Main kinase page
TKL kinases
tkl tree
TKL tree with Pfam domains included
tkl sequence alignment (warning!! insertions are deleted)
Additional domains and groups
Pfam links :
Activin_recp
ANF_receptor
Ank
Guanylate_cyc
ACT
DAG_PE-bind
SH3
LIM
LRR
PAS
PB1
PDZ
RBD
SAM
CARD
Death
DUF1162
pdb links
(1b6c)
(1ias) TGFbR1
Phospho.ELM links:
TGFbR2 (A);
ILK (D);
Click for subgroup
group A, including ALK4.h TGFbR1.h ALK7.h BMPR1B.h BMPR1A.h ALK2.h ALK1.h TGFbR2.h BMPR2.h MISR2.h ACTR2.h
group B, including TAK1.h DLK.h LZK.h MLK2.h MLK3.h MLK4.h MLK1.h ZAK.h
group C, including RIPK3.h RIPK1.h RIPK2.h ANKRD3.h SgK288.h MLKL.h SgK496.h
group D, including ILK.h ANPb.h ANPa.h HSER.h CYGF.h CYGD.h
group E, including LIMK2.h LIMK1.h TESK2.h TESK1.h SgK493.h KSR2.h KSR1.h SgK307.h BRAF.h RAF1.h ARAF.h
group F, including MOS.h HH498.h
group G, including NRBP2.h NRBP1.h Wnk4.h Wnk3.h Wnk2.h Wnk1.h
group H, including PBK.h LRRK2.h LRRK1.h HRIps.h
Sequence entropy, over all 5915 protein kinases (red) and 502 TKL kinases (green)
Residues which distinguish TKL from other kinases (TGFbR1.h as reference): E223 C369 H102 A389 W370 H146 L381 L105 M362 P222
residues in order of increasing entropy
covariation analysis
residues in order of decreasing number of covariation partners
list of covariation partners, .human sequence as reference