------------------
--------NLLAMKEVNLHNPAFGKDKKDRD----------------SSV
RNIVSELTIIKEQLY-----------------HPNIVRYYKTFLE-----
-----------------------------------------NDRLYIVME
LIEG----------------------------------------------
--APLGEHFSSLKEKHHH--------------------------------
--------------------------------------------------
-------------------------------------FTEERLWKIFIQL
CLALRYLHKEK-----------RIVHRDQTPNNIMLGDK-----------
--------DKVTVTDFGLAKQK-QE-------------------------
----------------------------NSKLTSVVGTILYSCPEVLKS-
--------------------EPY-------GEKADVWAVGCILYQMATL-
-----------SPPFYSTN------------------MLSLATKIVEA--
--------------------------------------------------
----------------------VYEPVPEGIYS---EKVTDTISRC----
LTPDAEARP-------DIVEVSSMISD----------------------
>NEK11
YVLQQKLGSGSFGTVYLVSDKKAKR-------------------------
------GEELKVLKEISVGELNPNE------------------------T
VQANLEAQLLSKLD------------------HPAIVKFHASFVE-----
-----------------------------------------QDNFCIITE
YCEG----------------------------------------------
--RDLDDKIQEYKQAGKI--------------------------------
--------------------------------------------------
-------------------------------------FPENQIIEWFIQL
LLGVDYMHER------------RILHRDLKSKNVFLKN------------
--------NLLKIGDFGVSRLLMGS-------------------------
----------------------------CDLATTLTGTPHYMSPEALKH-
--------------------QGY-------DTKSDIWSLACILYEMCCM-
-----------NHAFAGSN------------------FLSIVLKIVEG--
--------------------------------------------------
---------------------DTPSLPERYPKE---LNAIMESMLN----
KNPSLRPSA-------IEILKIPYL------------------------
>SgK495
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
--------------------------------------------------
---NLQHYVIKEKR------------------------------------
--------------------------------------------------
-------------------------------------LSERETVVIFYDV
VRVVEALHQK------------NIVHRDLKLGNMVLNKRTHR--------
--------ITITNFCLGKHLVSE---------------------------
----------------------------GDLLKDQRGSPAYISPDVLSG-
--------------------RPY------RGKPSDMWALGVVLFTMLYG-
-----------QFPFYDSI------------------PQELFRKIKAA--
--------------------------------------------------
--------------------EYTIPEDGRVSEN---TVCLIRKLLV----
LDPQQRLAA-------ADVLEAL--------------------------
>Trb1
LAEREHVSRALCIHTG----------------------------------
--------RELRCKVFPIKH-----------------------------Y
QDKIRPYIQLPS--------------------HSNITGIVEVILG-----
-----------------------------------------ETKAYVFFE
KDF-----------------------------------------------
--GDMHSYVRSRKR------------------------------------
--------------------------------------------------
-------------------------------------LREEEAARLFKQI
VSAVAHCHQS------------AIVLGDLKLRKFVFSTEERTQL------
--------RLESLEDTHIMKGE----------------------------
----------------------------DDALSDKHGCPAYVSPEILNTT
--------------------GTY------SGKAADVWSLGVMLYTLLVG-
-----------RYPFHDSD------------------PSALFSKIRRG--
--------------------------------------------------
----------------------QFCIPEHISPK---ARCLIRSLLR----
REPSERLTA-------PEILLHPWF------------------------
>Trb2
YLLLEPLEGDHVFRAVHLHSG-----------------------------
--------EELVCKVFDISC-----------------------------Y
QESLAPCFCLSA--------------------HSNINQITEIILG-----
-----------------------------------------ETKAYVFFE
RSY-----------------------------------------------
--GDMHSFVRTCKK------------------------------------
--------------------------------------------------
-------------------------------------LREEEAARLFYQI
ASAVAHCHDG------------GLVLRDLKLRKFIFKDEERTRV------
--------KLESLEDAYILRGD----------------------------
----------------------------DDSLSDKHGCPAYVSPEILNTS
--------------------GSY------SGKAADVWSLGVMLYTMLVG-
-----------RYPFHDIE------------------PSSLFSKIRRG--
--------------------------------------------------
----------------------QFNIPETLSPK---AKCLIRSILR----
REPSERLTS-------QEILDHPWF------------------------
>Trb3
LLEPEEGGRAYQALHCPTG-------------------------------
--------TEYTCKVYPV------------------------------QE
ALAVLEPYARLPP-------------------HKHVARPTEVLAG-----
-----------------------------------------TQLLYAFFT
RTH-----------------------------------------------
--GDMHSLVRSRHR------------------------------------
--------------------------------------------------
-------------------------------------IPEPEAAVLFRQM
ATALAHCHQH------------GLVLRDLKLCRFVFADRERKKL------
--------VLENLEDSCVLTGP----------------------------
----------------------------DDSLWDKHACPAYVGPEILSSR
--------------------ASY------SGKAADVWSLGVALFTMLAG-
-----------HYPFQDSE------------------PVLLFGKIRRG--
--------------------------------------------------
----------------------AYALPAGLSAP---ARCLVRCLLR----
REPAERLTA-------TGILLHPWL------------------------
>PASK
YSTMSPLGSGAFGFVWTAVDKEKN--------------------------
--------KEVVVKFIKKEKVLEDCW------------------IEDPKL
GKVTLEIAILSRVE------------------HANIIKVLDIFEN-----
-----------------------------------------QGFFQLVME
KHG-----------------------------------------------
--SGLDLFAFIDRHPR----------------------------------
--------------------------------------------------
-------------------------------------LDEPLASYIFRQL
VSAVGYLRLK------------DIIHRDIKDENIVIAED-----------
--------FTIKLIDFGSAAYLE---------------------------
---------------------------RGKLFYTFCGTIEYCAPEVLMG-
--------------------NPY------RGPELEMWSLGVTLYTLVFE-
-----------ENPFCELE--------------------ETVEAA-----
--------------------------------------------------
-----------------------IHPPYLVSKE---LMSLVSGLLQ----
PVPERRTTL-------EKLVTDPWV------------------------
>LKB1
YLMGDLLGEGSYGKVKEVLDSETL--------------------------
--------CRRAVKILKKKKLRRI----------------------PNGE
ANVKKEIQLLRRLR------------------HKNVIQLVDVLYN-----
---------------------------------------EEKQKMYMVME
YCVC----------------------------------------------
--GMQEMLDSVPEKR-----------------------------------
--------------------------------------------------
-------------------------------------FPVCQAHGYFCQL
IDGLEYLHSQ------------GIVHKDIKPGNLLLTTG-----------
--------GTLKISDLGVAEALHPF-------------------------
--------------------------AADDTCRTSQGSPAFQPPEIANGL
--------------------DTF------SGFKVDIWSAGVTLYNITTG-
-----------LYPFEGD---------------------NIYKLFENIG-
--------------------------------------------------
--------------------KGSYAIPGDCGPP---LSDLLKGMLE----
YEPAKRFSI-------RQIRQHSWF------------------------
>chk1_1ia8.PDB
WDLVQTLGEGAYGEVQLAVNRVTE--------------------------
--------EAVAVKIVDMKR---C-------------------------P
ENIKKEICINKMLN------------------HENVVKFYGHRRE-----
-----------------------------------------GNIQYLFLE
YCSG----------------------------------------------
--GELFDRIEPDI-------------------------------------
--------------------------------------------------
------------------------------------GMPEPDAQRFFHQL
MAGVVYLHGI------------GITHRDIKPENLLLDER-----------
--------DNLKISDFGLATVFRYN-------------------------
--------------------------NRERLLNKMCGTLPYVAPELLKR-
--------------------REF------HAEPVDVWSCGIVLTAMLAG-
-----------ELPWDQPSD----------------SCQEYSDWKEK---
--------------------------------------------------
--------------------KTYLNPWKKIDSA---PLALLHKILV----
ENPSARITI-------PDIKKDRWYNKPLKKGAKR--------------
>CHK1
WDLVQTLGEGAYGEVQLAVNRVTE--------------------------
--------EAVAVKIVDMKRAVDC-------------------------P
ENIKKEICINKMLN------------------HENVVKFYGHRRE-----
-----------------------------------------GNIQYLFLE
YCSG----------------------------------------------
--GELFDRIEPDI-------------------------------------
--------------------------------------------------
------------------------------------GMPEPDAQRFFHQL
MAGVVYLHGI------------GITHRDIKPENLLLDER-----------
--------DNLKISDFGLATVFRYN-------------------------
--------------------------NRERLLNKMCGTLPYVAPELLKR-
--------------------REF------HAEPVDVWSCGIVLTAMLAG-
-----------ELPWDQPSD----------------SCQEYSDWKEK---
--------------------------------------------------
--------------------KTYLNPWKKIDSA---PLALLHKILV----
ENPSARITI-------PDIKKDRWY------------------------
>PIM1
YQVGPLLGSGGFGSVYSGIRVSDN--------------------------
--------LPVAIKHVEKDRISDWGELPN--------------------G
TRVPMEVVLLKKVSS----------------GFSGVIRLLDWFER-----
-----------------------------------------PDSFVLILE
RPEPV---------------------------------------------
--QDLFDFITERG-------------------------------------
--------------------------------------------------
------------------------------------ALQEELARSFFWQV
LEAVRHCHNC------------GVLHRDIKDENILIDLNR----------
--------GELKLIDFGSGALL----------------------------
---------------------------KDTVYTDFDGTRVYSPPEWIRY-
--------------------HRY------HGRSAAVWSLGILLYDMVCG-
-----------DIPFEHD--------------------EEIIRGQVFF--
--------------------------------------------------
--------------------------RQRVSSE---CQHLIRWCLA----
LRPSDRPTF-------EEIQNHPWM------------------------
>PIM2
YRLGPLLGKGGFGTVFAGHRLTDR--------------------------
--------LQVAIKVIPRNRVLGWSPLSD--------------------S
VTCPLEVALLWKVGAG--------------GGHPGVIRLLDWFET-----
-----------------------------------------QEGFMLVLE
RPLPA---------------------------------------------
--QDLFDYITEKG-------------------------------------
--------------------------------------------------
------------------------------------PLGEGPSRCFFGQV
VAAIQHCHSR------------GVVHRDIKDENILIDLRR----------
--------GCAKLIDFGSGALL----------------------------
---------------------------HDEPYTDFDGTRVYSPPEWISR-
--------------------HQY------HALPATVWSLGILLYDMVCG-
-----------DIPFERD--------------------QEILEAELHF--
--------------------------------------------------
--------------------------PAHVSPD---CCALIRRCLA----
PKPSSRPSL-------EEILLDPWM------------------------
>PIM3
YQVGAVLGSGGFGTVYAGSRIADG--------------------------
--------LPVAVKHVVKERVTEWGSLG---------------------G
ATVPLEVVLLRKVGAA--------------GGARGVIRLLDWFER-----
-----------------------------------------PDGFLLVLE
RPEPA---------------------------------------------
--QDLFDFITERG-------------------------------------
--------------------------------------------------
------------------------------------ALDEPLARRFFAQV
LAAVRHCHSC------------GVVHRDIKDENLLVDLRS----------
--------GELKLIDFGSGALL----------------------------
---------------------------KDTVYTDFDGTRVYSPPEWIRY-
--------------------HRY------HGRSATVWSLGVLLYDMVCG-
-----------DIPFEQD--------------------EEILRGRLLF--
--------------------------------------------------
--------------------------RRRVSPE---CQQLIRWCLS----
LRPSERPSL-------DQIAAHPWM------------------------
>Obscn-b
FAFQTQIQRGRFSVVRQCWEKASG--------------------------
--------RALAAKIIPYHPKD---------------------------K
TAVLREYEALKGLR------------------HPHLAQLHAAYLS-----
-----------------------------------------PRHLVLILE
LCSG----------------------------------------------
--PELLPCLAERAS------------------------------------
--------------------------------------------------
-------------------------------------YSESEVKDYLWQM
LSATQYLHNQ------------HILHLDLRSENMIITEY-----------
--------NLLKVVDLGNAQSLSQE-------------------------
---------------------------KVLPSDKFKDYLETMAPELLEG-
--------------------QGA-------VPQTDIWAIGVTAFIMLSA-
-----------EYPVSSEG------------------ARDLQRGLRKGLV
RL------------------------------------------------
-----------------------SRCYAGLSGG---AVAFLRSTLC----
AQPWGRPCA-------SSCLQCPWL------------------------
>Obscn
YEVKEEIGRGVFGFVKRVQHKGNK--------------------------
--------ILCAAKFIPLRSRT---------------------------R
AQAYRERDILAALS------------------HPLVTGLLDQFET-----
-----------------------------------------RKTLILILE
LCSS----------------------------------------------
--EELLDRLYRKGV------------------------------------
--------------------------------------------------
-------------------------------------VTEAEVKVYIQQL
VEGLHYLHSH------------GVLHLDIKPSNILMVHPAR---------
--------EDIKICDFGFAQNITP--------------------------
----------------------------AELQFSQYGSPEFVSPEIIQQ-
--------------------NPV-------SEASDIWAMGVISYLSLTC-
-----------SSPFAGES------------------DRATLLNVLEGRV
SW------------------------------------------------
----------------------SSPMAAHLSED---AKDFIKATLQ----
RAPQARPSA-------AQCLSHPWF------------------------
>SPEG-b
YTFLEEKARGRFGVVRACRENATG--------------------------
--------RTFVAKIVPYAAEG---------------------------K
RRVLQEYEVLRTLH------------------HERIMSLHEAYIT-----
-----------------------------------------PRYLVLIAE
SCGN----------------------------------------------
--RELLCGLSDRFR------------------------------------
--------------------------------------------------
-------------------------------------YSEDDVATYMVQL
LQGLDYLHGH------------HVLHLDIKPDNLLLAPD-----------
--------NALKIVDFGSAQPYNPQ-------------------------
---------------------------ALRPLGHRTGTLEFMAPEMVKG-
--------------------EPI-------GSATDIWGAGVLTYIMLSG-
-----------RSPFYEPD------------------PQETEARIVGGRF
DA------------------------------------------------
-----------------------FQLYPNTSQS---ATLFLRKVLS----
VHPWSRPSL-------QDCLAHPWL------------------------
>SPEG
YDIHQEIGRGAFSYLRRIVERSSG--------------------------
--------LEFAAKFIPSQAKP---------------------------K
ASARREARLLARLQ------------------HDCVLYFHEAFER-----
-----------------------------------------RRGLVIVTE
LCT-----------------------------------------------
--EELLERIARKPT------------------------------------
--------------------------------------------------
-------------------------------------VCESEIRAYMRQV
LEGIHYLHQS------------HVLHLDVKPENLLVWDGAAGE-------
--------QQVRICDFGNAQELT---------------------------
---------------------------PGEPQYCQYGTPEFVAPEIVNQ-
--------------------SPV-------SGVTDIWPVGVVAFLCLTG-
-----------ISPFVGEN------------------DRTTLMNIRNYNV
AF------------------------------------------------
-----------------------EETTFLSLSR---EARGFLIKVL----
VQDRLRPTA-------EETLEHPWF------------------------
>Trad
YTELNEIGRGRFSIVKKCIHKATR--------------------------
--------KDVAVKFVSKKMKK---------------------------K
EQAAHEAALLQHLQ------------------HPQYITLHDTYES-----
-----------------------------------------PTSYILILE
LMDD----------------------------------------------
--GRLLDYLMNHDE------------------------------------
--------------------------------------------------
-------------------------------------LMEEKVAFYIRDI
MEALQYLHNC------------RVAHLDIKPENLLIDLRIPV--------
--------PRVKLIDLEDAVQIS---------------------------
---------------------------GHFHIHHLLGNPEFAAPEVIQG-
--------------------IPV-------SLGTDIWSIGVLTYVMLSG-
-----------VSPFLDES------------------KEETCINVCRVDF
SF------------------------------------------------
----------------------PHEYFCGVSNA---ARDFINVILQ----
EDFRRRPTA-------ATCLQHPWL------------------------
>Trio
YSEVAELGRGRFSVVKKCDQKGTK--------------------------
--------RAVATKFVNKKLMK---------------------------R
DQVTHELGILQSLQ------------------HPLLVGLLDTFET-----
-----------------------------------------PTSYILVLE
MADQ----------------------------------------------
--GRLLDCVVRWGS------------------------------------
--------------------------------------------------
-------------------------------------LTEGKIRAHLGEV
LEAVRYLHNC------------RIAHLDLKPENILVDESLAK--------
--------PTIKLADFGDAVQLN---------------------------
---------------------------TTYYIHQLLGNPEFAAPEIILG-
--------------------NPV-------SLTSDTWSVGVLTYVLLSG-
-----------VSPFLDDS------------------VEETCLNICRLDF
SF------------------------------------------------
----------------------PDDYFKGVSQK---AKEFVCFLLQ----
EDPAKRPSA-------ALALQEQWL------------------------
>TTN
YMIAEDLGRGEFGIVHRCVETSSK--------------------------
--------KTYMAKFVKVKGTD---------------------------Q
VLVKKEISILNIAR------------------HRNILHLHESFES-----
-----------------------------------------MEELVMIFE
FISG----------------------------------------------
--LDIFERINTSAFE-----------------------------------
--------------------------------------------------
-------------------------------------LNEREIVSYVHQV
CEALQFLHSH------------NIGHFDIRPENIIYQTRRS---------
--------STIKIIEFGQARQLKPG-------------------------
-----------------------------DNFRLLFTAPEYYAPEVHQH-
--------------------DVV-------STATDMWSLGTLVYVLLSG-
-----------INPFLAET------------------NQQIIENIMNAEY
TF------------------------------------------------
----------------------DEEAFKEISIE---AMDFVDRLLV----
KERKSRMTA-------SEALQHPWL------------------------
>DAPK1
YDTGEELGSGQFAVVKKCREKSTG--------------------------
--------LQYAAKFIKKRRTKSSRRG--------------------VSR
EDIEREVSILKEIQ------------------HPNVITLHEVYEN-----
-----------------------------------------KTDVILILE
LVAG----------------------------------------------
--GELFDFLAEKES------------------------------------
--------------------------------------------------
-------------------------------------LTEEEATEFLKQI
LNGVYYLHSL------------QIAHFDLKPENIMLLDRNVPK-------
--------PRIKIIDFGLAHKIDFG-------------------------
-----------------------------NEFKNIFGTPEFVAPEIVNY-
--------------------EPL-------GLEADMWSIGVITYILLSG-
-----------ASPFLGDT------------------KQETLANVSAVNY
EF------------------------------------------------
----------------------EDEYFSNTSAL---AKDFIRRLLV----
KDPKKRMTI-------QDSLQHPWI------------------------
>DAPK2
YDIGEELGSGQFAIVKKCREKSTG--------------------------
--------LEYAAKFIKKRQSRASRRG--------------------VSR
EEIEREVSILRQVL------------------HHNVITLHDVYEN-----
-----------------------------------------RTDVVLILE
LVSG----------------------------------------------
--GELFDFLAQKES------------------------------------
--------------------------------------------------
-------------------------------------LSEEEATSFIKQI
LDGVNYLHTK------------KIAHFDLKPENIMLLDKNIPI-------
--------PHIKLIDFGLAHEIEDG-------------------------
-----------------------------VEFKNIFGTPEFVAPEIVNY-
--------------------EPL-------GLEADMWSIGVITYILLSG-
-----------ASPFLGDT------------------KQETLANITAVSY
DF------------------------------------------------
----------------------DEEFFSQTSEL---AKDFIRKLLV----
KETRKRLTI-------QEALRHPWI------------------------
>DAPK3
YEMGEELGSGQFAIVRKCRQKGTG--------------------------
--------KEYAAKFIKKRRLSSSRRG--------------------VSR
EEIEREVNILREIR------------------HPNIITLHDIFEN-----
-----------------------------------------KTDVVLILE
LVSG----------------------------------------------
--GELFDFLAEKES------------------------------------
--------------------------------------------------
-------------------------------------LTEDEATQFLKQI
LDGVHYLHSK------------RIAHFDLKPENIMLLDKNVPN-------
--------PRIKLIDFGIAHKIEAG-------------------------
-----------------------------NEFKNIFGTPEFVAPEIVNY-
--------------------EPL-------GLEADMWSIGVITYILLSG-
-----------ASPFLGET------------------KQETLTNISAVNY
DF------------------------------------------------
----------------------DEEYFSNTSEL---AKDFIRRLLV----
KDPKRRMTI-------AQSLEHSWI------------------------
>DRAK1
LCPGRELGRGKFAVVRKCIKKDSG--------------------------
--------KEFAAKFMRKRRKGQD------------------------CR
MEIIHEIAVLELAQD-----------------NPWVINLHEVYET-----
-----------------------------------------ASEMILVLE
YAAG----------------------------------------------
--GEIFDQCVADREEA----------------------------------
--------------------------------------------------
-------------------------------------FKEKDVQRLMRQI
LEGVHFLHTR------------DVVHLDLKPQNILLTSESPL--------
--------GDIKIVDFGLSRILKNS-------------------------
-----------------------------EELREIMGTPEYVAPEILSY-
--------------------DPI-------SMATDMWSIGVLTYVMLTG-
-----------ISPFLGND------------------KQETFLNISQMNL
SY------------------------------------------------
----------------------SEEEFDVLSES---AVDFIRTLLV----
KKPEDRATA-------EECLKHPWL------------------------
>DRAK2
ILTSKELGRGKFAVVRQCISKSTG--------------------------
--------QEYAAKFLKKRRRGQD------------------------CR
AEILHEIAVLELAKS-----------------CPRVINLHEVYEN-----
-----------------------------------------TSEIILILE
YAAG----------------------------------------------
--GEIFSLCLPELAEM----------------------------------
--------------------------------------------------
-------------------------------------VSENDVIRLIKQI
LEGVYYLHQN------------NIVHLDLKPQNILLSSIYPL--------
--------GDIKIVDFGMSRKIGHA-------------------------
-----------------------------CELREIMGTPEYLAPEILNY-
--------------------DPI-------TTATDMWNIGIIAYMLLTH-
-----------TSPFVGED------------------NQETYLNISQVNV
DY------------------------------------------------
----------------------SEETFSSVSQL---ATDFIQSLLV----
KNPEKRPTA-------EICLSHSWL------------------------
>smMLCK
YDIEERLGSGKFGQVFRLVEKKTR--------------------------
--------KVWAGKFFKAYSAKEK--------------------------
ENIRQEISIMNCLH------------------HPKLVQCVDAFEE-----
-----------------------------------------KANIVMVLE
IVSG----------------------------------------------
--GELFERIIDEDFE-----------------------------------
--------------------------------------------------
-------------------------------------LTERECIKYMRQI
SEGVEYIHKQ------------GIVHLDLKPENIMCVNKTG---------
--------TRIKLIDFGLARRLENA-------------------------
-----------------------------GSLKVLFGTPEFVAPEVINY-
--------------------EPI-------GYATDMWSIGVICYILVSG-
-----------LSPFMGDN------------------DNETLANVTSATW
DF------------------------------------------------
----------------------DDEAFDEISDD---AKDFISNLLK----
KDMKNRLDC-------TQCLQHPWL------------------------
>skMLCK
MNSKEALGGGKFGAVCTCMEKATG--------------------------
--------LKLAAKVIKKQTPKDK--------------------------
EMVLLEIEVMNQLN------------------HRNLIQLYAAIET-----
-----------------------------------------PHEIVLFME
YIEG----------------------------------------------
--GELFERIVDEDYH-----------------------------------
--------------------------------------------------
-------------------------------------LTEVDTMVFVRQI
CDGILFMHKM------------RVLHLDLKPENILCVNTTG---------
--------HLVKIIDFGLARRYNPN-------------------------
-----------------------------EKLKVNFGTPEFLSPEVVNY-
--------------------DQI-------SDKTDMWSMGVITYMLLSG-
-----------LSPFLGDD------------------DTETLNNVLSGNW
YF------------------------------------------------
----------------------DEETFEAVSDE---AKDFVSNLIV----
KDQRARMNA-------AQCLAHPWL------------------------
>caMLCK
VCQHEVLGGGRFGQVHRCTEKSTG--------------------------
--------LPLAAKIIKVKSAKDR--------------------------
EDVKNEINIMNQLS------------------HVNLIQLYDAFES-----
-----------------------------------------KHSCTLVME
YVDG----------------------------------------------
--GELFDRITDEKYH-----------------------------------
--------------------------------------------------
-------------------------------------LTELDVVLFTRQI
CEGVHYLHQH------------YILHLDLKPENILCVNQTG---------
--------HQIKIIDFGLARRYKPR-------------------------
-----------------------------EKLKVNFGTPEFLAPEVVNY-
--------------------EFV-------SFPTDMWSVGVITYMLLSG-
-----------LSPFLGET------------------DAETMNFIVNCSW
DF------------------------------------------------
----------------------DADTFEGLSEE---AKDFVSRLLV----
KEKSCRMSA-------TQCLKHEWL------------------------
>SgK085
VSKTEILGGGRFGQVHKCEETATG--------------------------
--------LKLAAKIIKTRGMKDK--------------------------
EEVKNEISVMNQLD------------------HANLIQLYDAFES-----
-----------------------------------------KNDIVLVME
YVDG----------------------------------------------
--GELFDRIIDESYN-----------------------------------
--------------------------------------------------
-------------------------------------LTELDTILFMKQI
CEGIRHMHQM------------YILHLDLKPENILCVNRDA---------
--------KQIKIIDFGLARRYKPR-------------------------
-----------------------------EKLKVNFGTPEFLAPEVVNY-
--------------------DFV-------SFPTDMWSVGVIAYMLLSG-
-----------LSPFLGDN------------------DAETLNNILACRW
DL------------------------------------------------
----------------------EDEEFQDISEE---AKEFISKLLI----
KEKSWRISA-------SEALKHPWL------------------------
>SSTK
YKLGRTIGEGSYSKVKVATSKKYK--------------------------
--------GTVAIKVVDRRRAPPDFV-----------------------N
KFLPRELSILRGVR------------------HPHIVHVFEFIEVC----
-----------------------------------------NGKLYIVME
AAA-----------------------------------------------
--TDLLQAVQRNGR------------------------------------
--------------------------------------------------
-------------------------------------IPGVQARDLFAQI
AGAVRYLHDH------------HLVHRDLKCENVLLSPDE----------
--------RRVKLTDFGFGRQAHGY-------------------------
----------------------------PDLSTTYCGSAAYASPEVLLG-
--------------------IPY------DPKKYDVWSMGVVLYVMVTG-
-----------CMPFDDSD------------------IAGLPRRQKRG--
--------------------------------------------------
---------------------VLYPEGLELSER---CKALIAELLQ----
FSPSARPSA-------GQVARNCWL------------------------
>TSSK1
YLLGINLGEGSYAKVKSAYSERLK--------------------------
--------FNVAIKIIDRKKAPADFL-----------------------E
KFLPREIEILAMLN------------------HCSIIKTYEIFETS----
-----------------------------------------HGKVYIVME
LAVQ----------------------------------------------
--GDLLELIKTRGA------------------------------------
--------------------------------------------------
-------------------------------------LHEDEARKKFHQL
SLAIKYCHDL------------DVVHRDLKCDNLLLDKD-----------
--------FNIKLSDFSFSKRCLRDDSG----------------------
---------------------------RMALSKTFCGSPAYAAPEVLQG-
--------------------IPY------QPKVYDIWSLGVILYIMVCG-
-----------SMPYDDSN------------------IKKMLRIQKEHRV
NF------------------------------------------------
------------------------PRSKHLTGE---CKDLIYHMLQ----
PDVNRRLHI-------DEILSHCWM------------------------
>TSSK2
YIVGINLGKGSYAKVKSAYSERLK--------------------------
--------FNVAVKIIDRRKTPTDFV-----------------------E
RFLPREMDILATVN------------------HGSIIKTYEIFETS----
-----------------------------------------DGRIYIIME
LGVQ----------------------------------------------
--GDLLEFIKCQGA------------------------------------
--------------------------------------------------
-------------------------------------LHEDVARKMFRQL
SSAVKYCHDL------------DIVHRDLKCENLLLDKD-----------
--------FNIKLSDFGFSKRCLRDSNG----------------------
---------------------------RIILSKTFCGSAAYAAPEVLQS-
--------------------IPY------QPKVYDIWSLGVILYIMVCG-
-----------SMPYDDSD------------------IRKMLRIQKEHRV
DF------------------------------------------------
------------------------PRSKNLTCE---CKDLIYRMLQ----
PDVSQRLHI-------DEILSHSWL------------------------
>TSSK3
YQLGKTIGEGTYSKVKEAFSKKHQ--------------------------
--------RKVAIKVIDKMGGPSEFI-----------------------Q
RFLPRELQIVRTLD------------------HKNIIQVYEMLESA----
-----------------------------------------DGKICLVME
LAEG----------------------------------------------
--GDVFDCVLNGGP------------------------------------
--------------------------------------------------
-------------------------------------LPESRAKALFRQM
VEAIRYCHGC------------GVAHRDLKCENALLQG------------
--------FNLKLTDFGFAKVLPKSHR-----------------------
-----------------------------ELSQTFCGSTAYAAPEVLQG-
--------------------IPH------DSKKGDVWSMGVVLYVMLCA-
-----------SLPFDDTD------------------IPKMLWQQQKG-V
SF------------------------------------------------
------------------------PTHLSISAD---CQDLLKRLLE----
PDMILRPSI-------EEVSWHPWL------------------------
>TSSK4
YEVGKAIGHGSYGSVYEAFYTKQK--------------------------
--------VMVAVKIISKKKASDDYL-----------------------N
KFLPREIQVMKVLR------------------HKYLINFYRAIES-----
-----------------------------------------TSRVYIILE
LAQG----------------------------------------------
--GDVLEWIQRYGA------------------------------------
--------------------------------------------------
-------------------------------------CSEPLAGKWFSQL
TLGIAYLHSK------------SIVHRDLKLENLLLDKW-----------
--------ENVKISDFGFAKMVPSNQPVGCSP------------------
--------------------SYRQVNCFSHLSQTYCGSFAYACPEILRG-
--------------------LPY------NPFLSDTWSMGVILYTLVVA-
-----------HLPFDDTN------------------LKKLLRETQKE-V
TF------------------------------------------------
------------------------PANHTISQE----CKNLILQML----
RQATKRATI-------LDIIKDSWV------------------------
>SNRK
YDLDKTLGRGHFACGTCSRHVFTG--------------------------
--------EKVAVKVIDKTKLDTLA------------------------T
GHLFQEVRCMKLVQ------------------HPNIVRLYEVIDT-----
-----------------------------------------QTKLYLILE
LGDG----------------------------------------------
--GDMFDYIMKHEEG-----------------------------------
--------------------------------------------------
-------------------------------------LNEDLAKKYFAQI
VHAISYCHKL------------HVVHRDLKPENVVFFEKQ----------
--------GLVKLTDFGFSNKFQP--------------------------
----------------------------GKKLTTSCGSLAYSAPEILLG-
--------------------DEY------DAPAVDIWSLGVILFMLVCG-
-----------QPPFQEAN------------------DSETLTMIMDC--
--------------------------------------------------
----------------------KYTVPSHVSKE---CKDLITRMLQ----
RDPKRRASL-------EEIENHPWL------------------------
>NIM1
YRIRGEIGSGNFSQVKLGIHSLTK--------------------------
--------EKVAIKILDKTKLDQKT------------------------Q
RLLSREISSMEKLH------------------HPNIIRLYEVVET-----
-----------------------------------------LSKLHLVME
YAGG----------------------------------------------
--GELFGKISTEGK------------------------------------
--------------------------------------------------
-------------------------------------LSEPESKLIFSQI
VSAVKHMHEN------------QIIHRDLKAENVFYTSN-----------
--------TCVKVGDFGFSTVSKK--------------------------
----------------------------GEMLNTFCGSPPYAAPELFRD-
--------------------EHY------IGIYVDIWALGVLLYFMVTG-
-----------TMPFRAET------------------VAKLKKSILEG--
--------------------------------------------------
----------------------TYSVPPHVSEP---CHRLIRGVLQ----
QIPTERYGI-------DCIMNDEWM------------------------
>HUNK
LIGSRKLGEGSFAKVREGLHVLTG--------------------------
--------EKVAIKVIDKKRAKKDTY----------------------VT
KNLRREGQIQQMIR------------------HPNITQLLDILET-----
-----------------------------------------ENSYYLVME
LCPG----------------------------------------------
--GNLMHKIYEKKR------------------------------------
--------------------------------------------------
-------------------------------------LEESEARRYIRQL
ISAVEHLHRA------------GVVHRDLKIENLLLDED-----------
--------NNIKLIDFGLSNCAGILGY-----------------------
----------------------------SDPFSTQCGSPAYAAPELLAR-
--------------------KKY-------GPKIDVWSIGVNMYAMLTG-
-----------TLPFTVEP------------------FSLRALYQKMVDK
E-------------------------------------------------
----------------------MNPLPTQLSTG---AISFLRSLLE----
PDPVKRPNI-------QQALANRWL------------------------
>MELK
YELHETIGTGGFAKVKLACHILTG--------------------------
--------EMVAIKIMDKNTLGSD-------------------------L
PRIKTEIEALKNLR------------------HQHICQLYHVLET-----
-----------------------------------------ANKIFMVLE
YCPG----------------------------------------------
--GELFDYIISQDR------------------------------------
--------------------------------------------------
-------------------------------------LSEEETRVVFRQI
VSAVAYVHSQ------------GYAHRDLKPENLLFDEY-----------
--------HKLKLIDFGLCAKPKGNK------------------------
----------------------------DYHLQTCCGSLAYAAPELIQG-
--------------------KSY------LGSEADVWSMGILLYVLMCG-
-----------FLPFDDDN------------------VMALYKKIMRG--
--------------------------------------------------
----------------------KYDVPKWLSPS---SILLLQQMLQ----
VDPKKRISM-------KNLLNHPWI------------------------
>AMPKa1
YILGDTLGVGTFGKVKVGKHELTG--------------------------
--------HKVAVKILNRQKIRSLD-----------------------VV
GKIRREIQNLKLFR------------------HPHIIKLYQVIST-----
-----------------------------------------PSDIFMVME
YVSG----------------------------------------------
--GELFDYICKNGR------------------------------------
--------------------------------------------------
-------------------------------------LDEKESRRLFQQI
LSGVDYCHRH------------MVVHRDLKPENVLLDAH-----------
--------MNAKIADFGLSNMMS---------------------------
---------------------------DGEFLRTSCGSPNYAAPEVISG-
--------------------RLY------AGPEVDIWSSGVILYALLCG-
-----------TLPFDDDH------------------VPTLFKKICDG--
--------------------------------------------------
----------------------IFYTPQYLNPS---VISLLKHMLQ----
VDPMKRASI-------KDIREHEWF------------------------
>AMPKa2
YVLGDTLGVGTFGKVKIGEHQLTG--------------------------
--------HKVAVKILNRQKIRSLD-----------------------VV
GKIKREIQNLKLFR------------------HPHIIKLYQVIST-----
-----------------------------------------PTDFFMVME
YVSG----------------------------------------------
--GELFDYICKHGR------------------------------------
--------------------------------------------------
-------------------------------------VEEMEARRLFQQI
LSAVDYCHRH------------MVVHRDLKPENVLLDAH-----------
--------MNAKIADFGLSNMMS---------------------------
---------------------------DGEFLRTSCGSPNYTAPEVISG-
--------------------RLY------AGPEVDIWSCGVILYALLCG-
-----------TLPFDDEH------------------VPTLFKKIRGG--
--------------------------------------------------
----------------------VFYIPEYLNRS---VATLLMHMLQ----
VDPLKRATI-------KDIREHEWF------------------------
>BRSK1
YRLEKTLGKGQTGLVKLGVHCITG--------------------------
--------QKVAIKIVNREKLSES------------------------VL
MKVEREIAILKLIE------------------HPHVLKLHDVYEN-----
-----------------------------------------KKYLYLVLE
HVSG----------------------------------------------
--GELFDYLVKKGR------------------------------------
--------------------------------------------------
-------------------------------------LTPKEARKFFRQI
VSALDFCHSY------------SICHRDLKPENLLLDEK-----------
--------NNIRIADFGMASLQV---------------------------
---------------------------GDSLLETSCGSPHYACPEVIKG-
--------------------EKY------DGRRADMWSCGVILFALLVG-
-----------ALPFDDDN------------------LRQLLEKVKRG--
--------------------------------------------------
----------------------VFHMPHFIPPD---CQSLLRGMIE----
VEPEKRLSL-------EQIQKHPWY------------------------
>BRSK2
YRLEKTLGKGQTGLVKLGVHCVTC--------------------------
--------QKVAIKIVNREKLSES------------------------VL
MKVEREIAILKLIE------------------HPHVLKLHDVYEN-----
-----------------------------------------KKYLYLVLE
HVSG----------------------------------------------
--GELFDYLVKKGR------------------------------------
--------------------------------------------------
-------------------------------------LTPKEARKFFRQI
ISALDFCHSH------------SICHRDLKPENLLLDEK-----------
--------NNIRIADFGMASLQV---------------------------
---------------------------GDSLLETSCGSPHYACPEVIRG-
--------------------EKY------DGRKADVWSCGVILFALLVG-
-----------ALPFDDDN------------------LRQLLEKVKRG--
--------------------------------------------------
----------------------VFHMPHFIPPD---CQSLLRGMIE----
VDAARRLTL-------EHIQKHIWY------------------------
>NuaK1
YELQETLGKGTYGKVKRATERFSG--------------------------
--------RVVAIKSIRKDKIKDEQ-----------------------DM
VHIRREIEIMSSLN------------------HPHIISIYEVFEN-----
-----------------------------------------KDKIVIIME
YASK----------------------------------------------
--GELYDYISERRR------------------------------------
--------------------------------------------------
-------------------------------------LSERETRHFFRQI
VSAVHYCHKN------------GVVHRDLKLENILLDDN-----------
--------CNIKIADFGLSNLYQ---------------------------
---------------------------KDKFLQTFCGSPLYASPEIVNG-
--------------------RPY------RGPEVDSWALGVLLYTLVYG-
-----------TMPFDGFD------------------HKNLIRQISSG--
--------------------------------------------------
----------------------EYREPTQPSD----ARGLIRWMLM----
VNPDRRATI-------EDIANHWWV------------------------
>NuaK2
YEFLETLGKGTYGKVKKARESSG---------------------------
--------RLVAIKSIRKDKIKDEQ-----------------------DL
MHIRREIEIMSSLN------------------HPHIIAIHEVFEN-----
-----------------------------------------SSKIVIVME
YASR----------------------------------------------
--GDLYDYISERQQ------------------------------------
--------------------------------------------------
-------------------------------------LSEREARHFFRQI
VSAVHYCHQN------------RVVHRDLKLENILLDAN-----------
--------GNIKIADFGLSNLYH---------------------------
---------------------------QGKFLQTFCGSPLYASPEIVNG-
--------------------KPY------TGPEVDSWSLGVLLYILVHG-
-----------TMPFDGHD------------------HKILVKQISNG--
--------------------------------------------------
----------------------AYREPPKPSD----CLGLIRWLLM----
VNPTRRATL-------EDVASHWWV------------------------
>QSK
YEIDRTIGKGNFAVVKRATHLVTK--------------------------
--------AKVAIKIIDKTQLDEE------------------------NL
KKIFREVQIMKMLC------------------HPHIIRLYQVMET-----
-----------------------------------------ERMIYLVTE
YASG----------------------------------------------
--GEIFDHLVAHGR------------------------------------
--------------------------------------------------
-------------------------------------MAEKEARRKFKQI
VTAVYFCHCR------------NIVHRDLKAENLLLDAN-----------
--------LNIKIADFGFSNLFT---------------------------
---------------------------PGQLLKTWCGSPPYAAPELFEG-
--------------------KEY------DGPKVDIWSLGVVLYVLVCG-
-----------ALPFDGST------------------LQNLRARVLSG--
--------------------------------------------------
----------------------KFRIPFFMSTE---CEHLIRHMLV----
LDPNKRLSM-------EQICKHKWM------------------------
>SIK
YDIERTLGKGNFAVVKLARHRVTK--------------------------
--------TQVAIKIIDKTRLDSS------------------------NL
EKIYREVQLMKLLN------------------HPHIIKLYQVMET-----
-----------------------------------------KDMLYIVTE
FAKN----------------------------------------------
--GEMFDYLTSNGH------------------------------------
--------------------------------------------------
-------------------------------------LSENEARKKFWQI
LSAVEYCHDH------------HIVHRDLKTENLLLDGN-----------
--------MDIKLADFGFGNFYK---------------------------
---------------------------SGEPLSTWCGSPPYAAPEVFEG-
--------------------KEY------EGPQLDIWSLGVVLYVLVCG-
-----------SLPFDGPN------------------LPTLRQRVLEG--
--------------------------------------------------
----------------------RFRIPFFMSQD---CESLIRRMLV----
VDPARRITI-------AQIRQHRWM------------------------
>QIK
YDIEGTLGKGNFAVVKLGRHRITK--------------------------
--------TEVAIKIIDKSQLDAV------------------------NL
EKIYREVQIMKMLD------------------HPHIIKLYQVMET-----
-----------------------------------------KSMLYLVTE
YAKN----------------------------------------------
--GEIFDYLANHGR------------------------------------
--------------------------------------------------
-------------------------------------LNESEARRKFWQI
LSAVDYCHGR------------KIVHRDLKAENLLLDNN-----------
--------MNIKIADFGFGNFFK---------------------------
---------------------------SGELLATWCGSPPYAAPEVFEG-
--------------------QQY------EGPQLDIWSMGVVLYVLVCG-
-----------ALPFDGPT------------------LPILRQRVLEG--
--------------------------------------------------
----------------------RFRIPYFMSED---CEHLIRRMLV----
LDPSKRLTI-------AQIKEHKWM------------------------
>MARK1
YRLQKTIGKGNFAKVKLARHVLTG--------------------------
--------REVAVKIIDKTQLNPT------------------------SL
QKLFREVRIMKILN------------------HPNIVKLFEVIET-----
-----------------------------------------EKTLYLVME
YASG----------------------------------------------
--GEVFDYLVAHGR------------------------------------
--------------------------------------------------
-------------------------------------MKEKEARAKFRQI
VSAVQYCHQK------------YIVHRDLKAENLLLDGD-----------
--------MNIKIADFGFSNEFT---------------------------
---------------------------VGNKLDTFCGSPPYAAPELFQG-
--------------------KKY------DGPEVDVWSLGVILYTLVSG-
-----------SLPFDGQN------------------LKELRERVLRG--
--------------------------------------------------
----------------------KYRIPFYMSTD---CENLLKKLLV----
LNPIKRGSL-------EQIMKDRWM------------------------
>MARK2
YRLLKTIGKGNFAKVKLARHILTG--------------------------
--------KEVAVKIIDKTQLNSS------------------------SL
QKLFREVRIMKVLN------------------HPNIVKLFEVIET-----
-----------------------------------------EKTLYLVME
YASG----------------------------------------------
--GEVFDYLVAHGR------------------------------------
--------------------------------------------------
-------------------------------------MKEKEARAKFRQI
VSAVQYCHQK------------FIVHRDLKAENLLLDAD-----------
--------MNIKIADFGFSNEFT---------------------------
---------------------------FGNKLDTFCGSPPYAAPELFQG-
--------------------KKY------DGPEVDVWSLGVILYTLVSG-
-----------SLPFDGQN------------------LKELRERVLRG--
--------------------------------------------------
----------------------KYRIPFYMSTD---CENLLKKFLI----
LNPSKRGTL-------EQIMKDRWM------------------------
>MARK3
YRLLKTIGKGNFAKVKLARHILTG--------------------------
--------REVAIKIIDKTQLNPT------------------------SL
QKLFREVRIMKILN------------------HPNIVKLFEVIET-----
-----------------------------------------QKTLYLIME
YASG----------------------------------------------
--GKVFDYLVAHGR------------------------------------
--------------------------------------------------
-------------------------------------MKEKEARSKFRQI
VSAVQYCHQK------------RIVHRDLKAENLLLDAD-----------
--------MNIKIADFGFSNEFT---------------------------
---------------------------VGGKLDTFCGSPPYAAPELFQG-
--------------------KKY------DGPEVDVWSLGVILYTLVSG-
-----------SLPFDGQN------------------LKELRERVLRG--
--------------------------------------------------
----------------------KYRIPFYMSTD---CENLLKRFLV----
LNPIKRGTL-------EQIMKDRWI------------------------
>MARK4
YRLLRTIGKGNFAKVKLARHILTG--------------------------
--------REVAIKIIDKTQLNPS------------------------SL
QKLFREVRIMKGLN------------------HPNIVKLFEVIET-----
-----------------------------------------EKTLYLVME
YASA----------------------------------------------
--GEVFDYLVSHGR------------------------------------
--------------------------------------------------
-------------------------------------MKEKEARAKFRQI
VSAVHYCHQK------------NIVHRDLQAENLLLDAE-----------
--------ANIKIADFGFSNEFT---------------------------
---------------------------LGSKLDTFCGSPPYAAPELFQG-
--------------------KKY------DGPEVDIWSLGVILYTLVSG-
-----------SLPFDGHN------------------LKELRERVLRG--
--------------------------------------------------
----------------------KYRVPFYMSTD---CESILRRFLV----
LNPAKRCTL-------EQIMKDKWI------------------------
>STK33
YTFGRILGKGSFGIVIEATDKETE--------------------------
--------TKWAIKKVNKEKAGSS------------------------AV
KLLEREVNILKSVK------------------HEHIIHLEQVFET-----
-----------------------------------------PKKMYLVME
LCED----------------------------------------------
--GELKEILDRKGH------------------------------------
--------------------------------------------------
-------------------------------------FSENETRWIIQSL
ASAIAYLHNN------------DIVHRDLKLENIMVKSSLIDDN------
----NEINLNIKVTDFGLAVKKQSRS------------------------
----------------------------EAMLQATCGTPIYMAPEVISA-
--------------------HDY-------SQQCDIWSIGVVMYMLLRG-
-----------EPPFLASS------------------EAKLFELIRKGEL
HF------------------------------------------------
----------------------ENAVWNSISDC---AKSVLKQLMK----
VDPAHRITA-------KELLDNQWL------------------------
>PKD1
IFPDEVLGSGQFGIVYGGKHRKTG--------------------------
--------RDVAIKIIDKLRFPTK------------------------QE
SQLRNEVAILQNLH------------------HPGVVNLECMFET-----
-----------------------------------------PERVFVVME
KLH-----------------------------------------------
--GDMLEMILSSEKGR----------------------------------
--------------------------------------------------
-------------------------------------LPEHITKFLITQI
LVALRHLHFK------------NIVHCDLKPENVLLASADP---------
-------FPQVKLCDFGFARIIGEKS------------------------
------------------------------FRRSVVGTPAYLAPEVLRN-
--------------------KGY-------NRSLDMWSVGVIIYVSLSG-
-----------TFPFNEDE------------------DIHDQIQNAAFMY
--------------------------------------------------
----------------------PPNPWKEISHE---AIDLINNLLQ----
VKMRKRYSV-------DKTLSHPWL------------------------
>PKD2
IFPDEVLGSGQFGVVYGGKHRKTG--------------------------
--------RDVAVKVIDKLRFPTK------------------------QE
SQLRNEVAILQSLR------------------HPGIVNLECMFET-----
-----------------------------------------PEKVFVVME
KLH-----------------------------------------------
--GDMLEMILSSEKGR----------------------------------
--------------------------------------------------
-------------------------------------LPERLTKFLITQI
LVALRHLHFK------------NIVHCDLKPENVLLASADP---------
-------FPQVKLCDFGFARIIGEKS------------------------
------------------------------FRRSVVGTPAYLAPEVLLN-
--------------------QGY-------NRSLDMWSVGVIMYVSLSG-
-----------TFPFNEDE------------------DINDQIQNAAFMY
--------------------------------------------------
----------------------PASPWSHISAG---AIDLINNLLQ----
VKMRKRYSV-------DKSLSHPWL------------------------
>PKD3
IFADEVLGSGQFGIVYGGKHRKTG--------------------------
--------RDVAIKVIDKMRFPTK------------------------QE
SQLRNEVAILQNLH------------------HPGIVNLECMFET-----
-----------------------------------------PERVFVVME
KLH-----------------------------------------------
--GDMLEMILSSEKSR----------------------------------
--------------------------------------------------
-------------------------------------LPERITKFMVTQI
LVALRNLHFK------------NIVHCDLKPENVLLASAEP---------
-------FPQVKLCDFGFARIIGEKS------------------------
------------------------------FRRSVVGTPAYLAPEVLRS-
--------------------KGY-------NRSLDMWSVGVIIYVSLSG-
-----------TFPFNEDE------------------DINDQIQNAAFMY
--------------------------------------------------
----------------------PPNPWREISGE---AIDLINNLLQ----
VKMRKRYSV-------DKSLSHPWL------------------------
>MNK1
KLTSELLGEGAYAKVQGAVSLQNG--------------------------
--------KEYAVKIIEKQAGHSR------------------------SR
VFREVETLYQCQG-------------------NKNILELIEFFED-----
-----------------------------------------DTRFYLVFE
KLQG----------------------------------------------
--GSILAHIQKQKH------------------------------------
--------------------------------------------------
-------------------------------------FNEREASRVVRDV
AAALDFLHTK------------GIAHRDLKPENILCESPEKV--------
------SPVKICDFDLGSGMKLNNSCTPITT-------------------
-----------------------------PELTTPCGSAEYMAPEVVEVF
TDQA----------------TFY-------DKRCDLWSLGVVLYIMLSG-
-----------YPPFVGHCGADCG---WDRGEVCRVCQNKLFESIQEGKY
EF------------------------------------------------
----------------------PDKDWAHISSE---AKDLISKLLV----
RDAKQRLSA-------AQVLQHPWV------------------------
>MNK2
QLQEDVLGEGAHARVQTCINLITS--------------------------
--------QEYAVKIIEKQPGHIR------------------------SR
VFREVEMLYQCQG-------------------HRNVLELIEFFEE-----
-----------------------------------------EDRFYLVFE
KMRG----------------------------------------------
--GSILSHIHKRRH------------------------------------
--------------------------------------------------
-------------------------------------FNELEASVVVQDV
ASALDFLHNK------------GIAHRDLKPENILCEHPNQV--------
------SPVKICDFDLGSGIKLNGDCSPIST-------------------
-----------------------------PELLTPCGSAEYMAPELVEAF
SEEA----------------SIY-------DKRCDLWSLGVILYILLSG-
-----------YPPFVGRCGSDCG---WDRGEACPACQNMLFESIQEGKY
EF------------------------------------------------
----------------------PDKDWAHISCA---AKDLISKLLV----
RDAKQRLSA-------AQVLQHPWV------------------------
>mapkap2_1kwp.PDB
KVTSQVLGLGINGKVLQIFNKRTQ--------------------------
--------EKFALKMLQDC-------------------------------
PKARREVELHWRAS-----------------QCPHIVRIVDVYENLY---
---------------------------------------AGRKCLLIVME
CLDG----------------------------------------------
--GELFSRIQDRGDQ-----------------------------------
--------------------------------------------------
------------------------------------AFTEREASEIMKSI
GEAIQYLHSI------------NIAHRDVKPENLLYTSKRP---------
-------NAILKLTDFGFAKETTS--------------------------
-----------------------------------------------GP-
--------------------EKY-------DKSCDMWSLGVIMYILLCG-
-----------YPPFYSNH--------------GLAISPGMKTRIRMYEF
--------------------------------------------------
----------------------PNPEWSEVSEE---VKMLIRNLLK----
TEPTQRMTI-------TEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERW
>MAPKAPK2
KVTSQVLGLGINGKVLQIFNKRTQ--------------------------
--------EKFALKMLQDC-------------------------------
PKARREVELHWRAS-----------------QCPHIVRIVDVYENLY---
---------------------------------------AGRKCLLIVME
CLDG----------------------------------------------
--GELFSRIQDRGDQ-----------------------------------
--------------------------------------------------
------------------------------------AFTEREASEIMKSI
GEAIQYLHSI------------NIAHRDVKPENLLYTSKRP---------
-------NAILKLTDFGFAKETTSH-------------------------
-----------------------------NSLTTPCYTPYYVAPEVLGP-
--------------------EKY-------DKSCDMWSLGVIMYILLCG-
-----------YPPFYSNH--------------GLAISPGMKTRIRMGQY
EF------------------------------------------------
----------------------PNPEWSEVSEE---VKMLIRNLLK----
TEPTQRMTI-------TEFMNHPWI------------------------
>MAPKAPK3
QLSKQVLGLGVNGKVLECFHRRTG--------------------------
--------QKCALKLLYDS-------------------------------
PKARQEVDHHWQAS-----------------GGPHIVCILDVYENMH---
---------------------------------------HGKRCLLIIME
CMEG----------------------------------------------
--GELFSRIQERGDQ-----------------------------------
--------------------------------------------------
------------------------------------AFTEREAAEIMRDI
GTAIQFLHSH------------NIAHRDVKPENLLYTSKEK---------
-------DAVLKLTDFGFAKETTQ--------------------------
-----------------------------NALQTPCYTPYYVAPEVLGP-
--------------------EKY-------DKSCDMWSLGVIMYILLCG-
-----------FPPFYSNT--------------GQAISPGMKRRIRLGQY
GF------------------------------------------------
----------------------PNPEWSEVSED---AKQLIRLLLK----
TDPTERLTI-------TQFMNHPWI------------------------
>MAPKAPK5
INWTQKLGAGISGPVRVCVKKSTQ--------------------------
--------ERFALKILLDR-------------------------------
PKARNEVRLHMMCA-----------------THPNIVQIIEVFANSVQFP
------------------------------------HESSPRARLLIVME
MMEG----------------------------------------------
--GELFHRISQHRH------------------------------------
--------------------------------------------------
-------------------------------------FTEKQASQVTKQI
ALALRHCHLL------------NIAHRDLKPENLLFKDNSL---------
-------DAPVKLCDFGFAKIDQ---------------------------
-----------------------------GDLMTPQFTPYYVAPQVLEAQ
RRHQKEKSGII---PTSPTPYTY-------NKSCDLWSLGVIIYVMLCG-
-----------YPPFYSKH---------------------HSRTIPKDMR
RKIMTGSFEF----------------------------------------
----------------------PEEEWSQISEM---AKDVVRKLLK----
VKPERRLTI-------EGVLDHPWL------------------------
>RSK1-b
YEIKEDIGVGSYSVCKRCVHKATD--------------------------
--------TEYAVKIIDKSKRD----------------------------
PSEEIEILLRYGQ-------------------HPNIITLKDVYDD-----
-----------------------------------------GKFVYLVME
LMRG----------------------------------------------
--GELLDRILRQRY------------------------------------
--------------------------------------------------
-------------------------------------FSEREASDVLCTI
TKTMDYLHSQ------------GVVHRDLKPSNILYRDESGSP-------
--------ESIRVCDFGFAKQLRAGN------------------------
-----------------------------GLLMTPCYTANFVAPEVLKR-
--------------------QGY-------DAACDIWSLGILLYTMLAG-
-----------FTPFANGP---------------DDTPEEILARIGSGKY
AL------------------------------------------------
----------------------SGGNWDSISDA---AKDVVSKMLH----
VDPHQRLTA-------MQVLKHPWV------------------------
>RSK2-b
YEVKEDIGVGSYSVCKRCIHKATN--------------------------
--------MEFAVKIIDKSKRD----------------------------
PTEEIEILLRYGQ-------------------HPNIITLKDVYDD-----
-----------------------------------------GKYVYVVTE
LMKG----------------------------------------------
--GELLDKILRQKF------------------------------------
--------------------------------------------------
-------------------------------------FSEREASAVLFTI
TKTVEYLHAQ------------GVVHRDLKPSNILYVDESGNP-------
--------ESIRICDFGFAKQLRAEN------------------------
-----------------------------GLLMTPCYTANFVAPEVLKR-
--------------------QGY-------DAACDIWSLGVLLYTMLTG-
-----------YTPFANGP---------------DDTPEEILARIGSGKF
SL------------------------------------------------
----------------------SGGYWNSVSDT---AKDLVSKMLH----
VDPHQRLTA-------ALVLRHPWI------------------------
>RSK3-b
YVVKETIGVGSYSECKRCVHKATN--------------------------
--------MEYAVKVIDKSKRD----------------------------
PSEEIEILLRYGQ-------------------HPNIITLKDVYDD-----
-----------------------------------------GKHVYLVTE
LMRG----------------------------------------------
--GELLDKILRQKF------------------------------------
--------------------------------------------------
-------------------------------------FSEREASFVLHTI
GKTVEYLHSQ------------GVVHRDLKPSNILYVDESGNP-------
--------ECLRICDFGFAKQLRAEN------------------------
-----------------------------GLLMTPCYTANFVAPEVLKR-
--------------------QGY-------DEGCDIWSLGILLYTMLAG-
-----------YTPFANGPSD---------------TPEEILTRIGSGKF
TL------------------------------------------------
----------------------SGGNWNTVSET---AKDLVSKMLH----
VDPHQRLTA-------KQVLQHPWV------------------------
>RSK4-b
YELKEDIGVGSYSVCKRCIHATTN--------------------------
--------MEFAVKIIDKSKRD----------------------------
PSEEIEILMRYGQ-------------------HPNIITLKDVFDD-----
-----------------------------------------GRYVYLVTD
LMKG----------------------------------------------
--GELLDRILKQKC------------------------------------
--------------------------------------------------
-------------------------------------FSEREASDILYVI
SKTVDYLHCQ------------GVVHRDLKPSNILYMDESASA-------
--------DSIRICDFGFAKQLRGEN------------------------
-----------------------------GLLLTPCYTANFVAPEVLMQ-
--------------------QGY-------DAACDIWSLGVLFYTMLAG-
-----------YTPFANGPND---------------TPEEILLRIGNGKF
SL------------------------------------------------
----------------------SGGNWDNISDG---AKDLLSHMLH----
MDPHQRYTA-------EQILKHSWI------------------------
>MSK1-b
DLKDKPLGEGSFSICRKCVHKKSN--------------------------
--------QAFAVKIISKRME-----------------------------
ANTQKEITALKLCEG-----------------HPNIVKLHEVFHD-----
-----------------------------------------QLHTFLVME
LLNG----------------------------------------------
--GELFERIKKKKH------------------------------------
--------------------------------------------------
-------------------------------------FSETEASYIMRKL
VSAVSHMHDV------------GVVHRDLKPENLLFTDENDN--------
--------LEIKIIDFGFARLKPPDN------------------------
-----------------------------QPLKTPCFTLHYAAPELLNQ-
--------------------NGY-------DESCDLWSLGVILYTMLSG-
-----------QVPFQSHDRS------------------LTCTSAVEIMK
KIKKGDFSF-----------------------------------------
----------------------EGEAWKNVSQE---AKDLIQGLLT----
VDPNKRLKM-------SGLRYNEWL------------------------
>MSK2-b
------LGQGSFSVCRRCRQRQSG--------------------------
--------QEFAVKILSRRLE-----------------------------
ANTQREVAALRLCQS-----------------HPNVVNLHEVHHD-----
-----------------------------------------QLHTYLVLE
LLRG----------------------------------------------
--GELLEHIRKKRH------------------------------------
--------------------------------------------------
-------------------------------------FSESEASQILRSL
VSAVSFMHEEA-----------GVVHRDLKPENILYADDTPG--------
--------APVKIIDFGFARLRPQSP------------------------
----------------------------GVPMQTPCFTLQYAAPELLAQ-
--------------------QGY-------DESCDLWSLGVILYMMLSG-
-----------QVPFQGASGQ------------------GGQSQAAEIMC
KIREGRFSL-----------------------------------------
----------------------DGEAWQGVSEE---AKELVRGLLT----
VDPAKRLKL-------EGLRGSSWL------------------------
>CASK
YELCEVIGKGPFSVVRRCINRETG--------------------------
--------QQFAVKIVDVAKFTSSPG---------------------LST
EDLKREASICHMLK------------------HPHIVELLETYSS-----
-----------------------------------------DGMLYMVFE
FMDG----------------------------------------------
--ADLCFEIVKRADAG----------------------------------
--------------------------------------------------
-----------------------------------FVYSEAVASHYMRQI
LEALRYCHDN------------NIIHRDVKPHCVLLASKENS--------
--------APVKLGGFGVAIQLGES-------------------------
----------------------------GLVAGGRVGTPHFMAPEVVKR-
--------------------EPY-------GKPVDVWGCGVILFILLSG-
-----------CLPFYGTKER------------------LFEGIIKGKYK
MN------------------------------------------------
-----------------------PRQWSHISES---AKDLVRRMLM----
LDPAERITV-------YEALNHPWL------------------------
>CaMK2a
YQLFEELGKGAFSVVRRCVKVLAG--------------------------
--------QEYAAKIINTKKLSARD------------------------H
QKLEREARICRLLK------------------HPNIVRLHDSISE-----
-----------------------------------------EGHHYLIFD
LVTG----------------------------------------------
--GELFEDIVAREY------------------------------------
--------------------------------------------------
-------------------------------------YSEADASHCIQQI
LEAVLHCHQM------------GVVHRDLKPENLLLASKLKG--------
--------AAVKLADFGLAIEVEGE-------------------------
----------------------------QQAWFGFAGTPGYLSPEVLRK-
--------------------DPY-------GKPVDLWACGVILYILLVG-
-----------YPPFWDEDQH------------------RLYQQIKAGAY
DF------------------------------------------------
----------------------PSPEWDTVTPE---AKDLINKMLT----
INPSKRITA-------AEALKHPWI------------------------
>CaMK2b
YQLYEDIGKGAFSVVRRCVKLCTG--------------------------
--------HEYAAKIINTKKLSARD------------------------H
QKLEREARICRLLK------------------HSNIVRLHDSISE-----
-----------------------------------------EGFHYLVFD
LVTG----------------------------------------------
--GELFEDIVAREY------------------------------------
--------------------------------------------------
-------------------------------------YSEADASHCIQQI
LEAVLHCHQM------------GVVHRDLKPENLLLASKCKG--------
--------AAVKLADFGLAIEVQGD-------------------------
----------------------------QQAWFGFAGTPGYLSPEVLRK-
--------------------EAY-------GKPVDIWACGVILYILLVG-
-----------YPPFWDEDQH------------------KLYQQIKAGAY
DF------------------------------------------------
----------------------PSPEWDTVTPE---AKNLINQMLT----
INPAKRITA-------HEALKHPWV------------------------
>CaMK2g
YQLFEELGKGAFSVVRRCVKKTST--------------------------
--------QEYAAKIINTKKLSARD------------------------H
QKLEREARICRLLK------------------HPNIVRLHDSISE-----
-----------------------------------------EGFHYLVFD
LVTG----------------------------------------------
--GELFEDIVAREY------------------------------------
--------------------------------------------------
-------------------------------------YSEADASHCIHQI
LESVNHIHQH------------DIVHRDLKPENLLLASKCKG--------
--------AAVKLADFGLAIEVQGE-------------------------
----------------------------QQAWFGFAGTPGYLSPEVLRK-
--------------------DPY-------GKPVDIWACGVILYILLVG-
-----------YPPFWDEDQH------------------KLYQQIKAGAY
DF------------------------------------------------
----------------------PSPEWDTVTPE---AKNLINQMLT----
INPAKRITA-------DQALKHPWV------------------------
>CaMK2d
YQLFEELGKGAFSVVRRCMKIPTG--------------------------
--------QGYAAKIINTKKLSARD------------------------H
QKLEREARICRLLK------------------HPNIVRLHDSISE-----
-----------------------------------------EGFHYLVFD
LVTG----------------------------------------------
--GELFEDIVAREY------------------------------------
--------------------------------------------------
-------------------------------------YSEADASHCIQQI
LESVNHCHLN------------GIVHRDLKPENLLLASKSKG--------
--------AAVKLADFGLAIEVQGD-------------------------
----------------------------QQAWFGFAGTPGYLSPEVLRK-
--------------------DPY-------GKPVDMWACGVILYILLVG-
-----------YPPFWDEDQH------------------RLYQQIKAGAY
DF------------------------------------------------
----------------------PSPEWDTVTPE---AKDLINKMLT----
INPAKRITA-------SEALKHPWI------------------------
>phk_2phk.PDB
YEPKEILGRGVSSVVRRCIHKPTC--------------------------
--------KEYAVKIIDVTGGGSFSAEEVQ-----------------ELR
EATLKEVDILRKVSG-----------------HPNIIQLKDTYET-----
-----------------------------------------NTFFFLVFD
LMKK----------------------------------------------
--GELFDYLTEKVT------------------------------------
--------------------------------------------------
-------------------------------------LSEKETRKIMRAL
LEVICALHKL------------NIVHRDLKPENILLDDD-----------
--------MNIKLTDFGFSCQLDP--------------------------
----------------------------GEKLREVCGTPSYLAPEIIECS
MNDNH---------------PGY-------GKEVDMWSTGVIMYTLLAG-
-----------SPPFWHRKQM------------------LMLRMIMSGNY
QF------------------------------------------------
----------------------GSPEWDDYSDT---VKDLVSRFLV----
VQPQKRYTA-------EEALAHPFFQQ----------------------
>PHKg1
YEPKEILGRGVSSVVRRCIHKPTS--------------------------
--------QEYAVKVIDVTGGGSFSPEEVR-----------------ELR
EATLKEVDILRKVSG-----------------HPNIIQLKDTYET-----
-----------------------------------------NTFFFLVFD
LMKR----------------------------------------------
--GELFDYLTEKVT------------------------------------
--------------------------------------------------
-------------------------------------LSEKETRKIMRAL
LEVICTLHKL------------NIVHRDLKPENILLDDN-----------
--------MNIKLTDFGFSCQLEP--------------------------
----------------------------GERLREVCGTPSYLAPEIIECS
MNEDH---------------PGY-------GKEVDMWSTGVIMYTLLAG-
-----------SPPFWHRKQM------------------LMLRMIMSGNY
QF------------------------------------------------
----------------------GSPEWDDYSDT---VKDLVSRFLV----
VQPQNRYTA-------EEALAHPFF------------------------
>PHKg2
YDPKDVIGRGVSSVVRRCVHRATG--------------------------
--------HEFAVKIMEVTAERLSPEQLEE------------------VR
EATRRETHILRQVAG-----------------HPHIITLIDSYES-----
-----------------------------------------SSFMFLVFD
LMRK----------------------------------------------
--GELFDYLTEKVA------------------------------------
--------------------------------------------------
-------------------------------------LSEKETRSIMRSL
LEAVSFLHAN------------NIVHRDLKPENILLDDN-----------
--------MQIRLSDFGFSCHLEP--------------------------
----------------------------GEKLRELCGTPGYLAPEILKCS
MDETH---------------PGY-------GKEVDLWACGVILFTLLAG-
-----------SPPFWHRRQI------------------LMLRMIMEGQY
QF------------------------------------------------
----------------------SSPEWDDRSST---VKDLISRLLQ----
VDPEARLTA-------EQALQHPFF------------------------
>CHK2
YIMSKTLGSGACGEVKLAFERKTC--------------------------
--------KKVAIKIISKRKFAIGSAREAD------------------PA
LNVETEIEILKKLN------------------HPCIIKIKNFFDA-----
------------------------------------------EDYYIVLE
LMEG----------------------------------------------
--GELFDKVVGNKR------------------------------------
--------------------------------------------------
-------------------------------------LKEATCKLYFYQM
LLAVQYLHEN------------GIIHRDLKPENVLLSSQEED--------
--------CLIKITDFGHSKILGE--------------------------
----------------------------TSLMRTLCGTPTYLAPEVLVSV
GT------------------AGY-------NRAVDCWSLGVILFICLSG-
-----------YPPFSEHRTQ-----------------VSLKDQITSGKY
NF------------------------------------------------
----------------------IPEVWAEVSEK---ALDLVKKLLV----
VDPKARFTT-------EEALRHPWL------------------------
>DCAMKL1
YKVGRTIGDGNFAVVKECVERSTA--------------------------
--------REYALKIIKKSKCRGK-------------------------E
HMIQNEVSILRRVK------------------HPNIVLLIEEMDV-----
-----------------------------------------PTELYLVME
LVKG----------------------------------------------
--GDLFDAITSTNK------------------------------------
--------------------------------------------------
-------------------------------------YTERDASGMLYNL
ASAIKYLHSL------------NIVHRDIKPENLLVYEHQDGS-------
--------KSLKLGDFGLATIVD---------------------------
-----------------------------GPLYTVCGTPTYVAPEIIAE-
--------------------TGY-------GLKVDIWAAGVITYILLCG-
-----------FPPFRGSGDD----------------QEVLFDQILMGQV
DF------------------------------------------------
----------------------PSPYWDNVSDS---AKELITMMLL----
VDVDQRFSA-------VQVLEHPWV------------------------
>DCAMKL2
YKIGKVIGDGNFAVVKECIDRSTG--------------------------
--------KEFALKIIDKAKCCGK-------------------------E
HLIENEVSILRRVK------------------HPNIIMLVEEMET-----
-----------------------------------------ATELFLVME
LVKG----------------------------------------------
--GDLFDAITSSTK------------------------------------
--------------------------------------------------
-------------------------------------YTERDGSAMVYNL
ANALRYLHGL------------SIVHRDIKPENLLVCEYPDGT-------
--------KSLKLGDFGLATVVE---------------------------
-----------------------------GPLYTVCGTPTYVAPEIIAE-
--------------------TGY-------GLKVDIWAAGVITYILLCG-
-----------FPPFRSENNL----------------QEDLFDQILAGKL
EF------------------------------------------------
----------------------PAPYWDNITDS---AKELISQMLQ----
VNVEARCTA-------GQILSHPWV------------------------
>DCAMKL3
YETGRVIGDGNFAVVKECRHRETR--------------------------
--------QAYAMKIIDKSRLKGK-------------------------E
DMVDSEILIIQSLS------------------HPNIVKLHEVYET-----
-----------------------------------------DMEIYLILE
YVQG----------------------------------------------
--GDLFDAIIESVK------------------------------------
--------------------------------------------------
-------------------------------------FPEPDAALMIMDL
CKALVHMHDK------------SIVHRDLKPENLLVQRNEDKS-------
--------TTLKLADFGLAKHVV---------------------------
-----------------------------RPIFTVCGTPTYVAPEILSE-
--------------------KGY-------GLEVDMWAAGVILYILLCG-
-----------FPPFRSPERD----------------QDELFNIIQLGHF
EFL-----------------------------------------------
-----------------------PPYWDNISDA---AKDLVSRLLV----
VDPKKRYTA-------HQVLQHPWI------------------------
>VACAMKL
YDLGQVIKTEEFCEIFRAKDKTTG--------------------------
--------KLHTCKKFQKRDGRKVR-------------------------
KAAKNEIGILKMVK------------------HPNILQLVDVFVT-----
-----------------------------------------RKEYFIFLE
LATG----------------------------------------------
--REVFDWILDQGY------------------------------------
--------------------------------------------------
-------------------------------------YSERDTSNVVRQV
LEAVAYLHSL------------KIVHRNLKLENLVYYNRLKNS-------
---------KIVISDFHLAKLEN---------------------------
-----------------------------GLIKEPCGTPEYLG-------
--------------------------------------------------
-----------NPPFYEEVEEDDYENHDK----------NLFRKILAGDY
EFDS----------------------------------------------
------------------------PYWDDISQA---AKDLVTRLME----
VEQDQRITA-------EEAISHEWI------------------------
>PSKH1
YDIKALIGRGSFSRVVRVEHRATR--------------------------
--------QPYAIKMIETKYREGR--------------------------
EVCESELRVLRRVR------------------HANIIQLVEVFET-----
-----------------------------------------QERVYMVME
LATG----------------------------------------------
--GELFDRIIAKGS------------------------------------
--------------------------------------------------
-------------------------------------FTERDATRVLQMV
LDGVRYLHAL------------GITHRDLKPENLLYYHPGTD--------
--------SKIIITDFGLASARKKG-------------------------
---------------------------DDCLMKTTCGTPEYIAPEVLVR-
--------------------KPY-------TNSVDMWALGVIAYILLSG-
-----------TMPFEDDNRT------------------RLYRQILRGKY
SYSGE---------------------------------------------
-------------------------PWPSVSNL---AKDFIDRLLT----
VDPGARMTA-------LQALRHPWV------------------------
>PSKH2
YDIKALIGTGSFSRVVRVEQKTTK--------------------------
--------KPFAIKVMETREREGR--------------------------
EACVSELSVLRRVS------------------HRYIVQLMEIFET-----
-----------------------------------------EDQVYMVME
LATG----------------------------------------------
--GELFDRLIAQGS------------------------------------
--------------------------------------------------
-------------------------------------FTERDAVRILQMV
ADGIRYLHAL------------QITHRNLKPENLLYYHPGEE--------
--------SKILITDFGLAYSGKKS-------------------------
---------------------------GDWTMKTLCGTPEYIAPEVLLR-
--------------------KPY-------TSAVDMWALGVITYALLSG-
-----------FLPFDDESQT------------------RLYRKILKGKY
NYTGE---------------------------------------------
-------------------------PWPSISHL---AKDFIDKLLI----
LEAGHRMSA-------GQALDHPWV------------------------
>CaMK1a
YDFRDVLGTGAFSEVILAEDKRTQ--------------------------
--------KLVAIKCIAKEALEGK-------------------------E
GSMENEIAVLHKIK------------------HPNIVALDDIYES-----
-----------------------------------------GGHLYLIMQ
LVSG----------------------------------------------
--GELFDRIVEKGF------------------------------------
--------------------------------------------------
-------------------------------------YTERDASRLIFQV
LDAVKYLHDL------------GIVHRDLKPENLLYYSLDED--------
--------SKIMISDFGLSKMEDP--------------------------
----------------------------GSVLSTACGTPGYVAPEVLAQ-
--------------------KPY-------SKAVDCWSIGVIAYILLCG-
-----------YPPFYDENDA------------------KLFEQILKAEY
EFDS----------------------------------------------
------------------------PYWDDISDS---AKDFIRHLME----
KDPEKRFTC-------EQALQHPWI------------------------
>CaMK1b
YEIRERLGSGAFSEVVLAQERGSA--------------------------
--------HLVALKCIPKKALRGK-------------------------E
ALVENEIAVLRRIS------------------HPNIVALEDVHES-----
-----------------------------------------PSHLYLAME
LVTG----------------------------------------------
--GELFDRIMERGS------------------------------------
--------------------------------------------------
-------------------------------------YTEKDASHLVGQV
LGAVSYLHSL------------GIVHRDLKPENLLYATPFED--------
--------SKIMVSDFGLSKIQAG--------------------------
-----------------------------NMLGTACGTPGYVAPELLEQ-
--------------------KPY-------GKAVDVWALGVISYILLCG-
-----------YPPFYDESDP------------------ELFSQILRASY
EFDS----------------------------------------------
------------------------PFWGDISES---AKDFIRHLLE----
RDPQKRFTC-------QQALRHLWV------------------------
>CaMK1g
FIFMEVLGSGAFSEVFLVKQRLTG--------------------------
--------KLFALKCIKKSPAFR--------------------------D
SSLENEIAVLKKIK------------------HENIVTLEDIYES-----
-----------------------------------------TTHYYLVMQ
LVSG----------------------------------------------
--GELFDRILERGV------------------------------------
--------------------------------------------------
-------------------------------------YTEKDASLVIQQV
LSAVKYLHEN------------GIVHRDLKPENLLYLTPEEN--------
--------SKIMITDFGLSKMEQN--------------------------
-----------------------------GIMSTACGTPGYVAPEVLAQ-
--------------------KPY-------SKAVDCWSIGVITYILLCG-
-----------YPPFYEETES------------------KLFEKIKEGYY
EFES----------------------------------------------
------------------------PFWDDISES---AKDFICHLLE----
KDPNERYTC-------EKALSHPWI------------------------
>CaMK1d
FEFKETLGTGAFSEVVLAEEKATG--------------------------
--------KLFAVKCIPKKALKGK-------------------------E
SSIENEIAVLRKIK------------------HENIVALEDIYES-----
-----------------------------------------PNHLYLVMQ
LVSG----------------------------------------------
--GELFDRIVEKGF------------------------------------
--------------------------------------------------
-------------------------------------YTEKDASTLIRQV
LDAVYYLHRM------------GIVHRDLKPENLLYYSQDEE--------
--------SKIMISDFGLSKMEGKG-------------------------
-----------------------------DVMSTACGTPGYVAPEVLAQ-
--------------------KPY-------SKAVDCWSIGVIAYILLCG-
-----------YPPFYDENDS------------------KLFEQILKAEY
EFDS----------------------------------------------
------------------------PYWDDISDS---AKDFIRNLME----
KDPNKRYTC-------EQAARHPWI------------------------
>CaMK4
FEVESELGRGATSIVYRCKQKGTQ--------------------------
--------KPYALKVLKKTVD----------------------------K
KIVRTEIGVLLRLS------------------HPNIIKLKEIFET-----
-----------------------------------------PTEISLVLE
LVTG----------------------------------------------
--GELFDRIVEKGY------------------------------------
--------------------------------------------------
-------------------------------------YSERDAADAVKQI
LEAVAYLHEN------------GIVHRDLKPENLLYATPAPD--------
--------APLKIADFGLSKIVEHQ-------------------------
-----------------------------VLMKTVCGTPGYCAPEILRG-
--------------------CAY-------GPEVDMWSVGIITYILLCG-
-----------FEPFYDERGD------------------QFMFRRILNCE
YYFIS---------------------------------------------
------------------------PWWDEVSLN---AKDLVRKLIV----
LDPKKRLTT-------FQALQHPWV------------------------
>