Additional domains and groups
list of covariation partners, PHK.human sequence as reference
PAK1 residue,number (entropy) -- covariation partners
Y1 (2.90) covaries with -- 3 17 31 84 91 126 132 185 218 219 263 273 275 282 351 362
T2 (3.73) covaries with -- 51 93 95 252 350
R3 (3.72) covaries with -- 1 5 16 29 35 65 95 129 137 185 266 267 273 347 352
F4 (3.60) covaries with -- 8 354 362
E5 (3.89) covaries with -- 3 17 127 273
K6 (3.86) covaries with -- 10 39 49 84 348
I7 (2.14) covaries with -- 88
G8 (1.82) covaries with -- 4
Q9 (3.56) covaries with -- 51 66 67 68 94 95 225 243 329 332
G10 (0.87) covaries with -- 6 15
A11 (2.87) covaries with -- 188 263 346
S12 (2.81) covaries with -- 15 20 54 82 105 180 262 273 354 356
G13 (1.67) covaries with -- 186 343
T14 (3.57) covaries with -- 19 22 99 100 165 340 346
V15 (1.50) covaries with -- 10 12
Y16 (3.19) covaries with -- 3 55 65 136 218 268 273 279
T17 (3.49) covaries with -- 1 5 21 39 207
A18 (2.55) covaries with -- 90
M19 (3.61) covaries with -- 14
D20 (3.54) covaries with -- 12 68 183
V21 (3.54) covaries with -- 17 52 115
A22 (3.76) covaries with -- 14 81 86 134 211
-23 (3.70) covaries with --
-24 (2.75) covaries with --
-25 (2.58) covaries with --
-26 (2.78) covaries with --
T27 (3.16) covaries with --
G28 (3.27) covaries with --
Q29 (3.63) covaries with -- 3 136 146 239 243
E30 (3.44) covaries with -- 60 106 185
V31 (2.76) covaries with -- 1 35 51 57 83 84 93 130 183 209 219 226 229 240 252 265 266 274 275 280 362
A32 (1.07) covaries with -- 96
I33 (2.56) covaries with -- 54 93 146 252 268 274
K34 (0.81) covaries with --
Q35 (3.39) covaries with -- 3 31 56 58 59 130 133 135 143 152 186 211 218 265 275 277
M36 (2.67) covaries with -- 58 82 94 158 188 211 214 216 265
N37 (3.76) covaries with -- 50 57 91 95 110 112 133 213 214 217 219 243 260 280 344
L38 (3.45) covaries with -- 40 348
Q39 (3.81) covaries with -- 6 17 60 69 96 166 183 214 226 273 275
Q40 (3.85) covaries with -- 38 55 80 91 109 130 160 186 243 259 260 265 268
Q41 (3.54) covaries with -- 60 133 347
-42 (3.54) covaries with --
-43 (3.21) covaries with --
-44 (2.99) covaries with --
-45 (1.57) covaries with --
-46 (2.80) covaries with --
-47 (3.41) covaries with -- 238
-48 (2.83) covaries with -- 54
-49 (3.63) covaries with -- 6 51 110 111 189 203 204
-50 (3.71) covaries with -- 37 166 203 204 243
-51 (3.93) covaries with -- 2 9 31 49 54 60 67 203 219 245 253 348 378
-52 (3.73) covaries with -- 21 133
P53 (3.43) covaries with -- 236 279 348
K54 (3.92) covaries with -- 12 33 48 51 57 59 88 92 93 155 165 179 185 189 203 214 236 243 263 275 343 348 350
K55 (3.65) covaries with -- 16 40 60 83 100 108 112 114 137 179 211 236 238 266 276 279 282 348 356 390
E56 (3.54) covaries with -- 35 106 127 133 136 205 209 210 214 240 276 280
L57 (3.64) covaries with -- 31 37 54 86 106 143 159 160 165 185 203 212 219 227 254 273
I58 (2.59) covaries with -- 35 36 80 98 144 268 398
I59 (3.77) covaries with -- 35 54 111 127 130 185 252 267 268 273 275 347
N60 (3.45) covaries with -- 30 39 41 51 55 91 108 133 185 188 211 226 258 348
E61 (1.28) covaries with -- 65
I62 (2.95) covaries with -- 67 80 83 188 212 218 219 243 263 348
L63 (3.75) covaries with -- 69 106 130 137 177 207 226 227 259 280 346 365
V64 (2.87) covaries with -- 91 106 262 343 347 349 351 365 398
M65 (2.88) covaries with -- 3 16 61 112 213 216 218 246 266 268 277 348
R66 (3.35) covaries with -- 9 74 80 217 268 352
E67 (3.65) covaries with -- 9 51 62 86 91 96 179 212 214 218 277 349 365
N68 (3.15) covaries with -- 9 20 159 216 252 354
K69 (3.65) covaries with -- 39 63 76 115 264
-70 (3.23) covaries with --
-71 (0.00) covaries with --
-72 (1.00) covaries with --
-73 (2.70) covaries with --
N74 (2.19) covaries with -- 66 90
P75 (3.29) covaries with -- 189
N76 (2.76) covaries with -- 69 90 114 188 268
I77 (2.11) covaries with --
V78 (2.20) covaries with --
N79 (3.36) covaries with -- 82 177 355
Y80 (2.49) covaries with -- 40 58 62 66 218 259 268 347
L81 (3.04) covaries with -- 22 91 180 184 186 215
D82 (2.75) covaries with -- 12 36 79 161 343
S83 (3.11) covaries with -- 31 55 62 85 185 187 213 280
Y84 (3.58) covaries with -- 1 6 31 92 108 163 210 240 354 357
L85 (3.75) covaries with -- 83 107 114
V86 (3.87) covaries with -- 22 57 67 94 110 188 208
-87 (3.54) covaries with --
-88 (3.88) covaries with -- 7 54 133 186
G89 (3.52) covaries with --
D90 (3.61) covaries with -- 18 74 76 91 115 251
E91 (3.81) covaries with -- 1 37 40 60 64 67 81 90 133 183 186 210 211 214 273 367
L92 (2.81) covaries with -- 54 84 159 218 219 266 271 274 275 276 390
W93 (3.20) covaries with -- 2 31 33 54 133 155 218 227 242
V94 (2.30) covaries with -- 9 36 86 180
V95 (2.62) covaries with -- 2 3 9 37 132 134 135 153 210 244 265 368 371
M96 (1.83) covaries with -- 32 39 67 180 216 259 274
E97 (1.20) covaries with -- 113 177 186 188 281
Y98 (2.44) covaries with -- 58 213 382
L99 (2.21) covaries with -- 14 112 130 155 240 243 252 276 362
A100 (3.29) covaries with -- 14 55 185 186 189 348
G101 (2.94) covaries with --
-102 (0.00) covaries with --
G103 (1.96) covaries with -- 212 356
S104 (1.93) covaries with --
L105 (2.33) covaries with -- 12 172
T106 (3.27) covaries with -- 30 56 57 63 64 160 258 262 343 352
D107 (3.38) covaries with -- 85 139 188 274 390
V108 (2.78) covaries with -- 55 60 84 153 185 218 258
V109 (2.98) covaries with -- 40 139 185 213 244
T110 (3.58) covaries with -- 37 49 86 258 354
E111 (3.94) covaries with -- 49 59 229 238 245 273
-112 (3.84) covaries with -- 37 55 65 99 130 133 137 165 176 207 210 211 212 214 218 225 236 262 266 273 354
-113 (3.61) covaries with -- 97 115 238 353
-114 (3.60) covaries with -- 55 76 85 131 207 211 276
-115 (3.96) covaries with -- 21 69 90 113 368
-116 (2.85) covaries with --
-117 (2.98) covaries with --
-118 (2.97) covaries with --
-119 (2.00) covaries with --
-120 (2.32) covaries with --
-121 (3.26) covaries with --
-122 (3.06) covaries with --
-123 (3.16) covaries with --
T124 (3.45) covaries with -- 352
C125 (3.64) covaries with -- 133 144
M126 (2.62) covaries with -- 1 145 243 275
D127 (3.35) covaries with -- 5 56 59 254
E128 (1.55) covaries with --
G129 (3.93) covaries with -- 3 185 355
Q130 (3.79) covaries with -- 31 35 40 59 63 99 112 155 189 238 266 341
I131 (2.24) covaries with -- 114 212 255
A132 (3.06) covaries with -- 1 95 133 134 163 177 207 243 263 274 362
A133 (3.90) covaries with -- 35 37 41 52 56 60 88 91 93 112 125 132 137 159 177 185 188 189 212 214 217 218 219 242 259 263 268 275 349
V134 (2.47) covaries with -- 22 95 132 137 183 185 214 224 354 358
C135 (2.84) covaries with -- 35 95 243 271 276 280
R136 (3.65) covaries with -- 16 29 56 146 185 243 267
E137 (2.86) covaries with -- 3 55 63 112 133 134 139 210 224 265 268 277 279 282 354 361
C138 (2.68) covaries with -- 160 353
L139 (1.96) covaries with -- 107 109 137 146 213 243 390
Q140 (3.55) covaries with -- 360
A141 (1.09) covaries with --
L142 (1.65) covaries with --
E143 (3.72) covaries with -- 35 57 166 175
F144 (2.58) covaries with -- 58 125 213
L145 (1.36) covaries with -- 126
H146 (1.28) covaries with -- 29 33 136 139 217 279
S147 (3.51) covaries with -- 329 333
N148 (3.35) covaries with -- 186 280 376
-149 (3.00) covaries with --
-150 (1.00) covaries with --
Q151 (3.25) covaries with -- 346
V152 (2.61) covaries with -- 35 186 188 215
I153 (2.16) covaries with -- 95 108
H154 (0.19) covaries with --
R155 (1.27) covaries with -- 54 93 99 130 163 183 185 211 263 265
D156 (0.97) covaries with -- 204
I157 (1.67) covaries with --
K158 (0.75) covaries with -- 36
S159 (2.06) covaries with -- 57 68 92 133 165 225 243 258 266
D160 (2.77) covaries with -- 40 57 106 138 213
N161 (0.82) covaries with -- 82
I162 (1.69) covaries with -- 253
L163 (1.41) covaries with -- 84 132 155 176 179 206
L164 (2.34) covaries with -- 266
G165 (3.02) covaries with -- 14 54 57 112 159 351 353
-166 (3.76) covaries with -- 39 50 143
-167 (3.62) covaries with -- 175 202 256 266
-168 (2.37) covaries with --
-169 (0.97) covaries with --
-170 (1.00) covaries with --
-171 (1.00) covaries with --
M172 (3.82) covaries with -- 105 242
d173 (3.43) covaries with --
G174 (2.17) covaries with -- 378
S175 (3.87) covaries with -- 143 167 213 243 346 378
V176 (2.15) covaries with -- 112 163 218
K177 (1.65) covaries with -- 63 79 97 132 133 343
L178 (1.56) covaries with -- 203 354
T179 (2.43) covaries with -- 54 55 67 163 352 372
D180 (0.49) covaries with -- 12 81 94 96 185 212 216
F181 (1.23) covaries with --
G182 (0.87) covaries with -- 216 225 263
F183 (2.59) covaries with -- 20 31 39 91 134 155 186 207 209 211 212 218 258 263 274 351 354
C184 (2.05) covaries with -- 81 215 216
A185 (2.93) covaries with -- 1 3 30 54 57 59 60 83 100 108 109 129 133 134 136 155 180 186 187 209 210 212 213 214 215 248 258 266 276
Q186 (3.82) covaries with -- 13 35 40 81 88 91 97 100 148 152 183 185 188 189 209 212 219 226 242 252 257 263 271 275 280 321 339 341 346 351
I187 (2.83) covaries with -- 83 185 226
T188 (3.75) covaries with -- 11 36 60 62 76 86 97 107 133 152 186 228 243 255 263 273
P189 (3.66) covaries with -- 49 54 75 100 130 133 186 207 238 348 354
-190 (0.00) covaries with --
-191 (1.58) covaries with --
-192 (1.00) covaries with --
-193 (2.00) covaries with --
-194 (2.00) covaries with --
-195 (2.00) covaries with --
-196 (2.58) covaries with --
-197 (2.80) covaries with --
-198 (2.80) covaries with --
-199 (3.15) covaries with --
-200 (3.25) covaries with --
-201 (2.92) covaries with -- 203 205
-202 (3.37) covaries with -- 167
-203 (3.85) covaries with -- 49 50 51 54 57 178 201 211
-204 (3.68) covaries with -- 49 50 156 210 275
-205 (3.59) covaries with -- 56 201 206
E206 (3.63) covaries with -- 163 205 209
Q207 (3.93) covaries with -- 17 63 112 114 132 183 189 226 280 282
S208 (3.84) covaries with -- 86 210 212 229 347
K209 (3.80) covaries with -- 31 56 183 185 186 206 266 268 274 278
R210 (3.77) covaries with -- 56 84 91 95 112 137 185 204 208 219 242 243 263 277 351
S211 (3.79) covaries with -- 22 35 36 55 60 91 112 114 155 183 203
T212 (3.24) covaries with -- 57 62 67 103 112 131 133 180 183 185 186 208 216 219 263 268 274
M213 (3.29) covaries with -- 37 65 83 98 109 139 144 160 175 185 217 218 258 275 277
V214 (3.24) covaries with -- 36 37 39 54 56 67 91 112 133 134 185 219 249 252 274 276 350 351 362
G215 (0.99) covaries with -- 81 152 184 185 216 354
T216 (1.86) covaries with -- 36 65 68 96 180 182 184 212 215 279
P217 (3.08) covaries with -- 37 66 133 146 213 263 266 273 276 278
Y218 (3.29) covaries with -- 1 16 35 62 65 67 80 92 93 108 112 133 176 183 213 224 252 265 274 279 347
W219 (1.71) covaries with -- 1 31 37 51 57 62 92 133 186 210 212 214 224 225 243 267 276 347
M220 (1.35) covaries with --
A221 (1.37) covaries with --
P222 (0.37) covaries with --
E223 (0.19) covaries with --
V224 (2.48) covaries with -- 134 137 218 219 243 252 268 347
V225 (2.51) covaries with -- 9 112 159 182 219 226 249 263 281
T226 (3.70) covaries with -- 31 39 60 63 186 187 207 225 273 280 281 282 341 347 352 354
R227 (3.52) covaries with -- 57 63 93 258 276
-228 (3.45) covaries with -- 188 229 349
-229 (3.69) covaries with -- 31 111 208 228 236
-230 (3.46) covaries with --
-231 (2.21) covaries with --
-232 (2.80) covaries with --
-233 (2.31) covaries with --
-234 (2.58) covaries with --
-235 (3.09) covaries with --
-236 (3.66) covaries with -- 53 54 55 112 229 266
-237 (3.50) covaries with --
K238 (3.65) covaries with -- 47 55 111 113 130 189 279 391
A239 (3.51) covaries with -- 29
Y240 (3.00) covaries with -- 31 56 84 99 242
-241 (2.90) covaries with --
G242 (2.98) covaries with -- 93 133 172 186 210 240 244 334
P243 (3.85) covaries with -- 9 29 37 40 50 54 62 99 126 132 135 136 139 159 175 188 210 219 224 245 260 265 279 347
K244 (2.88) covaries with -- 95 109 242
V245 (2.38) covaries with -- 51 111 243 253 258
D246 (0.71) covaries with -- 65 346
I247 (1.42) covaries with --
W248 (0.98) covaries with -- 185 277
S249 (1.31) covaries with -- 214 225
L250 (2.29) covaries with -- 365
G251 (0.66) covaries with -- 90
I252 (1.94) covaries with -- 2 31 33 59 68 99 186 214 218 224 258 263 275 362
M253 (2.26) covaries with -- 51 162 245
A254 (2.64) covaries with -- 57 127 259
I255 (2.30) covaries with -- 131 188 257 275 280 349 363
E256 (0.91) covaries with -- 167
M257 (2.25) covaries with -- 186 255
I258 (2.87) covaries with -- 60 106 108 110 159 183 185 213 227 245 252 275
E259 (3.39) covaries with -- 40 63 80 96 133 254 265 267 341 354
G260 (2.83) covaries with -- 37 40 243
-261 (2.00) covaries with --
E262 (3.63) covaries with -- 12 64 106 112 279 354 357
P263 (3.20) covaries with -- 1 11 54 62 132 133 155 182 183 186 188 210 212 217 225 252 265 266 267 347
P264 (1.40) covaries with -- 69
Y265 (2.97) covaries with -- 31 35 36 40 95 137 155 218 243 259 263 276 282 354
L266 (3.81) covaries with -- 3 31 55 65 92 112 130 159 164 167 185 209 217 236 263 275 277 346 352 366
N267 (3.62) covaries with -- 3 59 136 219 259 263 273 279
E268 (3.72) covaries with -- 16 33 40 58 59 65 66 76 80 133 137 209 212 224 271 273 275 277 280
-269 (3.48) covaries with -- 274
-270 (3.68) covaries with -- 361
-271 (3.71) covaries with -- 92 135 186 268
-272 (3.42) covaries with --
N273 (3.48) covaries with -- 1 3 5 12 16 39 57 59 91 111 112 188 217 226 267 268 276 279
P274 (3.47) covaries with -- 31 33 92 96 107 132 183 209 212 214 218 269 276 277
L275 (3.59) covaries with -- 1 31 35 39 54 59 92 126 133 186 204 213 252 255 258 266 268 276 277 279
R276 (3.42) covaries with -- 55 56 92 99 114 135 185 214 217 219 227 265 273 274 275 279 282 354
A277 (3.14) covaries with -- 35 65 67 137 210 213 248 266 268 274 275 279 347
L278 (3.01) covaries with -- 209 217 281
Y279 (3.51) covaries with -- 16 53 55 137 146 216 218 238 243 262 267 273 275 276 277
L280 (3.62) covaries with -- 31 37 56 63 83 135 148 186 207 226 255 268 354 358
I281 (2.68) covaries with -- 97 225 226 278 356
A282 (3.13) covaries with -- 1 55 137 207 226 265 276 347
T283 (3.10) covaries with --
-284 (1.00) covaries with --
-285 (1.58) covaries with --
-286 (0.00) covaries with --
-287 (0.00) covaries with --
-288 (0.00) covaries with --
-289 (0.00) covaries with --
-290 (0.00) covaries with --
-291 (0.00) covaries with --
-292 (0.00) covaries with --
-293 (0.00) covaries with --
-294 (0.00) covaries with --
-295 (0.00) covaries with --
-296 (0.00) covaries with --
-297 (0.00) covaries with --
-298 (0.00) covaries with --
-299 (0.00) covaries with --
-300 (0.00) covaries with --
-301 (0.00) covaries with --
-302 (1.00) covaries with --
-303 (1.58) covaries with --
-304 (2.00) covaries with --
-305 (2.00) covaries with --
-306 (2.00) covaries with --
-307 (2.58) covaries with --
-308 (2.32) covaries with --
-309 (1.58) covaries with --
-310 (2.00) covaries with --
-311 (2.58) covaries with --
-312 (2.00) covaries with --
-313 (2.32) covaries with --
-314 (2.80) covaries with --
-315 (2.32) covaries with --
-316 (2.32) covaries with --
-317 (2.58) covaries with --
-318 (2.31) covaries with --
-319 (2.80) covaries with --
-320 (2.31) covaries with --
-321 (3.00) covaries with -- 186 323
-322 (3.16) covaries with --
-323 (2.80) covaries with -- 321 330
-324 (2.78) covaries with --
-325 (3.45) covaries with --
-326 (2.98) covaries with --
-327 (2.98) covaries with --
-328 (3.31) covaries with --
-329 (3.32) covaries with -- 9 147 333 343 344 379
-330 (2.99) covaries with -- 323
-331 (3.15) covaries with --
-332 (3.15) covaries with -- 9 333 367
-333 (2.96) covaries with -- 147 329 332 336 343
-334 (3.30) covaries with -- 242 344
-335 (3.29) covaries with -- 343 352 392
-336 (2.91) covaries with -- 333 338 339 343
-337 (2.91) covaries with --
-338 (3.39) covaries with -- 336 339 343
-339 (3.32) covaries with -- 186 336 338 341 342 343 346
-340 (3.82) covaries with -- 14 341 342 343 346 349
-341 (3.67) covaries with -- 130 186 226 259 339 340 349
-342 (3.30) covaries with -- 339 340
-343 (3.65) covaries with -- 13 54 64 82 106 177 329 333 335 336 338 339 340
-344 (3.73) covaries with -- 37 329 334 345 355
-345 (3.88) covaries with -- 344 371
-346 (3.80) covaries with -- 11 14 63 151 175 186 246 266 339 340 347
N347 (3.90) covaries with -- 3 41 59 64 80 208 218 219 224 226 243 263 277 282 346 348 349 372 378
G348 (3.80) covaries with -- 6 38 51 53 54 55 60 62 65 100 189 347 349 352 354 358 360 372
T349 (3.79) covaries with -- 64 67 133 228 255 340 341 347 348 355 356 357 365 371 372
P350 (3.51) covaries with -- 2 54 214 372 378
E351 (3.60) covaries with -- 1 64 165 183 186 210 214
L352 (3.78) covaries with -- 3 66 106 124 179 226 266 335 348 353 356 371
Q353 (3.69) covaries with -- 113 138 165 352
N354 (3.89) covaries with -- 4 12 68 84 110 112 134 137 178 183 189 215 226 259 262 265 276 280 348 355 358 362 368 371
P355 (3.81) covaries with -- 79 129 344 349 354 359 399
E356 (3.79) covaries with -- 12 55 103 281 349 352
K357 (3.95) covaries with -- 84 262 349 363
L358 (3.28) covaries with -- 134 280 348 354 365 366 372
S359 (2.48) covaries with -- 355 364 370 371 399
A360 (3.65) covaries with -- 140 348
I361 (3.71) covaries with -- 137 270 392 395
F362 (2.95) covaries with -- 1 4 31 99 132 214 252 354 365
R363 (3.60) covaries with -- 255 357 365
D364 (3.52) covaries with -- 359 365 396
F365 (2.32) covaries with -- 63 64 67 250 349 358 362 363 364 367 370 399
L366 (2.41) covaries with -- 266 358 369 399
N367 (3.55) covaries with -- 91 332 365
R368 (3.94) covaries with -- 95 115 354
C369 (2.48) covaries with -- 366 371
L370 (2.35) covaries with -- 359 365
D371 (3.62) covaries with -- 95 345 349 352 354 359 369
M372 (3.37) covaries with -- 179 347 348 349 350 358
-373 (0.00) covaries with --
-374 (0.00) covaries with --
-375 (0.00) covaries with --
D376 (3.05) covaries with -- 148
V377 (3.24) covaries with -- 378
E378 (3.77) covaries with -- 51 174 175 347 350 377
K379 (3.65) covaries with -- 329
R380 (0.37) covaries with --
G381 (2.94) covaries with --
S382 (2.96) covaries with -- 98
-383 (0.00) covaries with --
-384 (0.00) covaries with --
-385 (0.00) covaries with --
-386 (0.00) covaries with --
-387 (0.00) covaries with --
-388 (0.00) covaries with --
-389 (1.98) covaries with --
A390 (2.92) covaries with -- 55 92 107 139
K391 (3.75) covaries with -- 238 395
E392 (3.43) covaries with -- 335 361 394
L393 (1.78) covaries with -- 394
L394 (2.95) covaries with -- 392 393
Q395 (3.65) covaries with -- 361 391
H396 (2.79) covaries with -- 364
Q397 (3.61) covaries with --
F398 (2.45) covaries with -- 58 64
L399 (2.85) covaries with -- 355 359 365 366